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The map label for this gene is pepA [H]

Identifier: 103486206

GI number: 103486206

Start: 717618

End: 719021

Strand: Reverse

Name: pepA [H]

Synonym: Sala_0713

Alternate gene names: 103486206

Gene position: 719021-717618 (Counterclockwise)

Preceding gene: 103486208

Following gene: 103486205

Centisome position: 21.49

GC content: 66.6

Gene sequence:

>1404_bases
ATGATCGACTATTCCGACTTGATCCAGCCCGATAAGGGGCAGGATGCGCGCACAATCCATCTCGTCGACAAGAAAAGCCA
TGACGAGTGGCTGAAGGGGCGCAGCCCGCGCGAACGCGCGCATCTGGCCGCGATCGACTTCAAACCCGATGCCTATGCCC
ACGCCATCCTGCCCGGCGACGATCCTGACAAATGGTCGGTCGTCACGACGGTGGCCGATGTCGAAAAGCTGTCCGCATGG
TGCCTCGCCAAGCTGGGGCAGATCCTCCCCGAAGGCCGCTACCGTCTCGACGGACATCAGCCCGGACAGGCGATGTTCGG
CTGGATGAGCGCGCAATATCGCTTTGATGCCTATAAATCGGAAACGACCGCGAAAGGACCGCGCGTCCTGCTCACCAGCG
ACGTCGCGGCGATCGCACCCATGATAGCCGAGGCGCGCGCGGTGGCGCTCGTGCGCGATCTCGTCAACACGCCCGCCGCC
GATATGGGTCCGGCTGCCATCGAAAAGACCGCCGAGCGCATCGCCAGGGCGCACGGCGGCAAGCTGACCGTCACCAAGGG
CGAGGCGCTCGAACAGGGCTATCCCATGATCCACGCGGTCGGCCGCGCCGCCGCCAAGCACCACGCGCCGCGCCTGATCG
AGATCGAATGGGGCAAGGCGGATCATCCCCGCGTCGCGCTCGTCGGCAAGGGGATCAGCTTCGACAGCGGCGGCCTCGAT
ATCAAGCCGGCGGCGGGAATGCGGCTGATGAAAAAGGATATGGGCGGGGCCGCGCACGTGCTGGCGCTGGCCGAACTGGT
GATGGCAAGCGGACTGCCCGTGCGGCTGCATTGTCTTGTCGCGGCGGCCGAAAACGCCATTTCGTCCGATGCCTTTCGTC
CCGGCGACGTGCTCAAAAGCCGGAAGGGTTTGACCGTCGAAATCGGCAACACTGACGCCGAAGGCCGCCTCGTGCTCGGC
GATGCGTTGACGAAAGCCGGGGAATCAAAGCCCGAGTTGATCGTCGATTTCGCGACGCTGACGGGTGCCGCGCGCGTCGC
GCTCGGGCCCGACCTGCCGCCGCTCTTCGCCAATGACGACGCGCTCGCCGAAGCGATGCTGGTGGGCGGCATCGCGCGCG
ACGACCCGCTGTGGCGGATGCCGCTGTGGGACGGCTATGCCGACCTCCTCGAAACCGACATCGCCGACCTGGGCAATGCG
GGCAGTTCGCCGTTCGCCGGCGCGATCACTGCGGCCCTGTTCCTGAAGCGCTTTGTTCCCGATGGCGCCGCCTGGGCGCA
TATCGACACCTTCGCCTGGCGTCCGTCGGCGAAACCCGGCCGACCAAAAGGAGGCGCGGCGCTGGGGCTGCGCGCCGCAT
GGGCGATGCTGCAGACGCGCTACGACCGCCGCGGCAAGGCTTGA

Upstream 100 bases:

>100_bases
GGCAAGCAACGAAACGGCGTTTCGCCAGGGTCTTTTGTTCGTCATGCAGGCATAACGCCGGGAATCGACAAAATATCCCG
ATCGGCCTAGCACGGCGGGC

Downstream 100 bases:

>100_bases
TAAAGCCTCGGTCGCTGGTCTAATGGCCCGCGATTGTCCGCACTCGACGGACCCCGGTTGCAACAGGACGGCACGTGAAA
GCAGAGAGCGGTGACAATAT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MIDYSDLIQPDKGQDARTIHLVDKKSHDEWLKGRSPRERAHLAAIDFKPDAYAHAILPGDDPDKWSVVTTVADVEKLSAW
CLAKLGQILPEGRYRLDGHQPGQAMFGWMSAQYRFDAYKSETTAKGPRVLLTSDVAAIAPMIAEARAVALVRDLVNTPAA
DMGPAAIEKTAERIARAHGGKLTVTKGEALEQGYPMIHAVGRAAAKHHAPRLIEIEWGKADHPRVALVGKGISFDSGGLD
IKPAAGMRLMKKDMGGAAHVLALAELVMASGLPVRLHCLVAAAENAISSDAFRPGDVLKSRKGLTVEIGNTDAEGRLVLG
DALTKAGESKPELIVDFATLTGAARVALGPDLPPLFANDDALAEAMLVGGIARDDPLWRMPLWDGYADLLETDIADLGNA
GSSPFAGAITAALFLKRFVPDGAAWAHIDTFAWRPSAKPGRPKGGAALGLRAAWAMLQTRYDRRGKA

Sequences:

>Translated_467_residues
MIDYSDLIQPDKGQDARTIHLVDKKSHDEWLKGRSPRERAHLAAIDFKPDAYAHAILPGDDPDKWSVVTTVADVEKLSAW
CLAKLGQILPEGRYRLDGHQPGQAMFGWMSAQYRFDAYKSETTAKGPRVLLTSDVAAIAPMIAEARAVALVRDLVNTPAA
DMGPAAIEKTAERIARAHGGKLTVTKGEALEQGYPMIHAVGRAAAKHHAPRLIEIEWGKADHPRVALVGKGISFDSGGLD
IKPAAGMRLMKKDMGGAAHVLALAELVMASGLPVRLHCLVAAAENAISSDAFRPGDVLKSRKGLTVEIGNTDAEGRLVLG
DALTKAGESKPELIVDFATLTGAARVALGPDLPPLFANDDALAEAMLVGGIARDDPLWRMPLWDGYADLLETDIADLGNA
GSSPFAGAITAALFLKRFVPDGAAWAHIDTFAWRPSAKPGRPKGGAALGLRAAWAMLQTRYDRRGKA
>Mature_467_residues
MIDYSDLIQPDKGQDARTIHLVDKKSHDEWLKGRSPRERAHLAAIDFKPDAYAHAILPGDDPDKWSVVTTVADVEKLSAW
CLAKLGQILPEGRYRLDGHQPGQAMFGWMSAQYRFDAYKSETTAKGPRVLLTSDVAAIAPMIAEARAVALVRDLVNTPAA
DMGPAAIEKTAERIARAHGGKLTVTKGEALEQGYPMIHAVGRAAAKHHAPRLIEIEWGKADHPRVALVGKGISFDSGGLD
IKPAAGMRLMKKDMGGAAHVLALAELVMASGLPVRLHCLVAAAENAISSDAFRPGDVLKSRKGLTVEIGNTDAEGRLVLG
DALTKAGESKPELIVDFATLTGAARVALGPDLPPLFANDDALAEAMLVGGIARDDPLWRMPLWDGYADLLETDIADLGNA
GSSPFAGAITAALFLKRFVPDGAAWAHIDTFAWRPSAKPGRPKGGAALGLRAAWAMLQTRYDRRGKA

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=325, Percent_Identity=36, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI47155554, Length=310, Percent_Identity=31.9354838709677, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=43.0817610062893, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1790710, Length=396, Percent_Identity=35.3535353535354, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17556903, Length=286, Percent_Identity=36.7132867132867, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=260, Percent_Identity=31.9230769230769, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355725, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24661038, Length=292, Percent_Identity=33.5616438356164, Blast_Score=148, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21357381, Length=296, Percent_Identity=36.4864864864865, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI221379063, Length=296, Percent_Identity=36.4864864864865, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI221379062, Length=296, Percent_Identity=36.4864864864865, Blast_Score=131, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24662227, Length=298, Percent_Identity=30.2013422818792, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129969, Length=297, Percent_Identity=30.976430976431, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355645, Length=337, Percent_Identity=28.7833827893175, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662223, Length=337, Percent_Identity=28.7833827893175, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=336, Percent_Identity=30.6547619047619, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19922386, Length=359, Percent_Identity=28.4122562674095, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161077148, Length=341, Percent_Identity=28.7390029325513, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20130057, Length=341, Percent_Identity=28.7390029325513, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646701, Length=179, Percent_Identity=35.195530726257, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646703, Length=179, Percent_Identity=35.195530726257, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358201, Length=179, Percent_Identity=35.195530726257, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 49859; Mature: 49859

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDYSDLIQPDKGQDARTIHLVDKKSHDEWLKGRSPRERAHLAAIDFKPDAYAHAILPGD
CCCCHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCHHHCEEEEEECCCCCEEEEECCCC
DPDKWSVVTTVADVEKLSAWCLAKLGQILPEGRYRLDGHQPGQAMFGWMSAQYRFDAYKS
CCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCEEEHHHCC
ETTAKGPRVLLTSDVAAIAPMIAEARAVALVRDLVNTPAADMGPAAIEKTAERIARAHGG
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
KLTVTKGEALEQGYPMIHAVGRAAAKHHAPRLIEIEWGKADHPRVALVGKGISFDSGGLD
EEEEECCHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCE
IKPAAGMRLMKKDMGGAAHVLALAELVMASGLPVRLHCLVAAAENAISSDAFRPGDVLKS
ECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHC
RKGLTVEIGNTDAEGRLVLGDALTKAGESKPELIVDFATLTGAARVALGPDLPPLFANDD
CCCCEEEECCCCCCCEEEECHHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCCCCCCH
ALAEAMLVGGIARDDPLWRMPLWDGYADLLETDIADLGNAGSSPFAGAITAALFLKRFVP
HHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
DGAAWAHIDTFAWRPSAKPGRPKGGAALGLRAAWAMLQTRYDRRGKA
CCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIDYSDLIQPDKGQDARTIHLVDKKSHDEWLKGRSPRERAHLAAIDFKPDAYAHAILPGD
CCCCHHHCCCCCCCCCEEEEEEECCCCHHHHCCCCCHHHCEEEEEECCCCCEEEEECCCC
DPDKWSVVTTVADVEKLSAWCLAKLGQILPEGRYRLDGHQPGQAMFGWMSAQYRFDAYKS
CCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHCEEEHHHCC
ETTAKGPRVLLTSDVAAIAPMIAEARAVALVRDLVNTPAADMGPAAIEKTAERIARAHGG
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
KLTVTKGEALEQGYPMIHAVGRAAAKHHAPRLIEIEWGKADHPRVALVGKGISFDSGGLD
EEEEECCHHHHCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCE
IKPAAGMRLMKKDMGGAAHVLALAELVMASGLPVRLHCLVAAAENAISSDAFRPGDVLKS
ECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHC
RKGLTVEIGNTDAEGRLVLGDALTKAGESKPELIVDFATLTGAARVALGPDLPPLFANDD
CCCCEEEECCCCCCCEEEECHHHHHCCCCCCCEEEEEHHHCCCEEEEECCCCCCCCCCCH
ALAEAMLVGGIARDDPLWRMPLWDGYADLLETDIADLGNAGSSPFAGAITAALFLKRFVP
HHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
DGAAWAHIDTFAWRPSAKPGRPKGGAALGLRAAWAMLQTRYDRRGKA
CCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA