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The map label for this gene is gltP [H]

Identifier: 103486449

GI number: 103486449

Start: 985046

End: 986293

Strand: Reverse

Name: gltP [H]

Synonym: Sala_0959

Alternate gene names: 103486449

Gene position: 986293-985046 (Counterclockwise)

Preceding gene: 103486457

Following gene: 103486448

Centisome position: 29.48

GC content: 68.19

Gene sequence:

>1248_bases
TTGAAATCCGCCTGGTTCATCCTTTCGGCGCTCGTCGCCGGCATGTTGCTGGGAATCGGCGTCGACATTGCAGCCCCCGG
CGCGGCGACCGCGTCGCTCGCCTTTGTCGAACCGGTGGGCCTCCTGTGGCTCAACGCGCTCAAGATGACGATCGTGCCGC
TGGTGGTTGCGCTGCTTATCACCGGTATCACCGCGACCGCCGACGCCGCGCGCGCGGGGCGGCTCGCCAGTCGTGCGGTG
ATGACCTTCCTCGCCGCGATCGTGCTGTCGGGGTTGATGTCGCTCGCGCTGACGCCGCTCCTGCTGCGTCTTTTCCCGCT
TTCGACCGCCGCGGCGGCGGCGCTGCGCGACGGGCTCGGCGGCGGCGGCGAGACGCCGCCCTCGCCGACCTTTTCGGACT
TCATCCTCGGCCTCGTGCCGACCAACCCGATCGCGGCGGCGGCCGAAACCGCGATCCTGCCGCTGATCGTCTTCACCACC
GTCTTTGCCTTCGCCATCACCCGCCTCGCCCCCGAACAACGCGCGACGCTGTCGGGGCTGTTCAAGGCGCTTGGCGACGC
GATGCTCATCGTCATCGGCTGGGTGCTCGCGCTTGCGCCGCTCGGCGTTTTTGCGCTGGGTTACGCGCTCGCGGTCAAGG
CCGGGCTCGCGGCTTTCGGCGGGCTTGTCCATTATGTGCTCATCGTCTCGGGCATCGGCGTCGCCTGCATCATGCTGGCG
CTGCTGCTGGCGGTGCTTGTCGTGCGCATTCCCGTCACCCGCTTCGTCCCCGCGATGGTGCCTACTTTGGCAGTGGCGAT
CAGCACGCAAAGCTCGCTCGCCAGCCTGCCCGCGATGCTCAAGGCTTCCGAAGAGTTGGGCGTCGCCCCGAAAAAGGCCG
ATGTCGTGCTGCCGCTCGCGGTCGCGCTGTTCCGTTTCACCAGCACCGCGATGAACCTCGCCGTGGTCATCTATGTCGCG
ACGCTGTTCGGGCTCGAACTGACGCCGTGGGAGATGGCGGCGGGGCTCGCGGTCGCGGTCGGTGCGGCGCTGAGCGCGGT
CAGCCTGCCGGGATCGATCAGCTTCGTCACCTCGATCGCGCCGATCGCCACGGCGATGGGCGTCCCCGTCGCGCCGCTGG
GACTCCTTGTCGCGGTCGAAACTTTCCCCGATATATTCCGCACCGTCGGCAATGTCGTCGCCGATGTCGCCGCGACGCGC
TTCGCCGCCGGCGAAGAAACGCACGCACCCGCAGGAGAAACGCCATGA

Upstream 100 bases:

>100_bases
TGTCCAGCCCAAAAACCGGTTCCCGTTTCGTCTGCAAGCTGCTCTAAGTCACGCTCATTTGCTTGGCAAGCTGACCAACG
AAGCGCGGGGAGAATCCGTC

Downstream 100 bases:

>100_bases
AATATCGCACGCTCGGCCACGGCCTCACCGTTTCCGCGATCGGCATCGGCTGCATGCCGATGATCAAGGGCGGCAATATC
CTTTATGGCGAGGCGGCCGA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKSAWFILSALVAGMLLGIGVDIAAPGAATASLAFVEPVGLLWLNALKMTIVPLVVALLITGITATADAARAGRLASRAV
MTFLAAIVLSGLMSLALTPLLLRLFPLSTAAAAALRDGLGGGGETPPSPTFSDFILGLVPTNPIAAAAETAILPLIVFTT
VFAFAITRLAPEQRATLSGLFKALGDAMLIVIGWVLALAPLGVFALGYALAVKAGLAAFGGLVHYVLIVSGIGVACIMLA
LLLAVLVVRIPVTRFVPAMVPTLAVAISTQSSLASLPAMLKASEELGVAPKKADVVLPLAVALFRFTSTAMNLAVVIYVA
TLFGLELTPWEMAAGLAVAVGAALSAVSLPGSISFVTSIAPIATAMGVPVAPLGLLVAVETFPDIFRTVGNVVADVAATR
FAAGEETHAPAGETP

Sequences:

>Translated_415_residues
MKSAWFILSALVAGMLLGIGVDIAAPGAATASLAFVEPVGLLWLNALKMTIVPLVVALLITGITATADAARAGRLASRAV
MTFLAAIVLSGLMSLALTPLLLRLFPLSTAAAAALRDGLGGGGETPPSPTFSDFILGLVPTNPIAAAAETAILPLIVFTT
VFAFAITRLAPEQRATLSGLFKALGDAMLIVIGWVLALAPLGVFALGYALAVKAGLAAFGGLVHYVLIVSGIGVACIMLA
LLLAVLVVRIPVTRFVPAMVPTLAVAISTQSSLASLPAMLKASEELGVAPKKADVVLPLAVALFRFTSTAMNLAVVIYVA
TLFGLELTPWEMAAGLAVAVGAALSAVSLPGSISFVTSIAPIATAMGVPVAPLGLLVAVETFPDIFRTVGNVVADVAATR
FAAGEETHAPAGETP
>Mature_415_residues
MKSAWFILSALVAGMLLGIGVDIAAPGAATASLAFVEPVGLLWLNALKMTIVPLVVALLITGITATADAARAGRLASRAV
MTFLAAIVLSGLMSLALTPLLLRLFPLSTAAAAALRDGLGGGGETPPSPTFSDFILGLVPTNPIAAAAETAILPLIVFTT
VFAFAITRLAPEQRATLSGLFKALGDAMLIVIGWVLALAPLGVFALGYALAVKAGLAAFGGLVHYVLIVSGIGVACIMLA
LLLAVLVVRIPVTRFVPAMVPTLAVAISTQSSLASLPAMLKASEELGVAPKKADVVLPLAVALFRFTSTAMNLAVVIYVA
TLFGLELTPWEMAAGLAVAVGAALSAVSLPGSISFVTSIAPIATAMGVPVAPLGLLVAVETFPDIFRTVGNVVADVAATR
FAAGEETHAPAGETP

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=402, Percent_Identity=27.6119402985075, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI5032093, Length=377, Percent_Identity=27.3209549071618, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI223468566, Length=258, Percent_Identity=27.906976744186, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI223468564, Length=248, Percent_Identity=28.2258064516129, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI66773030, Length=253, Percent_Identity=29.6442687747036, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI169790839, Length=248, Percent_Identity=28.2258064516129, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40254478, Length=435, Percent_Identity=25.2873563218391, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4827012, Length=250, Percent_Identity=29.2, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1790514, Length=410, Percent_Identity=26.5853658536585, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789947, Length=415, Percent_Identity=22.8915662650602, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=418, Percent_Identity=26.0765550239234, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=439, Percent_Identity=27.7904328018223, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193206505, Length=443, Percent_Identity=26.1851015801354, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=23.2227488151659, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71983099, Length=449, Percent_Identity=24.9443207126949, Blast_Score=68, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71983106, Length=449, Percent_Identity=24.9443207126949, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583025, Length=432, Percent_Identity=23.1481481481481, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137668, Length=432, Percent_Identity=23.1481481481481, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583023, Length=432, Percent_Identity=23.1481481481481, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 41931; Mature: 41931

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAWFILSALVAGMLLGIGVDIAAPGAATASLAFVEPVGLLWLNALKMTIVPLVVALLI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGITATADAARAGRLASRAVMTFLAAIVLSGLMSLALTPLLLRLFPLSTAAAAALRDGLG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGETPPSPTFSDFILGLVPTNPIAAAAETAILPLIVFTTVFAFAITRLAPEQRATLSGL
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FKALGDAMLIVIGWVLALAPLGVFALGYALAVKAGLAAFGGLVHYVLIVSGIGVACIMLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLAVLVVRIPVTRFVPAMVPTLAVAISTQSSLASLPAMLKASEELGVAPKKADVVLPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VALFRFTSTAMNLAVVIYVATLFGLELTPWEMAAGLAVAVGAALSAVSLPGSISFVTSIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
PIATAMGVPVAPLGLLVAVETFPDIFRTVGNVVADVAATRFAAGEETHAPAGETP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKSAWFILSALVAGMLLGIGVDIAAPGAATASLAFVEPVGLLWLNALKMTIVPLVVALLI
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGITATADAARAGRLASRAVMTFLAAIVLSGLMSLALTPLLLRLFPLSTAAAAALRDGLG
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGETPPSPTFSDFILGLVPTNPIAAAAETAILPLIVFTTVFAFAITRLAPEQRATLSGL
CCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FKALGDAMLIVIGWVLALAPLGVFALGYALAVKAGLAAFGGLVHYVLIVSGIGVACIMLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLAVLVVRIPVTRFVPAMVPTLAVAISTQSSLASLPAMLKASEELGVAPKKADVVLPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
VALFRFTSTAMNLAVVIYVATLFGLELTPWEMAAGLAVAVGAALSAVSLPGSISFVTSIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
PIATAMGVPVAPLGLLVAVETFPDIFRTVGNVVADVAATRFAAGEETHAPAGETP
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]