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The map label for this gene is hbpA [H]

Identifier: 99082526

GI number: 99082526

Start: 2825147

End: 2826733

Strand: Reverse

Name: hbpA [H]

Synonym: TM1040_2686

Alternate gene names: 99082526

Gene position: 2826733-2825147 (Counterclockwise)

Preceding gene: 99082528

Following gene: 99082525

Centisome position: 88.31

GC content: 61.69

Gene sequence:

>1587_bases
ATGAAACTTCTAGGGATGACGCGGCGTGGCGCGATGGCTGCGATGCTTGCGACGACGGCAATGGCGGGGGTGGCGATGGG
CGTGGCGCCTGCCGCAGCGCAGACACCGCCTGGCGTGCTGATCGTGGGCCAGATCGCAGAGCCAAAAGCGCTGGACCCGG
CGGCAGTGACGGCGGTAAATGACTTCCGCATCCTGATGAACGTCTATGACGGTCTGGTGCGCTACAAGGACGGCACGCTC
GAGGTCGAACCCGCGCTGGCGACCGACTGGAGCATCTCCGAAGATGGCACCGAATATACATTCACGCTGCGCGAAGGGGT
GTCGTTTCATGACGGCAGCGCCTTTGATGCCGAGGCGGTGGTGTTCAACTTTGAGCGCATGCTCAATGAGGATCACCCCT
ATCACAACACCGGCCCCTTCCCGCTGGCCTTCTTCTTTTCTGCCGTGGAGAGCGTCGAGGCCGTTGATGATCTGACGGTG
AAATTCAAACTGAACGCGCCCTATGCGCCGTTCCTGTCGAATCTCGCTTATCCTACAGGCCTGATTGTATCGCCTGAGGC
GGTCAAGACCCATGGCGCGGAGTTCGGCCGCAACCCCTCCGGCACCGGTGCTTTCAAATTTGCCGAGTGGCGCTCCAATG
AGGCCGTGGTGGTCGAGAAAAATCCCGACTACTGGGATGGCGCGGCAGAGCTGGACGCGGTGGTCTTTCGCCCGATCACC
GATGCCAACACCCGCACGGCAGAAATGCTGGCAGGTGGCATTGATCTGATGGTCGAGGTGCCGCCGGTGGCACTGTCGGA
GTTTCAGGGCGATGCTTTCACCGTGCATGAACAAGCCGGCCCGCACGTCTGGTTCCTGATCCTCAACGCCAAGGAAGGCC
CCTTTGCCGACAAGCGCGTCCGCCAAGCGGCGAATTACGCGATCAACAAATCCGCGATTGTGAACGATGTGCTTGAGGGC
ACGGCGGAGGTGGCCGCAGGCCCGACCCCGCCCGCCTTTGCCTGGGCCTACAATGAAACGCTCGAACCCTATCCCTATGA
CCCCGACAAGGCGCGGGAACTCCTGGCCGAGGCGGGTGCAGAAGGGGCGGAGCTGACGTTCTATGTGACCGAGGGCGGCT
CCGGCATGCTCGACCCTATCGCCATGGGCACTGCCATTCAGGCGGATCTCAACGCCGTGGGGCTGGATGTGAAGATCGAA
ACCTACGAGTGGAACACCTTCCTGGGCGAGGTCAATCCGGGGCTGGAGGGCAAGGCCGACATGGCCGAGATGGCCTGGAT
GACCAACGACCCCGACACGCTCCCCTTCCTGGCGCTGCGCACCGAAGCCTGGCCTGACAAGGGCGGCTTCAACTCCGGCT
ATTATTCCAACCCGAAGGTGGATGAGCTGTTGGAAGCGGCCCGCGTTGCGACCGATCAGGACGAGCGCGCCAAGCTTTAT
CAGGAGATGCAGACCATCGTGCAGGAAGATGCGCCTTGGGTCTTTGTCGCCAACTGGAAGCAGAATGCAGTGACCTCGGA
TCGGGTGGGCGATTTTGCCCTGCAGCCCTCGTTCTTCCTGCTGCTCGATGATGTGACCAAGAACTGA

Upstream 100 bases:

>100_bases
TCCGGGCGGGGGTCTTGCAGGTTTGGACTTGTATTTATCATGAAAATTTGCGTGGATACAATTAATCATGAAAAATAAAT
CTCAACAGAGAGGATGCGAT

Downstream 100 bases:

>100_bases
TGAGAGGTTTCGGATCGGGCTTTGCCCGATCCGACCCGCGCGCGCCCCGGCGGGGCGCGCGCTCCCGTTTGACTGAAACC
CCACTCCACCCATGTCGGTA

Product: extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MKLLGMTRRGAMAAMLATTAMAGVAMGVAPAAAQTPPGVLIVGQIAEPKALDPAAVTAVNDFRILMNVYDGLVRYKDGTL
EVEPALATDWSISEDGTEYTFTLREGVSFHDGSAFDAEAVVFNFERMLNEDHPYHNTGPFPLAFFFSAVESVEAVDDLTV
KFKLNAPYAPFLSNLAYPTGLIVSPEAVKTHGAEFGRNPSGTGAFKFAEWRSNEAVVVEKNPDYWDGAAELDAVVFRPIT
DANTRTAEMLAGGIDLMVEVPPVALSEFQGDAFTVHEQAGPHVWFLILNAKEGPFADKRVRQAANYAINKSAIVNDVLEG
TAEVAAGPTPPAFAWAYNETLEPYPYDPDKARELLAEAGAEGAELTFYVTEGGSGMLDPIAMGTAIQADLNAVGLDVKIE
TYEWNTFLGEVNPGLEGKADMAEMAWMTNDPDTLPFLALRTEAWPDKGGFNSGYYSNPKVDELLEAARVATDQDERAKLY
QEMQTIVQEDAPWVFVANWKQNAVTSDRVGDFALQPSFFLLLDDVTKN

Sequences:

>Translated_528_residues
MKLLGMTRRGAMAAMLATTAMAGVAMGVAPAAAQTPPGVLIVGQIAEPKALDPAAVTAVNDFRILMNVYDGLVRYKDGTL
EVEPALATDWSISEDGTEYTFTLREGVSFHDGSAFDAEAVVFNFERMLNEDHPYHNTGPFPLAFFFSAVESVEAVDDLTV
KFKLNAPYAPFLSNLAYPTGLIVSPEAVKTHGAEFGRNPSGTGAFKFAEWRSNEAVVVEKNPDYWDGAAELDAVVFRPIT
DANTRTAEMLAGGIDLMVEVPPVALSEFQGDAFTVHEQAGPHVWFLILNAKEGPFADKRVRQAANYAINKSAIVNDVLEG
TAEVAAGPTPPAFAWAYNETLEPYPYDPDKARELLAEAGAEGAELTFYVTEGGSGMLDPIAMGTAIQADLNAVGLDVKIE
TYEWNTFLGEVNPGLEGKADMAEMAWMTNDPDTLPFLALRTEAWPDKGGFNSGYYSNPKVDELLEAARVATDQDERAKLY
QEMQTIVQEDAPWVFVANWKQNAVTSDRVGDFALQPSFFLLLDDVTKN
>Mature_528_residues
MKLLGMTRRGAMAAMLATTAMAGVAMGVAPAAAQTPPGVLIVGQIAEPKALDPAAVTAVNDFRILMNVYDGLVRYKDGTL
EVEPALATDWSISEDGTEYTFTLREGVSFHDGSAFDAEAVVFNFERMLNEDHPYHNTGPFPLAFFFSAVESVEAVDDLTV
KFKLNAPYAPFLSNLAYPTGLIVSPEAVKTHGAEFGRNPSGTGAFKFAEWRSNEAVVVEKNPDYWDGAAELDAVVFRPIT
DANTRTAEMLAGGIDLMVEVPPVALSEFQGDAFTVHEQAGPHVWFLILNAKEGPFADKRVRQAANYAINKSAIVNDVLEG
TAEVAAGPTPPAFAWAYNETLEPYPYDPDKARELLAEAGAEGAELTFYVTEGGSGMLDPIAMGTAIQADLNAVGLDVKIE
TYEWNTFLGEVNPGLEGKADMAEMAWMTNDPDTLPFLALRTEAWPDKGGFNSGYYSNPKVDELLEAARVATDQDERAKLY
QEMQTIVQEDAPWVFVANWKQNAVTSDRVGDFALQPSFFLLLDDVTKN

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=499, Percent_Identity=30.8617234468938, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1787762, Length=498, Percent_Identity=31.3253012048193, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI1787052, Length=521, Percent_Identity=29.9424184261036, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1787551, Length=515, Percent_Identity=27.1844660194175, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789887, Length=473, Percent_Identity=28.3298097251586, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1787495, Length=524, Percent_Identity=25.1908396946565, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI87081878, Length=523, Percent_Identity=27.3422562141491, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1789397, Length=483, Percent_Identity=26.5010351966874, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57316; Mature: 57316

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLGMTRRGAMAAMLATTAMAGVAMGVAPAAAQTPPGVLIVGQIAEPKALDPAAVTAVN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHEEEHH
DFRILMNVYDGLVRYKDGTLEVEPALATDWSISEDGTEYTFTLREGVSFHDGSAFDAEAV
HHHHHHHHHHHHEEECCCCEEECCCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
VFNFERMLNEDHPYHNTGPFPLAFFFSAVESVEAVDDLTVKFKLNAPYAPFLSNLAYPTG
EEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCC
LIVSPEAVKTHGAEFGRNPSGTGAFKFAEWRSNEAVVVEKNPDYWDGAAELDAVVFRPIT
EEECCHHHHHCCHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHCCEEEEECCC
DANTRTAEMLAGGIDLMVEVPPVALSEFQGDAFTVHEQAGPHVWFLILNAKEGPFADKRV
CCCCHHHHHHHCCCEEEEECCCHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHH
RQAANYAINKSAIVNDVLEGTAEVAAGPTPPAFAWAYNETLEPYPYDPDKARELLAEAGA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCC
EGAELTFYVTEGGSGMLDPIAMGTAIQADLNAVGLDVKIETYEWNTFLGEVNPGLEGKAD
CCCEEEEEEECCCCCCCCHHHCCCEEECCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCC
MAEMAWMTNDPDTLPFLALRTEAWPDKGGFNSGYYSNPKVDELLEAARVATDQDERAKLY
HHHHHEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
QEMQTIVQEDAPWVFVANWKQNAVTSDRVGDFALQPSFFLLLDDVTKN
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCEEEEEEECCCCC
>Mature Secondary Structure
MKLLGMTRRGAMAAMLATTAMAGVAMGVAPAAAQTPPGVLIVGQIAEPKALDPAAVTAVN
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHEEEHH
DFRILMNVYDGLVRYKDGTLEVEPALATDWSISEDGTEYTFTLREGVSFHDGSAFDAEAV
HHHHHHHHHHHHEEECCCCEEECCCEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHH
VFNFERMLNEDHPYHNTGPFPLAFFFSAVESVEAVDDLTVKFKLNAPYAPFLSNLAYPTG
EEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHCCCCCC
LIVSPEAVKTHGAEFGRNPSGTGAFKFAEWRSNEAVVVEKNPDYWDGAAELDAVVFRPIT
EEECCHHHHHCCHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCHHHCCEEEEECCC
DANTRTAEMLAGGIDLMVEVPPVALSEFQGDAFTVHEQAGPHVWFLILNAKEGPFADKRV
CCCCHHHHHHHCCCEEEEECCCHHHHHCCCCEEEEECCCCCEEEEEEEECCCCCCHHHHH
RQAANYAINKSAIVNDVLEGTAEVAAGPTPPAFAWAYNETLEPYPYDPDKARELLAEAGA
HHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCC
EGAELTFYVTEGGSGMLDPIAMGTAIQADLNAVGLDVKIETYEWNTFLGEVNPGLEGKAD
CCCEEEEEEECCCCCCCCHHHCCCEEECCCCEEEEEEEEEEEEEEEEEECCCCCCCCCCC
MAEMAWMTNDPDTLPFLALRTEAWPDKGGFNSGYYSNPKVDELLEAARVATDQDERAKLY
HHHHHEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
QEMQTIVQEDAPWVFVANWKQNAVTSDRVGDFALQPSFFLLLDDVTKN
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEECCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]