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The map label for this gene is yxbG [H]

Identifier: 103486374

GI number: 103486374

Start: 889801

End: 890595

Strand: Direct

Name: yxbG [H]

Synonym: Sala_0884

Alternate gene names: 103486374

Gene position: 889801-890595 (Clockwise)

Preceding gene: 103486373

Following gene: 103486375

Centisome position: 26.6

GC content: 62.64

Gene sequence:

>795_bases
ATGAAGCTCGATAACAGCATCGCCGCCGTCGTGACCGGGGGAGCGTCGGGACTTGGCCGGGCAAGCGCCGAGGCGCTGGC
CCAGAGCGGCGTCAAGGTCGCCATTTTCGACGTGAATGAAGAGGGCGGACGCGCTGTCGCGGAAGCAATTGGCGGCATAT
TCTGCAAGGTCGATATCACCAGCGAGGATTCCGTCGTCGCGGGATATGAGGCGGCGCGCGCGGCGCATGGTCAGGAACGC
ATCCTTGTCCACTGCGCGCAGATTTCAAAGGGCGGAAAGACCGTGCGCTATGACAAGGCGAGCGGTGGCTATGTTCGCTA
TTCGACCGAGGATTATGCCTTTTCGGCGCAGGGCATTCTGATCGCCAGCTATCGCCTCGCGTCATTGGCTGCGCTTGGCA
TGGCGAATGCCGACCCGCTGAACGATGACGGCGAGCGCGGGACGATCATCCTGACCGCTTCGGCTGCGGCGCAGGACGCG
CAGATCGGCCAGGTCGGTTATGGTTCGCTCAAGGCGGGCGTGAACGGCCTCGTTCTGCCGATGGCGCGCGACTTGATGGA
CCTTGGCATACGGGTCAACTCCATCATGCCGGGAATATTCGCGACTCCGCCGATGCTGGCGGTCAAGGACAGGGCGCCCG
CCATCTTTGAAGGGCTCGCCGCGTCGGTGCCTTTCCCCAAGCGGTTGGGAAAACCCGAAGAGTTCGGCAGCCTGGTGCTG
GAACTCGCGCGTAACAGCTATTTCAACGGGCAAAATCTGCGGTTGGACGGCGCCATTCGCATGCCGCCGAAATAG

Upstream 100 bases:

>100_bases
GTGTTCCGACCGGGCGGGTTTCATCACCGGCCAGGTGCTGGTCGTCGATGGCGGCAATCTGGAAGTTCTGCAATAACCGA
AAAATGAAGGAAAAAGGAAG

Downstream 100 bases:

>100_bases
GAGCGGTCGGTGAACGCACCCCAGCAGTTTCCGTTTGCGCGCCAGTCCGCCGGTCCGGCTCCGCTGCGTCGTCCCGGTTC
GATCCGCCGCACGACGTCGA

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKLDNSIAAVVTGGASGLGRASAEALAQSGVKVAIFDVNEEGGRAVAEAIGGIFCKVDITSEDSVVAGYEAARAAHGQER
ILVHCAQISKGGKTVRYDKASGGYVRYSTEDYAFSAQGILIASYRLASLAALGMANADPLNDDGERGTIILTASAAAQDA
QIGQVGYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFATPPMLAVKDRAPAIFEGLAASVPFPKRLGKPEEFGSLVL
ELARNSYFNGQNLRLDGAIRMPPK

Sequences:

>Translated_264_residues
MKLDNSIAAVVTGGASGLGRASAEALAQSGVKVAIFDVNEEGGRAVAEAIGGIFCKVDITSEDSVVAGYEAARAAHGQER
ILVHCAQISKGGKTVRYDKASGGYVRYSTEDYAFSAQGILIASYRLASLAALGMANADPLNDDGERGTIILTASAAAQDA
QIGQVGYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFATPPMLAVKDRAPAIFEGLAASVPFPKRLGKPEEFGSLVL
ELARNSYFNGQNLRLDGAIRMPPK
>Mature_264_residues
MKLDNSIAAVVTGGASGLGRASAEALAQSGVKVAIFDVNEEGGRAVAEAIGGIFCKVDITSEDSVVAGYEAARAAHGQER
ILVHCAQISKGGKTVRYDKASGGYVRYSTEDYAFSAQGILIASYRLASLAALGMANADPLNDDGERGTIILTASAAAQDA
QIGQVGYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFATPPMLAVKDRAPAIFEGLAASVPFPKRLGKPEEFGSLVL
ELARNSYFNGQNLRLDGAIRMPPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=38.996138996139, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=36.6795366795367, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI15277342, Length=271, Percent_Identity=27.6752767527675, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=26.8774703557312, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787335, Length=257, Percent_Identity=29.5719844357977, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787905, Length=265, Percent_Identity=29.811320754717, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=266, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=262, Percent_Identity=37.4045801526718, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=27.1317829457364, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=262, Percent_Identity=27.8625954198473, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17737361, Length=257, Percent_Identity=40.8560311284047, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24639444, Length=258, Percent_Identity=27.906976744186, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27431; Mature: 27431

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDNSIAAVVTGGASGLGRASAEALAQSGVKVAIFDVNEEGGRAVAEAIGGIFCKVDIT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCEEEEEEEC
SEDSVVAGYEAARAAHGQERILVHCAQISKGGKTVRYDKASGGYVRYSTEDYAFSAQGIL
CCCCEEECHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEECCCEE
IASYRLASLAALGMANADPLNDDGERGTIILTASAAAQDAQIGQVGYGSLKAGVNGLVLP
EEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEHH
MARDLMDLGIRVNSIMPGIFATPPMLAVKDRAPAIFEGLAASVPFPKRLGKPEEFGSLVL
HHHHHHHHCEEEEHCCCCHHCCCCCEEECCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHH
ELARNSYFNGQNLRLDGAIRMPPK
HHHHCCCCCCCCEEECCEEECCCC
>Mature Secondary Structure
MKLDNSIAAVVTGGASGLGRASAEALAQSGVKVAIFDVNEEGGRAVAEAIGGIFCKVDIT
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCEEEEEEEC
SEDSVVAGYEAARAAHGQERILVHCAQISKGGKTVRYDKASGGYVRYSTEDYAFSAQGIL
CCCCEEECHHHHHHCCCCCEEEEEEEECCCCCCEEEEECCCCCEEEECCCCCEEECCCEE
IASYRLASLAALGMANADPLNDDGERGTIILTASAAAQDAQIGQVGYGSLKAGVNGLVLP
EEHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEEHH
MARDLMDLGIRVNSIMPGIFATPPMLAVKDRAPAIFEGLAASVPFPKRLGKPEEFGSLVL
HHHHHHHHCEEEEHCCCCHHCCCCCEEECCCCCHHHHHHHHCCCCHHHCCCHHHHHHHHH
ELARNSYFNGQNLRLDGAIRMPPK
HHHHCCCCCCCCEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]