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The map label for this gene is hisA

Identifier: 103488622

GI number: 103488622

Start: 3298441

End: 3299175

Strand: Reverse

Name: hisA

Synonym: Sala_3147

Alternate gene names: 103488622

Gene position: 3299175-3298441 (Counterclockwise)

Preceding gene: 103488623

Following gene: 103488621

Centisome position: 98.63

GC content: 71.16

Gene sequence:

>735_bases
TTGGCGGCCCTGACCATCTTCCCCGCGATCGACCTCAAGGCCGGACAGGTGGTGCGGCTGGCCGAGGGCGATATGGACCG
CGCGACCGTCTATGGCGACGATCCGGCGGCGCAGGCGCGGCGGTTCGCGGATGCAGGCGCGACGCACCTGCATGTCGTCG
ATCTCGACGGCGCCTTTGCGGGGGCGAGCGTCAACGGCGCGGCGGTCGAAAGCATCATCGCCGCCTTTCCGGGCCAGGTG
CAGGTCGGCGGGGGCATCCGCGACCGCGCGGGGGTCGATCGCTGGCTGGCGCTCGGCGTCGCGCGGGTGATTATCGGCAC
CGCGGCGCTCAAAGACCCGGAGTTCGTAAAGTCGGCGGCGCGCGACCTGCCCGGCCGGATCGTCGTCGGCGTCGATGCGC
GCGATGGCATGGTCGCGACCGAGGGCTGGGCCGATGTATCGGACGTGCGGGTCGAAGATCTGGCGCGCCGCTTCGAGGAT
GCGGGCGTCGCGGCGCTGCTGTTCACCGATGTCGGGCGCGACGGGCTGCTGAAAGGCTGCAATGTCGCGGCGACGGTGGC
GCTGGCGGGGGTCGTCGATATTCCGGTGATCGCGAGCGGCGGGGTTGCGGGGATCGAGGACATCCACGCACTGCGGCCCC
ATGTCGCCGATGGCATCGAGGGGGTGATTACGGGGCGCGCGCTCTATGACGGGCGGCTCGATCTGGCCGAGGCGATTGCG
GCGGGTGCGGCATGA

Upstream 100 bases:

>100_bases
CCTTCACCGCCGCCGTGGCGAAGGACAATGTCGTGGGTGTCCAGTTTCATCCCGAAAAAAGCCAGGCCTATGGCCTCGCG
ACGCTCGAAAGGTTCCTCGC

Downstream 100 bases:

>100_bases
AACATGCCTCCCTCCCCGTTCGTGTCGAGCGAAGTCGAGACACCTCGACGGACAGCGCCATGCTGCCGGGTGTCTCGATT
TCGCTCGACACGAACGGATT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAALTIFPAIDLKAGQVVRLAEGDMDRATVYGDDPAAQARRFADAGATHLHVVDLDGAFAGASVNGAAVESIIAAFPGQV
QVGGGIRDRAGVDRWLALGVARVIIGTAALKDPEFVKSAARDLPGRIVVGVDARDGMVATEGWADVSDVRVEDLARRFED
AGVAALLFTDVGRDGLLKGCNVAATVALAGVVDIPVIASGGVAGIEDIHALRPHVADGIEGVITGRALYDGRLDLAEAIA
AGAA

Sequences:

>Translated_244_residues
MAALTIFPAIDLKAGQVVRLAEGDMDRATVYGDDPAAQARRFADAGATHLHVVDLDGAFAGASVNGAAVESIIAAFPGQV
QVGGGIRDRAGVDRWLALGVARVIIGTAALKDPEFVKSAARDLPGRIVVGVDARDGMVATEGWADVSDVRVEDLARRFED
AGVAALLFTDVGRDGLLKGCNVAATVALAGVVDIPVIASGGVAGIEDIHALRPHVADGIEGVITGRALYDGRLDLAEAIA
AGAA
>Mature_243_residues
AALTIFPAIDLKAGQVVRLAEGDMDRATVYGDDPAAQARRFADAGATHLHVVDLDGAFAGASVNGAAVESIIAAFPGQVQ
VGGGIRDRAGVDRWLALGVARVIIGTAALKDPEFVKSAARDLPGRIVVGVDARDGMVATEGWADVSDVRVEDLARRFEDA
GVAALLFTDVGRDGLLKGCNVAATVALAGVVDIPVIASGGVAGIEDIHALRPHVADGIEGVITGRALYDGRLDLAEAIAA
GAA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=243, Percent_Identity=37.4485596707819, Blast_Score=134, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_SPHAL (Q1GNC2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_618183.1
- ProteinModelPortal:   Q1GNC2
- SMR:   Q1GNC2
- GeneID:   4082483
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_3147
- NMPDR:   fig|317655.9.peg.2996
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   SALA317655:SALA_3147-MONOMER
- BRENDA:   5.3.1.16
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 24822; Mature: 24691

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALTIFPAIDLKAGQVVRLAEGDMDRATVYGDDPAAQARRFADAGATHLHVVDLDGAFA
CCEEEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCC
GASVNGAAVESIIAAFPGQVQVGGGIRDRAGVDRWLALGVARVIIGTAALKDPEFVKSAA
CCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RDLPGRIVVGVDARDGMVATEGWADVSDVRVEDLARRFEDAGVAALLFTDVGRDGLLKGC
HCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCC
NVAATVALAGVVDIPVIASGGVAGIEDIHALRPHVADGIEGVITGRALYDGRLDLAEAIA
CHHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCHHHCCCCCEEECCEEECCCHHHHHHHH
AGAA
CCCC
>Mature Secondary Structure 
AALTIFPAIDLKAGQVVRLAEGDMDRATVYGDDPAAQARRFADAGATHLHVVDLDGAFA
CEEEEEEEEECCCCCEEEECCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCCCC
GASVNGAAVESIIAAFPGQVQVGGGIRDRAGVDRWLALGVARVIIGTAALKDPEFVKSAA
CCCCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
RDLPGRIVVGVDARDGMVATEGWADVSDVRVEDLARRFEDAGVAALLFTDVGRDGLLKGC
HCCCCEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCC
NVAATVALAGVVDIPVIASGGVAGIEDIHALRPHVADGIEGVITGRALYDGRLDLAEAIA
CHHHHHHHHHHHCCCEEECCCCCCHHHHHHHCCHHHCCCCCEEECCEEECCCHHHHHHHH
AGAA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA