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The map label for this gene is hemC [H]

Identifier: 162218053

GI number: 162218053

Start: 2004855

End: 2005859

Strand: Reverse

Name: hemC [H]

Synonym: Bcen_1813

Alternate gene names: 162218053

Gene position: 2005859-2004855 (Counterclockwise)

Preceding gene: 107023364

Following gene: 107023361

Centisome position: 60.88

GC content: 71.44

Gene sequence:

>1005_bases
ATGAATTCCGAGACCCCCGCGGCCGGGCCGCAGCAGGCACAGCCGCCCGCGACGTTGACGATTGCTTCGCGCGAGAGCCG
CCTGGCGATGTGGCAAGCCGAACATGTGCGTGATGCGCTGCGCAAATTATATCCAGCTTGTGACGTGAAAATCCTCGGGA
TGACGACGCGCGGCGATCAGATTCTCGATCGCACGCTGTCGAAGGTCGGCGGCAAGGGCCTGTTCGTGAAGGAACTGGAA
GCCGCGCTGGCCGACGGCCGCGCCGATCTCGCCGTGCATTCGCTGAAGGACGTGCCGATGGCGCTGCCCGACGGCTTCTC
GCTCGCCGCGATCATGGAACGCGAAGACCCGCGCGATGCCTTCGTGTCGAACGACTACGCGTCGCTCGACGCGCTGCCGG
CCGGCGCGGTCGTCGGCACATCGAGCCTGCGTCGCGAGGCGATGCTGCGGTCGCGTTATCCGCATCTCGAGGTCCTGCCG
CTGCGCGGCAACCTCGACACGCGGCTCGCGAAGCTCGACCGCGGCGACTACGCGGCGATCATCCTCGCGGCCGCCGGCCT
GAAACGCCTCGGCCTCGAAGCGCGGATTCGTGCGCTGCTCGACGTCGAGGCCAGCCCGCCCGCGGCGGGCCAGGGCGCGC
TCGGCATCGAGATCGCCGCGCACCGCGACGACGTCGCCGCGTGGCTCGCGCCGCTGCACGACCCGCAGACCGCGCTCGCG
GTCGAGGCCGAGCGGATGGTGTCGCGCGCGCTCGGCGGCAGTTGCGAGGTGCCGCTCGCCGCGCACGCGGTGTGGCGCGC
GGGCGAGCTGTACCTGACGGGACGCGTGTCGACCACCGACGGCAAGCGCGTGCTGACGGCCGAGGAATGCGGCGCGGTCG
TGACCGTCGCCGATGCGCTCGCGCTCGGCCGCGCGGTGTCCGACGAACTCGAGGCGCAAGGCGCGCTCGACATCGTCCAG
GCGCTGCTCGCGAGCTCGCAGGCCGCGGGCAAGGGCGACGCCTGA

Upstream 100 bases:

>100_bases
CGCGCGGAAGCAGGCCGGGCGCAGGCTCCGGGCCCGGGCGGGCCGGGGCGTGCGTGCTACCATTGTTCGATCTTCAATCC
CGTCCTTCGATGTTCCAGCA

Downstream 100 bases:

>100_bases
TGGCGGGCGGCGCGCGCGCGTTCACCGCTGTCCTGACGCGTCCGGACGGGCAGTCCGACGCGCTTGCGGCGCAACTGGCC
GATGCCGGCTGCGACGTGCT

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLASSQAAGKGDA

Sequences:

>Translated_334_residues
MNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLASSQAAGKGDA
>Mature_334_residues
MNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQILDRTLSKVGGKGLFVKELE
AALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDAFVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLP
LRGNLDTRLAKLDRGDYAAIILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALA
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADALALGRAVSDELEAQGALDIVQ
ALLASSQAAGKGDA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=267, Percent_Identity=47.940074906367, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI66933009, Length=267, Percent_Identity=47.940074906367, Blast_Score=242, Evalue=3e-64,
Organism=Escherichia coli, GI48994974, Length=302, Percent_Identity=53.6423841059603, Blast_Score=294, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6319996, Length=319, Percent_Identity=39.4984326018809, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20130425, Length=280, Percent_Identity=45.3571428571429, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35112; Mature: 35112

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQ
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
ILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHH
FVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAKLDRGDYAAI
HHCCCCHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCHHHH
ILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALA
HHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHH
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADAL
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCCCEEHHHHHH
ALGRAVSDELEAQGALDIVQALLASSQAAGKGDA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNSETPAAGPQQAQPPATLTIASRESRLAMWQAEHVRDALRKLYPACDVKILGMTTRGDQ
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHH
ILDRTLSKVGGKGLFVKELEAALADGRADLAVHSLKDVPMALPDGFSLAAIMEREDPRDA
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHH
FVSNDYASLDALPAGAVVGTSSLRREAMLRSRYPHLEVLPLRGNLDTRLAKLDRGDYAAI
HHCCCCHHHCCCCCCCEECHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCHHHH
ILAAAGLKRLGLEARIRALLDVEASPPAAGQGALGIEIAAHRDDVAAWLAPLHDPQTALA
HHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHH
VEAERMVSRALGGSCEVPLAAHAVWRAGELYLTGRVSTTDGKRVLTAEECGAVVTVADAL
HHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEEEEEEECCCCCEEEEHHHCCCEEHHHHHH
ALGRAVSDELEAQGALDIVQALLASSQAAGKGDA
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA