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The map label for this gene is adhI [H]

Identifier: 103487323

GI number: 103487323

Start: 1932992

End: 1934104

Strand: Reverse

Name: adhI [H]

Synonym: Sala_1839

Alternate gene names: 103487323

Gene position: 1934104-1932992 (Counterclockwise)

Preceding gene: 103487324

Following gene: 103487322

Centisome position: 57.82

GC content: 63.97

Gene sequence:

>1113_bases
ATGAAGACCCGCGCCGCCGTTGCGTTTGAAGCGAAGAAGCCGCTGGAAATCGTCGAACTCGACCTCGAAGGTCCGAAGGC
GGGTGAGGTGCTGGTCGAGATCATGGCGACCGGCATCTGCCATACGGATGCTTACACGCTTGACGGGTTCGACAGCGAGG
GCATCTTCCCGAGCGTGCTGGGGCATGAGGGCGCGGGCGTGGTGCGCGAGGTCGGCGCGGGCGTGACGAGCGTGGTGCCC
GGCGATCATGTGATCCCGCTCTACACCCCCGAATGCCGCCAGTGCAAAAGCTGCCTTTCGGGCAAGACCAACCTCTGCAC
CGCGATCCGTGCGACGCAGGGCAAGGGGCTGATGCCCGACGGCACGACGCGCTTCAGCTACAAGGGCCAGCCGATCTTTC
ATTATATGGGCTGCTCGACCTTCTCCAACTTCACCGTGCTTCCCGAAATCGCGGTCGCGAAGATCCGCGAGGACGCGCCC
TTTCAGCCCGCCTGCTACATCGGTTGCGGCGTCACCACCGGGGTCGGCGCGGTCATCAACACCGCGAAGGTGCAGGTCGG
CGACAATGTCGTTGTGTTCGGTTTGGGGGGTATCGGTCTCAACGTCATTCAGGGCGCGCGGCTTGCCGGGGCGAACAAGA
TCATCGGCGTCGACATCAATCCGGCGCGCGAGGAATGGGGCCGCAAGTTCGGAATGACCGAGTTCCTCAACTCGAAGGGC
ATGAGCCGCGAGGATGTCGTCGCGGCAATCGTCGCGATGACCGACGGCGGCGCCGATTACACCTTCGACGCCACGGGCAA
TACCGAGGTGATGCGCATCGCATTGGAAGCCTGCCACCGCGGCTGGGGCACCTCGATCATCATCGGCGTCGCCGAGGCGG
GCAAGGAGATCGCGACGCGGCCGTTCCAGCTCGTCACCGGGCGCAACTGGCGCGGCACCGCGTTCGGCGGCGCCAAGGGG
CGCACCGATGTGCCGAAGATCGTCGACATGTATATGACCGGCAAGATCGAGATCGACCCGATGATCACCCATGTCATGGG
CCTCGAAGAGATCAACAAGGGCTTCGACCTGATGCACGCGGGAGAGAGCATCCGGTCGGTCGTCGTATACTGA

Upstream 100 bases:

>100_bases
TGACTATCGCTTCTTTCCATGCCTTGCCGTCAAAGGAAGGATCACATGCTTGCATTGCCGCACCATTTGCCTGATTGGAG
CGCCCGAAAGGAGACGCCCC

Downstream 100 bases:

>100_bases
AGGAAAGGCTTTCCATGTTCAGCCATGTGGCGCTGGGGTCGAACGACATCGCAGCGAGCAAGAGGTTTTACGATGCGATC
CTGGGCGTCCTCGGCGCGGC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH; S-(hydroxymethyl)glutathione dehydrogenase [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKTRAAVAFEAKKPLEIVELDLEGPKAGEVLVEIMATGICHTDAYTLDGFDSEGIFPSVLGHEGAGVVREVGAGVTSVVP
GDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGKGLMPDGTTRFSYKGQPIFHYMGCSTFSNFTVLPEIAVAKIREDAP
FQPACYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGANKIIGVDINPAREEWGRKFGMTEFLNSKG
MSREDVVAAIVAMTDGGADYTFDATGNTEVMRIALEACHRGWGTSIIIGVAEAGKEIATRPFQLVTGRNWRGTAFGGAKG
RTDVPKIVDMYMTGKIEIDPMITHVMGLEEINKGFDLMHAGESIRSVVVY

Sequences:

>Translated_370_residues
MKTRAAVAFEAKKPLEIVELDLEGPKAGEVLVEIMATGICHTDAYTLDGFDSEGIFPSVLGHEGAGVVREVGAGVTSVVP
GDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGKGLMPDGTTRFSYKGQPIFHYMGCSTFSNFTVLPEIAVAKIREDAP
FQPACYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGANKIIGVDINPAREEWGRKFGMTEFLNSKG
MSREDVVAAIVAMTDGGADYTFDATGNTEVMRIALEACHRGWGTSIIIGVAEAGKEIATRPFQLVTGRNWRGTAFGGAKG
RTDVPKIVDMYMTGKIEIDPMITHVMGLEEINKGFDLMHAGESIRSVVVY
>Mature_370_residues
MKTRAAVAFEAKKPLEIVELDLEGPKAGEVLVEIMATGICHTDAYTLDGFDSEGIFPSVLGHEGAGVVREVGAGVTSVVP
GDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGKGLMPDGTTRFSYKGQPIFHYMGCSTFSNFTVLPEIAVAKIREDAP
FQPACYIGCGVTTGVGAVINTAKVQVGDNVVVFGLGGIGLNVIQGARLAGANKIIGVDINPAREEWGRKFGMTEFLNSKG
MSREDVVAAIVAMTDGGADYTFDATGNTEVMRIALEACHRGWGTSIIIGVAEAGKEIATRPFQLVTGRNWRGTAFGGAKG
RTDVPKIVDMYMTGKIEIDPMITHVMGLEEINKGFDLMHAGESIRSVVVY

Specific function: Oxidizes long-chain aliphatic alcohols, long-chain hydroxylated fatty acids and S-hydroxymethylglutathione (hmGSH) in increasing order of preference. Shows little or no activity with short-chain aliphatic alcohols [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=368, Percent_Identity=57.8804347826087, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=43.5135135135135, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI262073058, Length=371, Percent_Identity=44.4743935309973, Blast_Score=338, Evalue=4e-93,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=44.4743935309973, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=44, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI4501929, Length=370, Percent_Identity=42.972972972973, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4501933, Length=370, Percent_Identity=42.7027027027027, Blast_Score=328, Evalue=3e-90,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=40.650406504065, Blast_Score=319, Evalue=2e-87,
Organism=Homo sapiens, GI4501939, Length=362, Percent_Identity=40.8839779005525, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1786552, Length=370, Percent_Identity=61.6216216216216, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1788073, Length=364, Percent_Identity=27.1978021978022, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790045, Length=363, Percent_Identity=27.8236914600551, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=25.8485639686684, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787863, Length=362, Percent_Identity=25.1381215469613, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI226510992, Length=366, Percent_Identity=25.9562841530055, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081918, Length=221, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786518, Length=137, Percent_Identity=32.8467153284672, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786825, Length=380, Percent_Identity=25.5263157894737, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=53.6193029490617, Blast_Score=426, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=53.3333333333333, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=53.0612244897959, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562584, Length=372, Percent_Identity=28.2258064516129, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=27.6881720430108, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562876, Length=356, Percent_Identity=23.5955056179775, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=374, Percent_Identity=25.9358288770053, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=57.1428571428571, Blast_Score=445, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=26.4150943396226, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=374, Percent_Identity=27.2727272727273, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=357, Percent_Identity=28.0112044817927, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=357, Percent_Identity=28.0112044817927, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=386, Percent_Identity=26.6839378238342, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=372, Percent_Identity=25.5376344086022, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=363, Percent_Identity=24.5179063360882, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=55.9782608695652, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=27.2189349112426, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=24.5508982035928, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1; =1.1.1.284 [H]

Molecular weight: Translated: 39316; Mature: 39316

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRAAVAFEAKKPLEIVELDLEGPKAGEVLVEIMATGICHTDAYTLDGFDSEGIFPSVL
CCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHH
GHEGAGVVREVGAGVTSVVPGDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGKGLMPD
CCCCCCHHHHHCCCCEEECCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCCCCC
GTTRFSYKGQPIFHYMGCSTFSNFTVLPEIAVAKIREDAPFQPACYIGCGVTTGVGAVIN
CCEEEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCCEEEEECCCHHCHHHHEE
TAKVQVGDNVVVFGLGGIGLNVIQGARLAGANKIIGVDINPAREEWGRKFGMTEFLNSKG
EEEEEECCCEEEEEECCCCHHHHCCCEECCCCEEEEECCCHHHHHHHHHCCHHHHHHHCC
MSREDVVAAIVAMTDGGADYTFDATGNTEVMRIALEACHRGWGTSIIIGVAEAGKEIATR
CCHHHHEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCC
PFQLVTGRNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMGLEEINKGFDLMHA
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHEECCEEEECHHHHHHHCHHHHCCCCHHHHC
GESIRSVVVY
CCHHHEEECC
>Mature Secondary Structure
MKTRAAVAFEAKKPLEIVELDLEGPKAGEVLVEIMATGICHTDAYTLDGFDSEGIFPSVL
CCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHH
GHEGAGVVREVGAGVTSVVPGDHVIPLYTPECRQCKSCLSGKTNLCTAIRATQGKGLMPD
CCCCCCHHHHHCCCCEEECCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCCCCCC
GTTRFSYKGQPIFHYMGCSTFSNFTVLPEIAVAKIREDAPFQPACYIGCGVTTGVGAVIN
CCEEEEECCCEEEEEECCCCCCCCEECHHHHHHHHHCCCCCCCEEEEECCCHHCHHHHEE
TAKVQVGDNVVVFGLGGIGLNVIQGARLAGANKIIGVDINPAREEWGRKFGMTEFLNSKG
EEEEEECCCEEEEEECCCCHHHHCCCEECCCCEEEEECCCHHHHHHHHHCCHHHHHHHCC
MSREDVVAAIVAMTDGGADYTFDATGNTEVMRIALEACHRGWGTSIIIGVAEAGKEIATR
CCHHHHEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHCC
PFQLVTGRNWRGTAFGGAKGRTDVPKIVDMYMTGKIEIDPMITHVMGLEEINKGFDLMHA
CEEEEECCCCCCCCCCCCCCCCCCHHHHHHEECCEEEECHHHHHHHCHHHHCCCCHHHHC
GESIRSVVVY
CCHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631716 [H]