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The map label for this gene is cyaA [H]

Identifier: 99082488

GI number: 99082488

Start: 2782796

End: 2784190

Strand: Reverse

Name: cyaA [H]

Synonym: TM1040_2648

Alternate gene names: 99082488

Gene position: 2784190-2782796 (Counterclockwise)

Preceding gene: 99082489

Following gene: 99082487

Centisome position: 86.98

GC content: 61.86

Gene sequence:

>1395_bases
ATGGCTGATGTCGCCCTAACCAAAGCAGACCCGCCCGCGCGCGCGTCGCTGGATCCGATTTTGCAAGACGACGCTTTGCA
GTCCCAACACATCCATGCCGCGCTTGAGGAACACAAGAAGCGTGGCGTCGAGATGGCCGTTCTGGCGCGCTGGATCATCA
TGCCGATGGTGGCCGTGTTCCTCATTGCGGTCTATCCGGAGCCGTCGCAGCTTTATTATGTGGCGCTCCTCGCGCTCCTG
TGCGTCAACGGGTTTTTCATCCGCCGTTTTGCGCGGGTGGGGCGGTCGCGGGCCGAGCTGGGCCTGATCATGCTGGACCT
TGTGCTGATGACCTTTGGCATGGTGGTACCCAATCCGTTCGATCCGAACGAGATGCCGGTACCGATGCTGTATCAGTATG
ATAACTTCATGTATTTCTTTATTATTCTTGCAACCGGTGCCCTTGCCTACAGCTGGCGGACGGTGATGGCGATCGGGGTC
TGGGCAAGCGTGATCTGGCTCGGGGCGGCGGGGCTGATGTGGGCCTTCATGACCCCGGACGAAGAGCTGGCGCGGCGCCT
CTCCGAGGTGCTGGTGGACTGGCCGCATGTGCAGGATTTGTACAATCCAAACGACGTCGGATTCCGGTTTCGCATCCAGG
AAGCGATGGTGTTCCTGATGGTGGCGGCGATCCTTGCGCAATCCACCCGGCGGTTCTATCTGATGCTGGACCAGAATGCC
GATCTGGCGCGAGAGCGGGCCAATCTGTCGCGCTACTTCTCGCCCAATGTGGTCGACCAGCTGTCGCAGAACGACGAGGC
GATCAGCCAGGTGCGCACCTCGCGCATCGCGATTTTATTTGTTGATATCGTTGGCTTTACGCGACTGGCAGAGCATCGGG
ACGCGGTCGAGGTGATCGAGCTCTTGCGCGGGTTTCATGGCCGCATGGAGGCGGAAGTCTTTCGCCATGGCGGCACGCTC
GACAAATATCTTGGGGATGGGTTGATGGCGACCTTTGGCACGCCTGCTCCGGGCCCGCAGGATGCCTCGGACGCGCTGGC
CTGCGCGCGGGCGATGTGCGCGGTGCTGGACCAGTGGAACGCCGAGCGCCGCGCCACTGGAGAGCCTGAGATCCATGCTG
GCATCGGCATCCATTTTGGCGAGGCGGTGCAAGGCGACATCGGCGCAAACCGCCTGGAATACGCCGTCATTGGCACCGCC
GTGAACATCGCCTCGCGGCTTGAGGGCATGACCCGCCCGATGCAGGCCCGAATCGTGATGAGCGACGCCCTCTATCGCCG
GGTGCAAGAGGAGGGCGGTGCTGCGGCGCTTTTGCGCGGTTTTCACTGTACGCCGGAGCAAACCATCCGTGGACTGCAAG
AACCCATGCCGGTCTGGGCCCTGACGTCGCTTTGA

Upstream 100 bases:

>100_bases
GGTCTGGCGGGGTTTTTTGCATGTGACGCGACAAATGGCGCGTGTGCCTGCGCGGTTTTGGCGATAGAACTGGTAGCCAA
AATCCCCAAGGGAGGGCCGG

Downstream 100 bases:

>100_bases
TAAGCCATTCGTTAAGGGTCTGAACCTATGGTGACATCACCATTTCAAAAGGTTTATGTGATGTCGCAGATCCATCGAGA
CGAGCTGCTTTTCTGGTTCG

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MADVALTKADPPARASLDPILQDDALQSQHIHAALEEHKKRGVEMAVLARWIIMPMVAVFLIAVYPEPSQLYYVALLALL
CVNGFFIRRFARVGRSRAELGLIMLDLVLMTFGMVVPNPFDPNEMPVPMLYQYDNFMYFFIILATGALAYSWRTVMAIGV
WASVIWLGAAGLMWAFMTPDEELARRLSEVLVDWPHVQDLYNPNDVGFRFRIQEAMVFLMVAAILAQSTRRFYLMLDQNA
DLARERANLSRYFSPNVVDQLSQNDEAISQVRTSRIAILFVDIVGFTRLAEHRDAVEVIELLRGFHGRMEAEVFRHGGTL
DKYLGDGLMATFGTPAPGPQDASDALACARAMCAVLDQWNAERRATGEPEIHAGIGIHFGEAVQGDIGANRLEYAVIGTA
VNIASRLEGMTRPMQARIVMSDALYRRVQEEGGAAALLRGFHCTPEQTIRGLQEPMPVWALTSL

Sequences:

>Translated_464_residues
MADVALTKADPPARASLDPILQDDALQSQHIHAALEEHKKRGVEMAVLARWIIMPMVAVFLIAVYPEPSQLYYVALLALL
CVNGFFIRRFARVGRSRAELGLIMLDLVLMTFGMVVPNPFDPNEMPVPMLYQYDNFMYFFIILATGALAYSWRTVMAIGV
WASVIWLGAAGLMWAFMTPDEELARRLSEVLVDWPHVQDLYNPNDVGFRFRIQEAMVFLMVAAILAQSTRRFYLMLDQNA
DLARERANLSRYFSPNVVDQLSQNDEAISQVRTSRIAILFVDIVGFTRLAEHRDAVEVIELLRGFHGRMEAEVFRHGGTL
DKYLGDGLMATFGTPAPGPQDASDALACARAMCAVLDQWNAERRATGEPEIHAGIGIHFGEAVQGDIGANRLEYAVIGTA
VNIASRLEGMTRPMQARIVMSDALYRRVQEEGGAAALLRGFHCTPEQTIRGLQEPMPVWALTSL
>Mature_463_residues
ADVALTKADPPARASLDPILQDDALQSQHIHAALEEHKKRGVEMAVLARWIIMPMVAVFLIAVYPEPSQLYYVALLALLC
VNGFFIRRFARVGRSRAELGLIMLDLVLMTFGMVVPNPFDPNEMPVPMLYQYDNFMYFFIILATGALAYSWRTVMAIGVW
ASVIWLGAAGLMWAFMTPDEELARRLSEVLVDWPHVQDLYNPNDVGFRFRIQEAMVFLMVAAILAQSTRRFYLMLDQNAD
LARERANLSRYFSPNVVDQLSQNDEAISQVRTSRIAILFVDIVGFTRLAEHRDAVEVIELLRGFHGRMEAEVFRHGGTLD
KYLGDGLMATFGTPAPGPQDASDALACARAMCAVLDQWNAERRATGEPEIHAGIGIHFGEAVQGDIGANRLEYAVIGTAV
NIASRLEGMTRPMQARIVMSDALYRRVQEEGGAAALLRGFHCTPEQTIRGLQEPMPVWALTSL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557255, Length=309, Percent_Identity=23.9482200647249, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71995895, Length=221, Percent_Identity=25.7918552036199, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71995893, Length=237, Percent_Identity=25.3164556962025, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71995899, Length=221, Percent_Identity=25.7918552036199, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17551720, Length=169, Percent_Identity=26.6272189349112, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161078020, Length=206, Percent_Identity=28.1553398058252, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076872, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574512, Length=185, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583976, Length=277, Percent_Identity=25.9927797833935, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 51749; Mature: 51618

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVALTKADPPARASLDPILQDDALQSQHIHAALEEHKKRGVEMAVLARWIIMPMVAVF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIAVYPEPSQLYYVALLALLCVNGFFIRRFARVGRSRAELGLIMLDLVLMTFGMVVPNPF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPNEMPVPMLYQYDNFMYFFIILATGALAYSWRTVMAIGVWASVIWLGAAGLMWAFMTPD
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
EELARRLSEVLVDWPHVQDLYNPNDVGFRFRIQEAMVFLMVAAILAQSTRRFYLMLDQNA
HHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCC
DLARERANLSRYFSPNVVDQLSQNDEAISQVRTSRIAILFVDIVGFTRLAEHRDAVEVIE
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLRGFHGRMEAEVFRHGGTLDKYLGDGLMATFGTPAPGPQDASDALACARAMCAVLDQWN
HHHHHCCCHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AERRATGEPEIHAGIGIHFGEAVQGDIGANRLEYAVIGTAVNIASRLEGMTRPMQARIVM
CCCCCCCCCCEEECCCEEECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SDALYRRVQEEGGAAALLRGFHCTPEQTIRGLQEPMPVWALTSL
HHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure 
ADVALTKADPPARASLDPILQDDALQSQHIHAALEEHKKRGVEMAVLARWIIMPMVAVF
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LIAVYPEPSQLYYVALLALLCVNGFFIRRFARVGRSRAELGLIMLDLVLMTFGMVVPNPF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPNEMPVPMLYQYDNFMYFFIILATGALAYSWRTVMAIGVWASVIWLGAAGLMWAFMTPD
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCH
EELARRLSEVLVDWPHVQDLYNPNDVGFRFRIQEAMVFLMVAAILAQSTRRFYLMLDQNA
HHHHHHHHHHHHCCCCHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCC
DLARERANLSRYFSPNVVDQLSQNDEAISQVRTSRIAILFVDIVGFTRLAEHRDAVEVIE
HHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLRGFHGRMEAEVFRHGGTLDKYLGDGLMATFGTPAPGPQDASDALACARAMCAVLDQWN
HHHHHCCCHHHHHHHCCCCHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
AERRATGEPEIHAGIGIHFGEAVQGDIGANRLEYAVIGTAVNIASRLEGMTRPMQARIVM
CCCCCCCCCCEEECCCEEECCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
SDALYRRVQEEGGAAALLRGFHCTPEQTIRGLQEPMPVWALTSL
HHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]