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The map label for this gene is lpxK

Identifier: 99082482

GI number: 99082482

Start: 2776433

End: 2777434

Strand: Direct

Name: lpxK

Synonym: TM1040_2642

Alternate gene names: 99082482

Gene position: 2776433-2777434 (Clockwise)

Preceding gene: 99082481

Following gene: 99082485

Centisome position: 86.74

GC content: 68.06

Gene sequence:

>1002_bases
ATGCGCCCGCCTGAATTCTGGAACAAACCGCCCAGCCACTTTGACCTGCGCGCCTGCCTGCTGTCGCCGCTGGGCGCTCT
TTATGCCAAAGGCACTGCCACGCGGCTGCGCAAGGGCGCGCCCACACGGGCGCCAGTGCCGGTGATCTGTGTCGGCAATC
TCAATGCAGGTGGCACCGGCAAAACCCCGACCGTGATCTGGCTGATGGAGCAACTGGGCGCTGCCGGCCACGAGGTCCAT
GTGGTCTCGCGCGGCTATGGCGGGCGCCTTGAGGGGCCCGTTCAGGTGGACCCGCGCCGCCACAGCGCCGCCGATGTCGG
TGATGAGCCGCTGCTGATGGCTGCCTTTGGCGAGGTCTGGGTCGCCAGAGATCGCGGCGCGGGCGTCACCGAGGCCGCAG
CTGCCGGAGCCTCGGTAATCGTGATGGATGACGGGTTTCAGAACCCCTCGGTGGCCAAGGATTTCTCCATCATCGTGGTG
GACGCCAAACGCGGCTTTGGCAACGGGCGCTGCCTGCCTGCGGGGCCGCTGCGCGAGCCGGTTGCCACCGGCCTCAGCCG
CGCCGATCTGGTGCTGTCGCTGGGCGATGCGCGCGCACAAGAGACGTTTCAATCCATCTGGGGCGCAGAGATCCCGGTGC
CCCACCTCACCGGCCATGTGGAGCCGCTGCCCACCGGCATGCCATGGCAGGGCACCAAGGTGCTGGCTTTTGCGGGCATC
GGCCATCCAGAGAAATTCTTTGCCACACTGCGCGGACTGGGCGCCGAGCTTTGCCGGGCCGAGGCGCTCGAGGATCACCA
GACGCTTGCGCCCGCGCTCCTCACCCGTCTCGAACAGGAGGCACGCCTTCTGGGTGCGCAGCTGGTCACAACCGAAAAGG
ACGCCGTGCGCCTGCCGCTGAGCTTTCGGCCCAAGGTCATCACCCTGCCGGTGCGCCTGCGGGTCGCGCAGGGCGACACG
CTTCTGGCCCGCCTCAAAGACATCGCGCCGCCCCCCGACTAG

Upstream 100 bases:

>100_bases
ATGGCCCTTGCGGGCTGGCAGGTGGTGACCGAAGGTGCGGTCATGACAGACACCCTCCTAGAGCGGATCCAGGATCTGCT
GGATCAAAGCGAACTCTCCC

Downstream 100 bases:

>100_bases
GAGAGCGGCGCGCACAACCGTCAGCGACGGATCTCTTTAGCCTTCAAGCTCGGCGTCGATCAGCGCCTTCAGATCCTCAT
AGGGCTGGTTGGCGATCTTG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRPPEFWNKPPSHFDLRACLLSPLGALYAKGTATRLRKGAPTRAPVPVICVGNLNAGGTGKTPTVIWLMEQLGAAGHEVH
VVSRGYGGRLEGPVQVDPRRHSAADVGDEPLLMAAFGEVWVARDRGAGVTEAAAAGASVIVMDDGFQNPSVAKDFSIIVV
DAKRGFGNGRCLPAGPLREPVATGLSRADLVLSLGDARAQETFQSIWGAEIPVPHLTGHVEPLPTGMPWQGTKVLAFAGI
GHPEKFFATLRGLGAELCRAEALEDHQTLAPALLTRLEQEARLLGAQLVTTEKDAVRLPLSFRPKVITLPVRLRVAQGDT
LLARLKDIAPPPD

Sequences:

>Translated_333_residues
MRPPEFWNKPPSHFDLRACLLSPLGALYAKGTATRLRKGAPTRAPVPVICVGNLNAGGTGKTPTVIWLMEQLGAAGHEVH
VVSRGYGGRLEGPVQVDPRRHSAADVGDEPLLMAAFGEVWVARDRGAGVTEAAAAGASVIVMDDGFQNPSVAKDFSIIVV
DAKRGFGNGRCLPAGPLREPVATGLSRADLVLSLGDARAQETFQSIWGAEIPVPHLTGHVEPLPTGMPWQGTKVLAFAGI
GHPEKFFATLRGLGAELCRAEALEDHQTLAPALLTRLEQEARLLGAQLVTTEKDAVRLPLSFRPKVITLPVRLRVAQGDT
LLARLKDIAPPPD
>Mature_333_residues
MRPPEFWNKPPSHFDLRACLLSPLGALYAKGTATRLRKGAPTRAPVPVICVGNLNAGGTGKTPTVIWLMEQLGAAGHEVH
VVSRGYGGRLEGPVQVDPRRHSAADVGDEPLLMAAFGEVWVARDRGAGVTEAAAAGASVIVMDDGFQNPSVAKDFSIIVV
DAKRGFGNGRCLPAGPLREPVATGLSRADLVLSLGDARAQETFQSIWGAEIPVPHLTGHVEPLPTGMPWQGTKVLAFAGI
GHPEKFFATLRGLGAELCRAEALEDHQTLAPALLTRLEQEARLLGAQLVTTEKDAVRLPLSFRPKVITLPVRLRVAQGDT
LLARLKDIAPPPD

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=290, Percent_Identity=40.3448275862069, Blast_Score=161, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SILST (Q1GD92)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614636.1
- STRING:   Q1GD92
- GeneID:   4077945
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2642
- NMPDR:   fig|292414.1.peg.114
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q1GD92
- ProtClustDB:   PRK00652
- BioCyc:   SSP292414:TM1040_2642-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 35390; Mature: 35390

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPPEFWNKPPSHFDLRACLLSPLGALYAKGTATRLRKGAPTRAPVPVICVGNLNAGGTG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCC
KTPTVIWLMEQLGAAGHEVHVVSRGYGGRLEGPVQVDPRRHSAADVGDEPLLMAAFGEVW
CCCCEEEEHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCEE
VARDRGAGVTEAAAAGASVIVMDDGFQNPSVAKDFSIIVVDAKRGFGNGRCLPAGPLREP
EEECCCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
VATGLSRADLVLSLGDARAQETFQSIWGAEIPVPHLTGHVEPLPTGMPWQGTKVLAFAGI
HHHCCCHHHEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
GHPEKFFATLRGLGAELCRAEALEDHQTLAPALLTRLEQEARLLGAQLVTTEKDAVRLPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCC
SFRPKVITLPVRLRVAQGDTLLARLKDIAPPPD
CCCCEEEEEEEEEEEECCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MRPPEFWNKPPSHFDLRACLLSPLGALYAKGTATRLRKGAPTRAPVPVICVGNLNAGGTG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCEEEEECCCCCCCC
KTPTVIWLMEQLGAAGHEVHVVSRGYGGRLEGPVQVDPRRHSAADVGDEPLLMAAFGEVW
CCCCEEEEHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCEE
VARDRGAGVTEAAAAGASVIVMDDGFQNPSVAKDFSIIVVDAKRGFGNGRCLPAGPLREP
EEECCCCCCHHHHHCCCEEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHH
VATGLSRADLVLSLGDARAQETFQSIWGAEIPVPHLTGHVEPLPTGMPWQGTKVLAFAGI
HHHCCCHHHEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECC
GHPEKFFATLRGLGAELCRAEALEDHQTLAPALLTRLEQEARLLGAQLVTTEKDAVRLPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCC
SFRPKVITLPVRLRVAQGDTLLARLKDIAPPPD
CCCCEEEEEEEEEEEECCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA