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The map label for this gene is rnhA [H]

Identifier: 103486622

GI number: 103486622

Start: 1172105

End: 1172557

Strand: Reverse

Name: rnhA [H]

Synonym: Sala_1134

Alternate gene names: 103486622

Gene position: 1172557-1172105 (Counterclockwise)

Preceding gene: 103486623

Following gene: 103486619

Centisome position: 35.05

GC content: 64.9

Gene sequence:

>453_bases
ATGAGCGAGCGGCGTACGGTCATCGTCGCCACCGACGGGGCGTGCAAGGGCAATCCAGGCCCCGGCGGCTGGGGTGCCGT
CCTGCGCTGGGGCGAGGTGGTCAAGACATTGTCGGGAGGCGAGGCCGACACGACGAACAACCGCATGGAACTGATGGCGG
CGATCGAGGCGCTCGCGGCGCTCAAACGTCCGTGCAACGTCGAATTATCGACCGACAGCGTCTACGTCCGCGACGGTATC
ACCAAATGGATCTTCGGCTGGCAGAAAAACGGCTGGAAAACCGCCGCGAAAAAACCCGTTGCCAACGCCGACCTGTGGCA
ACGACTGATCAAGGAGGCCGCGCGGCACAAGGTCGAATGGCTGTGGGTCAAGGGCCATGCCGGGCACGGCGACAATGAAC
TCGCCGACCAGCTCGCCAGCGACGCTGCGCTGAAAATGGCGCGGGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCCACCGGGCGCGCTCGTCACCCGCAAGGATCCGGCGCCCTTTCTTGCACGGCTGCGGCGTTATCAGGCGGCCGACGCG
GCCGCGCTCTTCTCCGCAGC

Downstream 100 bases:

>100_bases
ACGCCAGCGCATTATTCCTATTCGGTTTCGCGGACTTCGGCACCCGGTCCATTCTTCTGAATCGACTCGATGGCGTTCTT
CGCCGATGCCTTGCTGCTAT

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MSERRTVIVATDGACKGNPGPGGWGAVLRWGEVVKTLSGGEADTTNNRMELMAAIEALAALKRPCNVELSTDSVYVRDGI
TKWIFGWQKNGWKTAAKKPVANADLWQRLIKEAARHKVEWLWVKGHAGHGDNELADQLASDAALKMARAR

Sequences:

>Translated_150_residues
MSERRTVIVATDGACKGNPGPGGWGAVLRWGEVVKTLSGGEADTTNNRMELMAAIEALAALKRPCNVELSTDSVYVRDGI
TKWIFGWQKNGWKTAAKKPVANADLWQRLIKEAARHKVEWLWVKGHAGHGDNELADQLASDAALKMARAR
>Mature_149_residues
SERRTVIVATDGACKGNPGPGGWGAVLRWGEVVKTLSGGEADTTNNRMELMAAIEALAALKRPCNVELSTDSVYVRDGIT
KWIFGWQKNGWKTAAKKPVANADLWQRLIKEAARHKVEWLWVKGHAGHGDNELADQLASDAALKMARAR

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids [H]

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain [H]

Homologues:

Organism=Homo sapiens, GI21359816, Length=148, Percent_Identity=37.8378378378378, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1786408, Length=140, Percent_Identity=62.1428571428571, Blast_Score=178, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI115532542, Length=143, Percent_Identity=37.7622377622378, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552509, Length=143, Percent_Identity=34.965034965035, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17137476, Length=143, Percent_Identity=34.965034965035, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156 [H]

Pfam domain/function: PF00075 RnaseH [H]

EC number: =3.1.26.4 [H]

Molecular weight: Translated: 16393; Mature: 16262

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERRTVIVATDGACKGNPGPGGWGAVLRWGEVVKTLSGGEADTTNNRMELMAAIEALAA
CCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LKRPCNVELSTDSVYVRDGITKWIFGWQKNGWKTAAKKPVANADLWQRLIKEAARHKVEW
HCCCCCEEECCCCEEECCCHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCEEE
LWVKGHAGHGDNELADQLASDAALKMARAR
EEEECCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SERRTVIVATDGACKGNPGPGGWGAVLRWGEVVKTLSGGEADTTNNRMELMAAIEALAA
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
LKRPCNVELSTDSVYVRDGITKWIFGWQKNGWKTAAKKPVANADLWQRLIKEAARHKVEW
HCCCCCEEECCCCEEECCCHHHHHHCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHCCEEE
LWVKGHAGHGDNELADQLASDAALKMARAR
EEEECCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA