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The map label for this gene is livH [H]

Identifier: 107021988

GI number: 107021988

Start: 473439

End: 475058

Strand: Reverse

Name: livH [H]

Synonym: Bcen_0430

Alternate gene names: 107021988

Gene position: 475058-473439 (Counterclockwise)

Preceding gene: 107021989

Following gene: 107021987

Centisome position: 14.42

GC content: 70.49

Gene sequence:

>1620_bases
ATGCCTACACGCTTTCGCCGAGCCGCCCGCGCGATCGTGGCATGCGCCGCCCTCGCGGGCCTGCTGCCGCACGCCGCGTT
CGCGCTGACGGCGGCCGACACCGCCGCGCTCGCCGGCGACGACTTCGACGCGAAGACGGCCGCGATCGAACGGCTCGCCG
CCGACACCGATCCGCGCGCCGTCGCGGTGCTCAACGCGCTGTCGAGCGGCGATGCGCTCGCGACCGGCGACGGCCACCTG
CTGATCCAGTCCGGCGACACCGCGCACGACGCGCTCACGCCGGCCGCGACGCCGGCCGGCGACGCGCAGCCGGTGATGCT
GAACAACCTGCTGCGCACGAAGATCGCCGGCGCGCTGTCGGGCCTCGCGCTCGCGTCGCCCGACGTGGCCGCGCGCCGCG
ACGCGATCGACGCGCTGCTGAAGTCGCCCGACCCGGCGCTCAAGCCGATGATCGACCGCGCCCGCGCAAAGGAAACCGAT
CCGGCGCTGAAACGCCGCCTCGATGCGCTGTGGGCGATCGCCGCACTGCACGATCCCGATCCGGCGAAGCGTCTCGAAGC
CGCGCAGGTGGTGGCTGCCCGCAGCGACCTCGACATGATCGAACAACTCCGCCCGCTCGTCGCGAAGAACGCCGACGGCA
GCTACGCGGAACCCGACGCACGCGTGCGCGACGCCGCACAACACGGGCTCGATACGTTGCACGCGCTGCAGCGCCGCGGC
GAGATCGTCGGCACGTTGTTCGCGGGCCTGTCGCTCGGCAGCGTGCTGCTGCTCGCCGCGCTCGGCCTCGCGATCACGTA
CGGGCTGATCGGCGTGATCAACATGGCGCACGGCGAATTCCTGATGATCGGTGCGTACGCAACCTATGTCGTGCAGACGC
TGATCCAGCGCTACGCGCCCGGCGCATTCGACTGGTATCCGCTCGTCGCCGTGCCCGTATCGTTCGCGGTGGCCGCCCTC
GTCGGCATCGTGCTCGAACGGCTCGTGCTGCGGCACCTGTACGGCCGCCCGCTCGAAACGCTGCTCGCGACCTTCGGCGT
GAGCCTGATCCTGATCCAGGCCACCCGCATGCTGTTCGGCGCGCAGAACGTGCAGGTCGTGAACCCGTCGTGGATGAGCG
GCGGCGTGACGGTGATGCAGAACCTGATCCTGCCGTACAACCGGCTCGCGATCCTCGCGTTCGCGCTCGCGGTGGTGTTC
GTCGCGTGGGCCGTGCTGACGAAGACGCGCCTCGGCCTGTTCGTGCGTGCGGTCACGCAGAACCGCCGGATGGCCGCCTG
CGTCGGCGTGAAGACCGCCCGCGTCGACGCATATGCGTTCGCATTCGGCGCGGGCATCGCGGGCCTCGGTGGCTGCGCGC
TGTCGCAGATCGGCAACGTGGGCCCCGATCTCGGCCAGAACTACATCATCGATTCGTTCATGGCCGTCGTGCTCGGCGGC
GTCGGCCAGATCGCCGGCACGGTGCTCGGCGGCTTCGGGCTCGGCCTCGCGAGCAAGGCGATCGAACCGTTCTGGGGCGC
CGTACTCGCGAAGATCGCGGTGCTCGTGATGATCGTGCTGTTCATCCAGAAACGCCCGCAGGGGATGTTCGCCCCGAAGG
GCCGCAGCGCGGAGGCTTGA

Upstream 100 bases:

>100_bases
CGCCCGCTGCCGATGCGCCGGCCGCGCTTGCCGTGACCCATCGCCCGCGCCGGCGCCACGCCACACCGCTCCCCTTTCCC
ACGCCCGACAGGATTCCCCG

Downstream 100 bases:

>100_bases
CGTGACTTCATACACCGATTCGATGTCGAACCCGGTCGCCGACGCGTCGAAGCCCGCTGCCGCCGCGCGCGCGGCGGACG
GCTTCGCGCTCGGCCTGCCG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MPTRFRRAARAIVACAALAGLLPHAAFALTAADTAALAGDDFDAKTAAIERLAADTDPRAVAVLNALSSGDALATGDGHL
LIQSGDTAHDALTPAATPAGDAQPVMLNNLLRTKIAGALSGLALASPDVAARRDAIDALLKSPDPALKPMIDRARAKETD
PALKRRLDALWAIAALHDPDPAKRLEAAQVVAARSDLDMIEQLRPLVAKNADGSYAEPDARVRDAAQHGLDTLHALQRRG
EIVGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTLIQRYAPGAFDWYPLVAVPVSFAVAAL
VGIVLERLVLRHLYGRPLETLLATFGVSLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALAVVF
VAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDAYAFAFGAGIAGLGGCALSQIGNVGPDLGQNYIIDSFMAVVLGG
VGQIAGTVLGGFGLGLASKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFAPKGRSAEA

Sequences:

>Translated_539_residues
MPTRFRRAARAIVACAALAGLLPHAAFALTAADTAALAGDDFDAKTAAIERLAADTDPRAVAVLNALSSGDALATGDGHL
LIQSGDTAHDALTPAATPAGDAQPVMLNNLLRTKIAGALSGLALASPDVAARRDAIDALLKSPDPALKPMIDRARAKETD
PALKRRLDALWAIAALHDPDPAKRLEAAQVVAARSDLDMIEQLRPLVAKNADGSYAEPDARVRDAAQHGLDTLHALQRRG
EIVGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTLIQRYAPGAFDWYPLVAVPVSFAVAAL
VGIVLERLVLRHLYGRPLETLLATFGVSLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALAVVF
VAWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDAYAFAFGAGIAGLGGCALSQIGNVGPDLGQNYIIDSFMAVVLGG
VGQIAGTVLGGFGLGLASKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFAPKGRSAEA
>Mature_538_residues
PTRFRRAARAIVACAALAGLLPHAAFALTAADTAALAGDDFDAKTAAIERLAADTDPRAVAVLNALSSGDALATGDGHLL
IQSGDTAHDALTPAATPAGDAQPVMLNNLLRTKIAGALSGLALASPDVAARRDAIDALLKSPDPALKPMIDRARAKETDP
ALKRRLDALWAIAALHDPDPAKRLEAAQVVAARSDLDMIEQLRPLVAKNADGSYAEPDARVRDAAQHGLDTLHALQRRGE
IVGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTLIQRYAPGAFDWYPLVAVPVSFAVAALV
GIVLERLVLRHLYGRPLETLLATFGVSLILIQATRMLFGAQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALAVVFV
AWAVLTKTRLGLFVRAVTQNRRMAACVGVKTARVDAYAFAFGAGIAGLGGCALSQIGNVGPDLGQNYIIDSFMAVVLGGV
GQIAGTVLGGFGLGLASKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFAPKGRSAEA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=297, Percent_Identity=28.956228956229, Blast_Score=93, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 56318; Mature: 56186

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTRFRRAARAIVACAALAGLLPHAAFALTAADTAALAGDDFDAKTAAIERLAADTDPRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHH
VAVLNALSSGDALATGDGHLLIQSGDTAHDALTPAATPAGDAQPVMLNNLLRTKIAGALS
HHHHHHHCCCCEEEECCCEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLALASPDVAARRDAIDALLKSPDPALKPMIDRARAKETDPALKRRLDALWAIAALHDPD
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
PAKRLEAAQVVAARSDLDMIEQLRPLVAKNADGSYAEPDARVRDAAQHGLDTLHALQRRG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
EIVGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTLIQRYAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCC
GAFDWYPLVAVPVSFAVAALVGIVLERLVLRHLYGRPLETLLATFGVSLILIQATRMLFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
AQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALAVVFVAWAVLTKTRLGLFVRAVTQ
CCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRRMAACVGVKTARVDAYAFAFGAGIAGLGGCALSQIGNVGPDLGQNYIIDSFMAVVLGG
CCCHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
VGQIAGTVLGGFGLGLASKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFAPKGRSAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PTRFRRAARAIVACAALAGLLPHAAFALTAADTAALAGDDFDAKTAAIERLAADTDPRA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHH
VAVLNALSSGDALATGDGHLLIQSGDTAHDALTPAATPAGDAQPVMLNNLLRTKIAGALS
HHHHHHHCCCCEEEECCCEEEEECCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GLALASPDVAARRDAIDALLKSPDPALKPMIDRARAKETDPALKRRLDALWAIAALHDPD
CCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
PAKRLEAAQVVAARSDLDMIEQLRPLVAKNADGSYAEPDARVRDAAQHGLDTLHALQRRG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
EIVGTLFAGLSLGSVLLLAALGLAITYGLIGVINMAHGEFLMIGAYATYVVQTLIQRYAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHCC
GAFDWYPLVAVPVSFAVAALVGIVLERLVLRHLYGRPLETLLATFGVSLILIQATRMLFG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHC
AQNVQVVNPSWMSGGVTVMQNLILPYNRLAILAFALAVVFVAWAVLTKTRLGLFVRAVTQ
CCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NRRMAACVGVKTARVDAYAFAFGAGIAGLGGCALSQIGNVGPDLGQNYIIDSFMAVVLGG
CCCHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
VGQIAGTVLGGFGLGLASKAIEPFWGAVLAKIAVLVMIVLFIQKRPQGMFAPKGRSAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]