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The map label for this gene is tetA [H]

Identifier: 107021838

GI number: 107021838

Start: 304277

End: 305476

Strand: Reverse

Name: tetA [H]

Synonym: Bcen_0278

Alternate gene names: 107021838

Gene position: 305476-304277 (Counterclockwise)

Preceding gene: 107021840

Following gene: 107021836

Centisome position: 9.27

GC content: 72.75

Gene sequence:

>1200_bases
ATGCTCTTGAACCCGTCCCTGATTGCCATCCTGGCCACGGTCCTGCTCGACGCGATCGGCGTCGGGATCGTGATGCCGAT
CCTGCCCGGGCTGCTGCGCTCGCTCGCCGCCGCGGGCAGCACCGACACCCACTACGGCATCCTGCTCGCGCTGTACGCGT
TCGCGCAGTTCCTGTGTGCGCCGCTGCTCGGCGCGCTGAGCGACCGTTTCGGTCGCCGCCCGGTGCTGCTCGCGTCGCTG
GCCGGCGCCGCGCTCGACTATCTGCTGATGGCGCTCGCGCCGACGCTCGCGTGGCTTTACGTCGGCCGGCTGATCGCGGG
CATCACCGGCGCGAACGCCGCGGTCGCGACCGCGTACGTGACCGACGTGACGGCCGAGCCCGACCGTGCACGGCGCTTCG
GCCAGCTCGGCGCGATGATGGGCATCGGCTTCATCGCCGGCCCGTTGATCGGCGGGCTGCTCGGCGTGCTGCATCTGCGT
GCGCCGTTCGTCGCGGCCGCGTTGCTCAACGCGCTGAATCTCCTGCTCGTATGGCGCGTGCTGCCGGAATCGCGGCCGCG
TTCTGCCCGCGAAGGCCAGGCGGTCGGCGCGCTCAACCCGTTCGCGAGCCTGCGCCGGCTGAGCGGCGCGCCCGCGCTCG
CGCCGCTGGTCGGCATCTACGTGATCGTGGCGCTCGTGTCGCAGGCGCCCGCGACGCTGTGGATTCTCTACGGCCAGGAA
CATTTCGGCTGGTCGACACCGGTCGCGGGGTTGTCGCTCGCCGGTTACGGCGCATGCCACGCGCTCGCGCAGGCGTTCGC
GATCGGGCCGCTGATCGCGCGGCTCGGCGAGCGGCGCGCGCTCGCGCTGGGCCTCGCGGGCGATGCGCTCGGGCTGGCGA
TCATCGCGTTCGCGACCGCCGCATGGGTGCCGTTCGCGCTGCTGCCGCTGTTCGCGGCTGGCGGCATGACGCTGCCGGCA
TTGCAGGCGATGCTCGCACGGCAGGTCGACGATGCACGCCAGGGAGAACTGCAAGGCACGCTGGCGAGCGTGGCGAGCCT
GATCGGCGTCGCGGGGCCGCTGGTCGTCACCGCGACCTACGCGGCGACGCGTACGACATGGCCAGGGCTCGTGTGGGCGG
CGGCCGCCCTGCTGTACCTGCTCGTGCCGCCGTTGCTGGCTGGCGCGCGCCCGGCGAACGCGCCGCGAGCGTCCGGATAA

Upstream 100 bases:

>100_bases
CGCAATACCGTGTCGCGCGTCAGTCGCGTGCCTGTGTCCTTCATCTCTATCACCGATAGGGAAACTGTGGAATACTGTGC
ACTCTATCATCGATAGAGTG

Downstream 100 bases:

>100_bases
GCGTCGGCGTGCGCCGTCGCGCTGAGCCCGCGACCGTCCGAAAAAAAACCGCCCGGATCGCTCCGGGCGGTTTTCCTGCT
GCATCTGCTTGCCCTGCGTC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLLNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAAAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLASL
AGAALDYLLMALAPTLAWLYVGRLIAGITGANAAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGVLHLR
APFVAAALLNALNLLLVWRVLPESRPRSAREGQAVGALNPFASLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE
HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAIIAFATAAWVPFALLPLFAAGGMTLPA
LQAMLARQVDDARQGELQGTLASVASLIGVAGPLVVTATYAATRTTWPGLVWAAAALLYLLVPPLLAGARPANAPRASG

Sequences:

>Translated_399_residues
MLLNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAAAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLASL
AGAALDYLLMALAPTLAWLYVGRLIAGITGANAAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGVLHLR
APFVAAALLNALNLLLVWRVLPESRPRSAREGQAVGALNPFASLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE
HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAIIAFATAAWVPFALLPLFAAGGMTLPA
LQAMLARQVDDARQGELQGTLASVASLIGVAGPLVVTATYAATRTTWPGLVWAAAALLYLLVPPLLAGARPANAPRASG
>Mature_399_residues
MLLNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAAAGSTDTHYGILLALYAFAQFLCAPLLGALSDRFGRRPVLLASL
AGAALDYLLMALAPTLAWLYVGRLIAGITGANAAVATAYVTDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGVLHLR
APFVAAALLNALNLLLVWRVLPESRPRSAREGQAVGALNPFASLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE
HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAIIAFATAAWVPFALLPLFAAGGMTLPA
LQAMLARQVDDARQGELQGTLASVASLIGVAGPLVVTATYAATRTTWPGLVWAAAALLYLLVPPLLAGARPANAPRASG

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=316, Percent_Identity=27.2151898734177, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI94721311, Length=316, Percent_Identity=28.4810126582279, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI225703104, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI225703102, Length=174, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI217416366, Length=184, Percent_Identity=34.7826086956522, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081738, Length=204, Percent_Identity=29.9019607843137, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71996331, Length=321, Percent_Identity=23.3644859813084, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551570, Length=143, Percent_Identity=30.0699300699301, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221513297, Length=358, Percent_Identity=27.0949720670391, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17738085, Length=337, Percent_Identity=25.2225519287834, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357569, Length=362, Percent_Identity=25.414364640884, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656463, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24656468, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161080926, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161080924, Length=362, Percent_Identity=25.414364640884, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 40852; Mature: 40852

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAAAGSTDTHYGILLALYAFAQFLCA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
PLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANAAVATAYV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGVLHLRAPFVAAALLNALNLLLVWRV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPESRPRSAREGQAVGALNPFASLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCH
HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAIIAFATA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
AWVPFALLPLFAAGGMTLPALQAMLARQVDDARQGELQGTLASVASLIGVAGPLVVTATY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AATRTTWPGLVWAAAALLYLLVPPLLAGARPANAPRASG
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MLLNPSLIAILATVLLDAIGVGIVMPILPGLLRSLAAAGSTDTHYGILLALYAFAQFLCA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
PLLGALSDRFGRRPVLLASLAGAALDYLLMALAPTLAWLYVGRLIAGITGANAAVATAYV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TDVTAEPDRARRFGQLGAMMGIGFIAGPLIGGLLGVLHLRAPFVAAALLNALNLLLVWRV
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPESRPRSAREGQAVGALNPFASLRRLSGAPALAPLVGIYVIVALVSQAPATLWILYGQE
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCH
HFGWSTPVAGLSLAGYGACHALAQAFAIGPLIARLGERRALALGLAGDALGLAIIAFATA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHH
AWVPFALLPLFAAGGMTLPALQAMLARQVDDARQGELQGTLASVASLIGVAGPLVVTATY
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
AATRTTWPGLVWAAAALLYLLVPPLLAGARPANAPRASG
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]