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The map label for this gene is thrC [H]

Identifier: 103486884

GI number: 103486884

Start: 1453095

End: 1454492

Strand: Reverse

Name: thrC [H]

Synonym: Sala_1398

Alternate gene names: 103486884

Gene position: 1454492-1453095 (Counterclockwise)

Preceding gene: 103486885

Following gene: 103486883

Centisome position: 43.48

GC content: 67.17

Gene sequence:

>1398_bases
ATGGACTATATCAGCACCCGCGGCTCAGCGCCGACCCTCGACTTTCGTGCCGCCACGCTCGCGGGCCTTGCCAGCGACGG
CGGGCTCTATGTGCCGACCAAATGGCCGCGGATGTCAGCAGATGAAATCCGCGCGCTCGCAGGCCTCGATTATGTCGAAA
CCGCGGTTCGCATCATGCGGCCCTTCGTCGAAAGCGTTTTGACCGAGGACGAACTGCGCGCGCTGTGCCGGGCCGCCTAT
GGCCGGTTCAGCCACGATGCGGTGACGCCGCTGGTCCAGCTCGATCATCGCCACTGGCTGCTCGAACTCTTCCATGGGCC
GACGCTGGCGTTCAAGGACGTCGCGCTGCAATTGCTCGGCGAATTGTTCGAGACGTTCCTGAGTGGCGGCGGCACCGACA
TCACGATCGTCGGCGCGACCTCCGGCGACACTGGATCGGCGGCGATCGAGGCCGTGGCGGGGCGTGAACATATCCAGATA
TTCATGCTGCATCCGGAGGGCCGCGTCAGCGACGTGCAGCGGCGCCAGATGACGACGGTGCTCGCGCCCAACGTCCACAA
TATCGCGATCGACGGCAGCTTCGACGATGCGCAGGCGATGGTGAAGCGGCTGTTCGGCGACGAAGCGGCGCGGGGCCAGG
TCAATCTGTCGGCGGTGAACAGCATCAACTGGGCGCGGCTGATGGCGCAGATCGTCTATTATTTCTATGCCGCCGTCCGC
CTCGGCGGACCCGACCGCCCGGTGGCGTTCAGCGTACCGACGGGCAATTTCGGCGATGTGTTCGCGGGCTATGTCGCGGC
GCAGATGGGCTTGCCGATCGCAAGGCTCGTCGTCGCCACGAACGTCAACGACATCCTCCACCGCGCGCTGACCAGCGGCG
ATTACAGCGCGGGGACGGTGACGCCCACCGCGACCCCCAGCATGGACATTCAGGTCAGCAGCAATTTCGAACGGCTGCTC
TTCGATCTCGCGGGCCGCGACGGCGCGGCCATTGCGGGGATGATGGCCGAGTTCGAGGCGAAGCGCGCGATGACCATCCC
CGCCGACATGCTGGCCGGCGCGCGCGACCTGTTTTCGAGCGCGCGCATCGACGGCGACGCGATGGCGCTCGCGCTGCGCT
GGGCGCGGGAACGCGGCGGACAGATCATCGACCCGCACAGCGCGGTGGGCCTCGCCGCGGCGCGCGCGCTGGAGATCGAC
GCCGAGATTCCGGTCGTCACGCTCGCGACGGCGCATCCGGCCAAGTTCCGCGAGGCGGTCGAGCGCGCGACCGGGGTACG
CCCACCACTGCCCGCGCGGCTGGGCAATCTGTTCGAGCGCGAGGAACGCTATACGAAGCTTCCCGGCGACTATGATGTCG
TCAAGGCCTTCATCCTCGCGGAAGCCGCGCGTGGCTGA

Upstream 100 bases:

>100_bases
GCAATGGTTCCTCTTTGCCGCCGCAGCACTGGTCATCTATATCCTCGCCGTGCGTCGCCGCTTGCGACCGTAAGCCGTCG
CCGCTAGGCGCATCTGCGTC

Downstream 100 bases:

>100_bases
TCTGTTGCCCCTCGTCACGCTCGTCGGCGCGGCGTGGGACGACTATGGGCTGGTCGACAGCGGGGGCGGCCGCAAGCTCG
AACGCTATGGCCGCTACCGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MDYISTRGSAPTLDFRAATLAGLASDGGLYVPTKWPRMSADEIRALAGLDYVETAVRIMRPFVESVLTEDELRALCRAAY
GRFSHDAVTPLVQLDHRHWLLELFHGPTLAFKDVALQLLGELFETFLSGGGTDITIVGATSGDTGSAAIEAVAGREHIQI
FMLHPEGRVSDVQRRQMTTVLAPNVHNIAIDGSFDDAQAMVKRLFGDEAARGQVNLSAVNSINWARLMAQIVYYFYAAVR
LGGPDRPVAFSVPTGNFGDVFAGYVAAQMGLPIARLVVATNVNDILHRALTSGDYSAGTVTPTATPSMDIQVSSNFERLL
FDLAGRDGAAIAGMMAEFEAKRAMTIPADMLAGARDLFSSARIDGDAMALALRWARERGGQIIDPHSAVGLAAARALEID
AEIPVVTLATAHPAKFREAVERATGVRPPLPARLGNLFEREERYTKLPGDYDVVKAFILAEAARG

Sequences:

>Translated_465_residues
MDYISTRGSAPTLDFRAATLAGLASDGGLYVPTKWPRMSADEIRALAGLDYVETAVRIMRPFVESVLTEDELRALCRAAY
GRFSHDAVTPLVQLDHRHWLLELFHGPTLAFKDVALQLLGELFETFLSGGGTDITIVGATSGDTGSAAIEAVAGREHIQI
FMLHPEGRVSDVQRRQMTTVLAPNVHNIAIDGSFDDAQAMVKRLFGDEAARGQVNLSAVNSINWARLMAQIVYYFYAAVR
LGGPDRPVAFSVPTGNFGDVFAGYVAAQMGLPIARLVVATNVNDILHRALTSGDYSAGTVTPTATPSMDIQVSSNFERLL
FDLAGRDGAAIAGMMAEFEAKRAMTIPADMLAGARDLFSSARIDGDAMALALRWARERGGQIIDPHSAVGLAAARALEID
AEIPVVTLATAHPAKFREAVERATGVRPPLPARLGNLFEREERYTKLPGDYDVVKAFILAEAARG
>Mature_465_residues
MDYISTRGSAPTLDFRAATLAGLASDGGLYVPTKWPRMSADEIRALAGLDYVETAVRIMRPFVESVLTEDELRALCRAAY
GRFSHDAVTPLVQLDHRHWLLELFHGPTLAFKDVALQLLGELFETFLSGGGTDITIVGATSGDTGSAAIEAVAGREHIQI
FMLHPEGRVSDVQRRQMTTVLAPNVHNIAIDGSFDDAQAMVKRLFGDEAARGQVNLSAVNSINWARLMAQIVYYFYAAVR
LGGPDRPVAFSVPTGNFGDVFAGYVAAQMGLPIARLVVATNVNDILHRALTSGDYSAGTVTPTATPSMDIQVSSNFERLL
FDLAGRDGAAIAGMMAEFEAKRAMTIPADMLAGARDLFSSARIDGDAMALALRWARERGGQIIDPHSAVGLAAARALEID
AEIPVVTLATAHPAKFREAVERATGVRPPLPARLGNLFEREERYTKLPGDYDVVKAFILAEAARG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=455, Percent_Identity=36.7032967032967, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI153792148, Length=487, Percent_Identity=31.4168377823409, Blast_Score=228, Evalue=1e-59,
Organism=Escherichia coli, GI1786185, Length=460, Percent_Identity=31.7391304347826, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=42.5438596491228, Blast_Score=344, Evalue=1e-95,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50072; Mature: 50072

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYISTRGSAPTLDFRAATLAGLASDGGLYVPTKWPRMSADEIRALAGLDYVETAVRIMR
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
PFVESVLTEDELRALCRAAYGRFSHDAVTPLVQLDHRHWLLELFHGPTLAFKDVALQLLG
HHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ELFETFLSGGGTDITIVGATSGDTGSAAIEAVAGREHIQIFMLHPEGRVSDVQRRQMTTV
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
LAPNVHNIAIDGSFDDAQAMVKRLFGDEAARGQVNLSAVNSINWARLMAQIVYYFYAAVR
CCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHH
LGGPDRPVAFSVPTGNFGDVFAGYVAAQMGLPIARLVVATNVNDILHRALTSGDYSAGTV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCEE
TPTATPSMDIQVSSNFERLLFDLAGRDGAAIAGMMAEFEAKRAMTIPADMLAGARDLFSS
CCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARIDGDAMALALRWARERGGQIIDPHSAVGLAAARALEIDAEIPVVTLATAHPAKFREAV
HCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHEEECCCCCEEEEECCCCHHHHHHH
ERATGVRPPLPARLGNLFEREERYTKLPGDYDVVKAFILAEAARG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDYISTRGSAPTLDFRAATLAGLASDGGLYVPTKWPRMSADEIRALAGLDYVETAVRIMR
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHH
PFVESVLTEDELRALCRAAYGRFSHDAVTPLVQLDHRHWLLELFHGPTLAFKDVALQLLG
HHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
ELFETFLSGGGTDITIVGATSGDTGSAAIEAVAGREHIQIFMLHPEGRVSDVQRRQMTTV
HHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHH
LAPNVHNIAIDGSFDDAQAMVKRLFGDEAARGQVNLSAVNSINWARLMAQIVYYFYAAVR
CCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEHHHCCCHHHHHHHHHHHHHHHHHH
LGGPDRPVAFSVPTGNFGDVFAGYVAAQMGLPIARLVVATNVNDILHRALTSGDYSAGTV
CCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCEE
TPTATPSMDIQVSSNFERLLFDLAGRDGAAIAGMMAEFEAKRAMTIPADMLAGARDLFSS
CCCCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ARIDGDAMALALRWARERGGQIIDPHSAVGLAAARALEIDAEIPVVTLATAHPAKFREAV
HCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHEEECCCCCEEEEECCCCHHHHHHH
ERATGVRPPLPARLGNLFEREERYTKLPGDYDVVKAFILAEAARG
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]