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The map label for this gene is czcD [H]

Identifier: 103488062

GI number: 103488062

Start: 2728043

End: 2728981

Strand: Direct

Name: czcD [H]

Synonym: Sala_2584

Alternate gene names: 103488062

Gene position: 2728043-2728981 (Clockwise)

Preceding gene: 103488061

Following gene: 103488063

Centisome position: 81.55

GC content: 62.19

Gene sequence:

>939_bases
ATGTCCGACGAGCTGGACAAACCGGGGACCGAAAAGCCCAACATTGCGGCACCGCCGGCGCATGATCACGGCAAAAATGC
GAACAGCAGGAGGCTGCTGCTCGCTCTCATCCTGACCGGTACCTTCCTGGTCGCAGAGGTCGTCGGTTCGTTCGTCTTCA
ACAGTCTCGCGCTCCTTTCGGACGCTGGGCACATGCTGACCGATGTCGCAGCGCTGATCATCGCGCTGATGGCGATCCGC
ATCGGAGCGCGACCGGCCGACGATCAGCGAACTTTTGGCTACAGACGCTTCGAGATCCTGGCGGCCGCCTTCAACGCGCT
CATGCTGTTCGCAGTCGCCATCTATGTCCTCGTTGAGGCACTCAACCGGTTCCGCGATCCTGAGCCGGTCCAGTCCACGG
GCATGCTGGTTGTCGCCGTGGCCGGTCTCGCCATCAATCTGATTTCCATGCGGCTGTTGAGCTCGGGCAAGGAGCAGAGC
CTCAACCTCAAAGGTGCCTATCTCGAGGTATGGGCAGACATGCTCGGCTCGATCGGGGTCATTGCCGGGGCCATAGCCAT
TCGTTTCACGGGCGCTACCTGGATCGATCCCGTCGTCGCCGTCGGCATTGGCCTCTGGGTGCTCCCCCGGACGTGGATTT
TGCTGCGCGATACGGCCAACGTTCTGCTGGAGGGCGTGCCGCGCGGCATGTCGCTGGACGAGGTGCGCAGGGCGATCAGT
GAGGTCTCGGGCGTGCAAAGTGCCCACGATCTTCACGTCTGGTCGATCACGACCGGCAATGTCAGCTGCTCCGTCCACAT
CGTGGTGGAGGACATCGCGCAAGCAGAGCCGACACGGACCCGCGTCGCACAAATGCTCGCGCAAGCCTTTCAAATCGGTC
ACGCGACCATTCAGACCGAGAGTAAGCAGTGCGCTGAGGCGCGTTCCACGCACAGCTGA

Upstream 100 bases:

>100_bases
CATGATCGCATCAATGGCGGCAGCCTCCCAGAGGCCGGCCCACCGACGGAACCGCAAACTTTGATGGAGTAAGCCGCTGA
TCCGTAAAAGGAGACGATCC

Downstream 100 bases:

>100_bases
CGGACAATGCATTTCGCCCCACTTGAAGGCTCAGATCTTCAAGCAACCGAGAGGAGGCCATCATGAGTTCAGCCGCAGAT
ACAGGACAAGGCATGCTCTG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MSDELDKPGTEKPNIAAPPAHDHGKNANSRRLLLALILTGTFLVAEVVGSFVFNSLALLSDAGHMLTDVAALIIALMAIR
IGARPADDQRTFGYRRFEILAAAFNALMLFAVAIYVLVEALNRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQS
LNLKGAYLEVWADMLGSIGVIAGAIAIRFTGATWIDPVVAVGIGLWVLPRTWILLRDTANVLLEGVPRGMSLDEVRRAIS
EVSGVQSAHDLHVWSITTGNVSCSVHIVVEDIAQAEPTRTRVAQMLAQAFQIGHATIQTESKQCAEARSTHS

Sequences:

>Translated_312_residues
MSDELDKPGTEKPNIAAPPAHDHGKNANSRRLLLALILTGTFLVAEVVGSFVFNSLALLSDAGHMLTDVAALIIALMAIR
IGARPADDQRTFGYRRFEILAAAFNALMLFAVAIYVLVEALNRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQS
LNLKGAYLEVWADMLGSIGVIAGAIAIRFTGATWIDPVVAVGIGLWVLPRTWILLRDTANVLLEGVPRGMSLDEVRRAIS
EVSGVQSAHDLHVWSITTGNVSCSVHIVVEDIAQAEPTRTRVAQMLAQAFQIGHATIQTESKQCAEARSTHS
>Mature_311_residues
SDELDKPGTEKPNIAAPPAHDHGKNANSRRLLLALILTGTFLVAEVVGSFVFNSLALLSDAGHMLTDVAALIIALMAIRI
GARPADDQRTFGYRRFEILAAAFNALMLFAVAIYVLVEALNRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQSL
NLKGAYLEVWADMLGSIGVIAGAIAIRFTGATWIDPVVAVGIGLWVLPRTWILLRDTANVLLEGVPRGMSLDEVRRAISE
VSGVQSAHDLHVWSITTGNVSCSVHIVVEDIAQAEPTRTRVAQMLAQAFQIGHATIQTESKQCAEARSTHS

Specific function: Necessary for activation of the czc determinant [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=315, Percent_Identity=29.8412698412698, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI52352805, Length=300, Percent_Identity=30.6666666666667, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI64762489, Length=312, Percent_Identity=28.8461538461538, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI289803013, Length=281, Percent_Identity=30.6049822064057, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803009, Length=281, Percent_Identity=30.6049822064057, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803007, Length=281, Percent_Identity=30.6049822064057, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803003, Length=281, Percent_Identity=30.6049822064057, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI21361112, Length=312, Percent_Identity=28.2051282051282, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI20070323, Length=343, Percent_Identity=25.9475218658892, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=28.4403669724771, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=38.5826771653543, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI52352803, Length=128, Percent_Identity=43.75, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI222080086, Length=126, Percent_Identity=31.7460317460317, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40255009, Length=126, Percent_Identity=31.7460317460317, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=282, Percent_Identity=41.8439716312057, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1790349, Length=256, Percent_Identity=23.046875, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193210990, Length=303, Percent_Identity=31.023102310231, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=307, Percent_Identity=31.9218241042345, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17555796, Length=304, Percent_Identity=31.9078947368421, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI32564488, Length=306, Percent_Identity=31.6993464052288, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17550442, Length=126, Percent_Identity=34.9206349206349, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550440, Length=126, Percent_Identity=34.9206349206349, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=225, Percent_Identity=32, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323899, Length=134, Percent_Identity=35.0746268656716, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=131, Percent_Identity=33.587786259542, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583858, Length=313, Percent_Identity=25.8785942492013, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24656728, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24656724, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24656720, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24656715, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21357035, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24585900, Length=143, Percent_Identity=32.8671328671329, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585898, Length=143, Percent_Identity=32.8671328671329, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585896, Length=143, Percent_Identity=32.8671328671329, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921672, Length=143, Percent_Identity=32.8671328671329, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645863, Length=125, Percent_Identity=37.6, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584409, Length=136, Percent_Identity=33.0882352941176, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574430, Length=136, Percent_Identity=33.0882352941176, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33509; Mature: 33378

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDELDKPGTEKPNIAAPPAHDHGKNANSRRLLLALILTGTFLVAEVVGSFVFNSLALLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAGHMLTDVAALIIALMAIRIGARPADDQRTFGYRRFEILAAAFNALMLFAVAIYVLVEA
HCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQSLNLKGAYLEVWADMLGSIGV
HHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IAGAIAIRFTGATWIDPVVAVGIGLWVLPRTWILLRDTANVLLEGVPRGMSLDEVRRAIS
HHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCHHHHHHHHH
EVSGVQSAHDLHVWSITTGNVSCSVHIVVEDIAQAEPTRTRVAQMLAQAFQIGHATIQTE
HHHCCCCCCCEEEEEEEECCEEEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
SKQCAEARSTHS
HHHHHHHHCCCC
>Mature Secondary Structure 
SDELDKPGTEKPNIAAPPAHDHGKNANSRRLLLALILTGTFLVAEVVGSFVFNSLALLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAGHMLTDVAALIIALMAIRIGARPADDQRTFGYRRFEILAAAFNALMLFAVAIYVLVEA
HCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNRFRDPEPVQSTGMLVVAVAGLAINLISMRLLSSGKEQSLNLKGAYLEVWADMLGSIGV
HHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IAGAIAIRFTGATWIDPVVAVGIGLWVLPRTWILLRDTANVLLEGVPRGMSLDEVRRAIS
HHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHCCCCCCCHHHHHHHHH
EVSGVQSAHDLHVWSITTGNVSCSVHIVVEDIAQAEPTRTRVAQMLAQAFQIGHATIQTE
HHHCCCCCCCEEEEEEEECCEEEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHEECC
SKQCAEARSTHS
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8829543 [H]