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The map label for this gene is sdhA [H]

Identifier: 103488508

GI number: 103488508

Start: 3178042

End: 3179856

Strand: Direct

Name: sdhA [H]

Synonym: Sala_3032

Alternate gene names: 103488508

Gene position: 3178042-3179856 (Clockwise)

Preceding gene: 103488507

Following gene: 103488510

Centisome position: 95.0

GC content: 65.34

Gene sequence:

>1815_bases
ATGACCGAAGCCTACAAGATCATCGATCATATCTATGACACGGTCGTCGTCGGCGCGGGCGGCTCGGGCCTGCGCGCGAC
GATGGGCAGCGCCGAGGCGGGGCTGAAGACCGCCTGCATCACCAAGGTGTTCCCGACGCGCAGCCACACCGTCGCGGCCC
AGGGCGGCATCGCCGCCAGCCTCGGCAACAATTCGCCCGACCATTGGCAATGGCACATGTACGATACCGTCAAGGGCTCC
GACTGGCTCGGCGACCAGGACGCGATCGAATATATGGTGCGCGAGGCGCCCGCCGCAGTCTACGAACTCGAACATGCGGG
CGTTCCGTTCAGCCGCAACGCCGACGGCACCATCTATCAGCGCCCGTTCGGCGGCCATATGCAGAATATGGGCGAAGGCC
CGCCGGTGCAGCGCACCTGCGCCGCGGCCGACCGCACCGGCCATGCGATGCTTCACGCGCTCTACCAACAGAGCCTGAAA
TATGACGCGGACTTTTTCATCGAATATTTTGCGCTCGACCTGATCATGGAAAATGGCGCCAATGGTCCCGAATGTCGCGG
CGTCATCGCGCTGTGCATGGAGGATGGCAGCATCCACCGCTTCCGATCGCAAGCCGTCGTGCTTGCGACGGGCGGCTATG
GCCGCTGCTATTTCACCGCGACGTCAGCGCACACCTGCACCGGCGACGGCGGCGGCATGGTGCTGCGCGCGGGCCTCCCG
CTTCAGGACATGGAGTTCGTCCAGTTTCACCCGACCGGCATTTACGGCGCGGGCGTGCTGATTACCGAGGGCGCACGCGG
CGAGGGCGGCTACCTCACCAATTCGGAAGGCGAGCGGTTCATGGAACGCTACGCCCCATCGGCGAAGGATCTGGCGTCGC
GCGACGTCGTCTCGCGCTCGATGGCGCTTGAAATCCGCGAAGGCCGCGGCGTCGGCCCGGATGCCGACCATATCTATCTG
CACCTCGACCATATCGACCCCGCGGTGCTCGCCGAGCGGCTGCCGGGAATCACCGAGAGCGGCAAGATTTTCGCCGGCGT
CGACCTCACGCGCCAGCCGCTGCCCGTCGTGCCGACGGTCCATTACAATATGGGCGGCATCCCCTGTAACTATCATGGCG
AGGTCGTCACGCTCGGCAAGGATGGTCCCGACACCGTCGTCCCCGGCCTGTTCGCGGTCGGCGAAGCGGCGTGCGTGTCG
GTCCACGGCGCGAACCGTCTCGGCTCGAACAGCCTGATCGACCTTGTCGTCTTCGGTCGCGCCACGGGTCATCGCCTCAA
GGAACTGCTCACCCCCGGCGCGGCGCAGCAGCCGCTGCCCAAGGACAGCGCCGATCTGGCGCTCGCGCGGCTCGATCATT
TCCGCCACGCCAGCGGCGGATCGCCCACTGCCGAAGTGCGCACCGAAATGCAGCGCGCGATGTCGGCGCACGCGGCGGTG
TTCCGCACCGACGAGCTGATGGCGGAGGGCAAGGAAAAGCTTGCGAAAACCTATGCGCGGATGGCCGACATCCACGTCAG
CGACCGCAGCCTCATCTGGAACACTGACCTTGTCGAAACGCTGGAGCTCGACAATCTGATCGCGCAGGCGACGGTGACGA
TGCACTCGGCGTTCAACCGCAAGGAAAGCCGCGGCGCCCACGCGCACGAGGATTTCCCGAACCGCGACGATGCGAACTGG
ATGAAACACAGCGTCGCCTGGTTCGACGGCTGGGGCGGCAAGGGGGGCGATGTCCGCCTCGATTACCGCCCGGTCCACGA
ATATACGCTGTCGGACGACGCCGAATATATCAAGCCGAAGGCACGTGTCTATTGA

Upstream 100 bases:

>100_bases
CTGTTGAACTTCTACGCGATCGGCGGCGCCGCCTATGGCATTTTCGCGATCGTGCGCATCGCGCTGGCGCCCGCGGCGCT
CGGCCCCGGGGGCATGTAAG

Downstream 100 bases:

>100_bases
GATGCCGGTGAAGTTGACGGATGCAGAAATCTGGTGCGTTCGGACGCCGGTCCAGGCTGTATCGACAATCAGAGGATGGC
ACGCCGAAAATGGCGGTTTT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTEAYKIIDHIYDTVVVGAGGSGLRATMGSAEAGLKTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWQWHMYDTVKGS
DWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNADGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLK
YDADFFIEYFALDLIMENGANGPECRGVIALCMEDGSIHRFRSQAVVLATGGYGRCYFTATSAHTCTGDGGGMVLRAGLP
LQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEIREGRGVGPDADHIYL
HLDHIDPAVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPCNYHGEVVTLGKDGPDTVVPGLFAVGEAACVS
VHGANRLGSNSLIDLVVFGRATGHRLKELLTPGAAQQPLPKDSADLALARLDHFRHASGGSPTAEVRTEMQRAMSAHAAV
FRTDELMAEGKEKLAKTYARMADIHVSDRSLIWNTDLVETLELDNLIAQATVTMHSAFNRKESRGAHAHEDFPNRDDANW
MKHSVAWFDGWGGKGGDVRLDYRPVHEYTLSDDAEYIKPKARVY

Sequences:

>Translated_604_residues
MTEAYKIIDHIYDTVVVGAGGSGLRATMGSAEAGLKTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWQWHMYDTVKGS
DWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNADGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLK
YDADFFIEYFALDLIMENGANGPECRGVIALCMEDGSIHRFRSQAVVLATGGYGRCYFTATSAHTCTGDGGGMVLRAGLP
LQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEIREGRGVGPDADHIYL
HLDHIDPAVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPCNYHGEVVTLGKDGPDTVVPGLFAVGEAACVS
VHGANRLGSNSLIDLVVFGRATGHRLKELLTPGAAQQPLPKDSADLALARLDHFRHASGGSPTAEVRTEMQRAMSAHAAV
FRTDELMAEGKEKLAKTYARMADIHVSDRSLIWNTDLVETLELDNLIAQATVTMHSAFNRKESRGAHAHEDFPNRDDANW
MKHSVAWFDGWGGKGGDVRLDYRPVHEYTLSDDAEYIKPKARVY
>Mature_603_residues
TEAYKIIDHIYDTVVVGAGGSGLRATMGSAEAGLKTACITKVFPTRSHTVAAQGGIAASLGNNSPDHWQWHMYDTVKGSD
WLGDQDAIEYMVREAPAAVYELEHAGVPFSRNADGTIYQRPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKY
DADFFIEYFALDLIMENGANGPECRGVIALCMEDGSIHRFRSQAVVLATGGYGRCYFTATSAHTCTGDGGGMVLRAGLPL
QDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMALEIREGRGVGPDADHIYLH
LDHIDPAVLAERLPGITESGKIFAGVDLTRQPLPVVPTVHYNMGGIPCNYHGEVVTLGKDGPDTVVPGLFAVGEAACVSV
HGANRLGSNSLIDLVVFGRATGHRLKELLTPGAAQQPLPKDSADLALARLDHFRHASGGSPTAEVRTEMQRAMSAHAAVF
RTDELMAEGKEKLAKTYARMADIHVSDRSLIWNTDLVETLELDNLIAQATVTMHSAFNRKESRGAHAHEDFPNRDDANWM
KHSVAWFDGWGGKGGDVRLDYRPVHEYTLSDDAEYIKPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=622, Percent_Identity=59.1639871382637, Blast_Score=724, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=556, Percent_Identity=55.5755395683453, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1790597, Length=585, Percent_Identity=42.0512820512821, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=28.8770053475936, Blast_Score=196, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17550100, Length=618, Percent_Identity=59.546925566343, Blast_Score=724, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=622, Percent_Identity=56.1093247588424, Blast_Score=686, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=602, Percent_Identity=61.6279069767442, Blast_Score=758, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=602, Percent_Identity=61.4617940199336, Blast_Score=741, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=621, Percent_Identity=60.2254428341385, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=621, Percent_Identity=60.2254428341385, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=621, Percent_Identity=60.2254428341385, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=621, Percent_Identity=52.0128824476651, Blast_Score=641, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65530; Mature: 65399

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAYKIIDHIYDTVVVGAGGSGLRATMGSAEAGLKTACITKVFPTRSHTVAAQGGIAAS
CCHHHHHHHHHHHHEEEECCCCCCEEECCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEE
LGNNSPDHWQWHMYDTVKGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNADGTIYQ
CCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCCCCEEEE
RPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFALDLIMENGA
CCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
NGPECRGVIALCMEDGSIHRFRSQAVVLATGGYGRCYFTATSAHTCTGDGGGMVLRAGLP
CCCCCCEEEEEEECCCCEEEECCCEEEEEECCCCEEEEEECCCCEEECCCCCEEEECCCC
LQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRS
CCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHH
MALEIREGRGVGPDADHIYLHLDHIDPAVLAERLPGITESGKIFAGVDLTRQPLPVVPTV
HEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEE
HYNMGGIPCNYHGEVVTLGKDGPDTVVPGLFAVGEAACVSVHGANRLGSNSLIDLVVFGR
ECCCCCCCCCCCCCEEEECCCCCCHHHCHHHHHCCEEEEEEECCCCCCCCCEEEEEEECC
ATGHRLKELLTPGAAQQPLPKDSADLALARLDHFRHASGGSPTAEVRTEMQRAMSAHAAV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
FRTDELMAEGKEKLAKTYARMADIHVSDRSLIWNTDLVETLELDNLIAQATVTMHSAFNR
HHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
KESRGAHAHEDFPNRDDANWMKHSVAWFDGWGGKGGDVRLDYRPVHEYTLSDDAEYIKPK
HHHCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCEEEEEEECCCEECCCCHHHHCCC
ARVY
CCCC
>Mature Secondary Structure 
TEAYKIIDHIYDTVVVGAGGSGLRATMGSAEAGLKTACITKVFPTRSHTVAAQGGIAAS
CHHHHHHHHHHHHEEEECCCCCCEEECCCCCCCCHHHHHHHCCCCCCCEEEECCCEEEE
LGNNSPDHWQWHMYDTVKGSDWLGDQDAIEYMVREAPAAVYELEHAGVPFSRNADGTIYQ
CCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHEEHHHCCCCCCCCCCCEEEE
RPFGGHMQNMGEGPPVQRTCAAADRTGHAMLHALYQQSLKYDADFFIEYFALDLIMENGA
CCCCCHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCC
NGPECRGVIALCMEDGSIHRFRSQAVVLATGGYGRCYFTATSAHTCTGDGGGMVLRAGLP
CCCCCCEEEEEEECCCCEEEECCCEEEEEECCCCEEEEEECCCCEEECCCCCEEEECCCC
LQDMEFVQFHPTGIYGAGVLITEGARGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRS
CCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHH
MALEIREGRGVGPDADHIYLHLDHIDPAVLAERLPGITESGKIFAGVDLTRQPLPVVPTV
HEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCEE
HYNMGGIPCNYHGEVVTLGKDGPDTVVPGLFAVGEAACVSVHGANRLGSNSLIDLVVFGR
ECCCCCCCCCCCCCEEEECCCCCCHHHCHHHHHCCEEEEEEECCCCCCCCCEEEEEEECC
ATGHRLKELLTPGAAQQPLPKDSADLALARLDHFRHASGGSPTAEVRTEMQRAMSAHAAV
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
FRTDELMAEGKEKLAKTYARMADIHVSDRSLIWNTDLVETLELDNLIAQATVTMHSAFNR
HHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
KESRGAHAHEDFPNRDDANWMKHSVAWFDGWGGKGGDVRLDYRPVHEYTLSDDAEYIKPK
HHHCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCEEEEEEECCCEECCCCHHHHCCC
ARVY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA