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The map label for this gene is neuC [H]

Identifier: 103487060

GI number: 103487060

Start: 1647738

End: 1648880

Strand: Reverse

Name: neuC [H]

Synonym: Sala_1575

Alternate gene names: 103487060

Gene position: 1648880-1647738 (Counterclockwise)

Preceding gene: 103487061

Following gene: 103487059

Centisome position: 49.29

GC content: 60.8

Gene sequence:

>1143_bases
GTGACCAGTCCGAAACGCATCGTCTATCTGACCGGAACGCGGGCCGACTTCGGGCTGATGCTTCCTACCCTCCGCGCAAT
CGATCGTTCGCCGCACCTTGAACTGGAACTGCTGGTCACGGGAATGCATCTGTCGGACCGTTTCGGACGCACCGAGCGGG
AGGTCGAAGCCGCCGGCCTGAAGATCGGGCGTCGGATTCCCGTTCCCATCGACGATGACAGCGGGCACGGCATGGGGGTG
TCGACCGGGCTGATTACCTGCGCCGTTGCCGACTATCTGGCAGAAACAGCTTGCGATGTGCTGTTATTGCTGGGCGATCG
GGGGGAGATGCTGGCCGCCGCCACAGCCGGCCTTTTTGCCGACGTGCCGATCGTCCACGTCGCGGGAGGCGACCGATCGG
GATCGGTCGACGAATCCATCCGTCACGCCATTTCCAAGCTGGCGCATATCCACTGTGTTTCGAACGAGGATGCGCGTCAG
CGGCTGATCCGCATGGGCGAGGACCCCGACCGGATATTCGATGTGGGTGCGCCGGGGCTTGTCGGGCTGAAGAAGCCAGA
TCGCGCGACGGCGGCGATGGTCCGGAACCGTTATGGAATCGATGACGAGGAATCCTTTGTTCTGGTCCTTTTCCATCCTG
TGGTTCAGCAGGCTGCCGAGGCAGGGGCGCAATGGCGGGCCATGTTCGACGCGCTGGCGGGATTGCCTTTCCGATATGTG
GCGCTGATGCCGAACGCCGATCATGGCACGACGTCGATCCGAACCGAGATCGAAGCGATGCGCGATGCGGGACAGCTCAC
GACGATTGATCATATGCCGCGAGCGGATTATCTGGCATTGCTTGCAGAATGTCGTTTCCTGATCGGCAATTCGTCCAGTG
GCATCGTTGAGGCGGCGACGTTCGGAACGCCCGTCGTCAATGTCGGGGACAGGCAGTTTGGCAGGCTGCGCAGCGCGAAT
GTCTTTGACGCGCCGCCCGAAAGCGGTGCTATCGGCCGGGCGATAGAGAAAGCGATCGGTTTCGATCCGCAGGGGCTGCG
CAATGTCTATGGCGATCCGCATGCCGACATCAGAATTTGCGAAATACTGGAAAAGACCGATTTTTCGGCTTCCGCACTGC
GCATGAAGACCATTTCATACTAG

Upstream 100 bases:

>100_bases
CCGGCGACGGCATCGGTCCCGAACGGGCGGACTGGCTCTTTGCGCGCACGGCGGCGCGCGACATCGCGCGGGGCAGCAAG
CTGTGCGAGGATGATATCGG

Downstream 100 bases:

>100_bases
GGGTTCGTCAGTGGCTGCACCAAAGATCATCATTGTCGCAACAGGGGGGCTGGGCCGCGAGGCGCTCTGGGCTGCGCGCG
AATCGCGCGAGGGCTGGGAC

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MTSPKRIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGLKIGRRIPVPIDDDSGHGMGV
STGLITCAVADYLAETACDVLLLLGDRGEMLAAATAGLFADVPIVHVAGGDRSGSVDESIRHAISKLAHIHCVSNEDARQ
RLIRMGEDPDRIFDVGAPGLVGLKKPDRATAAMVRNRYGIDDEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPFRYV
ALMPNADHGTTSIRTEIEAMRDAGQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAATFGTPVVNVGDRQFGRLRSAN
VFDAPPESGAIGRAIEKAIGFDPQGLRNVYGDPHADIRICEILEKTDFSASALRMKTISY

Sequences:

>Translated_380_residues
MTSPKRIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGLKIGRRIPVPIDDDSGHGMGV
STGLITCAVADYLAETACDVLLLLGDRGEMLAAATAGLFADVPIVHVAGGDRSGSVDESIRHAISKLAHIHCVSNEDARQ
RLIRMGEDPDRIFDVGAPGLVGLKKPDRATAAMVRNRYGIDDEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPFRYV
ALMPNADHGTTSIRTEIEAMRDAGQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAATFGTPVVNVGDRQFGRLRSAN
VFDAPPESGAIGRAIEKAIGFDPQGLRNVYGDPHADIRICEILEKTDFSASALRMKTISY
>Mature_379_residues
TSPKRIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGLKIGRRIPVPIDDDSGHGMGVS
TGLITCAVADYLAETACDVLLLLGDRGEMLAAATAGLFADVPIVHVAGGDRSGSVDESIRHAISKLAHIHCVSNEDARQR
LIRMGEDPDRIFDVGAPGLVGLKKPDRATAAMVRNRYGIDDEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPFRYVA
LMPNADHGTTSIRTEIEAMRDAGQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAATFGTPVVNVGDRQFGRLRSANV
FDAPPESGAIGRAIEKAIGFDPQGLRNVYGDPHADIRICEILEKTDFSASALRMKTISY

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885285, Length=375, Percent_Identity=32.5333333333333, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI298566312, Length=375, Percent_Identity=32.5333333333333, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI190014632, Length=375, Percent_Identity=32.5333333333333, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI298566325, Length=343, Percent_Identity=31.4868804664723, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI298566315, Length=319, Percent_Identity=28.5266457680251, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 41076; Mature: 40945

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPKRIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGL
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHH
KIGRRIPVPIDDDSGHGMGVSTGLITCAVADYLAETACDVLLLLGDRGEMLAAATAGLFA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHC
DVPIVHVAGGDRSGSVDESIRHAISKLAHIHCVSNEDARQRLIRMGEDPDRIFDVGAPGL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCHHHEEECCCCCE
VGLKKPDRATAAMVRNRYGIDDEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPFRYV
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCEEEE
ALMPNADHGTTSIRTEIEAMRDAGQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAAT
EEECCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
FGTPVVNVGDRQFGRLRSANVFDAPPESGAIGRAIEKAIGFDPQGLRNVYGDPHADIRIC
CCCCEEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHH
EILEKTDFSASALRMKTISY
HHHHHCCCCHHHEEEEECCC
>Mature Secondary Structure 
TSPKRIVYLTGTRADFGLMLPTLRAIDRSPHLELELLVTGMHLSDRFGRTEREVEAAGL
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHH
KIGRRIPVPIDDDSGHGMGVSTGLITCAVADYLAETACDVLLLLGDRGEMLAAATAGLFA
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHC
DVPIVHVAGGDRSGSVDESIRHAISKLAHIHCVSNEDARQRLIRMGEDPDRIFDVGAPGL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHEEECCCCHHHHHHHHCCCCHHHEEECCCCCE
VGLKKPDRATAAMVRNRYGIDDEESFVLVLFHPVVQQAAEAGAQWRAMFDALAGLPFRYV
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCCEEEE
ALMPNADHGTTSIRTEIEAMRDAGQLTTIDHMPRADYLALLAECRFLIGNSSSGIVEAAT
EEECCCCCCCHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEE
FGTPVVNVGDRQFGRLRSANVFDAPPESGAIGRAIEKAIGFDPQGLRNVYGDPHADIRIC
CCCCEEECCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHH
EILEKTDFSASALRMKTISY
HHHHHCCCCHHHEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]