Click here to switch to the map view.

The map label for this gene is ccmA

Identifier: 103487306

GI number: 103487306

Start: 1920663

End: 1921247

Strand: Reverse

Name: ccmA

Synonym: Sala_1822

Alternate gene names: 103487306

Gene position: 1921247-1920663 (Counterclockwise)

Preceding gene: 103487307

Following gene: 103487305

Centisome position: 57.43

GC content: 71.45

Gene sequence:

>585_bases
GTGACGGTTCTGCTGGCGCTCGACGGCGTCGCGTGCATCCGCGGCGACCGGCTGGTCTTTGAGGAGCTGTCGCTCGCTCT
GAACCGCGGCGATGCGCTCTGGGTGCGCGGGCCGAACGGCGCGGGCAAATCGAGCCTGATCCGTCTCGCCGCCGGGCTGC
TGCGTCCCGCCGCGGGAAGGGTCGTGCGCCGCGGGCGGATCGCGCTGATCGACGAGGCGGCGGCGCTCGATTCCGAACTG
CCGCTGCGCCGCGCGCTCGATTTCTGGGCGCGGGTCGATACGGTCGACGGTCATGCCGTCGACCGGGCGATGGACATGAT
GGCGCTGAACACCCTGGCCGACGTGCCGGTGGCGATGCTTTCGACGGGGCAGCGAAGGCGCGCGGCGATGGTGCGGGTGA
TCGCCAGCGGCGCGCCGATCTGGCTGCTCGACGAACCCGCGAACGGGATGGACCAGGCCGCGACCGCGCGGCTGGTGGCG
GCGATTGCGACGCACCGCGCGAACGGCGGCGCGGTGTTGCTGGCGTCGCATTTCGCGCTGGCGATTCCCGATCTGGACGA
GCTGGTTATGGGGGTGTTGGCATGA

Upstream 100 bases:

>100_bases
GCGAACGGCTCGACTGGCTGGTGCGCCATGTGCTGATCCACGAGATCGGCCATCATTTCGGCTTTTCCGACGACGATATG
CACGCGCTTGAGGATATGGC

Downstream 100 bases:

>100_bases
ATCACCCCCCGTCAGCGCAGCGACGCAATCTCCAGCCCGAAGCATTGCGCGGCATCGATGGCCGGAGATTGCCGCGTCGC
CACGCTCCTCGTCGTGACCG

Product: heme exporter protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MTVLLALDGVACIRGDRLVFEELSLALNRGDALWVRGPNGAGKSSLIRLAAGLLRPAAGRVVRRGRIALIDEAAALDSEL
PLRRALDFWARVDTVDGHAVDRAMDMMALNTLADVPVAMLSTGQRRRAAMVRVIASGAPIWLLDEPANGMDQAATARLVA
AIATHRANGGAVLLASHFALAIPDLDELVMGVLA

Sequences:

>Translated_194_residues
MTVLLALDGVACIRGDRLVFEELSLALNRGDALWVRGPNGAGKSSLIRLAAGLLRPAAGRVVRRGRIALIDEAAALDSEL
PLRRALDFWARVDTVDGHAVDRAMDMMALNTLADVPVAMLSTGQRRRAAMVRVIASGAPIWLLDEPANGMDQAATARLVA
AIATHRANGGAVLLASHFALAIPDLDELVMGVLA
>Mature_193_residues
TVLLALDGVACIRGDRLVFEELSLALNRGDALWVRGPNGAGKSSLIRLAAGLLRPAAGRVVRRGRIALIDEAAALDSELP
LRRALDFWARVDTVDGHAVDRAMDMMALNTLADVPVAMLSTGQRRRAAMVRVIASGAPIWLLDEPANGMDQAATARLVAA
IATHRANGGAVLLASHFALAIPDLDELVMGVLA

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=175, Percent_Identity=30.8571428571429, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI6005701, Length=178, Percent_Identity=30.3370786516854, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI27477115, Length=178, Percent_Identity=28.6516853932584, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI27881501, Length=172, Percent_Identity=26.7441860465116, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI30795238, Length=172, Percent_Identity=26.7441860465116, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI153792144, Length=186, Percent_Identity=26.3440860215054, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI87082064, Length=187, Percent_Identity=33.6898395721925, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788165, Length=197, Percent_Identity=32.994923857868, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1786253, Length=174, Percent_Identity=30.4597701149425, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1790739, Length=194, Percent_Identity=27.319587628866, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1786803, Length=173, Percent_Identity=31.2138728323699, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787758, Length=168, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081782, Length=180, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787182, Length=171, Percent_Identity=30.9941520467836, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1790467, Length=190, Percent_Identity=25.2631578947368, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI87081791, Length=173, Percent_Identity=24.2774566473988, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=179, Percent_Identity=27.9329608938547, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI116007184, Length=158, Percent_Identity=29.1139240506329, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643674, Length=180, Percent_Identity=24.4444444444444, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45550390, Length=176, Percent_Identity=27.8409090909091, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_SPHAL (Q1GS38)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616867.1
- ProteinModelPortal:   Q1GS38
- SMR:   Q1GS38
- GeneID:   4082174
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1822
- NMPDR:   fig|317655.9.peg.1750
- HOGENOM:   HBG758042
- OMA:   DATAMET
- BioCyc:   SALA317655:SALA_1822-MONOMER
- BRENDA:   3.6.3.41
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 20473; Mature: 20342

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLLALDGVACIRGDRLVFEELSLALNRGDALWVRGPNGAGKSSLIRLAAGLLRPAAGR
CEEEEEECCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHH
VVRRGRIALIDEAAALDSELPLRRALDFWARVDTVDGHAVDRAMDMMALNTLADVPVAML
HHHCCCEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
STGQRRRAAMVRVIASGAPIWLLDEPANGMDQAATARLVAAIATHRANGGAVLLASHFAL
CCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEE
AIPDLDELVMGVLA
ECCCHHHHHHHHCC
>Mature Secondary Structure 
TVLLALDGVACIRGDRLVFEELSLALNRGDALWVRGPNGAGKSSLIRLAAGLLRPAAGR
EEEEEECCEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCHHHHH
VVRRGRIALIDEAAALDSELPLRRALDFWARVDTVDGHAVDRAMDMMALNTLADVPVAML
HHHCCCEEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHHH
STGQRRRAAMVRVIASGAPIWLLDEPANGMDQAATARLVAAIATHRANGGAVLLASHFAL
CCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCEE
AIPDLDELVMGVLA
ECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA