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The map label for this gene is nuoF1 [H]

Identifier: 103486791

GI number: 103486791

Start: 1365440

End: 1366732

Strand: Reverse

Name: nuoF1 [H]

Synonym: Sala_1305

Alternate gene names: 103486791

Gene position: 1366732-1365440 (Counterclockwise)

Preceding gene: 103486792

Following gene: 103486790

Centisome position: 40.86

GC content: 65.35

Gene sequence:

>1293_bases
ATGAGCCTCGCCGACAAGGACCGCATTTTCACCAATCTCTACGGCTTCCAGCCGTGGAACCTCAAAGCTGCGCAGGCGCG
CGGCGATTGGGATAATACCAGGGATCTGATGAAGCGCGGCCAGGACGCGATCATCGAGGAGATCAAGGCGTCGGGCCTGC
GCGGTCGCGGCGGCGCGGGCTTCCCGACGGGGCTCAAGTGGAGCTTCATGCCGAAGGAGCCGCGCGCCGACCGCCCGAGC
TTCCTTGTCATCAACGCCGACGAATCCGAACCGGGGTCGTGCAAGGACCGCGAGATCATCCGTCACGATCCGCACAAGCT
GATCGAAGGCGCGCTGATCGCGGGCTATGCGATGCGCGCCCGCGCCGCGTACATCTATATTCGCGGCGAGTTCATCCGCG
AGGCCGAAACACTCTTCGCGGCGGTGCAGGAGGCGTATGACGCCGGCCTGCTCGGCAAGAATGCGGCGAAGTCGGGTTAT
GACTTCGACGTTTTCGTCCACCGCGGCGCCGGCGCGTACATCTGCGGCGAAGAAACCGCGATGATCGAGAGCTTGGAAGG
CAAGAAGGGCCAGCCGCGTCTGAAACCCCCGTTCCCGGCGGGCGCGGGCCTCTATGGCTGCCCGACGACGGTGAACAATG
TCGAAAGCATCGCGGTCGTCCCGACGATCCTGCGGCGCGGCGCGCCGTGGTTCGCGAGCTTCGGGCGCGAGAATAACAAG
GGCACCAAGCTCTTCCAGATCAGCGGCCATGTGAACAAGCCGTGCGTCGTCGAGGAAGAGATGAGCATCCCCTTCCGCGA
ACTGATCGACAGGCATTGCGGCGGCATTCGCGGCGGCTGGGACAATCTGCTCGCGGTGATCCCCGGCGGTTCGTCGGTGC
CGCTGGTTCCGGCGGCGGAAATCATGGACTGCCCGATGGATTTCGACGGGCTGAAGGCCGTGGGTTCGGGCCTCGGCACC
GCGGCCGCGATCGTAATGGACAAGTCGACCGACGTCGTTCAGGCGATCAGCCGCATCAGCTATTTCTACAAGCATGAAAG
CTGCGGCCATTGCACGCCATGCCGCGAGGGCACCGGCTGGATGTGGCGCGTGATGGAGCGGCTGCGCACCGGCGACGCCG
ACATCAGCGAGATCGACACCTTGTTCGACGTGACCAAGCAGGTCGAAGGCCACACGATCTGCGCGCTCGGCGACGCCGCG
GCGTGGCCGATCCAGGGCCTGATCCGCCACTTCCGCCCCGAACTCGAACGCCGCATCCGCGAGAATGGTGGTGCGCTGGA
GGCGGCGGAGTGA

Upstream 100 bases:

>100_bases
CCTCATTCCTTCGTCATGCCGGACTTGATCCGGCATCCATCGCGGCGCTGAAGTCGTGGACCCCGGATCAAGTCCGGGGT
GACGGATTGGGAGCCGCCCG

Downstream 100 bases:

>100_bases
AGCGGCAATCGGCTATTCTGTGTACGGTTATGTCGGTTTACTCGCTCGGCAGCCAAATGGCTTACGCGCAGGCAACAGGG
ACGTACGTAGGGCCCTCGCC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSLADKDRIFTNLYGFQPWNLKAAQARGDWDNTRDLMKRGQDAIIEEIKASGLRGRGGAGFPTGLKWSFMPKEPRADRPS
FLVINADESEPGSCKDREIIRHDPHKLIEGALIAGYAMRARAAYIYIRGEFIREAETLFAAVQEAYDAGLLGKNAAKSGY
DFDVFVHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAPWFASFGRENNK
GTKLFQISGHVNKPCVVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAAEIMDCPMDFDGLKAVGSGLGT
AAAIVMDKSTDVVQAISRISYFYKHESCGHCTPCREGTGWMWRVMERLRTGDADISEIDTLFDVTKQVEGHTICALGDAA
AWPIQGLIRHFRPELERRIRENGGALEAAE

Sequences:

>Translated_430_residues
MSLADKDRIFTNLYGFQPWNLKAAQARGDWDNTRDLMKRGQDAIIEEIKASGLRGRGGAGFPTGLKWSFMPKEPRADRPS
FLVINADESEPGSCKDREIIRHDPHKLIEGALIAGYAMRARAAYIYIRGEFIREAETLFAAVQEAYDAGLLGKNAAKSGY
DFDVFVHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAPWFASFGRENNK
GTKLFQISGHVNKPCVVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAAEIMDCPMDFDGLKAVGSGLGT
AAAIVMDKSTDVVQAISRISYFYKHESCGHCTPCREGTGWMWRVMERLRTGDADISEIDTLFDVTKQVEGHTICALGDAA
AWPIQGLIRHFRPELERRIRENGGALEAAE
>Mature_429_residues
SLADKDRIFTNLYGFQPWNLKAAQARGDWDNTRDLMKRGQDAIIEEIKASGLRGRGGAGFPTGLKWSFMPKEPRADRPSF
LVINADESEPGSCKDREIIRHDPHKLIEGALIAGYAMRARAAYIYIRGEFIREAETLFAAVQEAYDAGLLGKNAAKSGYD
FDVFVHRGAGAYICGEETAMIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAPWFASFGRENNKG
TKLFQISGHVNKPCVVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAAEIMDCPMDFDGLKAVGSGLGTA
AAIVMDKSTDVVQAISRISYFYKHESCGHCTPCREGTGWMWRVMERLRTGDADISEIDTLFDVTKQVEGHTICALGDAAA
WPIQGLIRHFRPELERRIRENGGALEAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=69.2124105011933, Blast_Score=617, Evalue=1e-177,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=69.2124105011933, Blast_Score=617, Evalue=1e-177,
Organism=Escherichia coli, GI1788620, Length=407, Percent_Identity=42.2604422604423, Blast_Score=332, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17531727, Length=420, Percent_Identity=68.8095238095238, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI19920794, Length=418, Percent_Identity=69.8564593301435, Blast_Score=627, Evalue=1e-180,
Organism=Drosophila melanogaster, GI45550452, Length=426, Percent_Identity=65.4929577464789, Blast_Score=587, Evalue=1e-168,
Organism=Drosophila melanogaster, GI24653819, Length=418, Percent_Identity=48.0861244019139, Blast_Score=397, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24653817, Length=418, Percent_Identity=44.7368421052632, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47107; Mature: 46976

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLADKDRIFTNLYGFQPWNLKAAQARGDWDNTRDLMKRGQDAIIEEIKASGLRGRGGAG
CCCCCHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
FPTGLKWSFMPKEPRADRPSFLVINADESEPGSCKDREIIRHDPHKLIEGALIAGYAMRA
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHC
RAAYIYIRGEFIREAETLFAAVQEAYDAGLLGKNAAKSGYDFDVFVHRGAGAYICGEETA
EEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHH
MIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAPWFASFGRENNK
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCC
GTKLFQISGHVNKPCVVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAAE
CCEEEEECCCCCCCEEECHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHH
IMDCPMDFDGLKAVGSGLGTAAAIVMDKSTDVVQAISRISYFYKHESCGHCTPCREGTGW
HHCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
MWRVMERLRTGDADISEIDTLFDVTKQVEGHTICALGDAAAWPIQGLIRHFRPELERRIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ENGGALEAAE
HCCCCCCCCC
>Mature Secondary Structure 
SLADKDRIFTNLYGFQPWNLKAAQARGDWDNTRDLMKRGQDAIIEEIKASGLRGRGGAG
CCCCHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
FPTGLKWSFMPKEPRADRPSFLVINADESEPGSCKDREIIRHDPHKLIEGALIAGYAMRA
CCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHC
RAAYIYIRGEFIREAETLFAAVQEAYDAGLLGKNAAKSGYDFDVFVHRGAGAYICGEETA
EEEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHH
MIESLEGKKGQPRLKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAPWFASFGRENNK
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCCC
GTKLFQISGHVNKPCVVEEEMSIPFRELIDRHCGGIRGGWDNLLAVIPGGSSVPLVPAAE
CCEEEEECCCCCCCEEECHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHH
IMDCPMDFDGLKAVGSGLGTAAAIVMDKSTDVVQAISRISYFYKHESCGHCTPCREGTGW
HHCCCCCHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
MWRVMERLRTGDADISEIDTLFDVTKQVEGHTICALGDAAAWPIQGLIRHFRPELERRIR
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
ENGGALEAAE
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]