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The map label for this gene is emrY [H]

Identifier: 107022834

GI number: 107022834

Start: 1407674

End: 1409266

Strand: Reverse

Name: emrY [H]

Synonym: Bcen_1282

Alternate gene names: 107022834

Gene position: 1409266-1407674 (Counterclockwise)

Preceding gene: 107022835

Following gene: 107022833

Centisome position: 42.78

GC content: 67.61

Gene sequence:

>1593_bases
ATGAGCCGGCCGCCCGAGCGCGGCGGCGCGTCCGGCGGCACCTGGCGACCCGCCGCGAATCCGTGGCTCATCGCGATCGT
CGTCACGCTCGCCGCGTTCATGGAAGTGCTCGACACGACGATCGTCAACGTCGCGCTGCCGCACATCGCCGGCACGATGT
CGGCGAGCTACGACGAGGCGACCTGGACACTCACGTCGTATCTCGTCGCGAACGGCATCGTGCTGCCGATTTCGGGGTTC
CTCGGGCGCCTGCTTGGCCGCAAGCGCTACTTCCTGCTGTGCATCGCCGCGTTTACCGTGTGCTCGTTCCTGTGCGGCGT
CGCGACCAACCTCGGCGAACTGATCGTGTTCCGCGTGCTGCAAGGGCTGTTCGGCGGCGGGCTGCAGCCGAACCAGCAGT
CGATCATCCTCGATACGTTTCCGCCCGAGCAGCGCAATCGCGCGTTCTCGATCTCGGCGATCGCGATCGTCGTCGCGCCG
GTGCTCGGGCCGACGCTCGGCGGCTGGATCACCGACCATTTCTCGTGGCGCTGGGTGTTCCTGCTCAACGTGCCGATCGG
CGCGCTGACCGTGCTCGCGGTGATGCAGCTCGTCGAGGACCCGCCGTGGCGGCGCGACGCCGAACGCGGAATCTCGATCG
ACTACATCGGCATCGGGCTGATCGCGATCGGGCTCGGCTGCCTGCAGGTGATGCTCGATCGCGGCGAGGACGAGGACTGG
TTCGGCTCGAACTTCATCCGCGTCTTCGCCGTGCTGTCCGTGCTCGGGCTGGTCGGCGCGACGCTGTGGCTGCTGCGTAC
GAAGAAACCGGTGGTCGACCTGTCGTGCCTGCGCGACCGCAATTTCGCGCTCGGCTGCGTGACGATCGCGACGTTCGCGG
CCGTGCTGTACGGCAGCGCGGTGATCGTGCCGCAGCTCGCGCAGCAGCGTCTCGGCTACACGGCGACGCTCGCGGGGCTC
GTGCTGTCGCCCGGCGCGCTGCTGATCACGCTCGAGATTCCGCTCGTGAGCCGGCTGATGCCGCACGTGCAGACGCGCTA
TCTGGTCGGGTTCGGCTTCGTGCTGCTGTGCGCTTCGCTGATCTATTCGCGCACGCTGGTGCCGGACATCGACTACACGC
ACCTGATGTTGATCCGCTGCGCGCAGTCGCTCGCGATCGGCTTCATGTTCGTGCCGATCACGACGCTCGCGTACCTGACC
GTGCCGCAGCGGCTCAACGACGACGCGTCCGCGCTGTTCACGATGTTCCGCAACGTCGCGGGCTCGATCGGCATCTCGGT
GTCGACCGCGCTGATCCGCGAGCGCACGCAGGCGCGCATGGCGCATCTGTCCACGCACATGTCGACGCTGTCGCAGAACT
TCCAGGATGCGTTGCAGGAGAATGCGCGCGCGATCGGCGCGCTGACGGGCGCGCAGCCGTCGGCCGCGCTGCAGACGGCG
AGCGGGCGGCTGTACCAGACCTTCATCGAACAGGCGACGATCCTCGCGTATATCGACGTGTTCGCGATCCTCGCGGTGTT
CTGCGCGTTCAGCATTCCGCTGACGTTCCTGTTCTCGCCGGCGAAGGCCGCGGGCGGCGCGGGAGGGCATTGA

Upstream 100 bases:

>100_bases
GTTCACCTCAAATGACCGGCCGCCGTGCCGCGGCCGGTGCCGACCGGAGCGATCCGATGCCCGATACCCGCATGCCGTTC
CCGTTTCGCGAGGCCCGCCG

Downstream 100 bases:

>100_bases
TGATGACGATGCATCGACGCGGCCGTTGCCGACATTCGCTACCCGCACGCGGAATCGCCGCGATGCTCGCCGCCTGCGCG
GTGCTTGCGGGCTGTACCGT

Product: EmrB/QacA family drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSRPPERGGASGGTWRPAANPWLIAIVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGF
LGRLLGRKRYFLLCIAAFTVCSFLCGVATNLGELIVFRVLQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAP
VLGPTLGGWITDHFSWRWVFLLNVPIGALTVLAVMQLVEDPPWRRDAERGISIDYIGIGLIAIGLGCLQVMLDRGEDEDW
FGSNFIRVFAVLSVLGLVGATLWLLRTKKPVVDLSCLRDRNFALGCVTIATFAAVLYGSAVIVPQLAQQRLGYTATLAGL
VLSPGALLITLEIPLVSRLMPHVQTRYLVGFGFVLLCASLIYSRTLVPDIDYTHLMLIRCAQSLAIGFMFVPITTLAYLT
VPQRLNDDASALFTMFRNVAGSIGISVSTALIRERTQARMAHLSTHMSTLSQNFQDALQENARAIGALTGAQPSAALQTA
SGRLYQTFIEQATILAYIDVFAILAVFCAFSIPLTFLFSPAKAAGGAGGH

Sequences:

>Translated_530_residues
MSRPPERGGASGGTWRPAANPWLIAIVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGF
LGRLLGRKRYFLLCIAAFTVCSFLCGVATNLGELIVFRVLQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAP
VLGPTLGGWITDHFSWRWVFLLNVPIGALTVLAVMQLVEDPPWRRDAERGISIDYIGIGLIAIGLGCLQVMLDRGEDEDW
FGSNFIRVFAVLSVLGLVGATLWLLRTKKPVVDLSCLRDRNFALGCVTIATFAAVLYGSAVIVPQLAQQRLGYTATLAGL
VLSPGALLITLEIPLVSRLMPHVQTRYLVGFGFVLLCASLIYSRTLVPDIDYTHLMLIRCAQSLAIGFMFVPITTLAYLT
VPQRLNDDASALFTMFRNVAGSIGISVSTALIRERTQARMAHLSTHMSTLSQNFQDALQENARAIGALTGAQPSAALQTA
SGRLYQTFIEQATILAYIDVFAILAVFCAFSIPLTFLFSPAKAAGGAGGH
>Mature_529_residues
SRPPERGGASGGTWRPAANPWLIAIVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEATWTLTSYLVANGIVLPISGFL
GRLLGRKRYFLLCIAAFTVCSFLCGVATNLGELIVFRVLQGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPV
LGPTLGGWITDHFSWRWVFLLNVPIGALTVLAVMQLVEDPPWRRDAERGISIDYIGIGLIAIGLGCLQVMLDRGEDEDWF
GSNFIRVFAVLSVLGLVGATLWLLRTKKPVVDLSCLRDRNFALGCVTIATFAAVLYGSAVIVPQLAQQRLGYTATLAGLV
LSPGALLITLEIPLVSRLMPHVQTRYLVGFGFVLLCASLIYSRTLVPDIDYTHLMLIRCAQSLAIGFMFVPITTLAYLTV
PQRLNDDASALFTMFRNVAGSIGISVSTALIRERTQARMAHLSTHMSTLSQNFQDALQENARAIGALTGAQPSAALQTAS
GRLYQTFIEQATILAYIDVFAILAVFCAFSIPLTFLFSPAKAAGGAGGH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=450, Percent_Identity=36.6666666666667, Blast_Score=317, Evalue=2e-87,
Organism=Escherichia coli, GI1789042, Length=480, Percent_Identity=35.4166666666667, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1790195, Length=429, Percent_Identity=27.972027972028, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788392, Length=425, Percent_Identity=28.2352941176471, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081983, Length=340, Percent_Identity=28.5294117647059, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6322958, Length=165, Percent_Identity=32.1212121212121, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6325455, Length=186, Percent_Identity=27.9569892473118, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6321663, Length=152, Percent_Identity=31.5789473684211, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323735, Length=195, Percent_Identity=29.2307692307692, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 57113; Mature: 56982

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00092 N6_MTASE ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPPERGGASGGTWRPAANPWLIAIVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TWTLTSYLVANGIVLPISGFLGRLLGRKRYFLLCIAAFTVCSFLCGVATNLGELIVFRVL
HHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGPTLGGWITDHFSWRWVF
HHHHCCCCCCCCCEEEEECCCCHHCCCEEEHHHHHHHHHHHHCCHHCCHHHHCCCEEEEE
LLNVPIGALTVLAVMQLVEDPPWRRDAERGISIDYIGIGLIAIGLGCLQVMLDRGEDEDW
EEECCHHHHHHHHHHHHHCCCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
FGSNFIRVFAVLSVLGLVGATLWLLRTKKPVVDLSCLRDRNFALGCVTIATFAAVLYGSA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHCCH
VIVPQLAQQRLGYTATLAGLVLSPGALLITLEIPLVSRLMPHVQTRYLVGFGFVLLCASL
HHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSRTLVPDIDYTHLMLIRCAQSLAIGFMFVPITTLAYLTVPQRLNDDASALFTMFRNVA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHH
GSIGISVSTALIRERTQARMAHLSTHMSTLSQNFQDALQENARAIGALTGAQPSAALQTA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SGRLYQTFIEQATILAYIDVFAILAVFCAFSIPLTFLFSPAKAAGGAGGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure 
SRPPERGGASGGTWRPAANPWLIAIVVTLAAFMEVLDTTIVNVALPHIAGTMSASYDEA
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
TWTLTSYLVANGIVLPISGFLGRLLGRKRYFLLCIAAFTVCSFLCGVATNLGELIVFRVL
HHHHHHHHHHCCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGLFGGGLQPNQQSIILDTFPPEQRNRAFSISAIAIVVAPVLGPTLGGWITDHFSWRWVF
HHHHCCCCCCCCCEEEEECCCCHHCCCEEEHHHHHHHHHHHHCCHHCCHHHHCCCEEEEE
LLNVPIGALTVLAVMQLVEDPPWRRDAERGISIDYIGIGLIAIGLGCLQVMLDRGEDEDW
EEECCHHHHHHHHHHHHHCCCCCCCHHHCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
FGSNFIRVFAVLSVLGLVGATLWLLRTKKPVVDLSCLRDRNFALGCVTIATFAAVLYGSA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHCCH
VIVPQLAQQRLGYTATLAGLVLSPGALLITLEIPLVSRLMPHVQTRYLVGFGFVLLCASL
HHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
IYSRTLVPDIDYTHLMLIRCAQSLAIGFMFVPITTLAYLTVPQRLNDDASALFTMFRNVA
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHHHHHHHHHHH
GSIGISVSTALIRERTQARMAHLSTHMSTLSQNFQDALQENARAIGALTGAQPSAALQTA
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
SGRLYQTFIEQATILAYIDVFAILAVFCAFSIPLTFLFSPAKAAGGAGGH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]