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The map label for this gene is hom [H]

Identifier: 103486302

GI number: 103486302

Start: 815749

End: 817083

Strand: Direct

Name: hom [H]

Synonym: Sala_0810

Alternate gene names: 103486302

Gene position: 815749-817083 (Clockwise)

Preceding gene: 103486301

Following gene: 103486303

Centisome position: 24.39

GC content: 69.89

Gene sequence:

>1335_bases
ATGTCGCCCTATGCCACCCCGACCGCTCCCCGCCCGCCGCTCCGCGTCGCGCTTGCCGGGATCGGCGTCGTCGGCGGCGG
GGTGGTAAGGCTGCTCGAGGCGAACCGCGCCCTGATCGCGCGGCGCGCGGGTCGGCCGATCGAGATTGTCGCGGTGTCTG
CGCGCGACCGGCACAAGGATCGCGGCGTCGACCTGTCGCGCTATCGCTGGGAAGACGATATGGACGCGCTCGTCGCGGCG
GGCGATGTCGATGTCGTCGTCGAGATGATCGGCGGCGCCGACGGATCGGCGCTGACGCTGGCGCGCCGCGCGCTGGGCGC
GGGCAAGGCGCTGGTCACAGCGAACAAGGCGATGATCGCGCATCACGGGATCGATCTCGCCCGGATCGCCGAAGAAAAGG
ACACGCCGCTGAAATACGAAGCCGCTGTCGCGGGCGGCATCCCTGTCATCAAGGCGATCCGCGAAGGCGCGTCGGCGAAC
GAGATCGCGCGCGTCTATGGCATCCTCAACGGCACCTGCAATTATATCCTGACGCAAATGGAACGGAATGGCGCGAGCTT
CGCCGATGCGCTGGCCGCCGCGCAGGCCGAGGGCTATGCCGAGGCCGACCCGAGCTTCGATGTCGATGGCATCGACGCCG
CGCACAAGCTGTCGATTCTCGCCGCGCTCTGTTTCGGGACGCGGCTCGACATCGGCGCGGTGACTGCCGACGGCATCCGG
GGCCTGATCGCGGCCGACATCCGCGAGGCCGAGGCGCTGGGGCACCGCGTCCGCCTGATCGGCATGGCCGAGCGCGACAG
CGCCGGGAACGGCGGCGCCCTCTATCAGCATGTCCAGCCGTGCCTGGTGCCCGCCGACCATCCGCTCGCCTATGTGCCCG
GCGCGCTGAACGCCGTGGTCGCCGAGGGCAATTTTGTCGGCCGCCTGTTCTTCGAGGGCGCCGGCGCCGGGGCAGGACCG
ACCGCTTCGGCGATCGTGGCCGACATCATCGACATCGCGCGCGACGAATATGGCCCGGCCTTCGCGATGCCGGTCGATGC
ACTCGACGCGGCGCCCGCCGCCGATGCCGGCGCGCGCGTCGGCAAACATTATGTCCGCCTGATCGTCGAGGACCGGATCG
GCGTGCTCGCCGAGATCGCGGCGGCGATGCGCGACGCCGGCGTGTCGATCGAAAGCCTGATCCAGCGCGGCAGCGAAGAC
GGTGACGACGGCGTCGTCATCGTGCTCGTCACCCATGAAGGCCCGGCAAGCGCGATCCATGCGGCGCTCGCGATTCTGGC
GGGGTCGGACCATGTCGTCGGCGCGCCGATGCTGATGCCGATCCTGGCGCTCTAA

Upstream 100 bases:

>100_bases
GCGCAAAAGGCGCAGCGGGCTTGCCTCGGGCGCAAAAGCCGATAGGGCGGCGGCGACCAGCGGGGGCCGACCCCGCGCGC
CTTTGTGTGGAGACCCGATC

Downstream 100 bases:

>100_bases
CAGGCTGCGGAAAAACTCTTCCCGTTTAGGCGCTGTCTGCATTCATCGTAACCAGATCATGGCGCAAGCGAGATGGACGA
AGCCGATGAAGGCGGAGAGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSPYATPTAPRPPLRVALAGIGVVGGGVVRLLEANRALIARRAGRPIEIVAVSARDRHKDRGVDLSRYRWEDDMDALVAA
GDVDVVVEMIGGADGSALTLARRALGAGKALVTANKAMIAHHGIDLARIAEEKDTPLKYEAAVAGGIPVIKAIREGASAN
EIARVYGILNGTCNYILTQMERNGASFADALAAAQAEGYAEADPSFDVDGIDAAHKLSILAALCFGTRLDIGAVTADGIR
GLIAADIREAEALGHRVRLIGMAERDSAGNGGALYQHVQPCLVPADHPLAYVPGALNAVVAEGNFVGRLFFEGAGAGAGP
TASAIVADIIDIARDEYGPAFAMPVDALDAAPAADAGARVGKHYVRLIVEDRIGVLAEIAAAMRDAGVSIESLIQRGSED
GDDGVVIVLVTHEGPASAIHAALAILAGSDHVVGAPMLMPILAL

Sequences:

>Translated_444_residues
MSPYATPTAPRPPLRVALAGIGVVGGGVVRLLEANRALIARRAGRPIEIVAVSARDRHKDRGVDLSRYRWEDDMDALVAA
GDVDVVVEMIGGADGSALTLARRALGAGKALVTANKAMIAHHGIDLARIAEEKDTPLKYEAAVAGGIPVIKAIREGASAN
EIARVYGILNGTCNYILTQMERNGASFADALAAAQAEGYAEADPSFDVDGIDAAHKLSILAALCFGTRLDIGAVTADGIR
GLIAADIREAEALGHRVRLIGMAERDSAGNGGALYQHVQPCLVPADHPLAYVPGALNAVVAEGNFVGRLFFEGAGAGAGP
TASAIVADIIDIARDEYGPAFAMPVDALDAAPAADAGARVGKHYVRLIVEDRIGVLAEIAAAMRDAGVSIESLIQRGSED
GDDGVVIVLVTHEGPASAIHAALAILAGSDHVVGAPMLMPILAL
>Mature_443_residues
SPYATPTAPRPPLRVALAGIGVVGGGVVRLLEANRALIARRAGRPIEIVAVSARDRHKDRGVDLSRYRWEDDMDALVAAG
DVDVVVEMIGGADGSALTLARRALGAGKALVTANKAMIAHHGIDLARIAEEKDTPLKYEAAVAGGIPVIKAIREGASANE
IARVYGILNGTCNYILTQMERNGASFADALAAAQAEGYAEADPSFDVDGIDAAHKLSILAALCFGTRLDIGAVTADGIRG
LIAADIREAEALGHRVRLIGMAERDSAGNGGALYQHVQPCLVPADHPLAYVPGALNAVVAEGNFVGRLFFEGAGAGAGPT
ASAIVADIIDIARDEYGPAFAMPVDALDAAPAADAGARVGKHYVRLIVEDRIGVLAEIAAAMRDAGVSIESLIQRGSEDG
DDGVVIVLVTHEGPASAIHAALAILAGSDHVVGAPMLMPILAL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=254, Percent_Identity=28.3464566929134, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=86, Percent_Identity=34.8837209302326, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45653; Mature: 45522

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYATPTAPRPPLRVALAGIGVVGGGVVRLLEANRALIARRAGRPIEIVAVSARDRHKD
CCCCCCCCCCCCCCEEHEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
RGVDLSRYRWEDDMDALVAAGDVDVVVEMIGGADGSALTLARRALGAGKALVTANKAMIA
CCCCHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
HHGIDLARIAEEKDTPLKYEAAVAGGIPVIKAIREGASANEIARVYGILNGTCNYILTQM
HCCCCHHHHHCCCCCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHH
ERNGASFADALAAAQAEGYAEADPSFDVDGIDAAHKLSILAALCFGTRLDIGAVTADGIR
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLIAADIREAEALGHRVRLIGMAERDSAGNGGALYQHVQPCLVPADHPLAYVPGALNAVV
HHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCCEEEE
AEGNFVGRLFFEGAGAGAGPTASAIVADIIDIARDEYGPAFAMPVDALDAAPAADAGARV
ECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCHHHHH
GKHYVRLIVEDRIGVLAEIAAAMRDAGVSIESLIQRGSEDGDDGVVIVLVTHEGPASAIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHH
AALAILAGSDHVVGAPMLMPILAL
HHHHHHCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
SPYATPTAPRPPLRVALAGIGVVGGGVVRLLEANRALIARRAGRPIEIVAVSARDRHKD
CCCCCCCCCCCCCEEHEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
RGVDLSRYRWEDDMDALVAAGDVDVVVEMIGGADGSALTLARRALGAGKALVTANKAMIA
CCCCHHHHCCCCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
HHGIDLARIAEEKDTPLKYEAAVAGGIPVIKAIREGASANEIARVYGILNGTCNYILTQM
HCCCCHHHHHCCCCCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHH
ERNGASFADALAAAQAEGYAEADPSFDVDGIDAAHKLSILAALCFGTRLDIGAVTADGIR
HCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHH
GLIAADIREAEALGHRVRLIGMAERDSAGNGGALYQHVQPCLVPADHPLAYVPGALNAVV
HHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCEECCCCCEEEE
AEGNFVGRLFFEGAGAGAGPTASAIVADIIDIARDEYGPAFAMPVDALDAAPAADAGARV
ECCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCHHHHH
GKHYVRLIVEDRIGVLAEIAAAMRDAGVSIESLIQRGSEDGDDGVVIVLVTHEGPASAIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEEECCCCHHHHH
AALAILAGSDHVVGAPMLMPILAL
HHHHHHCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]