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The map label for this gene is cobB [H]

Identifier: 103488225

GI number: 103488225

Start: 2898365

End: 2899066

Strand: Direct

Name: cobB [H]

Synonym: Sala_2748

Alternate gene names: 103488225

Gene position: 2898365-2899066 (Clockwise)

Preceding gene: 103488223

Following gene: 103488227

Centisome position: 86.64

GC content: 68.38

Gene sequence:

>702_bases
ATGAGCCCCATCCGGAATATCGTCATCCTGACCGGCGCCGGCGTTTCGGCCGAAAGCGGCATCGACACCTTTCGCGACGC
GGGCGGCCTTTGGGAACAGCACCGCGTCGAAGATGTCGCCACCCCCGAAGGTTTTGCGCGCGACCCCGACCTCGTGCTGC
GCTTTTACGACATGCGGCGTGCGGCGATCCAGACGAAACAGCCCAATGCCGCGCACCGGGCGCTGGCGCGGCTCGATGCC
GAATGGGCGGGCGAGCTGCTGATCGTGACCCAGAATGTCGACGATCTGCACGAGCGCGCGGGCGCGCAGCGGCTCATCCA
CATGCACGGCACCCATCTGAACGCCTGGTGCACCGGCTGCGATACGCGCAGCCCGTGGACCGCGCCGCTGCTCGACAGAC
CGCCCTGTCCGGCGTGCGGCGCCGTCGGCCATCTGCGCCCCGATGTCGTCTGGTTCGGCGAGATGCCCTACCGGATGGAG
GAGATTTATCATGCGATCAATCGCGCCGACCTGTTCGTGTCGATCGGGACGTCGGGCGCGGTCTATCCCGCCGCGGGTTT
CGTGCGCGAAGCGCGTGCGGCGGGGGCGCGTACGCTGGAGCTCAACATGGAGCCCAGCCAGGGCAGCCACTGGTTCGACG
AAGCCCGCCACGGCCCCGCGACCTGGCTGGTGCCCGAATGGGTCGAGGAGATGCTCGGCTAG

Upstream 100 bases:

>100_bases
CTCCTTAGCCGCTCGCCTCGCGCAAAGTCGAGATGCCCGTCCGGCGGGAGCCTCCACGCATGTCTCGACTTCGCGCAGCG
CGAGCGGATAGAAAGGGCGC

Downstream 100 bases:

>100_bases
GATCAGGACCCGTTAGAGCGGCGTGCTGCGAAAAATGCGCGGAGCAGCCCCGCCGCTTCGCTTTCGCCGATCCCGTCGTA
AATCTCCGGCCGATGATGCA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSPIRNIVILTGAGVSAESGIDTFRDAGGLWEQHRVEDVATPEGFARDPDLVLRFYDMRRAAIQTKQPNAAHRALARLDA
EWAGELLIVTQNVDDLHERAGAQRLIHMHGTHLNAWCTGCDTRSPWTAPLLDRPPCPACGAVGHLRPDVVWFGEMPYRME
EIYHAINRADLFVSIGTSGAVYPAAGFVREARAAGARTLELNMEPSQGSHWFDEARHGPATWLVPEWVEEMLG

Sequences:

>Translated_233_residues
MSPIRNIVILTGAGVSAESGIDTFRDAGGLWEQHRVEDVATPEGFARDPDLVLRFYDMRRAAIQTKQPNAAHRALARLDA
EWAGELLIVTQNVDDLHERAGAQRLIHMHGTHLNAWCTGCDTRSPWTAPLLDRPPCPACGAVGHLRPDVVWFGEMPYRME
EIYHAINRADLFVSIGTSGAVYPAAGFVREARAAGARTLELNMEPSQGSHWFDEARHGPATWLVPEWVEEMLG
>Mature_232_residues
SPIRNIVILTGAGVSAESGIDTFRDAGGLWEQHRVEDVATPEGFARDPDLVLRFYDMRRAAIQTKQPNAAHRALARLDAE
WAGELLIVTQNVDDLHERAGAQRLIHMHGTHLNAWCTGCDTRSPWTAPLLDRPPCPACGAVGHLRPDVVWFGEMPYRMEE
IYHAINRADLFVSIGTSGAVYPAAGFVREARAAGARTLELNMEPSQGSHWFDEARHGPATWLVPEWVEEMLG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=232, Percent_Identity=40.0862068965517, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI6912664, Length=249, Percent_Identity=37.3493975903614, Blast_Score=167, Evalue=8e-42,
Organism=Homo sapiens, GI13787215, Length=236, Percent_Identity=37.7118644067797, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI6912662, Length=243, Percent_Identity=28.3950617283951, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI6912660, Length=209, Percent_Identity=32.5358851674641, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI63054862, Length=208, Percent_Identity=33.6538461538462, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7657575, Length=203, Percent_Identity=33.0049261083744, Blast_Score=81, Evalue=7e-16,
Organism=Escherichia coli, GI308199517, Length=228, Percent_Identity=56.578947368421, Blast_Score=258, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17541892, Length=198, Percent_Identity=31.8181818181818, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137536, Length=222, Percent_Identity=31.981981981982, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571445, Length=185, Percent_Identity=30.8108108108108, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25813; Mature: 25682

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIRNIVILTGAGVSAESGIDTFRDAGGLWEQHRVEDVATPEGFARDPDLVLRFYDMRR
CCCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AAIQTKQPNAAHRALARLDAEWAGELLIVTQNVDDLHERAGAQRLIHMHGTHLNAWCTGC
HHHCCCCCCHHHHHHHHHCHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCC
DTRSPWTAPLLDRPPCPACGAVGHLRPDVVWFGEMPYRMEEIYHAINRADLFVSIGTSGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCEEEEEECCCCC
VYPAAGFVREARAAGARTLELNMEPSQGSHWFDEARHGPATWLVPEWVEEMLG
CCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCCEECHHHHHHHCC
>Mature Secondary Structure 
SPIRNIVILTGAGVSAESGIDTFRDAGGLWEQHRVEDVATPEGFARDPDLVLRFYDMRR
CCCCEEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
AAIQTKQPNAAHRALARLDAEWAGELLIVTQNVDDLHERAGAQRLIHMHGTHLNAWCTGC
HHHCCCCCCHHHHHHHHHCHHHCCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEEECCC
DTRSPWTAPLLDRPPCPACGAVGHLRPDVVWFGEMPYRMEEIYHAINRADLFVSIGTSGA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCEEEEEECCCCC
VYPAAGFVREARAAGARTLELNMEPSQGSHWFDEARHGPATWLVPEWVEEMLG
CCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCCCCCEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA