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The map label for this gene is hrcA

Identifier: 103485748

GI number: 103485748

Start: 255834

End: 256877

Strand: Reverse

Name: hrcA

Synonym: Sala_0253

Alternate gene names: 103485748

Gene position: 256877-255834 (Counterclockwise)

Preceding gene: 103485755

Following gene: 103485747

Centisome position: 7.68

GC content: 67.15

Gene sequence:

>1044_bases
ATGACAACGCCCCCGATCACCGAACTTACCACGCGCGCGCGCGACGTGTTCCGGCTGGTCGTCGACGCCTATCTGGAGAC
GGGGCAGCCGGTGGGGTCGCGCACGCTGTCGAAACTTGCCACGCTCAACCTCTCGCCCGCGTCGATCCGCAACGTCATGC
AGGATCTGGAGGAATATGGCCTGCTCGCCAGCCCGCATACCAGCGCGGGGCGGATGCCGACCGAACAGGGACTGCGTCTG
TTCGTCGACGGGATGATGCAGGTTGCCGAACCCAGCGCCGAGGACCGTGCGCAGATCGAAGCGAGCCTGTCCGAAGGCGG
GCCGATCGAAAGCGCGCTGGCACAGGCGACCGCCGCGCTGTCGGGCCTGTCGGCGTGCGCGGGACTGGTGCTCGTCCCAA
AGCATGAGCGCGTGCTGAAACAGGTCGCCTTCGTCCCGATGTCGGAGCGGCAGGCGCTCGTCGTGCTCGTCGCGGGCGAC
GGCACGGTCGAGAACCGGATCATCGACGTACCCGCGGGGCTCGACCCCTCGGCGCTGGTCGAGGCGGGCAATTTCATTTC
GGCGACGCTGTCGGGCCTGACGCTGACCGAAGCGATGGCGCGCGTGCGCCGCGAGATCGAAGCCGAGCGCATCGCGATCG
ACCGCGCCGCGCAGGATCTGGTCAGCCGCGGGCTCGCCATATGGTCGTCCGACGGCGCCGATCGGCCGGTGCTGATCGTG
CGCGGACAGGCCAATTTGCTCGACGACAGCGCGGTCGGCGACCTCGACCGCGTGCGGCAATTGCTCGACGAACTCGAAAC
GAAACAGGACATTGCGCAATTGCTCGACAGCGCGCGCGAGGGCAGCGCGACGCGCATTTTCATCGGTTCCGAAAACAAGC
TCTTTTCGCTGTCGGGCTCGTCGGTTATCGCCGCGCCCTATCGCGGGGCGGACGGGCGCGTCGTCGGCGTGGTGGGCGTG
ATCGGCCCGACGCGCTTGAACTATGCCCGCATCGTTCCCATGGTGGATTTCACCGCCCAATCGCTCTCCAGACTGATACG
ATAG

Upstream 100 bases:

>100_bases
CTTTCTCCTCGTGAAGCTGTGCCGCGGCGCTTAGCCGCGCGCAGGGGGATTGGCCAGAGCATAGCTTGCTCTTGCCGCAC
CCGCTCCCTAAATCCTCCCC

Downstream 100 bases:

>100_bases
GTTTATGACGAACATGGAAAATGACACGCCGGTCGACGACGGCCAGACCGACGACGCCGCAACCGAAACCGAAACCGCGG
CGACCGAACCGCAGGACGAG

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTTPPITELTTRARDVFRLVVDAYLETGQPVGSRTLSKLATLNLSPASIRNVMQDLEEYGLLASPHTSAGRMPTEQGLRL
FVDGMMQVAEPSAEDRAQIEASLSEGGPIESALAQATAALSGLSACAGLVLVPKHERVLKQVAFVPMSERQALVVLVAGD
GTVENRIIDVPAGLDPSALVEAGNFISATLSGLTLTEAMARVRREIEAERIAIDRAAQDLVSRGLAIWSSDGADRPVLIV
RGQANLLDDSAVGDLDRVRQLLDELETKQDIAQLLDSAREGSATRIFIGSENKLFSLSGSSVIAAPYRGADGRVVGVVGV
IGPTRLNYARIVPMVDFTAQSLSRLIR

Sequences:

>Translated_347_residues
MTTPPITELTTRARDVFRLVVDAYLETGQPVGSRTLSKLATLNLSPASIRNVMQDLEEYGLLASPHTSAGRMPTEQGLRL
FVDGMMQVAEPSAEDRAQIEASLSEGGPIESALAQATAALSGLSACAGLVLVPKHERVLKQVAFVPMSERQALVVLVAGD
GTVENRIIDVPAGLDPSALVEAGNFISATLSGLTLTEAMARVRREIEAERIAIDRAAQDLVSRGLAIWSSDGADRPVLIV
RGQANLLDDSAVGDLDRVRQLLDELETKQDIAQLLDSAREGSATRIFIGSENKLFSLSGSSVIAAPYRGADGRVVGVVGV
IGPTRLNYARIVPMVDFTAQSLSRLIR
>Mature_346_residues
TTPPITELTTRARDVFRLVVDAYLETGQPVGSRTLSKLATLNLSPASIRNVMQDLEEYGLLASPHTSAGRMPTEQGLRLF
VDGMMQVAEPSAEDRAQIEASLSEGGPIESALAQATAALSGLSACAGLVLVPKHERVLKQVAFVPMSERQALVVLVAGDG
TVENRIIDVPAGLDPSALVEAGNFISATLSGLTLTEAMARVRREIEAERIAIDRAAQDLVSRGLAIWSSDGADRPVLIVR
GQANLLDDSAVGDLDRVRQLLDELETKQDIAQLLDSAREGSATRIFIGSENKLFSLSGSSVIAAPYRGADGRVVGVVGVI
GPTRLNYARIVPMVDFTAQSLSRLIR

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_SPHAL (Q1GWJ6)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_615309.1
- ProteinModelPortal:   Q1GWJ6
- SMR:   Q1GWJ6
- GeneID:   4083111
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_0253
- NMPDR:   fig|317655.9.peg.232
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   SALA317655:SALA_0253-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 36936; Mature: 36805

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPPITELTTRARDVFRLVVDAYLETGQPVGSRTLSKLATLNLSPASIRNVMQDLEEYG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
LLASPHTSAGRMPTEQGLRLFVDGMMQVAEPSAEDRAQIEASLSEGGPIESALAQATAAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
SGLSACAGLVLVPKHERVLKQVAFVPMSERQALVVLVAGDGTVENRIIDVPAGLDPSALV
HHHHHHCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCHHHHH
EAGNFISATLSGLTLTEAMARVRREIEAERIAIDRAAQDLVSRGLAIWSSDGADRPVLIV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEE
RGQANLLDDSAVGDLDRVRQLLDELETKQDIAQLLDSAREGSATRIFIGSENKLFSLSGS
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCC
SVIAAPYRGADGRVVGVVGVIGPTRLNYARIVPMVDFTAQSLSRLIR
EEEEECCCCCCCEEEEEEEECCCCCCCHHHEEHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TTPPITELTTRARDVFRLVVDAYLETGQPVGSRTLSKLATLNLSPASIRNVMQDLEEYG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
LLASPHTSAGRMPTEQGLRLFVDGMMQVAEPSAEDRAQIEASLSEGGPIESALAQATAAL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHH
SGLSACAGLVLVPKHERVLKQVAFVPMSERQALVVLVAGDGTVENRIIDVPAGLDPSALV
HHHHHHCCEEEECCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEECCCCCCHHHHH
EAGNFISATLSGLTLTEAMARVRREIEAERIAIDRAAQDLVSRGLAIWSSDGADRPVLIV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEE
RGQANLLDDSAVGDLDRVRQLLDELETKQDIAQLLDSAREGSATRIFIGSENKLFSLSGS
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCC
SVIAAPYRGADGRVVGVVGVIGPTRLNYARIVPMVDFTAQSLSRLIR
EEEEECCCCCCCEEEEEEEECCCCCCCHHHEEHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA