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The map label for this gene is trpE [H]

Identifier: 103486662

GI number: 103486662

Start: 1209690

End: 1211207

Strand: Direct

Name: trpE [H]

Synonym: Sala_1174

Alternate gene names: 103486662

Gene position: 1209690-1211207 (Clockwise)

Preceding gene: 103486661

Following gene: 103486663

Centisome position: 36.16

GC content: 67.79

Gene sequence:

>1518_bases
GTGACCCTGGAAGGCAGGGCCGCCGCGCTCGAAGCGCTGGCAGGGGGGCACGGCGCGGTCGTCTGGCAACGGTTGATCGC
CGACATCGAAACGCCGGTGTCGGCGGCGCTCAAGCTCATCGAACCGGAGCGCGGCGACTGGGTGCTCGAATCGGTCGAAA
GCGGCGAAACGCGGGGCCGTTACAGCCTGATCGGCCTCGATCCCGATCTGATGTTCGAAGTGCGCGGCGACGCGGCGCGC
ATCAACCGCGACTGGCGGCATGACCGCGATGCCTTTGTCCCGGTCGAGGCAGGCGCCTTGCAGGCGCTGCGCGATCTGGT
AGCCGAATGCCGGTTTGACGTGCCCGAAGGATTGCCCAAGGCGCTTGCGACGCTCGTGGGCTTCTTTGCCTATGAAACCA
TCGGCCTCGTTGAACGCATTCCGCGGGCGCCGGGCGCGGGCCTCGGCCTGCCCGACATGATTTTCGTGCGCCCGACGACG
ATCCTCGTCTTCGACCGGCTGGCTGACGAACTGTTCCTGATCGCGCCGATCTGGCCCGACGCGCGCGGTGCCATCGACCG
GATGATCGATACCGCCGGAGAGCGGCTCGAAAGCATCGCGGCGCGACTATCGAGCGCGAGCCCGCACGCCGATGGGGCCT
CGACCGCGGCGCTGACCCAAAGCATCACGGCGACGCCCGCGACGTCTCCTGAGCGCTTCGCGGCAATGGTCGCGGCGGCG
AAGGATTATATTGCGGCGGGCGATATTTTTCAGGTGGTGCTCTCGCAGCGTTTCTCGACCCCGTTCGACCTGCCGCCTTT
CGACCTTTACCGCGCGCTTCGCCGCGTCAACCCGTCGCCCTTCCTCTATTTTCTCGACCTGCCGGGCTTTGCGCTGATCG
GCTCGTCGCCCGAGATACTGGTGCGGGTGCGCGACGGCGAAATCACGATCCGCCCGATCGCGGGCACGCGCCCACGCGGG
CGCACGAGTGCGGAGGACGCCGAGAATCGCGAAAGCCTGCTCGCCGATCCCAAGGAGCGCGCCGAGCATCTGATGTTGCT
CGACCTGGGCCGCAATGACGTCGGCCGGGCAGCGATCGGCGGCAGCGTGTCCGTGACCGACAGCTACACGGTCGAGTTCT
ACAGCCATGTGATGCACATCGTGTCGAATGTCATCGGCCGCATCGCGCCGGGCAAGGACGCGATCGACGCGCTGTTCGCG
GGCTTCCCCGCCGGAACCGTCAGTGGCGCGCCCAAGGTTCGCGCGTGCCAGATCATTGCCGAACTGGAAGCCGATGCGCG
CGGCCCCTATGCGGGCGGCGTCGGCTATTTCGCGCCCGACGGCAATATGGACAGCTGCATCGTGCTGCGCACCGCGATCG
TCAAGGACGGCGTGATGCACGTCCAGGCGGGTGCGGGGATCGTCGCCGACAGCGACCCGGCTTACGAACAGCGTGAGTGC
GAGGCGAAGGCGGGAGCGCTCTTTGCCGCGGCGCGCGAGGCGGTGCGGATCGCGGGGACCGCGGGATACGGGCAGTAG

Upstream 100 bases:

>100_bases
CCGCCGAGGCCAGGCGGCGCGTCGGGGTGACGATCAACAAGGGGCTGGTCGACCAGCTGCGCCGCGAGCTGACCGGCACC
GCGCCGGTCGCCGAATAAGC

Downstream 100 bases:

>100_bases
GATTTCGGCCAAAGGCAAATCATTGCCCGCACCCGCCGGAATCACAACGCCCGGGCCTTGTTCCCAAGACCCGGGCGCCT
GTGACGAACACTCGCCATCC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MTLEGRAAALEALAGGHGAVVWQRLIADIETPVSAALKLIEPERGDWVLESVESGETRGRYSLIGLDPDLMFEVRGDAAR
INRDWRHDRDAFVPVEAGALQALRDLVAECRFDVPEGLPKALATLVGFFAYETIGLVERIPRAPGAGLGLPDMIFVRPTT
ILVFDRLADELFLIAPIWPDARGAIDRMIDTAGERLESIAARLSSASPHADGASTAALTQSITATPATSPERFAAMVAAA
KDYIAAGDIFQVVLSQRFSTPFDLPPFDLYRALRRVNPSPFLYFLDLPGFALIGSSPEILVRVRDGEITIRPIAGTRPRG
RTSAEDAENRESLLADPKERAEHLMLLDLGRNDVGRAAIGGSVSVTDSYTVEFYSHVMHIVSNVIGRIAPGKDAIDALFA
GFPAGTVSGAPKVRACQIIAELEADARGPYAGGVGYFAPDGNMDSCIVLRTAIVKDGVMHVQAGAGIVADSDPAYEQREC
EAKAGALFAAAREAVRIAGTAGYGQ

Sequences:

>Translated_505_residues
MTLEGRAAALEALAGGHGAVVWQRLIADIETPVSAALKLIEPERGDWVLESVESGETRGRYSLIGLDPDLMFEVRGDAAR
INRDWRHDRDAFVPVEAGALQALRDLVAECRFDVPEGLPKALATLVGFFAYETIGLVERIPRAPGAGLGLPDMIFVRPTT
ILVFDRLADELFLIAPIWPDARGAIDRMIDTAGERLESIAARLSSASPHADGASTAALTQSITATPATSPERFAAMVAAA
KDYIAAGDIFQVVLSQRFSTPFDLPPFDLYRALRRVNPSPFLYFLDLPGFALIGSSPEILVRVRDGEITIRPIAGTRPRG
RTSAEDAENRESLLADPKERAEHLMLLDLGRNDVGRAAIGGSVSVTDSYTVEFYSHVMHIVSNVIGRIAPGKDAIDALFA
GFPAGTVSGAPKVRACQIIAELEADARGPYAGGVGYFAPDGNMDSCIVLRTAIVKDGVMHVQAGAGIVADSDPAYEQREC
EAKAGALFAAAREAVRIAGTAGYGQ
>Mature_504_residues
TLEGRAAALEALAGGHGAVVWQRLIADIETPVSAALKLIEPERGDWVLESVESGETRGRYSLIGLDPDLMFEVRGDAARI
NRDWRHDRDAFVPVEAGALQALRDLVAECRFDVPEGLPKALATLVGFFAYETIGLVERIPRAPGAGLGLPDMIFVRPTTI
LVFDRLADELFLIAPIWPDARGAIDRMIDTAGERLESIAARLSSASPHADGASTAALTQSITATPATSPERFAAMVAAAK
DYIAAGDIFQVVLSQRFSTPFDLPPFDLYRALRRVNPSPFLYFLDLPGFALIGSSPEILVRVRDGEITIRPIAGTRPRGR
TSAEDAENRESLLADPKERAEHLMLLDLGRNDVGRAAIGGSVSVTDSYTVEFYSHVMHIVSNVIGRIAPGKDAIDALFAG
FPAGTVSGAPKVRACQIIAELEADARGPYAGGVGYFAPDGNMDSCIVLRTAIVKDGVMHVQAGAGIVADSDPAYEQRECE
AKAGALFAAAREAVRIAGTAGYGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=372, Percent_Identity=39.247311827957, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1788114, Length=391, Percent_Identity=33.5038363171356, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI87082077, Length=262, Percent_Identity=28.2442748091603, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786809, Length=265, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320935, Length=471, Percent_Identity=37.1549893842887, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6324361, Length=269, Percent_Identity=27.5092936802974, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53892; Mature: 53761

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEGRAAALEALAGGHGAVVWQRLIADIETPVSAALKLIEPERGDWVLESVESGETRGR
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCC
YSLIGLDPDLMFEVRGDAARINRDWRHDRDAFVPVEAGALQALRDLVAECRFDVPEGLPK
EEEEECCCCEEEEECCCHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHH
ALATLVGFFAYETIGLVERIPRAPGAGLGLPDMIFVRPTTILVFDRLADELFLIAPIWPD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCEEEEEECCCC
ARGAIDRMIDTAGERLESIAARLSSASPHADGASTAALTQSITATPATSPERFAAMVAAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
KDYIAAGDIFQVVLSQRFSTPFDLPPFDLYRALRRVNPSPFLYFLDLPGFALIGSSPEIL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEE
VRVRDGEITIRPIAGTRPRGRTSAEDAENRESLLADPKERAEHLMLLDLGRNDVGRAAIG
EEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEECC
GSVSVTDSYTVEFYSHVMHIVSNVIGRIAPGKDAIDALFAGFPAGTVSGAPKVRACQIIA
CCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEADARGPYAGGVGYFAPDGNMDSCIVLRTAIVKDGVMHVQAGAGIVADSDPAYEQREC
HHCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCEEEECCCCEEECCCCCHHHHHH
EAKAGALFAAAREAVRIAGTAGYGQ
HHHHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure 
TLEGRAAALEALAGGHGAVVWQRLIADIETPVSAALKLIEPERGDWVLESVESGETRGR
CCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHCCCCCCC
YSLIGLDPDLMFEVRGDAARINRDWRHDRDAFVPVEAGALQALRDLVAECRFDVPEGLPK
EEEEECCCCEEEEECCCHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHH
ALATLVGFFAYETIGLVERIPRAPGAGLGLPDMIFVRPTTILVFDRLADELFLIAPIWPD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCEEEEEECCCC
ARGAIDRMIDTAGERLESIAARLSSASPHADGASTAALTQSITATPATSPERFAAMVAAA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHH
KDYIAAGDIFQVVLSQRFSTPFDLPPFDLYRALRRVNPSPFLYFLDLPGFALIGSSPEIL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEE
VRVRDGEITIRPIAGTRPRGRTSAEDAENRESLLADPKERAEHLMLLDLGRNDVGRAAIG
EEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEECC
GSVSVTDSYTVEFYSHVMHIVSNVIGRIAPGKDAIDALFAGFPAGTVSGAPKVRACQIIA
CCEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
ELEADARGPYAGGVGYFAPDGNMDSCIVLRTAIVKDGVMHVQAGAGIVADSDPAYEQREC
HHCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHCCCEEEECCCCEEECCCCCHHHHHH
EAKAGALFAAAREAVRIAGTAGYGQ
HHHHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA