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The map label for this gene is 103487061

Identifier: 103487061

GI number: 103487061

Start: 1648877

End: 1649929

Strand: Reverse

Name: 103487061

Synonym: Sala_1576

Alternate gene names: NA

Gene position: 1649929-1648877 (Counterclockwise)

Preceding gene: 103487062

Following gene: 103487060

Centisome position: 49.32

GC content: 64.77

Gene sequence:

>1053_bases
ATGGTGAGCGGCGAGCGGTCCGTCGAACGGACATTCGTTATCGCGGAAGCGGGCGTCAACCACGACGGATCGCTCGACAA
GGCGTTGCGTCTTGTCGATATCGCCGTCGAGGCCGGAGCCGATGCGGTCAAGTTTCAGACATTCCGAACCGACGAGGTGG
TCACGCCCGACGCCGCCAAGGCCGCCTATCAACAACGTCAAACGGGCGCGGGCACGCAATATGAGATGATCCGGGCGCTC
GAGCTGGACGATGCCGCGCACGAAAGACTTGCGCGCCATTGCGCCGAGCGCGGGATCGAGTTCATGTCGACGCCCTTTGC
GCCTTGGGCGGTCGATATGCTGCTGGGCCTGGGAATGCGGCGGATCAAGATCGCCTCGGGCGAAATTGTCAACAAACCGC
TGATTGACAAGGTTGCAGGCTCGGGTCGGCCCATCATCCTATCGACCGGCATGGCCGAGATGGCGGAGGTCGTGAGGGCG
GTCGACTGGATACGCACGGCGCAAAGCGCGGCAGGCATCGCAATGTCACCGGGAGACCTCGTCGTCCTTCACTGCACCTC
CGAATATCCGGCGCCGGCCGCCAGCGTGAATCTGCGTGCCATGGATACGCTGGCTGCGGCGCTCGATGTGCCGGTCGGCT
ATTCGGATCACAGCCTGGGCATAGAGATTGCGGTCGCGGCGGTCGCGCGTGGCGCGGCGGTGATCGAAAAGCATTTTACC
GAAAACAGCCGCGATCACGGCCCCGATCACGCGGCGTCGCTGGAACCGGCGCAACTGCGCGCGATGGTCGATGCCATTCG
CAATGTCGAAGTTGCGCTTGGCGATGGCGTAAAGCGGCCCGCGCCGCTCGAGCTTCCGACGCGCGCGCTGGTTCGTCGCA
GCGCATTTGCGCTGACCGACATCAATAGGGGTGACAGGCTCGACGCCACGACCATCGCCTTTCTGCGTCCCGGCGACGGC
ATCGGTCCCGAACGGGCGGACTGGCTCTTTGCGCGCACGGCGGCGCGCGACATCGCGCGGGGCAGCAAGCTGTGCGAGGA
TGATATCGGGTGA

Upstream 100 bases:

>100_bases
CGAAAGCCGAAGAGATTGCGGACGCCATGCTGTTTCTCGCCAGCGATGGCGCGTCCTACATCAATGGCCAGAACATCGTG
GTTGACGGAGGGCTGACGAC

Downstream 100 bases:

>100_bases
CCAGTCCGAAACGCATCGTCTATCTGACCGGAACGCGGGCCGACTTCGGGCTGATGCTTCCTACCCTCCGCGCAATCGAT
CGTTCGCCGCACCTTGAACT

Product: N-acylneuraminate-9-phosphate synthase

Products: phosphate; N-acetylneuraminate

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MVSGERSVERTFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAKAAYQQRQTGAGTQYEMIRAL
ELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMRRIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRA
VDWIRTAQSAAGIAMSPGDLVVLHCTSEYPAPAASVNLRAMDTLAAALDVPVGYSDHSLGIEIAVAAVARGAAVIEKHFT
ENSRDHGPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTDINRGDRLDATTIAFLRPGDG
IGPERADWLFARTAARDIARGSKLCEDDIG

Sequences:

>Translated_350_residues
MVSGERSVERTFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAKAAYQQRQTGAGTQYEMIRAL
ELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMRRIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRA
VDWIRTAQSAAGIAMSPGDLVVLHCTSEYPAPAASVNLRAMDTLAAALDVPVGYSDHSLGIEIAVAAVARGAAVIEKHFT
ENSRDHGPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTDINRGDRLDATTIAFLRPGDG
IGPERADWLFARTAARDIARGSKLCEDDIG
>Mature_350_residues
MVSGERSVERTFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAKAAYQQRQTGAGTQYEMIRAL
ELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMRRIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRA
VDWIRTAQSAAGIAMSPGDLVVLHCTSEYPAPAASVNLRAMDTLAAALDVPVGYSDHSLGIEIAVAAVARGAAVIEKHFT
ENSRDHGPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTDINRGDRLDATTIAFLRPGDG
IGPERADWLFARTAARDIARGSKLCEDDIG

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=317, Percent_Identity=35.3312302839117, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21357081, Length=338, Percent_Identity=30.7692307692308, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: 2.5.1.56

Molecular weight: Translated: 37378; Mature: 37378

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSGERSVERTFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAK
CCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
AAYQQRQTGAGTQYEMIRALELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMR
HHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCC
RIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRAVDWIRTAQSAAGIAMSPGDL
EEEECCCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCCE
VVLHCTSEYPAPAASVNLRAMDTLAAALDVPVGYSDHSLGIEIAVAAVARGAAVIEKHFT
EEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
ENSRDHGPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHEEE
INRGDRLDATTIAFLRPGDGIGPERADWLFARTAARDIARGSKLCEDDIG
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure
MVSGERSVERTFVIAEAGVNHDGSLDKALRLVDIAVEAGADAVKFQTFRTDEVVTPDAAK
CCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHH
AAYQQRQTGAGTQYEMIRALELDDAAHERLARHCAERGIEFMSTPFAPWAVDMLLGLGMR
HHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHCCCC
RIKIASGEIVNKPLIDKVAGSGRPIILSTGMAEMAEVVRAVDWIRTAQSAAGIAMSPGDL
EEEECCCCCCCCCHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEECCCCE
VVLHCTSEYPAPAASVNLRAMDTLAAALDVPVGYSDHSLGIEIAVAAVARGAAVIEKHFT
EEEEECCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
ENSRDHGPDHAASLEPAQLRAMVDAIRNVEVALGDGVKRPAPLELPTRALVRRSAFALTD
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHEEE
INRGDRLDATTIAFLRPGDGIGPERADWLFARTAARDIARGSKLCEDDIG
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: phosphoenolpyruvate; N-acetyl-D-mannosamine; H2O

Specific reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]