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The map label for this gene is hemN [H]

Identifier: 99082388

GI number: 99082388

Start: 2689525

End: 2690880

Strand: Direct

Name: hemN [H]

Synonym: TM1040_2548

Alternate gene names: 99082388

Gene position: 2689525-2690880 (Clockwise)

Preceding gene: 99082386

Following gene: 99082394

Centisome position: 84.02

GC content: 59.66

Gene sequence:

>1356_bases
ATGACACAGGAATCTCAATTGGCGCGGCTCGGACTTTTCGACGCAAAGGTGCCCAGATATACAAGTTACCCGACTGCGCC
ACACTTCAACAATGACGTGAGCGCAGCGCGTTTTGCCTCCTGGATCGGGTCTATCAAGCCCGGCGCAGAAATCTCGCTAT
ACGTGCATGTGCCCTTCTGTCGCAGGCTGTGCTGGTTTTGCGCATGCCGCACGCAGGGCACGCAGTCCGAGTCACCTGTG
CGCGCCTACATAGAGGTGTTGAAGCAAGAACTTGCGCTTCTTGCGCGTGCCCTACCCGAAGGCGTCCGCCTTGCGCGGCT
GCATTGGGGCGGCGGGACGCCCACGCTCCTCAGTGCCGAAATGATCTCTGATCTGGCGGAGGCGATCTTTGCCGTGACGC
CGATGGCGAAGGGCGGCGAGTTCTCCGTTGAGATCGACCCAAATGAAATCGACGATGCGCGCCTCGACGCCCTCGCGGCG
GCGGGGATGAACCGTGCCTCGATCGGCGTTCAGGATTTTGACCCCCAGATCCAGGAAACCATCGGTCGCATTCAGCCTTT
TGATCTGACGCGCGACGCCGTCGACATGATCCGCGCGCGGGGCATCACAAGCCTCAATGCAGATATTCTCTTCGGGCTGC
CGCATCAGAACCGGATGCGCATGACCGAAAGCGTGCAAAAACTGCTGTCGCTCTCGCCGGATCGCGTGGCACTCTATGGC
TATGCCCATGTGCCATGGATGGCGCGGCGCCAGAATATGATTCCAACCGACAGCCTACCGTCACCTCAAACCCGACTACA
GTTGTTTGAGACCGCGCAGCGATTGTTTCAGTGGGATGGCTATCGCGAAATTGGTATCGACCATTTTGCCACGCCCCACG
ATGGGCTGGCGGTTGCGGCCCGGACGGGGCGGCTGCGCCGGAACTTTCAGGGTTACACCGATGATCGGGCAGATGTGTTG
ATCGGCCTTGGGGCATCCTCTATCTCGCGTTTTCCGCAGGGCTATGCTCAGAATGCTCCATCCACATCGGCCTACACCAA
GGCTATTCGTGACGGACAGTTTTCCACCGCGCGCGGCCATGTGTTTTCGGGCGAGGATTTGCTGCGTGGGCGCATGATCG
AAGCCCTGATGTGTGATTTCGAGATTGCAACCGACGATATTCGGGCACAGTTCGACATCACGCAAGACGCATTGGAGCGC
ATGTATCGCGAGGCCTCCGTCGCCTTTCCGGAAATGCTCGACGTCACCCCATCGGGGCTGCGGGTAAGACCCGAAGGCAA
GCCCCTGACGCGAATGGTGGCGCGCCACTTTGATGCCTATGACCTGAGCAAGGCCGGACATAGCTCGGCGATCTAG

Upstream 100 bases:

>100_bases
AATCCGCACATTCGACGGACTGAAATTGAGCAAGGGACATGTGTGCCTCTGGTTGATCTGTGTCAAAGCCGACGGTGCCA
GCTGACCCTACCCTAGTCGC

Downstream 100 bases:

>100_bases
ACATTCGGCGGTGGTGCAGCCCCATTCGTGGCAAGATGCGAGGGCTCTGCCCTCGCGCTCCCGGGATATTTTCTGTTAGA
AGAAGCGGCGCTAGGCACCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTQESQLARLGLFDAKVPRYTSYPTAPHFNNDVSAARFASWIGSIKPGAEISLYVHVPFCRRLCWFCACRTQGTQSESPV
RAYIEVLKQELALLARALPEGVRLARLHWGGGTPTLLSAEMISDLAEAIFAVTPMAKGGEFSVEIDPNEIDDARLDALAA
AGMNRASIGVQDFDPQIQETIGRIQPFDLTRDAVDMIRARGITSLNADILFGLPHQNRMRMTESVQKLLSLSPDRVALYG
YAHVPWMARRQNMIPTDSLPSPQTRLQLFETAQRLFQWDGYREIGIDHFATPHDGLAVAARTGRLRRNFQGYTDDRADVL
IGLGASSISRFPQGYAQNAPSTSAYTKAIRDGQFSTARGHVFSGEDLLRGRMIEALMCDFEIATDDIRAQFDITQDALER
MYREASVAFPEMLDVTPSGLRVRPEGKPLTRMVARHFDAYDLSKAGHSSAI

Sequences:

>Translated_451_residues
MTQESQLARLGLFDAKVPRYTSYPTAPHFNNDVSAARFASWIGSIKPGAEISLYVHVPFCRRLCWFCACRTQGTQSESPV
RAYIEVLKQELALLARALPEGVRLARLHWGGGTPTLLSAEMISDLAEAIFAVTPMAKGGEFSVEIDPNEIDDARLDALAA
AGMNRASIGVQDFDPQIQETIGRIQPFDLTRDAVDMIRARGITSLNADILFGLPHQNRMRMTESVQKLLSLSPDRVALYG
YAHVPWMARRQNMIPTDSLPSPQTRLQLFETAQRLFQWDGYREIGIDHFATPHDGLAVAARTGRLRRNFQGYTDDRADVL
IGLGASSISRFPQGYAQNAPSTSAYTKAIRDGQFSTARGHVFSGEDLLRGRMIEALMCDFEIATDDIRAQFDITQDALER
MYREASVAFPEMLDVTPSGLRVRPEGKPLTRMVARHFDAYDLSKAGHSSAI
>Mature_450_residues
TQESQLARLGLFDAKVPRYTSYPTAPHFNNDVSAARFASWIGSIKPGAEISLYVHVPFCRRLCWFCACRTQGTQSESPVR
AYIEVLKQELALLARALPEGVRLARLHWGGGTPTLLSAEMISDLAEAIFAVTPMAKGGEFSVEIDPNEIDDARLDALAAA
GMNRASIGVQDFDPQIQETIGRIQPFDLTRDAVDMIRARGITSLNADILFGLPHQNRMRMTESVQKLLSLSPDRVALYGY
AHVPWMARRQNMIPTDSLPSPQTRLQLFETAQRLFQWDGYREIGIDHFATPHDGLAVAARTGRLRRNFQGYTDDRADVLI
GLGASSISRFPQGYAQNAPSTSAYTKAIRDGQFSTARGHVFSGEDLLRGRMIEALMCDFEIATDDIRAQFDITQDALERM
YREASVAFPEMLDVTPSGLRVRPEGKPLTRMVARHFDAYDLSKAGHSSAI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=310, Percent_Identity=26.4516129032258, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI87082341, Length=441, Percent_Identity=36.0544217687075, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1789325, Length=286, Percent_Identity=27.2727272727273, Blast_Score=109, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 50102; Mature: 49970

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQESQLARLGLFDAKVPRYTSYPTAPHFNNDVSAARFASWIGSIKPGAEISLYVHVPFC
CCCHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHH
RRLCWFCACRTQGTQSESPVRAYIEVLKQELALLARALPEGVRLARLHWGGGTPTLLSAE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
MISDLAEAIFAVTPMAKGGEFSVEIDPNEIDDARLDALAAAGMNRASIGVQDFDPQIQET
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHCCCCCCCCHHHHHH
IGRIQPFDLTRDAVDMIRARGITSLNADILFGLPHQNRMRMTESVQKLLSLSPDRVALYG
HCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEE
YAHVPWMARRQNMIPTDSLPSPQTRLQLFETAQRLFQWDGYREIGIDHFATPHDGLAVAA
EECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
RTGRLRRNFQGYTDDRADVLIGLGASSISRFPQGYAQNAPSTSAYTKAIRDGQFSTARGH
HHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCHHHCCCCCHHHHHHHHHCCCCCCCCCC
VFSGEDLLRGRMIEALMCDFEIATDDIRAQFDITQDALERMYREASVAFPEMLDVTPSGL
EECCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHCCCHHHHCCCCCCC
RVRPEGKPLTRMVARHFDAYDLSKAGHSSAI
EECCCCCHHHHHHHHHCCCHHHHCCCCCCCC
>Mature Secondary Structure 
TQESQLARLGLFDAKVPRYTSYPTAPHFNNDVSAARFASWIGSIKPGAEISLYVHVPFC
CCHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECHHH
RRLCWFCACRTQGTQSESPVRAYIEVLKQELALLARALPEGVRLARLHWGGGTPTLLSAE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHH
MISDLAEAIFAVTPMAKGGEFSVEIDPNEIDDARLDALAAAGMNRASIGVQDFDPQIQET
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHCCCCCCCCHHHHHH
IGRIQPFDLTRDAVDMIRARGITSLNADILFGLPHQNRMRMTESVQKLLSLSPDRVALYG
HCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEE
YAHVPWMARRQNMIPTDSLPSPQTRLQLFETAQRLFQWDGYREIGIDHFATPHDGLAVAA
EECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEH
RTGRLRRNFQGYTDDRADVLIGLGASSISRFPQGYAQNAPSTSAYTKAIRDGQFSTARGH
HHHHHHHCCCCCCCCCCCEEEECCHHHHHHCCCHHHCCCCCHHHHHHHHHCCCCCCCCCC
VFSGEDLLRGRMIEALMCDFEIATDDIRAQFDITQDALERMYREASVAFPEMLDVTPSGL
EECCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCHHHHHHHHHHHHCCCHHHHCCCCCCC
RVRPEGKPLTRMVARHFDAYDLSKAGHSSAI
EECCCCCHHHHHHHHHCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8809776 [H]