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The map label for this gene is tyrB [H]

Identifier: 99082475

GI number: 99082475

Start: 2768685

End: 2769869

Strand: Direct

Name: tyrB [H]

Synonym: TM1040_2635

Alternate gene names: 99082475

Gene position: 2768685-2769869 (Clockwise)

Preceding gene: 99082474

Following gene: 99082478

Centisome position: 86.5

GC content: 62.11

Gene sequence:

>1185_bases
ATGTTCGAGAACCTCAAACCCCAGCCTGCCGACAAGATTCTGGCGCTGATGCAGATGTACCGCGAAGATCCGCGGGACCA
GAAGGTCGATCTGGGTGTAGGTGTCTACAAGAACGCCGAGGGTGTGACCCCGGTGATGCGCGCCGTGAAGGCCGCAGAAC
AGCGCATCATCGACGAGCAGACCACCAAGGCCTACACCGGCCTCGCGGGTGATCCCGCCTACGCCGACGCGATGATCGAC
CTCATCCTCGGTACCTCGGTCGAGCGCAGCAAGATCGCCGCCGTCGCGACCCCCGGTGGCACCGGTGCCGTGCGTCAGGC
CTTTGAACTGATCAAGATGGCCAACCCCGAGGCACGCGTTTTTGTGTCCGACCCCACCTGGCCCAACCACGTGTCGATCC
TGAAATACGTCGGCATCGAAACCGTGGTTTACCGCTACTTTGACACCGAGACCCGTGCCGTGAACTTCGACGGTATGATC
GAAGACCTCAAAGGCGCCAAGACAGGCGACGTGGTTCTGCTGCACGGCTGCTGCCACAACCCGACCGGTGCCAACCTCAA
CATCAGCCAGTGGCAAGCCGTGGTCGAGCTGCTCAACGAACGCGGCCTGATCCCGATGATCGACATCGCCTATCAGGGCT
TTGGCGACGGTCTCGAAGAAGACGCCGCCGGCGTGCGCCTTGTGGCCTCCTCGGTGCCAGAATGCCTGATCGCGGCGAGC
TGCTCCAAGAACTTTGGCATCTACCGCGAGCGCACCGGCCTTCTGATGGCGATCAGCCAGAAGGGCGACGAAGCCGGTCT
CAACCAAAAGACCCTCGCCTATCTGAACCGCCAGAACTACTCCTTCCCTCCTGATCACGGCGCACGCGTTGTGACCACGA
TCCTGAACGATCCCGAGCTGCGCGCGGATTGGCAGAAAGAGCTGGAAGAAACCCGCCTGGGCATGCTCGCCCTGCGCCAG
CAGCTCGCGGATGAGCTGCAGCGCCTCTCCGGGTCGGATCGCTTTGGCTTTATTGCAGAGCACCGCGGCATGTTCTCCCT
GCTCGGCACCACGCCCGAACTCGTCGAGAAAATGCGTGTAGACGCAGGGATTTACATGGTCGGGGACAGCCGTCTCAATA
TTGCGGGGCTCAACGCCCAGACCGTGCCGATCCTTGCCAAGGCGATCATCGACGCCGGCGTCTGA

Upstream 100 bases:

>100_bases
GGAGCGCATGGGCAAGCACGATCACGCGCTCTATGACGGCTCATGGAGCGAATGGGGCGCCTTCCCCACTCTTCCCGTTG
CAACCGGAGACAACTGAGAC

Downstream 100 bases:

>100_bases
TCCCGCGCTGAGATTTTAAAAAAACGCGCTCCCTCGGGGGTGCGTTTTTTAGTTTTTGGGGGGGCAGGCGTCGCGCTGTT
GGGGGCAGGCCTCGCCCGGA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MFENLKPQPADKILALMQMYREDPRDQKVDLGVGVYKNAEGVTPVMRAVKAAEQRIIDEQTTKAYTGLAGDPAYADAMID
LILGTSVERSKIAAVATPGGTGAVRQAFELIKMANPEARVFVSDPTWPNHVSILKYVGIETVVYRYFDTETRAVNFDGMI
EDLKGAKTGDVVLLHGCCHNPTGANLNISQWQAVVELLNERGLIPMIDIAYQGFGDGLEEDAAGVRLVASSVPECLIAAS
CSKNFGIYRERTGLLMAISQKGDEAGLNQKTLAYLNRQNYSFPPDHGARVVTTILNDPELRADWQKELEETRLGMLALRQ
QLADELQRLSGSDRFGFIAEHRGMFSLLGTTPELVEKMRVDAGIYMVGDSRLNIAGLNAQTVPILAKAIIDAGV

Sequences:

>Translated_394_residues
MFENLKPQPADKILALMQMYREDPRDQKVDLGVGVYKNAEGVTPVMRAVKAAEQRIIDEQTTKAYTGLAGDPAYADAMID
LILGTSVERSKIAAVATPGGTGAVRQAFELIKMANPEARVFVSDPTWPNHVSILKYVGIETVVYRYFDTETRAVNFDGMI
EDLKGAKTGDVVLLHGCCHNPTGANLNISQWQAVVELLNERGLIPMIDIAYQGFGDGLEEDAAGVRLVASSVPECLIAAS
CSKNFGIYRERTGLLMAISQKGDEAGLNQKTLAYLNRQNYSFPPDHGARVVTTILNDPELRADWQKELEETRLGMLALRQ
QLADELQRLSGSDRFGFIAEHRGMFSLLGTTPELVEKMRVDAGIYMVGDSRLNIAGLNAQTVPILAKAIIDAGV
>Mature_394_residues
MFENLKPQPADKILALMQMYREDPRDQKVDLGVGVYKNAEGVTPVMRAVKAAEQRIIDEQTTKAYTGLAGDPAYADAMID
LILGTSVERSKIAAVATPGGTGAVRQAFELIKMANPEARVFVSDPTWPNHVSILKYVGIETVVYRYFDTETRAVNFDGMI
EDLKGAKTGDVVLLHGCCHNPTGANLNISQWQAVVELLNERGLIPMIDIAYQGFGDGLEEDAAGVRLVASSVPECLIAAS
CSKNFGIYRERTGLLMAISQKGDEAGLNQKTLAYLNRQNYSFPPDHGARVVTTILNDPELRADWQKELEETRLGMLALRQ
QLADELQRLSGSDRFGFIAEHRGMFSLLGTTPELVEKMRVDAGIYMVGDSRLNIAGLNAQTVPILAKAIIDAGV

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=34.5360824742268, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI4504067, Length=391, Percent_Identity=32.2250639386189, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI117414139, Length=384, Percent_Identity=23.9583333333333, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=42.6767676767677, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790488, Length=393, Percent_Identity=39.9491094147583, Blast_Score=306, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI71981858, Length=394, Percent_Identity=32.994923857868, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI25147133, Length=385, Percent_Identity=31.9480519480519, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17569539, Length=396, Percent_Identity=31.3131313131313, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17569537, Length=397, Percent_Identity=24.9370277078086, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147136, Length=204, Percent_Identity=31.3725490196078, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17550384, Length=265, Percent_Identity=29.811320754717, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323055, Length=401, Percent_Identity=32.9177057356608, Blast_Score=242, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6322743, Length=421, Percent_Identity=29.2161520190024, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24580972, Length=394, Percent_Identity=34.7715736040609, Blast_Score=258, Evalue=7e-69,
Organism=Drosophila melanogaster, GI24580970, Length=394, Percent_Identity=34.7715736040609, Blast_Score=257, Evalue=9e-69,
Organism=Drosophila melanogaster, GI19920542, Length=387, Percent_Identity=34.8837209302326, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24654046, Length=395, Percent_Identity=34.4303797468354, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI19922362, Length=395, Percent_Identity=34.4303797468354, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43076; Mature: 43076

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLKPQPADKILALMQMYREDPRDQKVDLGVGVYKNAEGVTPVMRAVKAAEQRIIDEQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHH
TTKAYTGLAGDPAYADAMIDLILGTSVERSKIAAVATPGGTGAVRQAFELIKMANPEARV
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
FVSDPTWPNHVSILKYVGIETVVYRYFDTETRAVNFDGMIEDLKGAKTGDVVLLHGCCHN
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCCCCCCEEEEECCCCC
PTGANLNISQWQAVVELLNERGLIPMIDIAYQGFGDGLEEDAAGVRLVASSVPECLIAAS
CCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCHHHCHHHHHHHHCCHHHHHHH
CSKNFGIYRERTGLLMAISQKGDEAGLNQKTLAYLNRQNYSFPPDHGARVVTTILNDPEL
CCCCCCCEEECCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCC
RADWQKELEETRLGMLALRQQLADELQRLSGSDRFGFIAEHRGMFSLLGTTPELVEKMRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHCCCHHHHHHHHH
DAGIYMVGDSRLNIAGLNAQTVPILAKAIIDAGV
CCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFENLKPQPADKILALMQMYREDPRDQKVDLGVGVYKNAEGVTPVMRAVKAAEQRIIDEQ
CCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHH
TTKAYTGLAGDPAYADAMIDLILGTSVERSKIAAVATPGGTGAVRQAFELIKMANPEARV
HHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCEE
FVSDPTWPNHVSILKYVGIETVVYRYFDTETRAVNFDGMIEDLKGAKTGDVVLLHGCCHN
EECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCCCCCCEEEEECCCCC
PTGANLNISQWQAVVELLNERGLIPMIDIAYQGFGDGLEEDAAGVRLVASSVPECLIAAS
CCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCHHHCHHHHHHHHCCHHHHHHH
CSKNFGIYRERTGLLMAISQKGDEAGLNQKTLAYLNRQNYSFPPDHGARVVTTILNDPEL
CCCCCCCEEECCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCC
RADWQKELEETRLGMLALRQQLADELQRLSGSDRFGFIAEHRGMFSLLGTTPELVEKMRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHCCCHHHHHHHHH
DAGIYMVGDSRLNIAGLNAQTVPILAKAIIDAGV
CCCEEEEECCEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]