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The map label for this gene is rsh [H]

Identifier: 103488154

GI number: 103488154

Start: 2822946

End: 2825048

Strand: Direct

Name: rsh [H]

Synonym: Sala_2677

Alternate gene names: 103488154

Gene position: 2822946-2825048 (Clockwise)

Preceding gene: 103488149

Following gene: 103488155

Centisome position: 84.39

GC content: 63.77

Gene sequence:

>2103_bases
TTGAGGGTGATGCTGAGGCAATATGAACTTGTCGAGCGCGTGCGCGCCTATGATCCCGACGTCGACGAGGCGCTGCTCAA
CCGCGCCTATGTCTTTACGGTGCAAAAGCACGGCAGCCAGAAGCGCGCCTCGGGCGACCCCTATTTCAGCCATCCGGTTG
AGGTCGCGGGGATTTTGACCGACCTGCATCTCGACAGCGAAACGATCGTCACCGCGCTGCTCCACGACACGCTTGAGGAT
ACGCTGACGACGCCCGAGGAGATCGAACGCCTGTTCGGCCCCGACGTCGGGCGGCTGGTCGATGGCGTGACCAAATTGAG
CAAGATCGAGGCGCAAACCGAAAACGAGCGCGCCGCGGAAAATCTGCGCAAGTTCCTGCTCGCCATGTCCGACGACATCC
GCGTGCTGCTCGTCAAGCTCGCCGACCGGCTGCACAATATGCGCACGCTGCACTTCATCCAGAACCCCGAAAAAAGACGG
CGCATCGCCAGGGAGACGATGGACATCTATGCCCCGCTCGCCGAGCGGATCGGCATGTACGAATATATGCGCGAAATGCA
GTTGCTGGCGTTCCGCGAGCTCGAACCCGAAGCCTATGCGACGATCACCGGCCGCCTCGCCAAGCTGACCGCCGGCGGCA
AGGACAAGGTCGCCGCGATCAGCCGCGAGTTCAGGGAGCTGCTGTCCGCCGCGGGGATCGAGGCCGAGGTATCGGGGCGC
GAGAAGCATCCCTACTCGATCTGGCGCAAGATGCAGGAGCGCCACGTCAGTTTCGAGCAGGTGACCGACATCATCGCCTT
TCGCATCGTCACCCCGACCGACGCCGACTGCTATGCCGCGCTGGGGCTGATCCACCGCAAGTGGAAAATGGTGCCGGGCC
GCTTCAAGGACTATATCTCGACCCCCAAGCGCAACGGATACAAGTCGCTGCACACGACGATCATGCACCAGCAGAATATG
CGGATCGAAATCCAGATCCGCAGCGTCGGGATGCATCAGCAGTCCGAATTCGGCCTCGCCGCGCACTGGGCGTACAAGCA
GGGCGGCAGCGGCCCCGACGGGCAGGCGGGGTGGATCCGCGACCTCATCGAAATCCTCGAACAGACGCACGACCCCGACG
AGCTGCTCGAAAACACGCGCATCGCGATGTATCAGGATCGCATCTTTGCCTTTACCCCCAAGGGCAGCCTGCACCAGCTG
CCCAAGGGCGCAACGCCGGTCGATTTCGCTTATGCCGTCCACACCGGGCTCGGCGACCGCACCGTCGGGGCCAAGGTCAA
CGGGCGGCTTGTCCCGCTGCGTACGCAGCTTGTCAATGGCGATACGGTCGAAATCCTGTCGTCGGACAAACAGACGCCGC
AGCCCGCCTGGCTCGGCTTTGCGGTCACCGGCAAGGCGCGCGCGGCGATCCGCCGCCACGTCCGTTCAAAGGAAAAGGTC
GAACTCGCGGCTTTGGGTCGCAAGATGTACGACGAGATCGCCCGCCGCCTGCCGAACAAGGTCGGCGACAAGGCGCGTGC
CGCGGCGTTGACGCGCTTGAAACTCGAAGACGACAGCGCACTCTATATCGCGATCGCCAAGCAGCGGCTGACAGACGACG
CGGTGCTCGAGGCGCTGGTGCCCGGCATCACTGCCGAGATGAAGACCAAACCCGGCAAGCTTGTCCAGGGCGCGGCGGTG
TCGATTGCAGGATTGACGCCCGGCGTCGCCTATCAGCTCGCCGATTGCTGCCACCCGGTGCCCGGCGACCGGATCGTCGG
CCTGTCGCGTCCCGGCGAAGGGATCGAGGTGCATGTCATTGATTGCCCCAGCCTCGCCGATGGCGTCGATGCCGACTGGA
TCGACCTGCGCTGGCAGGAGGACAGCGAGGGCGGCAATGCACGGCTGTGCATCGTCATCCTGAACGAGCCGGGAACGCTG
GCCGAAATGTCGGGTATCCTTGCCGCCAATATGGCGAACATCACCAATTTGCGCCTGTCGAACCGCGAGGGCGGATTCCA
CACCTATGACGTCGTCGTCGAGGTGCGCGACGTCCAGCACCTGATGCGCATATTGTCGGCGCTGCGCGCGTCGGACAGCG
TCGTGCAGGCCGAGCGGTTATAG

Upstream 100 bases:

>100_bases
GGTCGCGCACGATGCTTCCAACGCGCTTTACCAAAATTGCTGACCTCCTGCGCGCCACGCACGCAAGTTTCGCATTGCAA
TATGCGCGCCAAGGGCGACA

Downstream 100 bases:

>100_bases
GCGGTTGGTTCCGCCCGCTTCGGGGTGGCGCACGGACCCTGGCTTTCTCTCGGTCGGCCTCTCGCTCGGCAGCGTGGAAG
GGCACGGCCGGAAGGATCTC

Product: (p)ppGpp synthetase I, SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MRVMLRQYELVERVRAYDPDVDEALLNRAYVFTVQKHGSQKRASGDPYFSHPVEVAGILTDLHLDSETIVTALLHDTLED
TLTTPEEIERLFGPDVGRLVDGVTKLSKIEAQTENERAAENLRKFLLAMSDDIRVLLVKLADRLHNMRTLHFIQNPEKRR
RIARETMDIYAPLAERIGMYEYMREMQLLAFRELEPEAYATITGRLAKLTAGGKDKVAAISREFRELLSAAGIEAEVSGR
EKHPYSIWRKMQERHVSFEQVTDIIAFRIVTPTDADCYAALGLIHRKWKMVPGRFKDYISTPKRNGYKSLHTTIMHQQNM
RIEIQIRSVGMHQQSEFGLAAHWAYKQGGSGPDGQAGWIRDLIEILEQTHDPDELLENTRIAMYQDRIFAFTPKGSLHQL
PKGATPVDFAYAVHTGLGDRTVGAKVNGRLVPLRTQLVNGDTVEILSSDKQTPQPAWLGFAVTGKARAAIRRHVRSKEKV
ELAALGRKMYDEIARRLPNKVGDKARAAALTRLKLEDDSALYIAIAKQRLTDDAVLEALVPGITAEMKTKPGKLVQGAAV
SIAGLTPGVAYQLADCCHPVPGDRIVGLSRPGEGIEVHVIDCPSLADGVDADWIDLRWQEDSEGGNARLCIVILNEPGTL
AEMSGILAANMANITNLRLSNREGGFHTYDVVVEVRDVQHLMRILSALRASDSVVQAERL

Sequences:

>Translated_700_residues
MRVMLRQYELVERVRAYDPDVDEALLNRAYVFTVQKHGSQKRASGDPYFSHPVEVAGILTDLHLDSETIVTALLHDTLED
TLTTPEEIERLFGPDVGRLVDGVTKLSKIEAQTENERAAENLRKFLLAMSDDIRVLLVKLADRLHNMRTLHFIQNPEKRR
RIARETMDIYAPLAERIGMYEYMREMQLLAFRELEPEAYATITGRLAKLTAGGKDKVAAISREFRELLSAAGIEAEVSGR
EKHPYSIWRKMQERHVSFEQVTDIIAFRIVTPTDADCYAALGLIHRKWKMVPGRFKDYISTPKRNGYKSLHTTIMHQQNM
RIEIQIRSVGMHQQSEFGLAAHWAYKQGGSGPDGQAGWIRDLIEILEQTHDPDELLENTRIAMYQDRIFAFTPKGSLHQL
PKGATPVDFAYAVHTGLGDRTVGAKVNGRLVPLRTQLVNGDTVEILSSDKQTPQPAWLGFAVTGKARAAIRRHVRSKEKV
ELAALGRKMYDEIARRLPNKVGDKARAAALTRLKLEDDSALYIAIAKQRLTDDAVLEALVPGITAEMKTKPGKLVQGAAV
SIAGLTPGVAYQLADCCHPVPGDRIVGLSRPGEGIEVHVIDCPSLADGVDADWIDLRWQEDSEGGNARLCIVILNEPGTL
AEMSGILAANMANITNLRLSNREGGFHTYDVVVEVRDVQHLMRILSALRASDSVVQAERL
>Mature_700_residues
MRVMLRQYELVERVRAYDPDVDEALLNRAYVFTVQKHGSQKRASGDPYFSHPVEVAGILTDLHLDSETIVTALLHDTLED
TLTTPEEIERLFGPDVGRLVDGVTKLSKIEAQTENERAAENLRKFLLAMSDDIRVLLVKLADRLHNMRTLHFIQNPEKRR
RIARETMDIYAPLAERIGMYEYMREMQLLAFRELEPEAYATITGRLAKLTAGGKDKVAAISREFRELLSAAGIEAEVSGR
EKHPYSIWRKMQERHVSFEQVTDIIAFRIVTPTDADCYAALGLIHRKWKMVPGRFKDYISTPKRNGYKSLHTTIMHQQNM
RIEIQIRSVGMHQQSEFGLAAHWAYKQGGSGPDGQAGWIRDLIEILEQTHDPDELLENTRIAMYQDRIFAFTPKGSLHQL
PKGATPVDFAYAVHTGLGDRTVGAKVNGRLVPLRTQLVNGDTVEILSSDKQTPQPAWLGFAVTGKARAAIRRHVRSKEKV
ELAALGRKMYDEIARRLPNKVGDKARAAALTRLKLEDDSALYIAIAKQRLTDDAVLEALVPGITAEMKTKPGKLVQGAAV
SIAGLTPGVAYQLADCCHPVPGDRIVGLSRPGEGIEVHVIDCPSLADGVDADWIDLRWQEDSEGGNARLCIVILNEPGTL
AEMSGILAANMANITNLRLSNREGGFHTYDVVVEVRDVQHLMRILSALRASDSVVQAERL

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=138, Percent_Identity=39.8550724637681, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790082, Length=711, Percent_Identity=37.1308016877637, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789147, Length=690, Percent_Identity=32.8985507246377, Blast_Score=368, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25143118, Length=132, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24650996, Length=120, Percent_Identity=38.3333333333333, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 78173; Mature: 78173

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMLRQYELVERVRAYDPDVDEALLNRAYVFTVQKHGSQKRASGDPYFSHPVEVAGILT
CCHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
DLHLDSETIVTALLHDTLEDTLTTPEEIERLFGPDVGRLVDGVTKLSKIEAQTENERAAE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHH
NLRKFLLAMSDDIRVLLVKLADRLHNMRTLHFIQNPEKRRRIARETMDIYAPLAERIGMY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EYMREMQLLAFRELEPEAYATITGRLAKLTAGGKDKVAAISREFRELLSAAGIEAEVSGR
HHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
EKHPYSIWRKMQERHVSFEQVTDIIAFRIVTPTDADCYAALGLIHRKWKMVPGRFKDYIS
CCCCHHHHHHHHHHCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHC
TPKRNGYKSLHTTIMHQQNMRIEIQIRSVGMHQQSEFGLAAHWAYKQGGSGPDGQAGWIR
CCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEEHHCCCCCCCCCHHHHH
DLIEILEQTHDPDELLENTRIAMYQDRIFAFTPKGSLHQLPKGATPVDFAYAVHTGLGDR
HHHHHHHCCCCHHHHHCCCCEEEEECEEEEECCCCCHHHCCCCCCCCHHHHHHHCCCCCC
TVGAKVNGRLVPLRTQLVNGDTVEILSSDKQTPQPAWLGFAVTGKARAAIRRHVRSKEKV
CCCCCCCCEEEEEEHEECCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCHHHH
ELAALGRKMYDEIARRLPNKVGDKARAAALTRLKLEDDSALYIAIAKQRLTDDAVLEALV
HHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHEEEECCCCEEEEEEEHHHCCHHHHHHHHH
PGITAEMKTKPGKLVQGAAVSIAGLTPGVAYQLADCCHPVPGDRIVGLSRPGEGIEVHVI
CCCCHHCCCCCCCEECCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEE
DCPSLADGVDADWIDLRWQEDSEGGNARLCIVILNEPGTLAEMSGILAANMANITNLRLS
ECCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEE
NREGGFHTYDVVVEVRDVQHLMRILSALRASDSVVQAERL
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MRVMLRQYELVERVRAYDPDVDEALLNRAYVFTVQKHGSQKRASGDPYFSHPVEVAGILT
CCHHHHHHHHHHHHHHCCCCHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
DLHLDSETIVTALLHDTLEDTLTTPEEIERLFGPDVGRLVDGVTKLSKIEAQTENERAAE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHH
NLRKFLLAMSDDIRVLLVKLADRLHNMRTLHFIQNPEKRRRIARETMDIYAPLAERIGMY
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
EYMREMQLLAFRELEPEAYATITGRLAKLTAGGKDKVAAISREFRELLSAAGIEAEVSGR
HHHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
EKHPYSIWRKMQERHVSFEQVTDIIAFRIVTPTDADCYAALGLIHRKWKMVPGRFKDYIS
CCCCHHHHHHHHHHCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHC
TPKRNGYKSLHTTIMHQQNMRIEIQIRSVGMHQQSEFGLAAHWAYKQGGSGPDGQAGWIR
CCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEEHHCCCCCCCCCHHHHH
DLIEILEQTHDPDELLENTRIAMYQDRIFAFTPKGSLHQLPKGATPVDFAYAVHTGLGDR
HHHHHHHCCCCHHHHHCCCCEEEEECEEEEECCCCCHHHCCCCCCCCHHHHHHHCCCCCC
TVGAKVNGRLVPLRTQLVNGDTVEILSSDKQTPQPAWLGFAVTGKARAAIRRHVRSKEKV
CCCCCCCCEEEEEEHEECCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHCCHHHH
ELAALGRKMYDEIARRLPNKVGDKARAAALTRLKLEDDSALYIAIAKQRLTDDAVLEALV
HHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHEEEECCCCEEEEEEEHHHCCHHHHHHHHH
PGITAEMKTKPGKLVQGAAVSIAGLTPGVAYQLADCCHPVPGDRIVGLSRPGEGIEVHVI
CCCCHHCCCCCCCEECCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEE
DCPSLADGVDADWIDLRWQEDSEGGNARLCIVILNEPGTLAEMSGILAANMANITNLRLS
ECCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHEEEEEE
NREGGFHTYDVVVEVRDVQHLMRILSALRASDSVVQAERL
CCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA