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The map label for this gene is recQ [H]

Identifier: 99082499

GI number: 99082499

Start: 2793914

End: 2795953

Strand: Reverse

Name: recQ [H]

Synonym: TM1040_2659

Alternate gene names: 99082499

Gene position: 2795953-2793914 (Counterclockwise)

Preceding gene: 99082500

Following gene: 99082498

Centisome position: 87.35

GC content: 65.34

Gene sequence:

>2040_bases
ATGCACGACGCAATCCCCCTGTTGCGCGATATCTTTGGATTCGATGACTTTCGTCCCGGTCAGGAGGAAATCGTCGAGGC
CGTGAGCGCGGGCGAAAACGTGCTCGCGATCATGCCCACGGGGGGTGGTAAATCCCTTTGTTATCAGTTGCCTGCGCTGC
GCCGCGCGGGGATCACGGTGGTGATCTCGCCGCTGATTGCGCTGATGCGCGATCAGGTCCGCGCCTTGCAGGAGGCCGGG
GTCTGTGCCGGGGCGCTTACTTCTGGCAATACGGAAGAAGAGACCGAGGCGGTCTGGAACGCCATCGAGGCGGGCGAGCT
GAAGCTTTTGTACATGGCGCCCGAACGGTTGGCGGCGGGCAGCGCCATGGGCATGCTGCGCCGGATTGGTGTCTCGCTGA
TCGCGGTGGACGAGGCCCACTGCGTCAGCCAATGGGGCCATGATTTCCGCCCGGATTACCTGCGCATCGGCGAGCTGCGC
CGCGCGCTCGACGTGCCCTTGGCAGCCTTTACCGCCACGGCAGATCAGGAAACCCAGGCCGAGATCGTCCAGAAACTGTT
CGACGGTGAGGCGCCGCGCGCCTTCTTGCGCGGCTTTGACCGGCCCAATATTCACCTCGCCTTTGCCGCCAAGGACAGCC
CGCGCAAACAGATCCTCGAGTTCGCCGATGCGCGGCGCGGCCAGTCGGGCATTGTCTATTGCGGCACCCGCGCCAAGACC
GAGGACATCGCCCGCGCGCTCGAGGCCTCTGGCCATGTCGCCTGCCATTATCACGGCGGCATGGAGGCCGAGGACCGGCG
CATCGTCGAGACACGTTTCGCGCGCGAGGATGGGCTGATCGTGGTGGCTACGGTGGCCTTTGGCATGGGCATCGACAAGC
CCGACATCCGCTGGGTCGCCCACGCCGACCTACCCAAGAGCATCGAAGCCTATTATCAGGAAATCGGCCGCGCCGGCCGC
GATGGGGCGCCCGCCGAGACGATGACGCTCTTTGGTCCCGAAGACATCCGCCTGCGCCGCAACCAGATTGACGAGGGGCT
TGCACCGCCCGAACGGCGCGGCGCGGATCATGCGCGGCTCAACGCATTGCTGGGGCTGGCGGAGGCCATGAGTTGTCGCC
GTCAGAGCCTGCTGAGTTATTTTGGTGAAAATCCAGAGCCTTGCGGCCATTGCGATCTGTGCGACACGCCGGTTGAGACC
TTTGACGGCACCACCGCCGTGCGAAAGGCGCTCTCGGCCATTCTGCGCACCGAGGAGACCTATGGCGCGGGGCATCTCAT
TGACATTCTGATCGGCAACGCCAACGACCGCGTGCGCCAGAAGGGGCATGACGATCTGTCGGTTTTTGCTTGCGGGCGCG
AGCATTCAAAGCCCGAGTGGCAGGCGATTTTCCGGCAGATGATGGGGCGCGATCTGGTGCGGCCGGACCCGGAGCGTCAC
GGGGCACTCAGGATGACCGAACCGGCGCTGCCGATCCTGCGTGGCGAGGACAGCATCACCCTGCGCAAGGACACCATCAA
ATCCGCCACCCGCCGCCCGGCGGTCAAGGCGCTGGTCTCGGATGAGGATGCGCCCCTTTTGTCGGCGCTGAAGGCCAAGC
GGCGCGCCCTCGCCGAGGCGCAAAAAGTCCCGGCCTATGTGATCTTTCCCGATCGGACCCTCATCGAGATGGCGGAGAAC
CGCCCGCAAAGCCTGGATGAAATGGCGCGGATTTCGGGCGTGGGCGCCAAAAAGCTCGAGCGGTATGGCGATGCGTTTCT
CAGTGTGATCACCGGCGAGGCCGAAGCGCTGCACCCGGCGCGGCGCAAGCTGGCGGGGCGCGCGCAGGGGTCGATTTACG
ATACACTTCTGGAGGTGCAGGCGCGGCTGCAACGCGGCGAATGCGGCACTCAGAAACCGCTGACTTGCTCGGCCTCGCAA
CTGGCCAAAGTGGCGCAGATGCGCAGCGATGACGAGAGCGGGATGGAGCGGCTGTTGGGGGAGCGCCGCGCGCAACGGTT
TGCCTCGGCGTTTCTGGAGGTCCTGCGCGGCGCGGGCTAG

Upstream 100 bases:

>100_bases
GCTTGGGCGCCGCTTCTGGGCTGAGGCCCTCTTGCCCCCCGATTCCAGCTGTGGGATTGTGCCGCTCATAACCTGAGCAG
ACCAACCCACAGGCCCCCGC

Downstream 100 bases:

>100_bases
GTCATCGCCCAGATTTGACCGGACCTTGCCGCAGCAGCGCTTGGCACCCGTGCGAATTGCGTTACAACTCTGGGCAAGTT
CACCTGACAGGAGTGCAGCC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 679

Protein sequence:

>679_residues
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITVVISPLIALMRDQVRALQEAG
VCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAGSAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELR
RALDVPLAAFTATADQETQAEIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKT
EDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVAHADLPKSIEAYYQEIGRAGR
DGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARLNALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVET
FDGTTAVRKALSAILRTEETYGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERH
GALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEAQKVPAYVIFPDRTLIEMAEN
RPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPARRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQ
LAKVAQMRSDDESGMERLLGERRAQRFASAFLEVLRGAG

Sequences:

>Translated_679_residues
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITVVISPLIALMRDQVRALQEAG
VCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAGSAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELR
RALDVPLAAFTATADQETQAEIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKT
EDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVAHADLPKSIEAYYQEIGRAGR
DGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARLNALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVET
FDGTTAVRKALSAILRTEETYGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERH
GALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEAQKVPAYVIFPDRTLIEMAEN
RPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPARRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQ
LAKVAQMRSDDESGMERLLGERRAQRFASAFLEVLRGAG
>Mature_679_residues
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITVVISPLIALMRDQVRALQEAG
VCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAGSAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELR
RALDVPLAAFTATADQETQAEIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKT
EDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVAHADLPKSIEAYYQEIGRAGR
DGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARLNALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVET
FDGTTAVRKALSAILRTEETYGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERH
GALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEAQKVPAYVIFPDRTLIEMAEN
RPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPARRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQ
LAKVAQMRSDDESGMERLLGERRAQRFASAFLEVLRGAG

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=653, Percent_Identity=32.6186830015314, Blast_Score=309, Evalue=4e-84,
Organism=Homo sapiens, GI14591902, Length=460, Percent_Identity=37.3913043478261, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI14591904, Length=460, Percent_Identity=37.3913043478261, Blast_Score=281, Evalue=1e-75,
Organism=Homo sapiens, GI169218196, Length=500, Percent_Identity=34, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI110735439, Length=500, Percent_Identity=34.2, Blast_Score=267, Evalue=3e-71,
Organism=Homo sapiens, GI148612816, Length=506, Percent_Identity=36.7588932806324, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI51242943, Length=356, Percent_Identity=40.7303370786517, Blast_Score=245, Evalue=1e-64,
Organism=Homo sapiens, GI51242947, Length=357, Percent_Identity=40.6162464985994, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI284005309, Length=357, Percent_Identity=39.7759103641457, Blast_Score=222, Evalue=1e-57,
Organism=Homo sapiens, GI148613856, Length=344, Percent_Identity=23.546511627907, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI38201710, Length=344, Percent_Identity=23.546511627907, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994977, Length=588, Percent_Identity=45.7482993197279, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI87082221, Length=345, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787016, Length=349, Percent_Identity=22.9226361031519, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71987997, Length=424, Percent_Identity=38.4433962264151, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71987993, Length=424, Percent_Identity=38.4433962264151, Blast_Score=276, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI25145561, Length=492, Percent_Identity=34.1463414634146, Blast_Score=270, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI32564293, Length=493, Percent_Identity=34.4827586206897, Blast_Score=269, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17552866, Length=416, Percent_Identity=36.7788461538462, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17537549, Length=366, Percent_Identity=24.3169398907104, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71995718, Length=376, Percent_Identity=23.1382978723404, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71995724, Length=135, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507121, Length=135, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=485, Percent_Identity=34.8453608247423, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24646066, Length=630, Percent_Identity=30.4761904761905, Blast_Score=273, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24664226, Length=431, Percent_Identity=35.4988399071926, Blast_Score=244, Evalue=2e-64,
Organism=Drosophila melanogaster, GI62472181, Length=424, Percent_Identity=35.6132075471698, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24664230, Length=424, Percent_Identity=35.6132075471698, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21358123, Length=374, Percent_Identity=37.4331550802139, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28574962, Length=337, Percent_Identity=22.8486646884273, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24642151, Length=355, Percent_Identity=24.5070422535211, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 74457; Mature: 74457

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITV
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLIALMRDQVRALQEAGVCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAG
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHH
SAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELRRALDVPLAAFTATADQETQA
HHHHHHHHCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHH
EIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKT
HHHHHHHCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCH
EDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVA
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEE
HADLPKSIEAYYQEIGRAGRDGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARL
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHCCCHHHHH
NALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVETFDGTTAVRKALSAILRTEET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHH
YGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERH
CCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEA
CCEEECCCCCCEEECCCCEEEEHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QKVPAYVIFPDRTLIEMAENRPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPA
HHCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQLAKVAQMRSDDESGMERLLG
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
ERRAQRFASAFLEVLRGAG
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHDAIPLLRDIFGFDDFRPGQEEIVEAVSAGENVLAIMPTGGGKSLCYQLPALRRAGITV
CCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHH
VISPLIALMRDQVRALQEAGVCAGALTSGNTEEETEAVWNAIEAGELKLLYMAPERLAAG
HHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHH
SAMGMLRRIGVSLIAVDEAHCVSQWGHDFRPDYLRIGELRRALDVPLAAFTATADQETQA
HHHHHHHHCCCEEEEECHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHH
EIVQKLFDGEAPRAFLRGFDRPNIHLAFAAKDSPRKQILEFADARRGQSGIVYCGTRAKT
HHHHHHHCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCH
EDIARALEASGHVACHYHGGMEAEDRRIVETRFAREDGLIVVATVAFGMGIDKPDIRWVA
HHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCEEEE
HADLPKSIEAYYQEIGRAGRDGAPAETMTLFGPEDIRLRRNQIDEGLAPPERRGADHARL
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCCCHHCCCHHHHH
NALLGLAEAMSCRRQSLLSYFGENPEPCGHCDLCDTPVETFDGTTAVRKALSAILRTEET
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHH
YGAGHLIDILIGNANDRVRQKGHDDLSVFACGREHSKPEWQAIFRQMMGRDLVRPDPERH
CCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GALRMTEPALPILRGEDSITLRKDTIKSATRRPAVKALVSDEDAPLLSALKAKRRALAEA
CCEEECCCCCCEEECCCCEEEEHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QKVPAYVIFPDRTLIEMAENRPQSLDEMARISGVGAKKLERYGDAFLSVITGEAEALHPA
HHCCEEEEECCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHH
RRKLAGRAQGSIYDTLLEVQARLQRGECGTQKPLTCSASQLAKVAQMRSDDESGMERLLG
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH
ERRAQRFASAFLEVLRGAG
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]