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The map label for this gene is atpB

Identifier: 103486565

GI number: 103486565

Start: 1107705

End: 1108490

Strand: Direct

Name: atpB

Synonym: Sala_1076

Alternate gene names: 103486565

Gene position: 1107705-1108490 (Clockwise)

Preceding gene: 103486564

Following gene: 103486566

Centisome position: 33.11

GC content: 59.92

Gene sequence:

>786_bases
GTGGCGGCGGAATCCGGCAAGATCGACCCGATGCACCAGTTCGAGGTGACCCCGCTCGGCGGCGGTTTCAACCTTGGCGG
GCAAGAGGTTCTATTCACCAACAGCGCGCTTTGGATGGTCGTTGCCGCGATCACGCTCGGCCTGTTCATGTGGGGCGGGA
TGCGCCGCCAGCTCGTCCCGGGCCGCTGGCAGGTCGCGGTCGAAGGCTTCACCGGCTTCATTTCGAGCATGATGATGGCG
AATATCGGCACCGAAGGCCGCAAATATACGCCCTATGTCTTTTCGCTCTTCATGTTCATCCTCTTCTGCAACCTGCTCGG
CATGTTGCCGCTGGGTGTGCTGGGGCTGCATCCCTTCACCGTCACCAGCCATATTGCGATTACCGGCGTCCTCGCCCTGA
TCAGCTTCGCGATCGTCCTTGTCGTCGGTTTCTGGCGCCATGGCCTCCATTTCTTCTCGCTCTTCGTGCCGCACGGCACG
CCGCTGCCGATGATCCCGATCATCGCGCCGATCGAGTTCGTGTCCTTCATGGTCCGACCGTTCAGCCTCGGTCTGCGTCT
GTTCGTCGCGATGACGGCGGGCCACGTGTTGCTGAAGGTGCTTTCGGGCTTTGTCATCAACGGTTTCAACGCTGAAACCC
TGTGGCTCGGTTCGATCGTGTCGGTGCTCAGTTTCACGTTGATGATCGGCATCAGCGCGCTCGAACTGCTGGTCGCCGGC
ATTCAGGCCTATGTTTTCGCCCTGTTGACCTCGCTTTATATCAATGACGCGGTCAACCTCCACTAA

Upstream 100 bases:

>100_bases
TCATCCGCCTGACAACAACGCCCCGCAAATAGCGGGACGCAAAGGACATTATTGGCGGGACGGCCGGACGCGCCGCCCCG
CATTGCGCGTGGAGTGAAGA

Downstream 100 bases:

>100_bases
TCCCGTTTATAACAAACGTTTATACCAAGGAGTTACGATAATGGACGCAGAAGCAGCAAAGCTGATCGGTGCCGGTCTCG
CCGCGATCGGTGCCGGCATG

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MAAESGKIDPMHQFEVTPLGGGFNLGGQEVLFTNSALWMVVAAITLGLFMWGGMRRQLVPGRWQVAVEGFTGFISSMMMA
NIGTEGRKYTPYVFSLFMFILFCNLLGMLPLGVLGLHPFTVTSHIAITGVLALISFAIVLVVGFWRHGLHFFSLFVPHGT
PLPMIPIIAPIEFVSFMVRPFSLGLRLFVAMTAGHVLLKVLSGFVINGFNAETLWLGSIVSVLSFTLMIGISALELLVAG
IQAYVFALLTSLYINDAVNLH

Sequences:

>Translated_261_residues
MAAESGKIDPMHQFEVTPLGGGFNLGGQEVLFTNSALWMVVAAITLGLFMWGGMRRQLVPGRWQVAVEGFTGFISSMMMA
NIGTEGRKYTPYVFSLFMFILFCNLLGMLPLGVLGLHPFTVTSHIAITGVLALISFAIVLVVGFWRHGLHFFSLFVPHGT
PLPMIPIIAPIEFVSFMVRPFSLGLRLFVAMTAGHVLLKVLSGFVINGFNAETLWLGSIVSVLSFTLMIGISALELLVAG
IQAYVFALLTSLYINDAVNLH
>Mature_260_residues
AAESGKIDPMHQFEVTPLGGGFNLGGQEVLFTNSALWMVVAAITLGLFMWGGMRRQLVPGRWQVAVEGFTGFISSMMMAN
IGTEGRKYTPYVFSLFMFILFCNLLGMLPLGVLGLHPFTVTSHIAITGVLALISFAIVLVVGFWRHGLHFFSLFVPHGTP
LPMIPIIAPIEFVSFMVRPFSLGLRLFVAMTAGHVLLKVLSGFVINGFNAETLWLGSIVSVLSFTLMIGISALELLVAGI
QAYVFALLTSLYINDAVNLH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Homo sapiens, GI251831112, Length=201, Percent_Identity=32.8358208955224, Blast_Score=95, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6226527, Length=259, Percent_Identity=33.5907335907336, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_SPHAL (Q1GU79)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616126.1
- ProteinModelPortal:   Q1GU79
- GeneID:   4082341
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1076
- NMPDR:   fig|317655.9.peg.1015
- HOGENOM:   HBG734175
- OMA:   MDQFIVK
- ProtClustDB:   PRK05815
- BioCyc:   SALA317655:SALA_1076-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 28416; Mature: 28284

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x119004f8)-; HASH(0x10fc8e68)-; HASH(0xf650cf0)-; HASH(0x11e28a9c)-; HASH(0x10c05f84)-; HASH(0x10d10a40)-; HASH(0x11876ce0)-; HASH(0x1130ce58)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure 
AAESGKIDPMHQFEVTPLGGGFNLGGQEVLFTNSALWMVVAAITLGLFMWGGMRRQLVP
CCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHCCCC
GRWQVAVEGFTGFISSMMMANIGTEGRKYTPYVFSLFMFILFCNLLGMLPLGVLGLHPFT
CCCEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VTSHIAITGVLALISFAIVLVVGFWRHGLHFFSLFVPHGTPLPMIPIIAPIEFVSFMVRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
FSLGLRLFVAMTAGHVLLKVLSGFVINGFNAETLWLGSIVSVLSFTLMIGISALELLVAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAYVFALLTSLYINDAVNLH
HHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA