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The map label for this gene is msrA [H]

Identifier: 103485736

GI number: 103485736

Start: 245964

End: 246497

Strand: Reverse

Name: msrA [H]

Synonym: Sala_0240

Alternate gene names: 103485736

Gene position: 246497-245964 (Counterclockwise)

Preceding gene: 103485737

Following gene: 103485735

Centisome position: 7.37

GC content: 65.54

Gene sequence:

>534_bases
ATGACCCGTGAGACCGCCATTTTTGCCGGAGGCTGCTTCTGGTGCACCGAGGCTGTCTTCCAGTCGCTCGCGGGCGTCGA
GCGCGTCGAAAGCGGCTATATCGGCGGCACCGTCGCCAATCCGACCTACAAGCAGGTGTGCGGCGGCGACACCGGCCATG
CCGAGGCGATCCGCATCACCTTCGATCCGGCGGTGATCGGCTATGACGATCTGCTCGACGTGTTTTTCGCAACGCACGAT
CCGACGCAGCTCAACCGCCAGGGCAATGACGTCGGCACGCAATATCGCAGCGCGATCTTCCCGCTCGACGACGCGCAGGC
GGCGGCCGCGCGCAGAGGCATCGAGCGCGCCGCGCCCGACTGGCCGGCGCCGATCGTCACGACGATCGAAAACGCATCCG
AATGGTATCCGGCCGAGGATTATCACCAGGCCTATTGGGAGGGCGAAGGGCAGCGCAACCCCTATTGCATGGCGGTGATC
CCCCCCAAGCTCGCCAAGCTGCGCAAGGGGTTCGCGGAGCGGCTTCGCAACTGA

Upstream 100 bases:

>100_bases
GCTGCACCCACCGCTCGTCGATGCACCGCCGCCCTTGGAATAAGCGCGCGCGCATCCTATTTCGGCGGCATCCCACCCCT
CCCCGACAAGGATCGACGCC

Downstream 100 bases:

>100_bases
TTTCATTGGACCGTCATCCCGGCGAAGGCCGGGATCTCGCCGTTGCGTGGTGATGCAAGGTCGAGATCCCGGCCTTCGCC
GGGATGACGAATCATGTGCG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTRETAIFAGGCFWCTEAVFQSLAGVERVESGYIGGTVANPTYKQVCGGDTGHAEAIRITFDPAVIGYDDLLDVFFATHD
PTQLNRQGNDVGTQYRSAIFPLDDAQAAAARRGIERAAPDWPAPIVTTIENASEWYPAEDYHQAYWEGEGQRNPYCMAVI
PPKLAKLRKGFAERLRN

Sequences:

>Translated_177_residues
MTRETAIFAGGCFWCTEAVFQSLAGVERVESGYIGGTVANPTYKQVCGGDTGHAEAIRITFDPAVIGYDDLLDVFFATHD
PTQLNRQGNDVGTQYRSAIFPLDDAQAAAARRGIERAAPDWPAPIVTTIENASEWYPAEDYHQAYWEGEGQRNPYCMAVI
PPKLAKLRKGFAERLRN
>Mature_176_residues
TRETAIFAGGCFWCTEAVFQSLAGVERVESGYIGGTVANPTYKQVCGGDTGHAEAIRITFDPAVIGYDDLLDVFFATHDP
TQLNRQGNDVGTQYRSAIFPLDDAQAAAARRGIERAAPDWPAPIVTTIENASEWYPAEDYHQAYWEGEGQRNPYCMAVIP
PKLAKLRKGFAERLRN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=44.6540880503145, Blast_Score=135, Evalue=1e-32,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=44.6540880503145, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=44.2477876106195, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790665, Length=156, Percent_Identity=54.4871794871795, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=39.1608391608392, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=152, Percent_Identity=39.4736842105263, Blast_Score=111, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=34.7058823529412, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=34.1176470588235, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=34.375, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19521; Mature: 19390

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRETAIFAGGCFWCTEAVFQSLAGVERVESGYIGGTVANPTYKQVCGGDTGHAEAIRIT
CCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCCEEEEEE
FDPAVIGYDDLLDVFFATHDPTQLNRQGNDVGTQYRSAIFPLDDAQAAAARRGIERAAPD
ECCCEECHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
WPAPIVTTIENASEWYPAEDYHQAYWEGEGQRNPYCMAVIPPKLAKLRKGFAERLRN
CCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRETAIFAGGCFWCTEAVFQSLAGVERVESGYIGGTVANPTYKQVCGGDTGHAEAIRIT
CCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHCCCCCCCCEEEEEE
FDPAVIGYDDLLDVFFATHDPTQLNRQGNDVGTQYRSAIFPLDDAQAAAARRGIERAAPD
ECCCEECHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
WPAPIVTTIENASEWYPAEDYHQAYWEGEGQRNPYCMAVIPPKLAKLRKGFAERLRN
CCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA