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The map label for this gene is hmgA [H]

Identifier: 99082461

GI number: 99082461

Start: 2753377

End: 2754732

Strand: Direct

Name: hmgA [H]

Synonym: TM1040_2621

Alternate gene names: 99082461

Gene position: 2753377-2754732 (Clockwise)

Preceding gene: 99082458

Following gene: 99082462

Centisome position: 86.02

GC content: 58.92

Gene sequence:

>1356_bases
ATGACCCGTCACGCTTTGCCGGACCAGATGATCCAGGCCCCGTCCAATCAGGGCACCCACGAGGGGTATATGCCCGGATT
TGGAAATGATTTCGAAACCGAAGCCCTGCCCGGCGCCCTGCCCCAAGGCATGAACAGCCCGCAGAAATGCGAATATGGGC
TCTATGGCGAACAGCTTTCCGGCACCGCCTTTACGGCGGAACGCCCCGAACGCACCTGGTGCTATCGCATCCGCCCCAGC
GTGAAGCATTCGCACCGCTACGAGAAAATCGACCTGCCTTATTGGAAGAGCGCGCCGCATATTCCCGAAGATGTGATTTC
GCTTGGCCAATACCGCTGGGACCCGGTGCCGCATACCGAAGAGGGCCTCACCTGGCTCACTGGCATGCGCACGATGACCA
CGGCGGGGGATGTGAACACCCAAGTCGGTATGGCGACCCATATCTACCTCGTGACCGAATCGATGAAGGATGAATATTTC
TTCTCCGCCGACTCGGAACTTCTGGTGGTGCCGCAAGAAGGCCGCCTGCGCTTTGCGACAGAGCTTGGGATCATCGACAT
TGAGCCCAAGGAGATCGCCATCCTTCCGCGCGGACTGGTCTATCGCGTCGAAGTGCTCGAAGGTCCCGCGCGCGGCTTTG
TCTGCGAAAACTACGGACAGAAATTCGACCTGCCCGGCCGCGGCCCGATCGGTGCGAATTGCATGGCGAACCCGCGGGAT
TTCAAGGCCCCCGTGGCGGCCTTTGAAGATCGCGAGGCGCCCTCAACACTGACCGTGAAATGGTGTGGCCAGTTCCATGA
GACCAAGATCGGCCAGAGCCCTCTGGACGTGGTCGCCTGGCACGGCAACTACGCGCCCTATAAATACGACCTGCGCACCT
ATTGCCCGGTCGGGGCGATCCTGTTTGACCATCCGGATCCGTCGATCTTTACCGTGCTCACCGCGCCCTCTGGCCAGCCG
GGCACGGCCAATATCGACTTTGTGCTGTTCCGCGAACGCTGGATGGTGGCGGAAAACACCTTCCGCCCGCCGTGGTATCA
CAAGAACATCATGTCGGAGCTGATGGGCAATATCTACGGGCAGTATGACGCCAAACCGCAGGGCTTTGTCCCCGGTGGTG
TAAGCCTTCACAACATGATGCTGCCGCATGGACCTGACCGGGAGGCCTTTGAAGGGGCGTCGAATTCGAACCTTGGCCCC
GAGAAACTCGACAATACCATGTCGTTCATGTTCGAAACACGTTTCCCCCAGCATCTGACAGAGTTTGCAGCCAAGGAAGC
ACCGCTTCAGGATACGTATATTGATTGCTGGAGCGACCTTGAGAAGAAATTCGACGGCACGCCCGGTAAGAAATAG

Upstream 100 bases:

>100_bases
CGCAAAATCATCATTTTTCGACATGCCCAGGCTGTGCCTCCCTTGTTAGTTACAAAATCAACTATTACCGAGAGGAAAAT
GCAAGAGGAGGTTGGTCAAA

Downstream 100 bases:

>100_bases
GGAGGCTGGGGGCGCTGCCCCCTCTGCGGCCCCAATTGGGGCCGCATTCACCCCCGAGATATTTGTAAAAAGCTGAAGGA
GGGCCAGCAGAGCCCTCACC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTRHALPDQMIQAPSNQGTHEGYMPGFGNDFETEALPGALPQGMNSPQKCEYGLYGEQLSGTAFTAERPERTWCYRIRPS
VKHSHRYEKIDLPYWKSAPHIPEDVISLGQYRWDPVPHTEEGLTWLTGMRTMTTAGDVNTQVGMATHIYLVTESMKDEYF
FSADSELLVVPQEGRLRFATELGIIDIEPKEIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCMANPRD
FKAPVAAFEDREAPSTLTVKWCGQFHETKIGQSPLDVVAWHGNYAPYKYDLRTYCPVGAILFDHPDPSIFTVLTAPSGQP
GTANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPQGFVPGGVSLHNMMLPHGPDREAFEGASNSNLGP
EKLDNTMSFMFETRFPQHLTEFAAKEAPLQDTYIDCWSDLEKKFDGTPGKK

Sequences:

>Translated_451_residues
MTRHALPDQMIQAPSNQGTHEGYMPGFGNDFETEALPGALPQGMNSPQKCEYGLYGEQLSGTAFTAERPERTWCYRIRPS
VKHSHRYEKIDLPYWKSAPHIPEDVISLGQYRWDPVPHTEEGLTWLTGMRTMTTAGDVNTQVGMATHIYLVTESMKDEYF
FSADSELLVVPQEGRLRFATELGIIDIEPKEIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCMANPRD
FKAPVAAFEDREAPSTLTVKWCGQFHETKIGQSPLDVVAWHGNYAPYKYDLRTYCPVGAILFDHPDPSIFTVLTAPSGQP
GTANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPQGFVPGGVSLHNMMLPHGPDREAFEGASNSNLGP
EKLDNTMSFMFETRFPQHLTEFAAKEAPLQDTYIDCWSDLEKKFDGTPGKK
>Mature_450_residues
TRHALPDQMIQAPSNQGTHEGYMPGFGNDFETEALPGALPQGMNSPQKCEYGLYGEQLSGTAFTAERPERTWCYRIRPSV
KHSHRYEKIDLPYWKSAPHIPEDVISLGQYRWDPVPHTEEGLTWLTGMRTMTTAGDVNTQVGMATHIYLVTESMKDEYFF
SADSELLVVPQEGRLRFATELGIIDIEPKEIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCMANPRDF
KAPVAAFEDREAPSTLTVKWCGQFHETKIGQSPLDVVAWHGNYAPYKYDLRTYCPVGAILFDHPDPSIFTVLTAPSGQPG
TANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYGQYDAKPQGFVPGGVSLHNMMLPHGPDREAFEGASNSNLGPE
KLDNTMSFMFETRFPQHLTEFAAKEAPLQDTYIDCWSDLEKKFDGTPGKK

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=437, Percent_Identity=45.9954233409611, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17507969, Length=430, Percent_Identity=49.5348837209302, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24583650, Length=441, Percent_Identity=44.8979591836735, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 50790; Mature: 50659

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHALPDQMIQAPSNQGTHEGYMPGFGNDFETEALPGALPQGMNSPQKCEYGLYGEQLS
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GTAFTAERPERTWCYRIRPSVKHSHRYEKIDLPYWKSAPHIPEDVISLGQYRWDPVPHTE
CCEEECCCCCCCEEEEECCCCHHCCCCEEECCCCCCCCCCCCHHHHHHHCEECCCCCCCC
EGLTWLTGMRTMTTAGDVNTQVGMATHIYLVTESMKDEYFFSADSELLVVPQEGRLRFAT
CCCCHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCEEECCCCCEEEECCCCCEEEEE
ELGIIDIEPKEIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCMANPRD
ECCEEEECCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEECCCCCCCCCCCCCCCCHH
FKAPVAAFEDREAPSTLTVKWCGQFHETKIGQSPLDVVAWHGNYAPYKYDLRTYCPVGAI
CCCCHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCEEECCCCCCCCCEE
LFDHPDPSIFTVLTAPSGQPGTANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYG
EEECCCCCEEEEEECCCCCCCCCCEEEEEEECEEEECCCCCCCCHHHHHHHHHHHHHHCC
QYDAKPQGFVPGGVSLHNMMLPHGPDREAFEGASNSNLGPEKLDNTMSFMFETRFPQHLT
CCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
EFAAKEAPLQDTYIDCWSDLEKKFDGTPGKK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TRHALPDQMIQAPSNQGTHEGYMPGFGNDFETEALPGALPQGMNSPQKCEYGLYGEQLS
CCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GTAFTAERPERTWCYRIRPSVKHSHRYEKIDLPYWKSAPHIPEDVISLGQYRWDPVPHTE
CCEEECCCCCCCEEEEECCCCHHCCCCEEECCCCCCCCCCCCHHHHHHHCEECCCCCCCC
EGLTWLTGMRTMTTAGDVNTQVGMATHIYLVTESMKDEYFFSADSELLVVPQEGRLRFAT
CCCCHHHCCEEEEECCCCCCCCCCEEEEEEEEECCCCCEEECCCCCEEEECCCCCEEEEE
ELGIIDIEPKEIAILPRGLVYRVEVLEGPARGFVCENYGQKFDLPGRGPIGANCMANPRD
ECCEEEECCCEEEEECCCEEEEEEEECCCCCCCEECCCCCEECCCCCCCCCCCCCCCCHH
FKAPVAAFEDREAPSTLTVKWCGQFHETKIGQSPLDVVAWHGNYAPYKYDLRTYCPVGAI
CCCCHHHHCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCEEECCCCCCCCCEE
LFDHPDPSIFTVLTAPSGQPGTANIDFVLFRERWMVAENTFRPPWYHKNIMSELMGNIYG
EEECCCCCEEEEEECCCCCCCCCCEEEEEEECEEEECCCCCCCCHHHHHHHHHHHHHHCC
QYDAKPQGFVPGGVSLHNMMLPHGPDREAFEGASNSNLGPEKLDNTMSFMFETRFPQHLT
CCCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
EFAAKEAPLQDTYIDCWSDLEKKFDGTPGKK
HHHHHCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10220173; 11481430 [H]