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The map label for this gene is nuoE [H]

Identifier: 103486792

GI number: 103486792

Start: 1366845

End: 1367513

Strand: Reverse

Name: nuoE [H]

Synonym: Sala_1306

Alternate gene names: 103486792

Gene position: 1367513-1366845 (Counterclockwise)

Preceding gene: 103486793

Following gene: 103486791

Centisome position: 40.88

GC content: 64.42

Gene sequence:

>669_bases
ATGGCTGACGCACCCCAAATCCCTGACGAAGCCGAAACCCGCGCGCGGTGGGGCGCTTTTGCGTGGACGGCGGAAAATGC
CGAAAAGGCGAAGGCGGTTATCGCGCGCTATCCCGCGGGGCGCCAGCGTTCGGCGGTGATGCCTTTGCTCGACCTTGCGC
AGCGCCAGGTCGGCGCCGAGACGCAGACGCAGGGCTGGCTGCCCGTGCCGGTGATCGAATATGTCGCGGCCCAGCTCGAT
ATGCCGTTCATCCGCGCCTATGAGGTCGCGACCTTCTATACCATGTATAATCTGGCGCCGGTCGGCCGCTATCATGTGCA
GGTGTGCGGAACGACACCGTGCCTGCTGCGCGGGTCGGACGATGTGACGGCGGCGTGCAAGAACCGCGGCATGGTGAAGG
GCAAGACGACGCCGGACGGGCTGTTCACCTTGAGCGAGGTCGAGTGCATGGGCACCTGCGCCAACGCGCCGATGGTCCAG
ATCAACGACGATAATTACGAAGACCTCGACTACGACAGCATGACGCGGATCCTCGACGAGCTTGCCGCGGGCAAACAGCC
CAAGACCGGCACGCAGAACCCGCGGCGCCACACGAGCGAGCCTGAGGGCGGGCCGACGACGCTGAAGGAAATGGTCGAGG
CCAATCATGACTATCGGAAGGAGTGGTGA

Upstream 100 bases:

>100_bases
TCTTCATGACATGGCGAATGATTCGACATGAAATCGACGAGTTTCAGCGCCTCAAAGCGATGGATGAGAATTCAGTAAGA
ACTAGCAGGAATGGCCGCTA

Downstream 100 bases:

>100_bases
TGATGACAAACGCCTCATTCCTTCGTCATGCCGGACTTGATCCGGCATCCATCGCGGCGCTGAAGTCGTGGACCCCGGAT
CAAGTCCGGGGTGACGGATT

Product: NADH-quinone oxidoreductase, E subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MADAPQIPDEAETRARWGAFAWTAENAEKAKAVIARYPAGRQRSAVMPLLDLAQRQVGAETQTQGWLPVPVIEYVAAQLD
MPFIRAYEVATFYTMYNLAPVGRYHVQVCGTTPCLLRGSDDVTAACKNRGMVKGKTTPDGLFTLSEVECMGTCANAPMVQ
INDDNYEDLDYDSMTRILDELAAGKQPKTGTQNPRRHTSEPEGGPTTLKEMVEANHDYRKEW

Sequences:

>Translated_222_residues
MADAPQIPDEAETRARWGAFAWTAENAEKAKAVIARYPAGRQRSAVMPLLDLAQRQVGAETQTQGWLPVPVIEYVAAQLD
MPFIRAYEVATFYTMYNLAPVGRYHVQVCGTTPCLLRGSDDVTAACKNRGMVKGKTTPDGLFTLSEVECMGTCANAPMVQ
INDDNYEDLDYDSMTRILDELAAGKQPKTGTQNPRRHTSEPEGGPTTLKEMVEANHDYRKEW
>Mature_221_residues
ADAPQIPDEAETRARWGAFAWTAENAEKAKAVIARYPAGRQRSAVMPLLDLAQRQVGAETQTQGWLPVPVIEYVAAQLDM
PFIRAYEVATFYTMYNLAPVGRYHVQVCGTTPCLLRGSDDVTAACKNRGMVKGKTTPDGLFTLSEVECMGTCANAPMVQI
NDDNYEDLDYDSMTRILDELAAGKQPKTGTQNPRRHTSEPEGGPTTLKEMVEANHDYRKEW

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=192, Percent_Identity=53.125, Blast_Score=205, Evalue=2e-53,
Organism=Escherichia coli, GI1788621, Length=162, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17561328, Length=192, Percent_Identity=52.0833333333333, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI18859877, Length=209, Percent_Identity=50.2392344497608, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI21355353, Length=191, Percent_Identity=45.5497382198953, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 24606; Mature: 24475

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAPQIPDEAETRARWGAFAWTAENAEKAKAVIARYPAGRQRSAVMPLLDLAQRQVGAE
CCCCCCCCCHHHHHHHHCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
TQTQGWLPVPVIEYVAAQLDMPFIRAYEVATFYTMYNLAPVGRYHVQVCGTTPCLLRGSD
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCC
DVTAACKNRGMVKGKTTPDGLFTLSEVECMGTCANAPMVQINDDNYEDLDYDSMTRILDE
CHHHHHHCCCEECCCCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
LAAGKQPKTGTQNPRRHTSEPEGGPTTLKEMVEANHDYRKEW
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
ADAPQIPDEAETRARWGAFAWTAENAEKAKAVIARYPAGRQRSAVMPLLDLAQRQVGAE
CCCCCCCCHHHHHHHHCEEEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCC
TQTQGWLPVPVIEYVAAQLDMPFIRAYEVATFYTMYNLAPVGRYHVQVCGTTPCLLRGSD
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEECCC
DVTAACKNRGMVKGKTTPDGLFTLSEVECMGTCANAPMVQINDDNYEDLDYDSMTRILDE
CHHHHHHCCCEECCCCCCCCCEEHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHH
LAAGKQPKTGTQNPRRHTSEPEGGPTTLKEMVEANHDYRKEW
HHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]