Click here to switch to the map view.

The map label for this gene is thlA [H]

Identifier: 107023150

GI number: 107023150

Start: 1775782

End: 1776972

Strand: Reverse

Name: thlA [H]

Synonym: Bcen_1599

Alternate gene names: 107023150

Gene position: 1776972-1775782 (Counterclockwise)

Preceding gene: 107023151

Following gene: 107023148

Centisome position: 53.94

GC content: 69.77

Gene sequence:

>1191_bases
ATGACGACTCAGGATCCGATCGTAATCGTGGGCGCGGCGCGCACGCCGATGGGTGGTTTTCAGGGCGACCTGGCGGCGGC
GAGCGCGAGCGACCTTGGCGCGGTGGCGATTCGCGCCGCGCTCGAGCGCGCGAACGTGCCGGCCGAACGCATCGAGGAAA
TCGTGTTCGGCTGCGTGCTGCCGGCCGGCCAGGGCCAGGCGCCCGCGCGACAGGCCGCGCTGAAGGCCGGGCTGCCGCTC
GCGGCGGGCGCGACCACGGTCAACAAGATGTGCGGTTCGGGGATGAAGGCGGCGATGTTCGCGCACGACCTGCTGCTGGC
CGGTTCGGCGGCGGTGGCCGTGGCGGGCGGGATGGAGAGCATGACGAATGCGCCGTACCTGCTGCCGAAGGCGCGCGCGG
GTATGCGCATGGGGCACGGGCAGGTGCTCGACCACATGTTCCTCGACGGGCTCGAGGACGCGTATGAAAAGGGCCGCCTG
ATGGGCACCTTCGCCGAGGATTGCGCGCAGGCGTACCAGTTCACGCGCGAAGCGCAGGATGCGTTCGCGATTGCGTCGCT
GACGCGGGCGCAGCGCGCGATCGCGGAAGGGCGGTTCGTGTCGGAAATCGCGCCGGTGACCGTGAAGGCCGGCAAGACGG
AAAGCGTCGTGTCGATCGACGAGCAGCCCGGCAAGGCGAAACTCGACAAGATCCCGACGCTGAAGCCGGCGTTTCGCGAC
GGCGGCACGGTGACGGCCGCGAACGCATCGTCGATCTCGGACGGCGCGGCCGCGCTCGTGATGATGCGCCGCTCGGAGGC
CGAGCGCCTCGGCCTCACGCCGAAGGCCGTGATCGTCGGGCATGCGACTCATGCGGACAAGCCCGGCCTGTTCGCGACTG
CACCGATCGGCGCGCTGCGCAAGCTGTCGGAGAAAACCGGCTGGAACCTGCGCGACGTCGACCTGTTCGAGATCAACGAA
GCGTTCGCGGTGGTGCCGATGGCCGCGATGCGCGACCTCGATCTGCCGCACGAGAAGGTGAACGTGCACGGCGGCGCGTG
CGCGCTCGGGCATCCGATCGGCGCATCGGGTGCGCGCGTGATGGTGACGCTGCTGGCCGCGCTCGAAACGTATGGCCTGA
CGCGCGGCGTCGCATCGCTGTGCATCGGCGGCGGTGAAGCAACGGCGGTTGCGATCGAGCGCATCGCGTAA

Upstream 100 bases:

>100_bases
GGTGCGCCACATCGCCGAGAACACGATGCTGAACGGCGAAGTCATCCGTCTCGATGGCGCGTTGCGCATGGCACCGCGCT
GACACTGGAGGAAGCGAATC

Downstream 100 bases:

>100_bases
CACTTCGCATCACGCATCACGTCGCATCGCATCGCATCGTTCGCACGGATGTGGCATCACGGGGGGCGCGTATCGCACGG
GACATCCCCGTGCGGTACGC

Product: Acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MTTQDPIVIVGAARTPMGGFQGDLAAASASDLGAVAIRAALERANVPAERIEEIVFGCVLPAGQGQAPARQAALKAGLPL
AAGATTVNKMCGSGMKAAMFAHDLLLAGSAAVAVAGGMESMTNAPYLLPKARAGMRMGHGQVLDHMFLDGLEDAYEKGRL
MGTFAEDCAQAYQFTREAQDAFAIASLTRAQRAIAEGRFVSEIAPVTVKAGKTESVVSIDEQPGKAKLDKIPTLKPAFRD
GGTVTAANASSISDGAAALVMMRRSEAERLGLTPKAVIVGHATHADKPGLFATAPIGALRKLSEKTGWNLRDVDLFEINE
AFAVVPMAAMRDLDLPHEKVNVHGGACALGHPIGASGARVMVTLLAALETYGLTRGVASLCIGGGEATAVAIERIA

Sequences:

>Translated_396_residues
MTTQDPIVIVGAARTPMGGFQGDLAAASASDLGAVAIRAALERANVPAERIEEIVFGCVLPAGQGQAPARQAALKAGLPL
AAGATTVNKMCGSGMKAAMFAHDLLLAGSAAVAVAGGMESMTNAPYLLPKARAGMRMGHGQVLDHMFLDGLEDAYEKGRL
MGTFAEDCAQAYQFTREAQDAFAIASLTRAQRAIAEGRFVSEIAPVTVKAGKTESVVSIDEQPGKAKLDKIPTLKPAFRD
GGTVTAANASSISDGAAALVMMRRSEAERLGLTPKAVIVGHATHADKPGLFATAPIGALRKLSEKTGWNLRDVDLFEINE
AFAVVPMAAMRDLDLPHEKVNVHGGACALGHPIGASGARVMVTLLAALETYGLTRGVASLCIGGGEATAVAIERIA
>Mature_395_residues
TTQDPIVIVGAARTPMGGFQGDLAAASASDLGAVAIRAALERANVPAERIEEIVFGCVLPAGQGQAPARQAALKAGLPLA
AGATTVNKMCGSGMKAAMFAHDLLLAGSAAVAVAGGMESMTNAPYLLPKARAGMRMGHGQVLDHMFLDGLEDAYEKGRLM
GTFAEDCAQAYQFTREAQDAFAIASLTRAQRAIAEGRFVSEIAPVTVKAGKTESVVSIDEQPGKAKLDKIPTLKPAFRDG
GTVTAANASSISDGAAALVMMRRSEAERLGLTPKAVIVGHATHADKPGLFATAPIGALRKLSEKTGWNLRDVDLFEINEA
FAVVPMAAMRDLDLPHEKVNVHGGACALGHPIGASGARVMVTLLAALETYGLTRGVASLCIGGGEATAVAIERIA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=47.0737913486005, Blast_Score=335, Evalue=3e-92,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=45.088161209068, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=35.7142857142857, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=36, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=31.3679245283019, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=28.7153652392947, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI87082165, Length=389, Percent_Identity=44.7300771208226, Blast_Score=327, Evalue=6e-91,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=50, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1787663, Length=398, Percent_Identity=36.6834170854271, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=36.6995073891626, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788683, Length=402, Percent_Identity=30.3482587064677, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=43.7340153452685, Blast_Score=292, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.6020671834625, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=39.2307692307692, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17535917, Length=391, Percent_Identity=35.2941176470588, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=32.5471698113208, Blast_Score=171, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=47.3551637279597, Blast_Score=332, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6322031, Length=391, Percent_Identity=32.9923273657289, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.5703324808184, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=45.7800511508951, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI17648125, Length=395, Percent_Identity=34.4303797468354, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI17137578, Length=422, Percent_Identity=30.8056872037915, Blast_Score=150, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40809; Mature: 40677

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQDPIVIVGAARTPMGGFQGDLAAASASDLGAVAIRAALERANVPAERIEEIVFGCVL
CCCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PAGQGQAPARQAALKAGLPLAAGATTVNKMCGSGMKAAMFAHDLLLAGSAAVAVAGGMES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHEEECCHHH
MTNAPYLLPKARAGMRMGHGQVLDHMFLDGLEDAYEKGRLMGTFAEDCAQAYQFTREAQD
HCCCCEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AFAIASLTRAQRAIAEGRFVSEIAPVTVKAGKTESVVSIDEQPGKAKLDKIPTLKPAFRD
HHHHHHHHHHHHHHHCCCHHHHHCCEEEECCCCCCEEEECCCCCCCHHCCCCCCCCHHCC
GGTVTAANASSISDGAAALVMMRRSEAERLGLTPKAVIVGHATHADKPGLFATAPIGALR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCHHHHH
KLSEKTGWNLRDVDLFEINEAFAVVPMAAMRDLDLPHEKVNVHGGACALGHPIGASGARV
HHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCHHHEECCCCEEECCCCCCCCHHHH
MVTLLAALETYGLTRGVASLCIGGGEATAVAIERIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TTQDPIVIVGAARTPMGGFQGDLAAASASDLGAVAIRAALERANVPAERIEEIVFGCVL
CCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PAGQGQAPARQAALKAGLPLAAGATTVNKMCGSGMKAAMFAHDLLLAGSAAVAVAGGMES
CCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHEEECCHHH
MTNAPYLLPKARAGMRMGHGQVLDHMFLDGLEDAYEKGRLMGTFAEDCAQAYQFTREAQD
HCCCCEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHH
AFAIASLTRAQRAIAEGRFVSEIAPVTVKAGKTESVVSIDEQPGKAKLDKIPTLKPAFRD
HHHHHHHHHHHHHHHCCCHHHHHCCEEEECCCCCCEEEECCCCCCCHHCCCCCCCCHHCC
GGTVTAANASSISDGAAALVMMRRSEAERLGLTPKAVIVGHATHADKPGLFATAPIGALR
CCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCHHHHH
KLSEKTGWNLRDVDLFEINEAFAVVPMAAMRDLDLPHEKVNVHGGACALGHPIGASGARV
HHHHHCCCCCCCCCCEECCCHHHHHHHHHHHCCCCCHHHEECCCCEEECCCCCCCCHHHH
MVTLLAALETYGLTRGVASLCIGGGEATAVAIERIA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]