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The map label for this gene is phr [H]

Identifier: 103486487

GI number: 103486487

Start: 1020991

End: 1022364

Strand: Reverse

Name: phr [H]

Synonym: Sala_0998

Alternate gene names: 103486487

Gene position: 1022364-1020991 (Counterclockwise)

Preceding gene: 103486488

Following gene: 103486486

Centisome position: 30.56

GC content: 69.21

Gene sequence:

>1374_bases
GTGACGGCGTCGCTGCTCTGGCTGCGGCAGGATCTGCGCGTCCACGACCATCCCGCCCTGCTCGCGGCGATTGCCGGTGG
CGCCGTGATTCCGGTTTTCATCCTCGACGATGAAACGCCGGGGACCTGGAAGATCGGCGCGGCGCAGCGCTGGTGGCTGC
ACCACAGCCTGACCGCGCTGGGCGCGAGCCTGAAAAAACGCGGCAGCAAACTGATCCTGCGGCGCGGCGCGGCGCACACG
GAACTCGCCCGCATCGCGCGCGAAACGGGCAGCCGCCGGATTCACGCCACCCATGCCTACGAACCATGGTGGAAGCATAG
CGAGGAGCGCCTGCCGACGGACATCGCGCTGGTCCTGCACGACGGCAACTACCTCGCCGCGCCGGACAGCATCGTCAATG
GCCAGGGCGCGCGCTATCGCGTCTTCACCCCCTGGTATCGCCGCCTGCTCGACCATATGCCGCCCACACTCCCTCAGGCG
GCGCCCGACGCCGTTCCCGCACCCGCGAGCTGGCCGCGCTCGGACGATCTGGCCGACTGGGACTTGCTGCCGACGCGGCC
CAATTGGGCGGCGGGGTTCGGCGCGTGGTGCCCCGGCGAAAAGGGTGCGTGGCGCGCGGCGCGCGACTGGCTCGACGCGA
TCGGCGATTATAAGGCGCGGCGCGATTATCCCGCACAGCCCGCGACCTCGCGCCTGTCGCCGCACCTCCATTTCGGCGAA
ATCTCGCCGCGCGCGCTCTGGCATGCGATCGGCGAACGCGACGATGCCGGGGCGGAAAGCTATCGCTCGGAACTGGGCTG
GCGCGAGCATGGGATCAATCTGGTCGACCAGATGCCCGATTATGCCGACCGCAACGGCCGCGAGCTGTTCGACCGTTTCG
CCTGGCGGACCGGCGCCGACGCCGACCGCGACTTTGCCGCATGGACGCGCGGCCGCACCGGCTATCCCGTCGTCGATGCC
GGAATGCGCGAGCTGTGGCAGACGGGATGGATGCACAATCGCGTGCGGATGGTCACCGCCTCCTTCCTCGTCAAGCATCT
GCTCATCGACTGGCGGCGCGGCGAGCGCTGGTTCTGGGACACGTTGCTCGACGCCGATCTGGGGTCCAACGCGATGAACT
GGCAATATGTCGCGGGCACCGGGGTCGATGCCCCGGTCTTTTCGCGGATCATGTCGCCACTGCTGCAATGCGAGCGCTTC
GCGATGGCCGATTATGTCCGCGCCCATGTTCCCGAACTCGCGCATCTGTCCGACGCCGAGATTGCGGCGAGCCATGGCCG
CGACAGCGGCGCGCCGGGCTATCCCGAACCGCTGATCGGCCATGAAGCGGCGCGCGCGCGGGCCCTTGCCGCGTGGGAAG
CCGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GCGACTGGCTGTCGCACGGCTTTGTCGAACATGCGTGGCGCAGCGGTCACGATCTGGGCGCGGCGATCGCGACCGCGCGC
GCGCTGGCGGGGGTCGGCGG

Downstream 100 bases:

>100_bases
CATACCGCCCAAAGGACAGGTCGTCGCATCCGCGCGCATACCCTAGCTTTCATCCTGCCCCATCCCCCGGGGTGCGACAT
TTGGAAGGATGTAAAATGGC

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTASLLWLRQDLRVHDHPALLAAIAGGAVIPVFILDDETPGTWKIGAAQRWWLHHSLTALGASLKKRGSKLILRRGAAHT
ELARIARETGSRRIHATHAYEPWWKHSEERLPTDIALVLHDGNYLAAPDSIVNGQGARYRVFTPWYRRLLDHMPPTLPQA
APDAVPAPASWPRSDDLADWDLLPTRPNWAAGFGAWCPGEKGAWRAARDWLDAIGDYKARRDYPAQPATSRLSPHLHFGE
ISPRALWHAIGERDDAGAESYRSELGWREHGINLVDQMPDYADRNGRELFDRFAWRTGADADRDFAAWTRGRTGYPVVDA
GMRELWQTGWMHNRVRMVTASFLVKHLLIDWRRGERWFWDTLLDADLGSNAMNWQYVAGTGVDAPVFSRIMSPLLQCERF
AMADYVRAHVPELAHLSDAEIAASHGRDSGAPGYPEPLIGHEAARARALAAWEAARG

Sequences:

>Translated_457_residues
MTASLLWLRQDLRVHDHPALLAAIAGGAVIPVFILDDETPGTWKIGAAQRWWLHHSLTALGASLKKRGSKLILRRGAAHT
ELARIARETGSRRIHATHAYEPWWKHSEERLPTDIALVLHDGNYLAAPDSIVNGQGARYRVFTPWYRRLLDHMPPTLPQA
APDAVPAPASWPRSDDLADWDLLPTRPNWAAGFGAWCPGEKGAWRAARDWLDAIGDYKARRDYPAQPATSRLSPHLHFGE
ISPRALWHAIGERDDAGAESYRSELGWREHGINLVDQMPDYADRNGRELFDRFAWRTGADADRDFAAWTRGRTGYPVVDA
GMRELWQTGWMHNRVRMVTASFLVKHLLIDWRRGERWFWDTLLDADLGSNAMNWQYVAGTGVDAPVFSRIMSPLLQCERF
AMADYVRAHVPELAHLSDAEIAASHGRDSGAPGYPEPLIGHEAARARALAAWEAARG
>Mature_456_residues
TASLLWLRQDLRVHDHPALLAAIAGGAVIPVFILDDETPGTWKIGAAQRWWLHHSLTALGASLKKRGSKLILRRGAAHTE
LARIARETGSRRIHATHAYEPWWKHSEERLPTDIALVLHDGNYLAAPDSIVNGQGARYRVFTPWYRRLLDHMPPTLPQAA
PDAVPAPASWPRSDDLADWDLLPTRPNWAAGFGAWCPGEKGAWRAARDWLDAIGDYKARRDYPAQPATSRLSPHLHFGEI
SPRALWHAIGERDDAGAESYRSELGWREHGINLVDQMPDYADRNGRELFDRFAWRTGADADRDFAAWTRGRTGYPVVDAG
MRELWQTGWMHNRVRMVTASFLVKHLLIDWRRGERWFWDTLLDADLGSNAMNWQYVAGTGVDAPVFSRIMSPLLQCERFA
MADYVRAHVPELAHLSDAEIAASHGRDSGAPGYPEPLIGHEAARARALAAWEAARG

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI4758072, Length=477, Percent_Identity=26.4150943396226, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI188536100, Length=476, Percent_Identity=25.8403361344538, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI188536103, Length=433, Percent_Identity=24.2494226327945, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1786926, Length=480, Percent_Identity=33.5416666666667, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324962, Length=508, Percent_Identity=25.9842519685039, Blast_Score=150, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17137248, Length=447, Percent_Identity=27.9642058165548, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24585455, Length=447, Percent_Identity=27.9642058165548, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24648152, Length=521, Percent_Identity=25.7197696737044, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51350; Mature: 51219

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASLLWLRQDLRVHDHPALLAAIAGGAVIPVFILDDETPGTWKIGAAQRWWLHHSLTAL
CCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHH
GASLKKRGSKLILRRGAAHTELARIARETGSRRIHATHAYEPWWKHSEERLPTDIALVLH
HHHHHHCCCCEEHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHCCCHHCCCCEEEEEEE
DGNYLAAPDSIVNGQGARYRVFTPWYRRLLDHMPPTLPQAAPDAVPAPASWPRSDDLADW
CCCEEECCCHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DLLPTRPNWAAGFGAWCPGEKGAWRAARDWLDAIGDYKARRDYPAQPATSRLSPHLHFGE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
ISPRALWHAIGERDDAGAESYRSELGWREHGINLVDQMPDYADRNGRELFDRFAWRTGAD
CCHHHHHHHHCCCCCCCHHHHHHHCCHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCCC
ADRDFAAWTRGRTGYPVVDAGMRELWQTGWMHNRVRMVTASFLVKHLLIDWRRGERWFWD
CCCCHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TLLDADLGSNAMNWQYVAGTGVDAPVFSRIMSPLLQCERFAMADYVRAHVPELAHLSDAE
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHH
IAASHGRDSGAPGYPEPLIGHEAARARALAAWEAARG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TASLLWLRQDLRVHDHPALLAAIAGGAVIPVFILDDETPGTWKIGAAQRWWLHHSLTAL
CCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHH
GASLKKRGSKLILRRGAAHTELARIARETGSRRIHATHAYEPWWKHSEERLPTDIALVLH
HHHHHHCCCCEEHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHCCCHHCCCCEEEEEEE
DGNYLAAPDSIVNGQGARYRVFTPWYRRLLDHMPPTLPQAAPDAVPAPASWPRSDDLADW
CCCEEECCCHHCCCCCCEEEEECHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DLLPTRPNWAAGFGAWCPGEKGAWRAARDWLDAIGDYKARRDYPAQPATSRLSPHLHFGE
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
ISPRALWHAIGERDDAGAESYRSELGWREHGINLVDQMPDYADRNGRELFDRFAWRTGAD
CCHHHHHHHHCCCCCCCHHHHHHHCCHHHHCCCHHHHCCCCCCCCHHHHHHHHHHCCCCC
ADRDFAAWTRGRTGYPVVDAGMRELWQTGWMHNRVRMVTASFLVKHLLIDWRRGERWFWD
CCCCHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
TLLDADLGSNAMNWQYVAGTGVDAPVFSRIMSPLLQCERFAMADYVRAHVPELAHLSDAE
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHH
IAASHGRDSGAPGYPEPLIGHEAARARALAAWEAARG
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2501760 [H]