Click here to switch to the map view.

The map label for this gene is proC [H]

Identifier: 103485543

GI number: 103485543

Start: 46087

End: 46947

Strand: Direct

Name: proC [H]

Synonym: Sala_0045

Alternate gene names: 103485543

Gene position: 46087-46947 (Clockwise)

Preceding gene: 103485542

Following gene: 103485545

Centisome position: 1.38

GC content: 69.57

Gene sequence:

>861_bases
TTGCCAACAATAAATGAAGACCAGGGGATCATGACGAAGAGATTGAAGGATTTTCAGGGCCGGATGCTGCTGGTCGGGTG
CGGCAACATGGCCGGCGCGATGCTCGATCGCTGGCTGGCATCGGGGCTGGGCGCGGACCGCGTTGCGATCGTCGATCCGC
TTGCCGCGCCGCGCGAGGGCGTCGTTCAGTTCGCGTCGCTTGCCGAATGGTGCGCCGCGGGCGGCGGCGCCGACTGGATC
ATGCTGGGCATGAAGCCGCAGCAGCTTGGCGAGGTGGCGGGCGACCTTGCCGACGTCGTCACCGGCGACACGCACCTCCT
CTCGATCCTCGCGGGCGTTTCGCTCGCCGACCTTGCCGCGCGCTTTCCGGCTGCAAAGGCGCAGGTGCGTATCCTGCCCA
ATCTCGCCGCGCGCATCGGCGCGGGCGTGTCGGCGGTGGCGAGCAGCGGCGAGGCCGACATGGCGGCGGTCACCGCATTG
CTCGACCCGCTCGGCACCATTGTCGCGCTGGCTGACGATTCGACGATGGACCTCGTCACGGCCTTTACCGGAAGCGGTCC
CGCGTTCGTGTTTCGCCTGATCGAATCCTATGCGGCGGCGGGCGAGCGGCTGGGGCTGTCGGCGGAGGACGCGCTCAAAC
TTGCCACCGCGACCTTCGGCGGCGCCACCGCGCTGCTCGCCGACAGCGGCGAAAAGCCCGGCACGCTCATCGCACAGGTG
GCGAGCAAGGGCGGCACCACACAGGCGGGGCTCGACGTGCTCGACAGCGACGGCCAGCTCGCCGCGCTGCTCACCAATGT
CCTGCGCGCGGCGCGCGATCGCGGGCGCGAGCTTGCCGAGATCGCACGCGGCGAGGGCTGA

Upstream 100 bases:

>100_bases
TCGACATCATGCCGACGCTCGCGGCACTGATCGGCCTGCCGGTCGATGCGGGCGCCATCGATGGCCGCTGCCTCGACCTG
GTTTCGGGTCCGGACAGCAG

Downstream 100 bases:

>100_bases
TTTACAGCACGCCGCTCTAACCGGCCTCCTTCCCCAGCGTCGCGATGCGGCGCCGGTCGCGCGGCGGGACCAGCGCCTCG
CTGACCTGCCAGAAACCCGT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPTINEDQGIMTKRLKDFQGRMLLVGCGNMAGAMLDRWLASGLGADRVAIVDPLAAPREGVVQFASLAEWCAAGGGADWI
MLGMKPQQLGEVAGDLADVVTGDTHLLSILAGVSLADLAARFPAAKAQVRILPNLAARIGAGVSAVASSGEADMAAVTAL
LDPLGTIVALADDSTMDLVTAFTGSGPAFVFRLIESYAAAGERLGLSAEDALKLATATFGGATALLADSGEKPGTLIAQV
ASKGGTTQAGLDVLDSDGQLAALLTNVLRAARDRGRELAEIARGEG

Sequences:

>Translated_286_residues
MPTINEDQGIMTKRLKDFQGRMLLVGCGNMAGAMLDRWLASGLGADRVAIVDPLAAPREGVVQFASLAEWCAAGGGADWI
MLGMKPQQLGEVAGDLADVVTGDTHLLSILAGVSLADLAARFPAAKAQVRILPNLAARIGAGVSAVASSGEADMAAVTAL
LDPLGTIVALADDSTMDLVTAFTGSGPAFVFRLIESYAAAGERLGLSAEDALKLATATFGGATALLADSGEKPGTLIAQV
ASKGGTTQAGLDVLDSDGQLAALLTNVLRAARDRGRELAEIARGEG
>Mature_285_residues
PTINEDQGIMTKRLKDFQGRMLLVGCGNMAGAMLDRWLASGLGADRVAIVDPLAAPREGVVQFASLAEWCAAGGGADWIM
LGMKPQQLGEVAGDLADVVTGDTHLLSILAGVSLADLAARFPAAKAQVRILPNLAARIGAGVSAVASSGEADMAAVTALL
DPLGTIVALADDSTMDLVTAFTGSGPAFVFRLIESYAAAGERLGLSAEDALKLATATFGGATALLADSGEKPGTLIAQVA
SKGGTTQAGLDVLDSDGQLAALLTNVLRAARDRGRELAEIARGEG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=204, Percent_Identity=31.3725490196078, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI24797095, Length=277, Percent_Identity=28.8808664259928, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI24797097, Length=277, Percent_Identity=28.8808664259928, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI21361454, Length=215, Percent_Identity=28.3720930232558, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1786585, Length=257, Percent_Identity=29.5719844357977, Blast_Score=84, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17569021, Length=269, Percent_Identity=29.368029739777, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17540664, Length=217, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320861, Length=199, Percent_Identity=31.6582914572864, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=30.2238805970149, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24648116, Length=281, Percent_Identity=26.6903914590747, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24647700, Length=171, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29014; Mature: 28882

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTINEDQGIMTKRLKDFQGRMLLVGCGNMAGAMLDRWLASGLGADRVAIVDPLAAPREG
CCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VVQFASLAEWCAAGGGADWIMLGMKPQQLGEVAGDLADVVTGDTHLLSILAGVSLADLAA
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
RFPAAKAQVRILPNLAARIGAGVSAVASSGEADMAAVTALLDPLGTIVALADDSTMDLVT
HCCCCHHHEEEHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHH
AFTGSGPAFVFRLIESYAAAGERLGLSAEDALKLATATFGGATALLADSGEKPGTLIAQV
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ASKGGTTQAGLDVLDSDGQLAALLTNVLRAARDRGRELAEIARGEG
HHCCCCCHHCCHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCC
>Mature Secondary Structure 
PTINEDQGIMTKRLKDFQGRMLLVGCGNMAGAMLDRWLASGLGADRVAIVDPLAAPREG
CCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHH
VVQFASLAEWCAAGGGADWIMLGMKPQQLGEVAGDLADVVTGDTHLLSILAGVSLADLAA
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
RFPAAKAQVRILPNLAARIGAGVSAVASSGEADMAAVTALLDPLGTIVALADDSTMDLVT
HCCCCHHHEEEHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCHHHHH
AFTGSGPAFVFRLIESYAAAGERLGLSAEDALKLATATFGGATALLADSGEKPGTLIAQV
HHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHH
ASKGGTTQAGLDVLDSDGQLAALLTNVLRAARDRGRELAEIARGEG
HHCCCCCHHCCHHCCCCCHHHHHHHHHHHHHHHHCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA