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The map label for this gene is yhcA [H]

Identifier: 107023018

GI number: 107023018

Start: 1623911

End: 1625491

Strand: Reverse

Name: yhcA [H]

Synonym: Bcen_1466

Alternate gene names: 107023018

Gene position: 1625491-1623911 (Counterclockwise)

Preceding gene: 107023021

Following gene: 107023016

Centisome position: 49.34

GC content: 69.7

Gene sequence:

>1581_bases
ATGAACACGACGTTCGCCACCGGCAGTGCCGTGCCGGCGCCGGCCGCAGGCCCGGCCTCCGACATCCCGACGTTTCGGTC
GATCGCCGCGATCGCGGCCGTGCTGCTCGGCGCGATCATCGCGACGCTGACGTCGCGCATCACGTCGCTCGGGCTGGCCG
ACGTGCGCGGCGCGCTCGGGATCGGCTTCGACGAAGGCGCGTGGATCAACACCGCGTTCACCGCGTCGCAGATGTTCGTC
GGGCCGCTCGCGATCGCGGCGGCCTTCATGTTCGGCACGCGCCGCGTGCTGGTCGCGGGCGCCGTGGTGTTTCTCGGCGC
GGAAACCGTGCTGCCGCTGTGCACGCAATTCGGCGCGTTCATCGTGTGCCAGGCGATCGCGGGGCTCGCGTCCGGCGTGT
TCGTGCCGCTGACGGTCGGCTTCGTCGTGCGCACGCTGCCGCCGCGGCTGATTCCGTTCGGCATCGCCGCGTATGCGATG
AATCTCGAGATGTCGCTGAACCTGTCGGCCACGCTCGAAGGCTGGTACAGCGAACATTTGAGCTGGCGCTGGCTGTTCTG
GCAGAACGCGGCGCTGACCGTGCCGTTCATCGCATGCCTGATGCTGTCGCTCGCCGACGAGCCGATCAAGCGCTTCGCGT
CGGGCATCGATGCGCGCGGGATGCTGCTCGGCGCGGGCGGGTTCGCGTGCCTGTGCATCGCGCTCGACCAGGGCGAGCGG
CTGTTCTGGCTGCAGTCGCCGCTGATCGTCGCGTTGCTGGCCGCGGGCATCCTGATGATCGCCGCGTTCCTGATCCACGA
ACTCGCGTCGCCGCGCGCCGGGTTGGATCTCGGCTACCTCGCGCGGCCCAACATCGCGCTGCTGATCGTGCTCGTCGGCC
TCGTGCGTTTCACCGTGCTCAACACGAGCTTCATCCCGTCGCTGTTCCTCGCGAGCACGTACGGGCTGCGCCCGCTGCAG
ATCGGCGACACGCTGCGCTGGATCGCGATCCCGCAACTGCTGTTCGCGCCGTGCGTCGCGCTGCTGCTGCAGCGGGTCGA
TCCGCGCCGGCTGATCGTCGCCGGCTTCGCGATGGTGGCGATCGCGTTCGCGCTCGGCTCGCGGCTCACGCCGGTGTGGG
CCGAGCCCGACTTCATTCCGTCGCAGCTGCTGCAGGCGCTCGGTCAGACGATGGCGCTCACGTCGGTCATCTTCTTCTTC
GGCAAGCACGTGACGGCCGAGCACGCGTTGACGTTCGGCGCGGTCGTGCAGGCGACGCGCCTGCTGAGCGGGCAGCTCGG
CACGACGTCGATCGCGGTGATTCAGCGGATCAGGGAGGCTACCCATTCGAATCTCGTCGGTCTGCATGTGTCGCTGTCGG
ATCCCGAAACGCTCGAACGGCTGCGGGCCGGCGCGGCGTCGCTGGTCGCGCATGGCGCCACGTTCGCGACCGGCAACCAG
GCGGCCTATGCGCTCGTCGATCGCGCGGTGCGCGTGCAGGCCACGACGCTCGCGCTGGCCGACAACTTCCGGGTGGCGAT
GGCATTCGCGCTCGCCGGCGCGCTGCTCGGCATCCTGCTGCGCCCGGTGCGGGCGCCGTAA

Upstream 100 bases:

>100_bases
GGGGTGGGTGGGGTCATGATCGGCAAACTCCATCGTACGGGCAGGATTTGACGCACCGCGTTATGCTTGCGCCAGCTTGA
CAGGCGGGAGCCGCTCGACG

Downstream 100 bases:

>100_bases
GTGTGGCACCGGGCGGCCTGAAATTTCCTGAAAAGTCCTGAACGGCGCGTCCGTCGCGGCGGCATGCGCGCCGCCGCGAC
GGACCGCGTGCTTACGCCTG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MNTTFATGSAVPAPAAGPASDIPTFRSIAAIAAVLLGAIIATLTSRITSLGLADVRGALGIGFDEGAWINTAFTASQMFV
GPLAIAAAFMFGTRRVLVAGAVVFLGAETVLPLCTQFGAFIVCQAIAGLASGVFVPLTVGFVVRTLPPRLIPFGIAAYAM
NLEMSLNLSATLEGWYSEHLSWRWLFWQNAALTVPFIACLMLSLADEPIKRFASGIDARGMLLGAGGFACLCIALDQGER
LFWLQSPLIVALLAAGILMIAAFLIHELASPRAGLDLGYLARPNIALLIVLVGLVRFTVLNTSFIPSLFLASTYGLRPLQ
IGDTLRWIAIPQLLFAPCVALLLQRVDPRRLIVAGFAMVAIAFALGSRLTPVWAEPDFIPSQLLQALGQTMALTSVIFFF
GKHVTAEHALTFGAVVQATRLLSGQLGTTSIAVIQRIREATHSNLVGLHVSLSDPETLERLRAGAASLVAHGATFATGNQ
AAYALVDRAVRVQATTLALADNFRVAMAFALAGALLGILLRPVRAP

Sequences:

>Translated_526_residues
MNTTFATGSAVPAPAAGPASDIPTFRSIAAIAAVLLGAIIATLTSRITSLGLADVRGALGIGFDEGAWINTAFTASQMFV
GPLAIAAAFMFGTRRVLVAGAVVFLGAETVLPLCTQFGAFIVCQAIAGLASGVFVPLTVGFVVRTLPPRLIPFGIAAYAM
NLEMSLNLSATLEGWYSEHLSWRWLFWQNAALTVPFIACLMLSLADEPIKRFASGIDARGMLLGAGGFACLCIALDQGER
LFWLQSPLIVALLAAGILMIAAFLIHELASPRAGLDLGYLARPNIALLIVLVGLVRFTVLNTSFIPSLFLASTYGLRPLQ
IGDTLRWIAIPQLLFAPCVALLLQRVDPRRLIVAGFAMVAIAFALGSRLTPVWAEPDFIPSQLLQALGQTMALTSVIFFF
GKHVTAEHALTFGAVVQATRLLSGQLGTTSIAVIQRIREATHSNLVGLHVSLSDPETLERLRAGAASLVAHGATFATGNQ
AAYALVDRAVRVQATTLALADNFRVAMAFALAGALLGILLRPVRAP
>Mature_526_residues
MNTTFATGSAVPAPAAGPASDIPTFRSIAAIAAVLLGAIIATLTSRITSLGLADVRGALGIGFDEGAWINTAFTASQMFV
GPLAIAAAFMFGTRRVLVAGAVVFLGAETVLPLCTQFGAFIVCQAIAGLASGVFVPLTVGFVVRTLPPRLIPFGIAAYAM
NLEMSLNLSATLEGWYSEHLSWRWLFWQNAALTVPFIACLMLSLADEPIKRFASGIDARGMLLGAGGFACLCIALDQGER
LFWLQSPLIVALLAAGILMIAAFLIHELASPRAGLDLGYLARPNIALLIVLVGLVRFTVLNTSFIPSLFLASTYGLRPLQ
IGDTLRWIAIPQLLFAPCVALLLQRVDPRRLIVAGFAMVAIAFALGSRLTPVWAEPDFIPSQLLQALGQTMALTSVIFFF
GKHVTAEHALTFGAVVQATRLLSGQLGTTSIAVIQRIREATHSNLVGLHVSLSDPETLERLRAGAASLVAHGATFATGNQ
AAYALVDRAVRVQATTLALADNFRVAMAFALAGALLGILLRPVRAP

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=440, Percent_Identity=23.4090909090909, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789042, Length=482, Percent_Identity=21.1618257261411, Blast_Score=99, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55469; Mature: 55469

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTFATGSAVPAPAAGPASDIPTFRSIAAIAAVLLGAIIATLTSRITSLGLADVRGALG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
IGFDEGAWINTAFTASQMFVGPLAIAAAFMFGTRRVLVAGAVVFLGAETVLPLCTQFGAF
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVCQAIAGLASGVFVPLTVGFVVRTLPPRLIPFGIAAYAMNLEMSLNLSATLEGWYSEHL
HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCC
SWRWLFWQNAALTVPFIACLMLSLADEPIKRFASGIDARGMLLGAGGFACLCIALDQGER
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCE
LFWLQSPLIVALLAAGILMIAAFLIHELASPRAGLDLGYLARPNIALLIVLVGLVRFTVL
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NTSFIPSLFLASTYGLRPLQIGDTLRWIAIPQLLFAPCVALLLQRVDPRRLIVAGFAMVA
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IAFALGSRLTPVWAEPDFIPSQLLQALGQTMALTSVIFFFGKHVTAEHALTFGAVVQATR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLSGQLGTTSIAVIQRIREATHSNLVGLHVSLSDPETLERLRAGAASLVAHGATFATGNQ
HHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCHHHHHHCCCEEECCCC
AAYALVDRAVRVQATTLALADNFRVAMAFALAGALLGILLRPVRAP
HHHHHHHHHHHHHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTTFATGSAVPAPAAGPASDIPTFRSIAAIAAVLLGAIIATLTSRITSLGLADVRGALG
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHC
IGFDEGAWINTAFTASQMFVGPLAIAAAFMFGTRRVLVAGAVVFLGAETVLPLCTQFGAF
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVCQAIAGLASGVFVPLTVGFVVRTLPPRLIPFGIAAYAMNLEMSLNLSATLEGWYSEHL
HHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEEECCHHHHHHHHHHCC
SWRWLFWQNAALTVPFIACLMLSLADEPIKRFASGIDARGMLLGAGGFACLCIALDQGER
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCCE
LFWLQSPLIVALLAAGILMIAAFLIHELASPRAGLDLGYLARPNIALLIVLVGLVRFTVL
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NTSFIPSLFLASTYGLRPLQIGDTLRWIAIPQLLFAPCVALLLQRVDPRRLIVAGFAMVA
HHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
IAFALGSRLTPVWAEPDFIPSQLLQALGQTMALTSVIFFFGKHVTAEHALTFGAVVQATR
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LLSGQLGTTSIAVIQRIREATHSNLVGLHVSLSDPETLERLRAGAASLVAHGATFATGNQ
HHCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCHHHHHHCCCEEECCCC
AAYALVDRAVRVQATTLALADNFRVAMAFALAGALLGILLRPVRAP
HHHHHHHHHHHHHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]