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The map label for this gene is lysN [H]

Identifier: 99082428

GI number: 99082428

Start: 2728243

End: 2729457

Strand: Reverse

Name: lysN [H]

Synonym: TM1040_2588

Alternate gene names: 99082428

Gene position: 2729457-2728243 (Counterclockwise)

Preceding gene: 99082430

Following gene: 99082427

Centisome position: 85.27

GC content: 61.07

Gene sequence:

>1215_bases
ATGGCACTCTCTGCGCAATTTGCATCACGAATTGGACGGATGAAAGCATCGGAAATTCGCGAGCTTCTGAAGCTGTTGGA
TCAGCCGGGGATGCTGTCGTTTGCCGGGGGTATTCCTGATCCCGCGCTGTTTCCAGCCGAAGCCTTTGCCGAGGCATTTC
AGAATGCCCTTTCGCCCGCGCATCAGGCGCAATCGCTGCAATACTCGGTCTCTGAGGGCTATCTGCCGCTGCGCGAGTGG
CTTGCGACCTATATGTCCAAACTTGGTGTGACCTGTGGACCAGAGCATATCCTGATCACCTCGGGGTCTCAGCAGGCGCT
CGACTACCTTGGGAAACTCTTTCTCAGCCCGGGGGATACGGCGCTTGTCGGCTGGCCCACCTATCTGGGCGCATTGGCGG
CGTTCAACGCGTATGAGCCGCGCTATGACCGGCTGCGGGCTGGCGAGAACCAACCCACTGCGCATTACGCTGAGGCTGCC
AAGGCAGCAGGGGGGCGGGTCAAGTTTGCCTATCTCAGCCCCGATTTTGCAAACCCCACTGGCGAGACGATGACGCGTGC
GGAGCGTCTGCAGGTGCTCGCGACGGCAGAGGCGCTGGACGCGGCCGTCATCGAGGATGCGGCCTATCAGGATCTGCGGT
TTGATGGCGCGGCGGTGCCGCCGATCCTCACGCTGGAACTTGAGCGCAACGGAGGCGACATCGAGTCGTGCCGGACCATC
TATTGCGGAACGTTTTCCAAGACCCTGTCCCCCGGACTGCGAGTCGGATGGCTGGTGGCGGCAACGCCTGTTGTTCAGCA
ACTCGTGCTGATGAAGCAGGCCTCTGATCTCCACTCACCGACGATCAATCAGATCGCAACCTGTCAGGTGGCCGAGCAGC
TGTTTGACGCCCATGTCGACACGCTGCGGTCGGTCTATGGTCGGCGACGGGATGCTATGCTGGCCGCCCTTGAGGCACAT
ATGCCGGAGGGCGTGATCTGGACCAAACCCGAAGGCGGCATGTTCATCTGGGTTACCCTGCCCGAGGGGATGAGCGGGGC
CGAGCTTCTTGAATACGCGCTGAGCCGGGAAAAGGTGGCCTTTGTCCCCGGTCAGGCCTTCTATGCGGACGCGACAGGCC
GCAATACGCTGCGGCTCAGTTTTTCAAACAGCAATGAGGCCACAATCGAAGAGGGTGTGGCGCGGCTTGGTCGGGTCATC
CGGAGCATGGTCTGA

Upstream 100 bases:

>100_bases
CGCTGCAAGATCACGAAGGTTGAAATAATAGGTCAGAATCATTGACTTGTTTTCGGGTTTGCTGTCGGTTGCGCTGAAGT
GGCGAAAGGAAATGATCGAA

Downstream 100 bases:

>100_bases
AATCGGGTTATCCACAAGATATGGTGGGTTCCAGAGCCCATTACTCCTGATTTTGAGGCTCGGCCCGTTGACTCGGAGTG
CGCAAGGCTGCTGTGATTTC

Product: aminotransferase, class I and II

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MALSAQFASRIGRMKASEIRELLKLLDQPGMLSFAGGIPDPALFPAEAFAEAFQNALSPAHQAQSLQYSVSEGYLPLREW
LATYMSKLGVTCGPEHILITSGSQQALDYLGKLFLSPGDTALVGWPTYLGALAAFNAYEPRYDRLRAGENQPTAHYAEAA
KAAGGRVKFAYLSPDFANPTGETMTRAERLQVLATAEALDAAVIEDAAYQDLRFDGAAVPPILTLELERNGGDIESCRTI
YCGTFSKTLSPGLRVGWLVAATPVVQQLVLMKQASDLHSPTINQIATCQVAEQLFDAHVDTLRSVYGRRRDAMLAALEAH
MPEGVIWTKPEGGMFIWVTLPEGMSGAELLEYALSREKVAFVPGQAFYADATGRNTLRLSFSNSNEATIEEGVARLGRVI
RSMV

Sequences:

>Translated_404_residues
MALSAQFASRIGRMKASEIRELLKLLDQPGMLSFAGGIPDPALFPAEAFAEAFQNALSPAHQAQSLQYSVSEGYLPLREW
LATYMSKLGVTCGPEHILITSGSQQALDYLGKLFLSPGDTALVGWPTYLGALAAFNAYEPRYDRLRAGENQPTAHYAEAA
KAAGGRVKFAYLSPDFANPTGETMTRAERLQVLATAEALDAAVIEDAAYQDLRFDGAAVPPILTLELERNGGDIESCRTI
YCGTFSKTLSPGLRVGWLVAATPVVQQLVLMKQASDLHSPTINQIATCQVAEQLFDAHVDTLRSVYGRRRDAMLAALEAH
MPEGVIWTKPEGGMFIWVTLPEGMSGAELLEYALSREKVAFVPGQAFYADATGRNTLRLSFSNSNEATIEEGVARLGRVI
RSMV
>Mature_403_residues
ALSAQFASRIGRMKASEIRELLKLLDQPGMLSFAGGIPDPALFPAEAFAEAFQNALSPAHQAQSLQYSVSEGYLPLREWL
ATYMSKLGVTCGPEHILITSGSQQALDYLGKLFLSPGDTALVGWPTYLGALAAFNAYEPRYDRLRAGENQPTAHYAEAAK
AAGGRVKFAYLSPDFANPTGETMTRAERLQVLATAEALDAAVIEDAAYQDLRFDGAAVPPILTLELERNGGDIESCRTIY
CGTFSKTLSPGLRVGWLVAATPVVQQLVLMKQASDLHSPTINQIATCQVAEQLFDAHVDTLRSVYGRRRDAMLAALEAHM
PEGVIWTKPEGGMFIWVTLPEGMSGAELLEYALSREKVAFVPGQAFYADATGRNTLRLSFSNSNEATIEEGVARLGRVIR
SMV

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=414, Percent_Identity=28.743961352657, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI33469970, Length=414, Percent_Identity=28.743961352657, Blast_Score=174, Evalue=2e-43,
Organism=Escherichia coli, GI1787710, Length=393, Percent_Identity=28.7531806615776, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790797, Length=394, Percent_Identity=26.6497461928934, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788722, Length=365, Percent_Identity=26.8493150684932, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321000, Length=435, Percent_Identity=24.1379310344828, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356535, Length=422, Percent_Identity=24.8815165876777, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 43800; Mature: 43669

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALSAQFASRIGRMKASEIRELLKLLDQPGMLSFAGGIPDPALFPAEAFAEAFQNALSPA
CCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCHH
HQAQSLQYSVSEGYLPLREWLATYMSKLGVTCGPEHILITSGSQQALDYLGKLFLSPGDT
HHHHHHEEHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCC
ALVGWPTYLGALAAFNAYEPRYDRLRAGENQPTAHYAEAAKAAGGRVKFAYLSPDFANPT
EEEEHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCC
GETMTRAERLQVLATAEALDAAVIEDAAYQDLRFDGAAVPPILTLELERNGGDIESCRTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHEE
YCGTFSKTLSPGLRVGWLVAATPVVQQLVLMKQASDLHSPTINQIATCQVAEQLFDAHVD
EECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TLRSVYGRRRDAMLAALEAHMPEGVIWTKPEGGMFIWVTLPEGMSGAELLEYALSREKVA
HHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
FVPGQAFYADATGRNTLRLSFSNSNEATIEEGVARLGRVIRSMV
EECCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ALSAQFASRIGRMKASEIRELLKLLDQPGMLSFAGGIPDPALFPAEAFAEAFQNALSPA
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCHH
HQAQSLQYSVSEGYLPLREWLATYMSKLGVTCGPEHILITSGSQQALDYLGKLFLSPGDT
HHHHHHEEHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCC
ALVGWPTYLGALAAFNAYEPRYDRLRAGENQPTAHYAEAAKAAGGRVKFAYLSPDFANPT
EEEEHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCC
GETMTRAERLQVLATAEALDAAVIEDAAYQDLRFDGAAVPPILTLELERNGGDIESCRTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHEE
YCGTFSKTLSPGLRVGWLVAATPVVQQLVLMKQASDLHSPTINQIATCQVAEQLFDAHVD
EECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
TLRSVYGRRRDAMLAALEAHMPEGVIWTKPEGGMFIWVTLPEGMSGAELLEYALSREKVA
HHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
FVPGQAFYADATGRNTLRLSFSNSNEATIEEGVARLGRVIRSMV
EECCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA