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The map label for this gene is serA [H]

Identifier: 103486109

GI number: 103486109

Start: 626996

End: 628582

Strand: Reverse

Name: serA [H]

Synonym: Sala_0616

Alternate gene names: 103486109

Gene position: 628582-626996 (Counterclockwise)

Preceding gene: 103486110

Following gene: 103486108

Centisome position: 18.79

GC content: 64.34

Gene sequence:

>1587_bases
ATGACCCAACCCAAAGTCCTTATCAGCGACAAGATGGACCCCAAGGCCGCCGCAATCTTCAAGGAACGCGGTATCCGCGT
CGACGAAATCACCGGCAAAACCAGGGACGAGCTGATCGCGATGATCGGCGACTACGACGGCCTTGCGATCCGGTCCGCCA
CGAAAGTCACCGCCGACGTCCTTGCCGCCGCGACAAAGCTGAAGGTCGTCGGCCGGGCCGGGATCGGCGTCGACAATATC
GACATTCCGGAGGCGTCGAAAAAGGGCGTCGTCGTGATGAACACGCCCTTCGGCAATTCGATCACCACCGCCGAACATGC
GATCGCGATGATGTTCGCTCTCGCGCGCCAGATTCCCGAAGCCAATGCGCTGACGCAGGCGGGCAAATGGCCGAAGAACG
ACTTCATGGGCGTCGAGCTGACGTCGAAGACGCTCGGCCTGATCGGCTGCGGCAACATCGGCAGCATCGTCGCCGAACGC
GCGCTCGGCCTCAAGATGAAGGTTGTCGCCTTCGACCCCTTCCTGACCCCCGAACGCGCGATCGAGCTGGGCGTCGAGAA
GGTCGACCTCGACACTTTGCTCGCGCGCGCCGACTTCATCACGCTGCACACGCCGCTGACCGATCAGACGCGCAATGTGC
TGTCGAAGGAAAATCTCGCCAAAACCAGGAAGGGCGTGCGGATCATCAATTGCGCGCGCGGCGGGCTGATCGACGAAGCG
GCGCTGAAGGACGCGCTCGACAGCGGCCATGTCGCCGGCGCGGCGCTCGACGTGTTCGCGGTCGAGCCACCGCCGGCGGA
CCATCCGCTGTTCAACACCCCCAATTTCATCTGCACCCCGCATCTTGGCGCGTCGACCGACGAGGCGCAGGTCAATGTCG
CGATCCAGGTCGCCGAACAGATCAGCGATTATCTGCTCACCGGCGGCATAACCAATGCGCTGAACGTCCCCAGCCTGTCG
GCCGAGGAAGCGCCGAAGCTGCGCCCCTATATGAGCCTCGCCGAAAAGCTCGGCAGCCTCGTCGGCCAGCTTGCGCACGA
CAATCTGACGCACATCTCGGTCGAGGTCGAGGGTGCAGCGGCCGAACTCAACCTGAAACCGATCGTCGCTGCGGTGCTCA
CCGGGCTGATGCGCCGCTATTCGGACAGCGTGAACATGGTCAACGCGCCGCATCTCGCGCGCGAACGCGGCCTCGATGTG
CGCGAAGTGCGCCACGACCGCGAAGGCGATTATCACACGCTCGTCCGCGTGACCGTGGCGACCGAGGCGGGCGACCGTTC
GGTGGCGGGCACGCTGTTCGGCAACAACGAGCCGCGCCTCGTCGAAATGTTCGGCATCAAGGTCGAAGCCGACCTCGACG
GCGACATGCTCTATATCGTCAACGAGGACGCGCCGGGCTTCATCGGCCGCATCGGCAGCACGCTGGGCGACGCCGGACTC
AACATCGGCACCTTCCACCTCGGCCGCCGCGCCGCGGGCGGCGAAGCGGTGCTGCTGCTCAGCCTCGATTCGCCGATGCC
CGAACCGCTGTTGTGGCAAGTTTGCCAGCTTCCCGGCGTGAAGATGGTGAAGGGTCTGAAGTTCTGA

Upstream 100 bases:

>100_bases
GAATGCCCCCCCCGCTCTCACTTCTTTTCAACCACATAGGGCCGGTGAAGGCTTCCCCCTCTCCCCGGCCCTCTCCCCTG
AAGGGGAGAGGGAGTAGACA

Downstream 100 bases:

>100_bases
CGCATCACAACCTTCTCCCATTGGGAGAAGGATACGCAGCCTTGCCGCGAAGCGGCTAGGCGGAGTTGGATGAGGGGTTG
TGCCTTATCGTCGATGCACA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTQPKVLISDKMDPKAAAIFKERGIRVDEITGKTRDELIAMIGDYDGLAIRSATKVTADVLAAATKLKVVGRAGIGVDNI
DIPEASKKGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANALTQAGKWPKNDFMGVELTSKTLGLIGCGNIGSIVAER
ALGLKMKVVAFDPFLTPERAIELGVEKVDLDTLLARADFITLHTPLTDQTRNVLSKENLAKTRKGVRIINCARGGLIDEA
ALKDALDSGHVAGAALDVFAVEPPPADHPLFNTPNFICTPHLGASTDEAQVNVAIQVAEQISDYLLTGGITNALNVPSLS
AEEAPKLRPYMSLAEKLGSLVGQLAHDNLTHISVEVEGAAAELNLKPIVAAVLTGLMRRYSDSVNMVNAPHLARERGLDV
REVRHDREGDYHTLVRVTVATEAGDRSVAGTLFGNNEPRLVEMFGIKVEADLDGDMLYIVNEDAPGFIGRIGSTLGDAGL
NIGTFHLGRRAAGGEAVLLLSLDSPMPEPLLWQVCQLPGVKMVKGLKF

Sequences:

>Translated_528_residues
MTQPKVLISDKMDPKAAAIFKERGIRVDEITGKTRDELIAMIGDYDGLAIRSATKVTADVLAAATKLKVVGRAGIGVDNI
DIPEASKKGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANALTQAGKWPKNDFMGVELTSKTLGLIGCGNIGSIVAER
ALGLKMKVVAFDPFLTPERAIELGVEKVDLDTLLARADFITLHTPLTDQTRNVLSKENLAKTRKGVRIINCARGGLIDEA
ALKDALDSGHVAGAALDVFAVEPPPADHPLFNTPNFICTPHLGASTDEAQVNVAIQVAEQISDYLLTGGITNALNVPSLS
AEEAPKLRPYMSLAEKLGSLVGQLAHDNLTHISVEVEGAAAELNLKPIVAAVLTGLMRRYSDSVNMVNAPHLARERGLDV
REVRHDREGDYHTLVRVTVATEAGDRSVAGTLFGNNEPRLVEMFGIKVEADLDGDMLYIVNEDAPGFIGRIGSTLGDAGL
NIGTFHLGRRAAGGEAVLLLSLDSPMPEPLLWQVCQLPGVKMVKGLKF
>Mature_527_residues
TQPKVLISDKMDPKAAAIFKERGIRVDEITGKTRDELIAMIGDYDGLAIRSATKVTADVLAAATKLKVVGRAGIGVDNID
IPEASKKGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANALTQAGKWPKNDFMGVELTSKTLGLIGCGNIGSIVAERA
LGLKMKVVAFDPFLTPERAIELGVEKVDLDTLLARADFITLHTPLTDQTRNVLSKENLAKTRKGVRIINCARGGLIDEAA
LKDALDSGHVAGAALDVFAVEPPPADHPLFNTPNFICTPHLGASTDEAQVNVAIQVAEQISDYLLTGGITNALNVPSLSA
EEAPKLRPYMSLAEKLGSLVGQLAHDNLTHISVEVEGAAAELNLKPIVAAVLTGLMRRYSDSVNMVNAPHLARERGLDVR
EVRHDREGDYHTLVRVTVATEAGDRSVAGTLFGNNEPRLVEMFGIKVEADLDGDMLYIVNEDAPGFIGRIGSTLGDAGLN
IGTFHLGRRAAGGEAVLLLSLDSPMPEPLLWQVCQLPGVKMVKGLKF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=398, Percent_Identity=45.4773869346734, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=32.7137546468402, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=32.7137546468402, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI145580578, Length=277, Percent_Identity=32.4909747292419, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4557499, Length=277, Percent_Identity=32.4909747292419, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI145580575, Length=268, Percent_Identity=33.2089552238806, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=32.5301204819277, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=37.1134020618557, Blast_Score=173, Evalue=3e-44,
Organism=Escherichia coli, GI87082289, Length=294, Percent_Identity=31.2925170068027, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=35.2040816326531, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI87081824, Length=239, Percent_Identity=27.1966527196653, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788660, Length=306, Percent_Identity=28.4313725490196, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=48.2315112540193, Blast_Score=287, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI25147481, Length=283, Percent_Identity=31.4487632508834, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=342, Percent_Identity=34.5029239766082, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=34.7560975609756, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=275, Percent_Identity=30.5454545454545, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=25.8181818181818, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325144, Length=123, Percent_Identity=35.7723577235772, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=26.530612244898, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=45.6666666666667, Blast_Score=262, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=28.9473684210526, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574286, Length=303, Percent_Identity=30.03300330033, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574284, Length=274, Percent_Identity=27.7372262773723, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585514, Length=274, Percent_Identity=27.7372262773723, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574282, Length=274, Percent_Identity=27.7372262773723, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45552429, Length=274, Percent_Identity=27.7372262773723, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551003, Length=273, Percent_Identity=27.8388278388278, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28571528, Length=272, Percent_Identity=32.7205882352941, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=31.2741312741313, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=31.2741312741313, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=31.2741312741313, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=31.2741312741313, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=31.2741312741313, Blast_Score=118, Evalue=1e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56346; Mature: 56214

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPKVLISDKMDPKAAAIFKERGIRVDEITGKTRDELIAMIGDYDGLAIRSATKVTADV
CCCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHEEEECCCCCEEEECHHHHHHHH
LAAATKLKVVGRAGIGVDNIDIPEASKKGVVVMNTPFGNSITTAEHAIAMMFALARQIPE
HHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
ANALTQAGKWPKNDFMGVELTSKTLGLIGCGNIGSIVAERALGLKMKVVAFDPFLTPERA
CHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHH
IELGVEKVDLDTLLARADFITLHTPLTDQTRNVLSKENLAKTRKGVRIINCARGGLIDEA
HHHCCHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
ALKDALDSGHVAGAALDVFAVEPPPADHPLFNTPNFICTPHLGASTDEAQVNVAIQVAEQ
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEHHHHH
ISDYLLTGGITNALNVPSLSAEEAPKLRPYMSLAEKLGSLVGQLAHDNLTHISVEVEGAA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCE
AELNLKPIVAAVLTGLMRRYSDSVNMVNAPHLARERGLDVREVRHDREGDYHTLVRVTVA
EECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCEEEEEEEEEE
TEAGDRSVAGTLFGNNEPRLVEMFGIKVEADLDGDMLYIVNEDAPGFIGRIGSTLGDAGL
ECCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCC
NIGTFHLGRRAAGGEAVLLLSLDSPMPEPLLWQVCQLPGVKMVKGLKF
CEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCC
>Mature Secondary Structure 
TQPKVLISDKMDPKAAAIFKERGIRVDEITGKTRDELIAMIGDYDGLAIRSATKVTADV
CCCCEEEECCCCCHHHHHHHHCCCEEEECCCCCHHHHEEEECCCCCEEEECHHHHHHHH
LAAATKLKVVGRAGIGVDNIDIPEASKKGVVVMNTPFGNSITTAEHAIAMMFALARQIPE
HHHHHHEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
ANALTQAGKWPKNDFMGVELTSKTLGLIGCGNIGSIVAERALGLKMKVVAFDPFLTPERA
CHHHHHCCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCHHHH
IELGVEKVDLDTLLARADFITLHTPLTDQTRNVLSKENLAKTRKGVRIINCARGGLIDEA
HHHCCHHCCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHH
ALKDALDSGHVAGAALDVFAVEPPPADHPLFNTPNFICTPHLGASTDEAQVNVAIQVAEQ
HHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEHHHHH
ISDYLLTGGITNALNVPSLSAEEAPKLRPYMSLAEKLGSLVGQLAHDNLTHISVEVEGAA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCE
AELNLKPIVAAVLTGLMRRYSDSVNMVNAPHLARERGLDVREVRHDREGDYHTLVRVTVA
EECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCEEEEEEEEEE
TEAGDRSVAGTLFGNNEPRLVEMFGIKVEADLDGDMLYIVNEDAPGFIGRIGSTLGDAGL
ECCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCC
NIGTFHLGRRAAGGEAVLLLSLDSPMPEPLLWQVCQLPGVKMVKGLKF
CEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]