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The map label for this gene is pbpC [H]

Identifier: 103487864

GI number: 103487864

Start: 2510440

End: 2512629

Strand: Direct

Name: pbpC [H]

Synonym: Sala_2383

Alternate gene names: 103487864

Gene position: 2510440-2512629 (Clockwise)

Preceding gene: 103487863

Following gene: 103487865

Centisome position: 75.05

GC content: 71.78

Gene sequence:

>2190_bases
ATGCCTGCCGCCAACACGGTACAGCCGCTCGTTCGCCGGTTTTCCCGACCTTCTTCCCGCCGCTGGCCCCACGCGCTCGC
ATGGGCCGCCCTCGCGCTCCTCATCCTCACCACCATCGCGCACCTCGCCACCAGACCGCCGCCCATGCCCGCCTACGCCG
CCGTCCGCGCCGCCTGGCAGCCCAGCGAAGCCTGGCTCTACGACCGCGACGGCCACCTCCTCGACAGCGAGCGCGTCGAT
TTCGAGCGCCGCCGCCTTGCGTGGGTGCCGCTGCAAGACATCAGCCCCGCCGTCCGCACCGCCGTCGTCCAAAGCGAGGA
CCGCCGTTTCTGGTCGCATGGCGGGGTCGACTGGCTCGCAGTCGCCAGTGCCGTCCGGGCGCGCCTGACAATCTTGGGGG
GGACCGGCAATCGCTCGCGCGGCGCCTCGACGCTCGCGATGCAGCTCGCCGCCTTTCTCGACCCCGGCCTCGCGCAGCCC
GGCCAGCGCGACTGGCGCGCCAAGCTGCGCCAGATGCGCGCCGCGCAGCATCTCGCCGATGCGTGGACGCACGAGCAGAT
GCTCGAAGCCTATCTGAACCTCGTCCCCCTGCGCGGCGAGGCGCAGGGGATCGGCGCGGGCGCGGCGAGCCTGTTCGGCA
AGGCGCCGGCCGACATGAACCGCACCGACGCCGCGCTCTTCGCGGGGCTGCTCCCCAGCCCCGGCGCGGGCGCCGACGCG
CTCGCCCGCCGCGCGTGCCGTATCGCTGCGACACCCGACTGCACCGCGATCCGCGCCGCCGCCGCGACCCTCGTGTCGGG
CGAGCACGCTGCGCGCGCCGACCCCGGCCTTGCGCCGCACCTTGCCGTGCGCCTGCTCGACAAACCCGGCAAGCGCGTCA
CCACCACCATCGACCGCCGCATCCAGGCCGCCGCGATCGTCGCGCTGCGCCGCCAGCTCGCGGGGCTCGGTTCGGACCGC
GTCCGCGACGGCGCGGTCGTCGTGCTCGACAACGCCACCGGCGACGTGCTCGCCTATGTCGGCGGCGTCGGGTTGAAATC
GACCGCCGCCTCGGTCGACGGTGCCAATGCGCGGCGGCAGGCGGGATCGACGCTCAAGCCGCATCTCTACGCGCAGGTGA
TCGAACATGGCTGGCTCACCGCCGCGTCGATCCTCGACGACAGCCCGGTTCAGCTCGACACCGCCTCCGGCCTCTATGTC
CCCAAGAATTACGACCGCAGCTTCAAGGGGCCGGTCAGCGTCCGCCACGCGCTCGCCGCCTCGCTCAACGTCCCCGCCGT
CCGCGCGCTCGTCATCGACGACGTCCAGCAATTCCGTGACCGCCTCTGGGCGCTCGGCTATCACGGCCTCGTCGAGGATG
GCGAGTATTACGGCTTCTCCCTGGCGCTCGGATCGGCCGAAGTTTCTTTGGTCGAACAAGCCAACGCCTTTAGAACATTG
GCAAATAACGGAAACTGGTCCCCCGTCCGCTATCACCCCACGCGGCACCTTCGACACCATCCGCCGCGCCGGATCGTCAG
CCCCGCCGCCGCCTTCATCGTCGGCGACATCCTCGCCGACGCCGCCGCGCGCACCGACGCCTTCGGCGCCGACAGCGCGC
TCCGCCTCCCCTTCTGGGCCGCCGCCAAGACGGGGACGTCAAAGGGGATGCGCGACAATTGGTGCATCGGCTGGTCGGAC
CGCTTCACCGTCGCGGTGTGGGTCGGCAATCTGGAGGGCGATTCGATGCGCGCCGTCTCGGGCACCTCGGGCGCCGCCCC
CGTCTGGCGCGACGTGATGCTTGCGCTCCACGCCGGGCGTCCCGGCAAGCCACCCGCGATGCCCGCGGAGGTCGAGGTGC
GGCGGATCACGCTCCCCGGCACGCGCGAGCCGCCGCGCCGCGAGTATTTCGTGCGCGGCACCGCGCAGAATGAAATGGCG
GCCGCGCCCGCCATCGCGCGCCGTCCGCGCATCACCAGCCCGGTCAGCGGCAGCGTCTATGCGCTCGACCCCGACATCCC
GCCGGACCGGCAACGGCTGGCGGTGACGGTCAGCGGCGCGGTCGCCGGATATCGGCTGATTCTCGACAAAAAACCGCTCG
GCGACGCCGATGCGGGAGCGCAGATCATGCCGCGTCCGGGCAGCCATATGCTCGCGCTCGTCGATCCCGGCGGGCGAACG
ATCGACCGCATCCGCTTCACGGTGCGATAA

Upstream 100 bases:

>100_bases
TTGGCAGCTTGCTGCCTAGTCGTAGTGGGGTGGGGGCCAGCGGCCTTGCGCAAGGCGTCGGGCCCCCACCCCAAACCCCT
CCCCTGAAGGGGAGGGGCTT

Downstream 100 bases:

>100_bases
AGCGCCTGTCACACGCCTGAAATTAAGTTGCGCTGACGCGCGGAGCGGCTAGTCTGCCCCGCCAGGAGAGGCCCGCGCCG
GGCCCCAAAGGGGACAATTG

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 729; Mature: 728

Protein sequence:

>729_residues
MPAANTVQPLVRRFSRPSSRRWPHALAWAALALLILTTIAHLATRPPPMPAYAAVRAAWQPSEAWLYDRDGHLLDSERVD
FERRRLAWVPLQDISPAVRTAVVQSEDRRFWSHGGVDWLAVASAVRARLTILGGTGNRSRGASTLAMQLAAFLDPGLAQP
GQRDWRAKLRQMRAAQHLADAWTHEQMLEAYLNLVPLRGEAQGIGAGAASLFGKAPADMNRTDAALFAGLLPSPGAGADA
LARRACRIAATPDCTAIRAAAATLVSGEHAARADPGLAPHLAVRLLDKPGKRVTTTIDRRIQAAAIVALRRQLAGLGSDR
VRDGAVVVLDNATGDVLAYVGGVGLKSTAASVDGANARRQAGSTLKPHLYAQVIEHGWLTAASILDDSPVQLDTASGLYV
PKNYDRSFKGPVSVRHALAASLNVPAVRALVIDDVQQFRDRLWALGYHGLVEDGEYYGFSLALGSAEVSLVEQANAFRTL
ANNGNWSPVRYHPTRHLRHHPPRRIVSPAAAFIVGDILADAAARTDAFGADSALRLPFWAAAKTGTSKGMRDNWCIGWSD
RFTVAVWVGNLEGDSMRAVSGTSGAAPVWRDVMLALHAGRPGKPPAMPAEVEVRRITLPGTREPPRREYFVRGTAQNEMA
AAPAIARRPRITSPVSGSVYALDPDIPPDRQRLAVTVSGAVAGYRLILDKKPLGDADAGAQIMPRPGSHMLALVDPGGRT
IDRIRFTVR

Sequences:

>Translated_729_residues
MPAANTVQPLVRRFSRPSSRRWPHALAWAALALLILTTIAHLATRPPPMPAYAAVRAAWQPSEAWLYDRDGHLLDSERVD
FERRRLAWVPLQDISPAVRTAVVQSEDRRFWSHGGVDWLAVASAVRARLTILGGTGNRSRGASTLAMQLAAFLDPGLAQP
GQRDWRAKLRQMRAAQHLADAWTHEQMLEAYLNLVPLRGEAQGIGAGAASLFGKAPADMNRTDAALFAGLLPSPGAGADA
LARRACRIAATPDCTAIRAAAATLVSGEHAARADPGLAPHLAVRLLDKPGKRVTTTIDRRIQAAAIVALRRQLAGLGSDR
VRDGAVVVLDNATGDVLAYVGGVGLKSTAASVDGANARRQAGSTLKPHLYAQVIEHGWLTAASILDDSPVQLDTASGLYV
PKNYDRSFKGPVSVRHALAASLNVPAVRALVIDDVQQFRDRLWALGYHGLVEDGEYYGFSLALGSAEVSLVEQANAFRTL
ANNGNWSPVRYHPTRHLRHHPPRRIVSPAAAFIVGDILADAAARTDAFGADSALRLPFWAAAKTGTSKGMRDNWCIGWSD
RFTVAVWVGNLEGDSMRAVSGTSGAAPVWRDVMLALHAGRPGKPPAMPAEVEVRRITLPGTREPPRREYFVRGTAQNEMA
AAPAIARRPRITSPVSGSVYALDPDIPPDRQRLAVTVSGAVAGYRLILDKKPLGDADAGAQIMPRPGSHMLALVDPGGRT
IDRIRFTVR
>Mature_728_residues
PAANTVQPLVRRFSRPSSRRWPHALAWAALALLILTTIAHLATRPPPMPAYAAVRAAWQPSEAWLYDRDGHLLDSERVDF
ERRRLAWVPLQDISPAVRTAVVQSEDRRFWSHGGVDWLAVASAVRARLTILGGTGNRSRGASTLAMQLAAFLDPGLAQPG
QRDWRAKLRQMRAAQHLADAWTHEQMLEAYLNLVPLRGEAQGIGAGAASLFGKAPADMNRTDAALFAGLLPSPGAGADAL
ARRACRIAATPDCTAIRAAAATLVSGEHAARADPGLAPHLAVRLLDKPGKRVTTTIDRRIQAAAIVALRRQLAGLGSDRV
RDGAVVVLDNATGDVLAYVGGVGLKSTAASVDGANARRQAGSTLKPHLYAQVIEHGWLTAASILDDSPVQLDTASGLYVP
KNYDRSFKGPVSVRHALAASLNVPAVRALVIDDVQQFRDRLWALGYHGLVEDGEYYGFSLALGSAEVSLVEQANAFRTLA
NNGNWSPVRYHPTRHLRHHPPRRIVSPAAAFIVGDILADAAARTDAFGADSALRLPFWAAAKTGTSKGMRDNWCIGWSDR
FTVAVWVGNLEGDSMRAVSGTSGAAPVWRDVMLALHAGRPGKPPAMPAEVEVRRITLPGTREPPRREYFVRGTAQNEMAA
APAIARRPRITSPVSGSVYALDPDIPPDRQRLAVTVSGAVAGYRLILDKKPLGDADAGAQIMPRPGSHMLALVDPGGRTI
DRIRFTVR

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=556, Percent_Identity=32.3741007194245, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI1786343, Length=558, Percent_Identity=24.7311827956989, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI87082258, Length=291, Percent_Identity=28.1786941580756, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1789601, Length=244, Percent_Identity=27.0491803278689, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 78309; Mature: 78178

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAANTVQPLVRRFSRPSSRRWPHALAWAALALLILTTIAHLATRPPPMPAYAAVRAAWQ
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PSEAWLYDRDGHLLDSERVDFERRRLAWVPLQDISPAVRTAVVQSEDRRFWSHGGVDWLA
CCCCEEECCCCCEECCCCCCHHHHEEEEEEHHHCCHHHHHHHHHCCCHHHHHCCCHHHHH
VASAVRARLTILGGTGNRSRGASTLAMQLAAFLDPGLAQPGQRDWRAKLRQMRAAQHLAD
HHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
AWTHEQMLEAYLNLVPLRGEAQGIGAGAASLFGKAPADMNRTDAALFAGLLPSPGAGADA
HHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHH
LARRACRIAATPDCTAIRAAAATLVSGEHAARADPGLAPHLAVRLLDKPGKRVTTTIDRR
HHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHH
IQAAAIVALRRQLAGLGSDRVRDGAVVVLDNATGDVLAYVGGVGLKSTAASVDGANARRQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCHHHCCCCCCCHHHH
AGSTLKPHLYAQVIEHGWLTAASILDDSPVQLDTASGLYVPKNYDRSFKGPVSVRHALAA
CCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEECCCCEECCCCCCCCCCCCHHHHHHHHH
SLNVPAVRALVIDDVQQFRDRLWALGYHGLVEDGEYYGFSLALGSAEVSLVEQANAFRTL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
ANNGNWSPVRYHPTRHLRHHPPRRIVSPAAAFIVGDILADAAARTDAFGADSALRLPFWA
HCCCCCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEE
AAKTGTSKGMRDNWCIGWSDRFTVAVWVGNLEGDSMRAVSGTSGAAPVWRDVMLALHAGR
CCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCC
PGKPPAMPAEVEVRRITLPGTREPPRREYFVRGTAQNEMAAAPAIARRPRITSPVSGSVY
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHCCHHHCCCCCCCCCCCCEE
ALDPDIPPDRQRLAVTVSGAVAGYRLILDKKPLGDADAGAQIMPRPGSHMLALVDPGGRT
EECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCE
IDRIRFTVR
EEEEEEEEC
>Mature Secondary Structure 
PAANTVQPLVRRFSRPSSRRWPHALAWAALALLILTTIAHLATRPPPMPAYAAVRAAWQ
CCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
PSEAWLYDRDGHLLDSERVDFERRRLAWVPLQDISPAVRTAVVQSEDRRFWSHGGVDWLA
CCCCEEECCCCCEECCCCCCHHHHEEEEEEHHHCCHHHHHHHHHCCCHHHHHCCCHHHHH
VASAVRARLTILGGTGNRSRGASTLAMQLAAFLDPGLAQPGQRDWRAKLRQMRAAQHLAD
HHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
AWTHEQMLEAYLNLVPLRGEAQGIGAGAASLFGKAPADMNRTDAALFAGLLPSPGAGADA
HHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHH
LARRACRIAATPDCTAIRAAAATLVSGEHAARADPGLAPHLAVRLLDKPGKRVTTTIDRR
HHHHHHEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHHHH
IQAAAIVALRRQLAGLGSDRVRDGAVVVLDNATGDVLAYVGGVGLKSTAASVDGANARRQ
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHCCCCCCHHHCCCCCCCHHHH
AGSTLKPHLYAQVIEHGWLTAASILDDSPVQLDTASGLYVPKNYDRSFKGPVSVRHALAA
CCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEECCCCEECCCCCCCCCCCCHHHHHHHHH
SLNVPAVRALVIDDVQQFRDRLWALGYHGLVEDGEYYGFSLALGSAEVSLVEQANAFRTL
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
ANNGNWSPVRYHPTRHLRHHPPRRIVSPAAAFIVGDILADAAARTDAFGADSALRLPFWA
HCCCCCCCEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCEEE
AAKTGTSKGMRDNWCIGWSDRFTVAVWVGNLEGDSMRAVSGTSGAAPVWRDVMLALHAGR
CCCCCCCCCCCCCEEECCCCCEEEEEEEECCCCCCEEEECCCCCCCHHHHHHHHHHHCCC
PGKPPAMPAEVEVRRITLPGTREPPRREYFVRGTAQNEMAAAPAIARRPRITSPVSGSVY
CCCCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCCCHHHCCHHHCCCCCCCCCCCCEE
ALDPDIPPDRQRLAVTVSGAVAGYRLILDKKPLGDADAGAQIMPRPGSHMLALVDPGGRT
EECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCEEECCCCCCEEEEECCCCCE
IDRIRFTVR
EEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]