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The map label for this gene is gltP [H]

Identifier: 103486154

GI number: 103486154

Start: 672308

End: 673633

Strand: Direct

Name: gltP [H]

Synonym: Sala_0661

Alternate gene names: 103486154

Gene position: 672308-673633 (Clockwise)

Preceding gene: 103486153

Following gene: 103486156

Centisome position: 20.1

GC content: 64.48

Gene sequence:

>1326_bases
ATGGCCGAAGCAAGCATCGTGATGCCGGCCCAAGGGCATGAAGAGGCGCGCGCGCGGCGTCTGCAATGGCGGATGCTGGT
CGGGTTTGTCGTCGGCCTGCTCGCGGGACTCGCGGCGCATTATGGCGCTGCGGGCCAGCCGTGGGTTGACGAGGTGATTT
TCTATCTCGGCAAGGTCGGTGACATTTTCCTTCGCCTGCTCTTCATGCTGGTCATCCCGCTGCTGGTGTCGGCGTTGATC
GTCGGTGTCGCCGAAATGGGCGAGATGCGGGCGCTCAAGACCGTGGGATTGCGAACGCTGATCTATACGATCGTCGTGTC
GTCGATCGCGGTTGTGATCAGCCTGCTGGTCGTCAACCTTCTCCAGCCGGGTGCCGGCGTCGATCCGGAGGTCGCGCGTT
CGCTGATCGCCGACGGCGCCGAGCGCGCGGGCAGCATCATTCAGACGAGCCGCGAGGCCAAGGCCGGCGCCGACGCGATC
GTCGCGATCGTCCCCAATAATTTTTTCCTCGCGATGAGCCAGAATGACGTGCTTGCGGTGATGTTCTTCGCGCTGTTTTT
CGGCATCGGCCTGATGATGGTGCAGACGCCGCAGACGCAGGCGCTGAAAACCGCGATCGAGGGCGTGTTCGAGGTTGCGA
TGAAGCTGATCGGGCTGGTCATCCGCCTCGCGCCGATCGCGATCTTCTGTTTCATGTTCAACCTCGGCGCGCAGTTCGGC
GTCGATCTGCTCGTGCGCCTGTCGGCCTTCGTCGGTGTGGTGCTGCTTGCGCTCGGGCTTCAGATGTTCGTGGTCTTTCC
GATCCTGCTCAAGACGCTGGCGGGGAAATCGCCGATCGCCTTCTTCCGCGAAACGCAGGAAGCAACGGTGATGGCTTTTT
CGACCGCCTCGTCAAACGCGACGCTGCCCACGGCGCTGCGCGTCGCCCGGAACCAGTTGCACCTGCCCGACCGGGTCGCG
CGCTTCGTGCTGACCATCGGCGCGACGGCGAACCAGAATGGCACGGCGATGTTCGAAGGGGTGACGGTGATCTTCCTCGC
GCAATTCTTCGGGGTCGACCTGACGCTGCAGCAACAGATCATGGTGATGGCCGTGTGCATCCTTGGCGGCATCGGCACGG
CGGGCGTTCCGGCGGGTTCGCTGCCGGTGATCGCGCTGATCCTTGCCATGGTCGGTGTCCCCCCGGCGGGCATCGGGCTG
GTGCTCGGCGTCGACCGTTTCCTCGACATGTGCCGCACGACGCTGAACGTCATCGGCGACCTTGTCGCGGCGACGGTCGT
TTCGGCCGGGATCGACGATCGGCCGGAAGGGGACAGCCCCGGCTGA

Upstream 100 bases:

>100_bases
TGGCTGCGATCAGCCTGTTGATGTGAACGGTGCGGTTGCGCGCTATTTTGGGCACCGCTAGGGTCCGCGCCCTATTGGGT
CGCAAGCAGGGGAAAAGTGG

Downstream 100 bases:

>100_bases
TCCTTTTGGCTATTGATCGCGCACTTTGTTGGGCCGGTCGACGCGGTTGGCGCGCGCGGGGGGCGGGGGCGCCGATGGCG
TGTCCGCTCTCGGCGGCGGA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MAEASIVMPAQGHEEARARRLQWRMLVGFVVGLLAGLAAHYGAAGQPWVDEVIFYLGKVGDIFLRLLFMLVIPLLVSALI
VGVAEMGEMRALKTVGLRTLIYTIVVSSIAVVISLLVVNLLQPGAGVDPEVARSLIADGAERAGSIIQTSREAKAGADAI
VAIVPNNFFLAMSQNDVLAVMFFALFFGIGLMMVQTPQTQALKTAIEGVFEVAMKLIGLVIRLAPIAIFCFMFNLGAQFG
VDLLVRLSAFVGVVLLALGLQMFVVFPILLKTLAGKSPIAFFRETQEATVMAFSTASSNATLPTALRVARNQLHLPDRVA
RFVLTIGATANQNGTAMFEGVTVIFLAQFFGVDLTLQQQIMVMAVCILGGIGTAGVPAGSLPVIALILAMVGVPPAGIGL
VLGVDRFLDMCRTTLNVIGDLVAATVVSAGIDDRPEGDSPG

Sequences:

>Translated_441_residues
MAEASIVMPAQGHEEARARRLQWRMLVGFVVGLLAGLAAHYGAAGQPWVDEVIFYLGKVGDIFLRLLFMLVIPLLVSALI
VGVAEMGEMRALKTVGLRTLIYTIVVSSIAVVISLLVVNLLQPGAGVDPEVARSLIADGAERAGSIIQTSREAKAGADAI
VAIVPNNFFLAMSQNDVLAVMFFALFFGIGLMMVQTPQTQALKTAIEGVFEVAMKLIGLVIRLAPIAIFCFMFNLGAQFG
VDLLVRLSAFVGVVLLALGLQMFVVFPILLKTLAGKSPIAFFRETQEATVMAFSTASSNATLPTALRVARNQLHLPDRVA
RFVLTIGATANQNGTAMFEGVTVIFLAQFFGVDLTLQQQIMVMAVCILGGIGTAGVPAGSLPVIALILAMVGVPPAGIGL
VLGVDRFLDMCRTTLNVIGDLVAATVVSAGIDDRPEGDSPG
>Mature_440_residues
AEASIVMPAQGHEEARARRLQWRMLVGFVVGLLAGLAAHYGAAGQPWVDEVIFYLGKVGDIFLRLLFMLVIPLLVSALIV
GVAEMGEMRALKTVGLRTLIYTIVVSSIAVVISLLVVNLLQPGAGVDPEVARSLIADGAERAGSIIQTSREAKAGADAIV
AIVPNNFFLAMSQNDVLAVMFFALFFGIGLMMVQTPQTQALKTAIEGVFEVAMKLIGLVIRLAPIAIFCFMFNLGAQFGV
DLLVRLSAFVGVVLLALGLQMFVVFPILLKTLAGKSPIAFFRETQEATVMAFSTASSNATLPTALRVARNQLHLPDRVAR
FVLTIGATANQNGTAMFEGVTVIFLAQFFGVDLTLQQQIMVMAVCILGGIGTAGVPAGSLPVIALILAMVGVPPAGIGLV
LGVDRFLDMCRTTLNVIGDLVAATVVSAGIDDRPEGDSPG

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=425, Percent_Identity=29.6470588235294, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI40254478, Length=475, Percent_Identity=28, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI66773030, Length=463, Percent_Identity=27.4298056155508, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4827012, Length=265, Percent_Identity=31.6981132075472, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI21314632, Length=411, Percent_Identity=25.5474452554745, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI194239697, Length=183, Percent_Identity=36.6120218579235, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI223468564, Length=269, Percent_Identity=30.4832713754647, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI223468566, Length=269, Percent_Identity=30.4832713754647, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI5032093, Length=266, Percent_Identity=30.4511278195489, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI301601644, Length=170, Percent_Identity=37.0588235294118, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI262359914, Length=359, Percent_Identity=27.8551532033426, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1790514, Length=408, Percent_Identity=31.8627450980392, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1789947, Length=426, Percent_Identity=29.81220657277, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788024, Length=437, Percent_Identity=28.1464530892449, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1789473, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71996953, Length=460, Percent_Identity=28.4782608695652, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=414, Percent_Identity=27.536231884058, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71983099, Length=415, Percent_Identity=29.6385542168675, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=415, Percent_Identity=29.6385542168675, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=414, Percent_Identity=28.2608695652174, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=402, Percent_Identity=27.8606965174129, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=418, Percent_Identity=27.0334928229665, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24583025, Length=430, Percent_Identity=25.5813953488372, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17137668, Length=430, Percent_Identity=25.5813953488372, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24583023, Length=430, Percent_Identity=25.5813953488372, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI281360483, Length=437, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17137666, Length=437, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281360481, Length=437, Percent_Identity=26.3157894736842, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46524; Mature: 46393

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEASIVMPAQGHEEARARRLQWRMLVGFVVGLLAGLAAHYGAAGQPWVDEVIFYLGKVG
CCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DIFLRLLFMLVIPLLVSALIVGVAEMGEMRALKTVGLRTLIYTIVVSSIAVVISLLVVNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPGAGVDPEVARSLIADGAERAGSIIQTSREAKAGADAIVAIVPNNFFLAMSQNDVLAV
HCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHH
MFFALFFGIGLMMVQTPQTQALKTAIEGVFEVAMKLIGLVIRLAPIAIFCFMFNLGAQFG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLLVRLSAFVGVVLLALGLQMFVVFPILLKTLAGKSPIAFFRETQEATVMAFSTASSNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHEEEEEEECCCCC
TLPTALRVARNQLHLPDRVARFVLTIGATANQNGTAMFEGVTVIFLAQFFGVDLTLQQQI
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
MVMAVCILGGIGTAGVPAGSLPVIALILAMVGVPPAGIGLVLGVDRFLDMCRTTLNVIGD
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAATVVSAGIDDRPEGDSPG
HHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AEASIVMPAQGHEEARARRLQWRMLVGFVVGLLAGLAAHYGAAGQPWVDEVIFYLGKVG
CCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DIFLRLLFMLVIPLLVSALIVGVAEMGEMRALKTVGLRTLIYTIVVSSIAVVISLLVVNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQPGAGVDPEVARSLIADGAERAGSIIQTSREAKAGADAIVAIVPNNFFLAMSQNDVLAV
HCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHH
MFFALFFGIGLMMVQTPQTQALKTAIEGVFEVAMKLIGLVIRLAPIAIFCFMFNLGAQFG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDLLVRLSAFVGVVLLALGLQMFVVFPILLKTLAGKSPIAFFRETQEATVMAFSTASSNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHEEEEEEECCCCC
TLPTALRVARNQLHLPDRVARFVLTIGATANQNGTAMFEGVTVIFLAQFFGVDLTLQQQI
CHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
MVMAVCILGGIGTAGVPAGSLPVIALILAMVGVPPAGIGLVLGVDRFLDMCRTTLNVIGD
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVAATVVSAGIDDRPEGDSPG
HHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]