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The map label for this gene is soxR [H]

Identifier: 99082454

GI number: 99082454

Start: 2747739

End: 2748164

Strand: Reverse

Name: soxR [H]

Synonym: TM1040_2614

Alternate gene names: 99082454

Gene position: 2748164-2747739 (Counterclockwise)

Preceding gene: 99082459

Following gene: 99082452

Centisome position: 85.85

GC content: 59.86

Gene sequence:

>426_bases
ATGAAATTGCTCGACATCGGAGAAGTCGCAAAACAAAGCGGCACAAAGCCGTCGACGCTGCGCTATTACGAGGATAAGGG
CCTGATCCAGTCGCTGTCGCGCAATGGGCTGCGACGGCAATATGGACCTATGGTGCTGGAGCAGCTGGCGCTGATCGCGC
TTGGCAAGCAGGGCGGATTTTCGCTGGATGAAATCGGCGCGATGTTTGGCCCGGAAGGCCAGCCAGAGATTGCACGCACA
GAGCTTGATGCGCGCGCGGACGAGATCCAGAGACAGGCGCAGCGCTTGGAGGCTTTGTCCGATATGATGCGCCATGTTGC
CACCTGTCCGGCCTCCAACCACATGGAGTGCGACAAGTTCCAACGGCTGCTGCGGCTGGCGACGCGTATTCAGAGGCGCG
GCGGCACCCCCAAAGGAAAGAGTTGA

Upstream 100 bases:

>100_bases
CAGCGCAGGCAGGGTGGAAGGGGCGGCAGTCATTGAGATCTCCTTGCCAAAATCAATTTCGAAGGGCAGGCTACGAATTC
AAGTCAACTTGAGGTCAATA

Downstream 100 bases:

>100_bases
GCCCCGCGTTCGCGCAGGGCTCAGGCGATCCGGAGCTGCTCTGTTCTGAGGTCAGATCAGAGTGCCGAAGGGGAGATCAG
GTCAGGTCTTCGATGCGGGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MKLLDIGEVAKQSGTKPSTLRYYEDKGLIQSLSRNGLRRQYGPMVLEQLALIALGKQGGFSLDEIGAMFGPEGQPEIART
ELDARADEIQRQAQRLEALSDMMRHVATCPASNHMECDKFQRLLRLATRIQRRGGTPKGKS

Sequences:

>Translated_141_residues
MKLLDIGEVAKQSGTKPSTLRYYEDKGLIQSLSRNGLRRQYGPMVLEQLALIALGKQGGFSLDEIGAMFGPEGQPEIART
ELDARADEIQRQAQRLEALSDMMRHVATCPASNHMECDKFQRLLRLATRIQRRGGTPKGKS
>Mature_141_residues
MKLLDIGEVAKQSGTKPSTLRYYEDKGLIQSLSRNGLRRQYGPMVLEQLALIALGKQGGFSLDEIGAMFGPEGQPEIART
ELDARADEIQRQAQRLEALSDMMRHVATCPASNHMECDKFQRLLRLATRIQRRGGTPKGKS

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=120, Percent_Identity=36.6666666666667, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15714; Mature: 15714

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLDIGEVAKQSGTKPSTLRYYEDKGLIQSLSRNGLRRQYGPMVLEQLALIALGKQGGF
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
SLDEIGAMFGPEGQPEIARTELDARADEIQRQAQRLEALSDMMRHVATCPASNHMECDKF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QRLLRLATRIQRRGGTPKGKS
HHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKLLDIGEVAKQSGTKPSTLRYYEDKGLIQSLSRNGLRRQYGPMVLEQLALIALGKQGGF
CCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
SLDEIGAMFGPEGQPEIARTELDARADEIQRQAQRLEALSDMMRHVATCPASNHMECDKF
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
QRLLRLATRIQRRGGTPKGKS
HHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]