Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 99082861

GI number: 99082861

Start: 3188663

End: 3190258

Strand: Direct

Name: serA [H]

Synonym: TM1040_3021

Alternate gene names: 99082861

Gene position: 3188663-3190258 (Clockwise)

Preceding gene: 99082860

Following gene: 99082862

Centisome position: 99.62

GC content: 58.21

Gene sequence:

>1596_bases
ATGGCCCCCAAAGTACTCATCTCCGACAAACTCTCGGACGCCGCCGTTCAGATCTTCCGTGACCGCGGCATTGACGTGGA
TTTCCTACCCGATGTGGGCAAGGACAAGGAAAAGCTGGCTGAGATCATTGGCCAATATGATGGCCTCGCGATCCGCTCCG
CCACCAAAGTGACGCCGACCATTCTGGAAAACGCCACCAACCTAAAGGTGATTGGCCGCGCCGGGATCGGCACCGACAAC
ATCGACAAGGAAGCCGCGTCGAAAAAGGGTGTGATCGTCATGAACACTCCCTTCGGCAACATGATCACCACCGCCGAACA
TGCGATTGCGATGATGTTCGCCGTTGCGCGACAGGTCCCCGAGGCCTCTGCCTCGACCCATGCCGGGAAATGGGAAAAGT
CCAAATTCATGGGCGTTGAGCTGACCGGCAAGACCCTCGGTGTTATTGGTGCGGGCAACATTGGCGGCATCGTCTGCGAT
CGCGCCCGTGGGCTGAAGATGAAGGTTGTGGCCTATGATCCGTTCCTATCCGAGGAAAAGGCCAAGAAGATGCAGGTCGA
AAAGGTCGAGCTGGACGAACTGCTCGCGCGCGCTGATTTCATCACGCTTCATGTTCCGCTGACCGAGCAGACCAAGAATA
TCCTGAGCCGCGAAAACATCTCCAAGACCAAGAAAGGCGTGCGCATCATCAACTGTGCCCGTGGCGGTCTGGTGGATGAA
GAAGCCCTGGCCGAAGCCCTGACCTCCGGCCATGTGGCTGGCGCGGCATTTGATGTATTCTCTGTGGAGCCTGCGAAGGA
AAACCCGCTCTTCAACCTGCCCAACGTGGTCTGCACCCCGCACCTCGGCGCCGCGACGACCGAGGCGCAGGAAAACGTGG
CGCTGCAAGTCGCAGATCAGATGGCGAACTACCTCTTGACCGGTGCCGTTGAAAACGCGCTCAACATGCCATCGGTGACG
GCCGAGGAAGCCAAGATCATGGGGCCGTGGATCAAACTGGCCGATCATCTCGGGGCCTTTGCGGGTCAGATGACCGACGA
GCCGATTACTGCGATCAATGTGCTCTACGATGGTGTGGCAGCGGATATGAACCTCGACGCGCTGAACTGCTCGGTGGTTG
CAGGCATCATGAAAAAGGTGAACCCGGATGTGAACATGGTCTCGGCACCCGTTGTGGCCAAAGAACGCGGCATCCAGATC
TCTACCACCAATCAGGACAAGTCCGGCTCTTTTGATGGCTATATCAAGGTGACTGTCGTCACGGCAAAACGCGAGCGCTC
TGTCGCAGGCACCGTGTTCTCGGATGGCAAACCGCGCTTCATCCAGATCAAGGGCATCAATATCGATGCCGAAGTGGGCG
CGCATATGCTCTACACCACCAACCAGGACGTGCCGGGTATCATCGGCACCTTGGGTCAGACTTTGGGCGATATGGACGTC
AACATCGCGAACTTTACGCTTGGCCGAAACGAGGTCGGCGGCGAAGCGATCGCGCTCCTTTATGTGGATGCGGAGGTCCC
CGCAGACGCGCGTGCCAAGCTGGCAGAGACCGGTTACTTCACCCAGATCAAGCCGCTGGCCTTTGACGTCGCCTGA

Upstream 100 bases:

>100_bases
AGGCTAAAGGATAGCGTCTGGGCGTCAGCCCAGGCTGCGCCCAACCACTCCCGCTATTTCAGGCCGCACCCCGGCCCCCG
CAGACAAAGGACCAATGCAA

Downstream 100 bases:

>100_bases
GTATTGGGCATAGTTTGAAAACACGGCGGGCTCATCATTGGATGGGCCCGTTTTTGTTCCAACTCCCTGTTTTTTCTTGC
CTCACGAGGCAGGCACGCCA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAPKVLISDKLSDAAVQIFRDRGIDVDFLPDVGKDKEKLAEIIGQYDGLAIRSATKVTPTILENATNLKVIGRAGIGTDN
IDKEAASKKGVIVMNTPFGNMITTAEHAIAMMFAVARQVPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCD
RARGLKMKVVAYDPFLSEEKAKKMQVEKVELDELLARADFITLHVPLTEQTKNILSRENISKTKKGVRIINCARGGLVDE
EALAEALTSGHVAGAAFDVFSVEPAKENPLFNLPNVVCTPHLGAATTEAQENVALQVADQMANYLLTGAVENALNMPSVT
AEEAKIMGPWIKLADHLGAFAGQMTDEPITAINVLYDGVAADMNLDALNCSVVAGIMKKVNPDVNMVSAPVVAKERGIQI
STTNQDKSGSFDGYIKVTVVTAKRERSVAGTVFSDGKPRFIQIKGINIDAEVGAHMLYTTNQDVPGIIGTLGQTLGDMDV
NIANFTLGRNEVGGEAIALLYVDAEVPADARAKLAETGYFTQIKPLAFDVA

Sequences:

>Translated_531_residues
MAPKVLISDKLSDAAVQIFRDRGIDVDFLPDVGKDKEKLAEIIGQYDGLAIRSATKVTPTILENATNLKVIGRAGIGTDN
IDKEAASKKGVIVMNTPFGNMITTAEHAIAMMFAVARQVPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCD
RARGLKMKVVAYDPFLSEEKAKKMQVEKVELDELLARADFITLHVPLTEQTKNILSRENISKTKKGVRIINCARGGLVDE
EALAEALTSGHVAGAAFDVFSVEPAKENPLFNLPNVVCTPHLGAATTEAQENVALQVADQMANYLLTGAVENALNMPSVT
AEEAKIMGPWIKLADHLGAFAGQMTDEPITAINVLYDGVAADMNLDALNCSVVAGIMKKVNPDVNMVSAPVVAKERGIQI
STTNQDKSGSFDGYIKVTVVTAKRERSVAGTVFSDGKPRFIQIKGINIDAEVGAHMLYTTNQDVPGIIGTLGQTLGDMDV
NIANFTLGRNEVGGEAIALLYVDAEVPADARAKLAETGYFTQIKPLAFDVA
>Mature_530_residues
APKVLISDKLSDAAVQIFRDRGIDVDFLPDVGKDKEKLAEIIGQYDGLAIRSATKVTPTILENATNLKVIGRAGIGTDNI
DKEAASKKGVIVMNTPFGNMITTAEHAIAMMFAVARQVPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDR
ARGLKMKVVAYDPFLSEEKAKKMQVEKVELDELLARADFITLHVPLTEQTKNILSRENISKTKKGVRIINCARGGLVDEE
ALAEALTSGHVAGAAFDVFSVEPAKENPLFNLPNVVCTPHLGAATTEAQENVALQVADQMANYLLTGAVENALNMPSVTA
EEAKIMGPWIKLADHLGAFAGQMTDEPITAINVLYDGVAADMNLDALNCSVVAGIMKKVNPDVNMVSAPVVAKERGIQIS
TTNQDKSGSFDGYIKVTVVTAKRERSVAGTVFSDGKPRFIQIKGINIDAEVGAHMLYTTNQDVPGIIGTLGQTLGDMDVN
IANFTLGRNEVGGEAIALLYVDAEVPADARAKLAETGYFTQIKPLAFDVA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=417, Percent_Identity=41.726618705036, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI4557497, Length=328, Percent_Identity=30.1829268292683, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI61743967, Length=328, Percent_Identity=30.1829268292683, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI145580578, Length=317, Percent_Identity=30.5993690851735, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI4557499, Length=317, Percent_Identity=30.5993690851735, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI145580575, Length=286, Percent_Identity=32.5174825174825, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI6912396, Length=262, Percent_Identity=33.969465648855, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1789279, Length=323, Percent_Identity=38.0804953560372, Blast_Score=194, Evalue=9e-51,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=31.0769230769231, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=30.8, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI87081824, Length=256, Percent_Identity=25.390625, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=26.615969581749, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=44.7019867549669, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=32.421875, Blast_Score=139, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=333, Percent_Identity=36.036036036036, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=36.036036036036, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=30.0813008130081, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=267, Percent_Identity=27.7153558052434, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=27.5510204081633, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=92, Percent_Identity=39.1304347826087, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=42.6229508196721, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24646446, Length=304, Percent_Identity=31.9078947368421, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646448, Length=304, Percent_Identity=31.9078947368421, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646452, Length=304, Percent_Identity=31.9078947368421, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646450, Length=304, Percent_Identity=31.9078947368421, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI62472511, Length=304, Percent_Identity=31.9078947368421, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=26.4705882352941, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28574286, Length=233, Percent_Identity=30.0429184549356, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=32.0754716981132, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585514, Length=234, Percent_Identity=28.2051282051282, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI28574282, Length=234, Percent_Identity=28.2051282051282, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45551003, Length=233, Percent_Identity=28.3261802575107, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI28574284, Length=233, Percent_Identity=28.3261802575107, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI45552429, Length=234, Percent_Identity=28.2051282051282, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56525; Mature: 56393

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKVLISDKLSDAAVQIFRDRGIDVDFLPDVGKDKEKLAEIIGQYDGLAIRSATKVTPT
CCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
ILENATNLKVIGRAGIGTDNIDKEAASKKGVIVMNTPFGNMITTAEHAIAMMFAVARQVP
HHCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
EASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDRARGLKMKVVAYDPFLSEEK
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCHHH
AKKMQVEKVELDELLARADFITLHVPLTEQTKNILSRENISKTKKGVRIINCARGGLVDE
HHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCH
EALAEALTSGHVAGAAFDVFSVEPAKENPLFNLPNVVCTPHLGAATTEAQENVALQVADQ
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
MANYLLTGAVENALNMPSVTAEEAKIMGPWIKLADHLGAFAGQMTDEPITAINVLYDGVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHH
ADMNLDALNCSVVAGIMKKVNPDVNMVSAPVVAKERGIQISTTNQDKSGSFDGYIKVTVV
CCCCCCHHHHHHHHHHHHHCCCCCCEEECCEEEHHCCEEEEECCCCCCCCCCCEEEEEEE
TAKRERSVAGTVFSDGKPRFIQIKGINIDAEVGAHMLYTTNQDVPGIIGTLGQTLGDMDV
EECCCCCEEEEEECCCCCCEEEEEECEEEHHHCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRNEVGGEAIALLYVDAEVPADARAKLAETGYFTQIKPLAFDVA
EEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEECCEEEECC
>Mature Secondary Structure 
APKVLISDKLSDAAVQIFRDRGIDVDFLPDVGKDKEKLAEIIGQYDGLAIRSATKVTPT
CCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCHH
ILENATNLKVIGRAGIGTDNIDKEAASKKGVIVMNTPFGNMITTAEHAIAMMFAVARQVP
HHCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
EASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDRARGLKMKVVAYDPFLSEEK
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCHHH
AKKMQVEKVELDELLARADFITLHVPLTEQTKNILSRENISKTKKGVRIINCARGGLVDE
HHHHHHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCH
EALAEALTSGHVAGAAFDVFSVEPAKENPLFNLPNVVCTPHLGAATTEAQENVALQVADQ
HHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHH
MANYLLTGAVENALNMPSVTAEEAKIMGPWIKLADHLGAFAGQMTDEPITAINVLYDGVA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHH
ADMNLDALNCSVVAGIMKKVNPDVNMVSAPVVAKERGIQISTTNQDKSGSFDGYIKVTVV
CCCCCCHHHHHHHHHHHHHCCCCCCEEECCEEEHHCCEEEEECCCCCCCCCCCEEEEEEE
TAKRERSVAGTVFSDGKPRFIQIKGINIDAEVGAHMLYTTNQDVPGIIGTLGQTLGDMDV
EECCCCCEEEEEECCCCCCEEEEEECEEEHHHCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRNEVGGEAIALLYVDAEVPADARAKLAETGYFTQIKPLAFDVA
EEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]