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The map label for this gene is uvrC

Identifier: 99082360

GI number: 99082360

Start: 2659370

End: 2661277

Strand: Reverse

Name: uvrC

Synonym: TM1040_2520

Alternate gene names: 99082360

Gene position: 2661277-2659370 (Counterclockwise)

Preceding gene: 99082361

Following gene: 99082358

Centisome position: 83.14

GC content: 58.6

Gene sequence:

>1908_bases
ATGGCTCAGAATCATATGTCAGAGACTATGAACGACATCAGCGCAGAATCGCCCGACCAACCCGAGCCCCCCCGCACCGG
ATACGGTGTCATTCAGGCATACCTGAAGACGCTTGATTCATCGCCGGGCGTGTACCGTATGCTCGATCACGAAAGCAGGG
TGCTCTATGTCGGCAAGGCGCGCAATCTGCGGGCGCGGGTGTCCAATTACACCCGCCCGGGACATACGCAGCGCATCGAG
ACGATGATCTCACAAACCAGCCGCATGATGTTCCTGACAACGCGCACCGAAACCGAGGCGCTCTTGTTGGAGCAAAACCT
CATCAAGCAGCTGAAGCCCAAATACAATGTGCTGCTGCGCGACGATAAAAGTTTTCCCTACATCATGGTGAGCAAGAACC
ATGCTTTTCCGCAGCTGAAAAAGCACCGCGGCGCACGCAAGGGGAAGGCGAGCTTCTTTGGGCCCTTTGCCAGTGCCGGG
GCGGTGAACCGGACGTTGAATCAGTTGCAAAAAGCGTTCTTGCTGCGCAACTGCACAGACACCATGTTTGAAAACCGCAC
CCGGCCCTGCCTGCAGTATCAGATCAAACGCTGCTCTGGCCCATGTGTGGGAAAGATCTCGCAGGCGGATTACGCCGACA
GTGTCCGGGATGCAGAGCGGTTTCTGGCGGGACGCTCCACAAAGATCCAGGAAGAGCTTGGCGCTGAGATGCAAGCCGCC
TCGGAAGCGATGGAATATGAGCGCGCGGCAGCCTTGCGGGACCGGATCAAGGCGCTGACGCAGGTGCAATCGGCGCAGGG
CATCAACCCGCGTGGCGTGTCCGAGGCTGACATCATTGGCCTGCATTTGGAAAACGGGCTGGCCTGCGTGCAGGTGTTTT
TTATTCGCGCCAATCAGAACTGGGGCAATCAGGACTTCTACCCGCGCGTGGCCGAGGATATGTCCGCCGCCGAAGTCATG
GAGGCTTTCATTGGCCAGTTCTATGACAACAAGGATGTTCCACGTCAGCTCATCTTGTCGGATGACATCGAAAACGCAGA
TCTGATGGCTGTGGCACTCAGTGAGAAAGCCCGGCGCAAGGTGGAAATCGTGGTGCCCCAGCGGGGCGAGAAGACCGAGC
TTGTGGCCTCGGCTGTGCGCAATGCCCGTGAAAGCCTCGCTCGCCGGATGTCCGAGAGCGCCACACAGGCCAAACTTTTG
CGCGGCATTGCTGATGCTTTTGGGCTGGAAGCTCCGCCAAACCGCATCGAGGTTTACGACAACTCTCACATTCAGGGCAC
CAACGCCGTCGGTGGCATGATCGTCATGGGGCCTGAGGGCTTTATGAAAAACGCCTATCGTAAGTTCAACATCAAGGATG
GTGAGGTCATTGCAGGCGATGACTTTGGCATGATGAAGGCGGTGCTGAACCGCCGCTTCTCCCGCCTGTTGAAAGAAGAC
CCCGACCGCCAAAAGGGCATGTGGCCGGATCTTCTGCTCATTGACGGCGGTGCGGGGCAGGTATCGGCCGTGGCCGAGAT
CATGGAGGAGCATGGCGTGCAGGACATTCCCATGGTCGGGGTGGCCAAGGGTGTCGATCGCGACCATGGCAAGGAGGAGT
TCTACCGCCCCGGCGAAAACGCCTTTGCGCTGCAACGCAATGATCCTGTGCTTTACTTCATTCAACGCATGCGCGACGAG
GCGCACCGGTTTGCCATCGGCACCCACCGGGCCAAGCGGGCAAAATCTCTTGTGGCCAATCCATTGGATGACATTCCCGG
CGTCGGCGCGCGTCGCAAGAAGGCACTTCTGACGCATTTTGGCAGCGCCAAGGCGGTGAGCCGCGCGAACCTGTCGGATC
TCAAGGCGGTGGACGGCGTCTCAGACGCGCTGGCGGAAACGATCTACAACTATTTTCAGGTGCGCTGA

Upstream 100 bases:

>100_bases
TAAAGGGAAAATTCAAACAAGCCCAAAGTTACCCGCATTGTTATCCACAGGAATGGTGGATTCATCACAGCTTGAACTTC
ACGCCTGAAGATTGCAGCAC

Downstream 100 bases:

>100_bases
TTGCCATTTGTGGGTCCGGGGCTCGCCGGATCGTGACTGGATCTCGAACCTGTGGTGCCCACAAAATGAAACCCCCGCGA
CCGAGGTCTGCGGGGGTTTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MAQNHMSETMNDISAESPDQPEPPRTGYGVIQAYLKTLDSSPGVYRMLDHESRVLYVGKARNLRARVSNYTRPGHTQRIE
TMISQTSRMMFLTTRTETEALLLEQNLIKQLKPKYNVLLRDDKSFPYIMVSKNHAFPQLKKHRGARKGKASFFGPFASAG
AVNRTLNQLQKAFLLRNCTDTMFENRTRPCLQYQIKRCSGPCVGKISQADYADSVRDAERFLAGRSTKIQEELGAEMQAA
SEAMEYERAAALRDRIKALTQVQSAQGINPRGVSEADIIGLHLENGLACVQVFFIRANQNWGNQDFYPRVAEDMSAAEVM
EAFIGQFYDNKDVPRQLILSDDIENADLMAVALSEKARRKVEIVVPQRGEKTELVASAVRNARESLARRMSESATQAKLL
RGIADAFGLEAPPNRIEVYDNSHIQGTNAVGGMIVMGPEGFMKNAYRKFNIKDGEVIAGDDFGMMKAVLNRRFSRLLKED
PDRQKGMWPDLLLIDGGAGQVSAVAEIMEEHGVQDIPMVGVAKGVDRDHGKEEFYRPGENAFALQRNDPVLYFIQRMRDE
AHRFAIGTHRAKRAKSLVANPLDDIPGVGARRKKALLTHFGSAKAVSRANLSDLKAVDGVSDALAETIYNYFQVR

Sequences:

>Translated_635_residues
MAQNHMSETMNDISAESPDQPEPPRTGYGVIQAYLKTLDSSPGVYRMLDHESRVLYVGKARNLRARVSNYTRPGHTQRIE
TMISQTSRMMFLTTRTETEALLLEQNLIKQLKPKYNVLLRDDKSFPYIMVSKNHAFPQLKKHRGARKGKASFFGPFASAG
AVNRTLNQLQKAFLLRNCTDTMFENRTRPCLQYQIKRCSGPCVGKISQADYADSVRDAERFLAGRSTKIQEELGAEMQAA
SEAMEYERAAALRDRIKALTQVQSAQGINPRGVSEADIIGLHLENGLACVQVFFIRANQNWGNQDFYPRVAEDMSAAEVM
EAFIGQFYDNKDVPRQLILSDDIENADLMAVALSEKARRKVEIVVPQRGEKTELVASAVRNARESLARRMSESATQAKLL
RGIADAFGLEAPPNRIEVYDNSHIQGTNAVGGMIVMGPEGFMKNAYRKFNIKDGEVIAGDDFGMMKAVLNRRFSRLLKED
PDRQKGMWPDLLLIDGGAGQVSAVAEIMEEHGVQDIPMVGVAKGVDRDHGKEEFYRPGENAFALQRNDPVLYFIQRMRDE
AHRFAIGTHRAKRAKSLVANPLDDIPGVGARRKKALLTHFGSAKAVSRANLSDLKAVDGVSDALAETIYNYFQVR
>Mature_634_residues
AQNHMSETMNDISAESPDQPEPPRTGYGVIQAYLKTLDSSPGVYRMLDHESRVLYVGKARNLRARVSNYTRPGHTQRIET
MISQTSRMMFLTTRTETEALLLEQNLIKQLKPKYNVLLRDDKSFPYIMVSKNHAFPQLKKHRGARKGKASFFGPFASAGA
VNRTLNQLQKAFLLRNCTDTMFENRTRPCLQYQIKRCSGPCVGKISQADYADSVRDAERFLAGRSTKIQEELGAEMQAAS
EAMEYERAAALRDRIKALTQVQSAQGINPRGVSEADIIGLHLENGLACVQVFFIRANQNWGNQDFYPRVAEDMSAAEVME
AFIGQFYDNKDVPRQLILSDDIENADLMAVALSEKARRKVEIVVPQRGEKTELVASAVRNARESLARRMSESATQAKLLR
GIADAFGLEAPPNRIEVYDNSHIQGTNAVGGMIVMGPEGFMKNAYRKFNIKDGEVIAGDDFGMMKAVLNRRFSRLLKEDP
DRQKGMWPDLLLIDGGAGQVSAVAEIMEEHGVQDIPMVGVAKGVDRDHGKEEFYRPGENAFALQRNDPVLYFIQRMRDEA
HRFAIGTHRAKRAKSLVANPLDDIPGVGARRKKALLTHFGSAKAVSRANLSDLKAVDGVSDALAETIYNYFQVR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=38.752052545156, Blast_Score=438, Evalue=1e-124,
Organism=Escherichia coli, GI1788037, Length=192, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SILST (Q1GDL4)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614514.1
- ProteinModelPortal:   Q1GDL4
- STRING:   Q1GDL4
- GeneID:   4076522
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2520
- NMPDR:   fig|292414.1.peg.763
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q1GDL4
- ProtClustDB:   PRK00558
- BioCyc:   SSP292414:TM1040_2520-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70972; Mature: 70841

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNHMSETMNDISAESPDQPEPPRTGYGVIQAYLKTLDSSPGVYRMLDHESRVLYVGKA
CCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECC
RNLRARVSNYTRPGHTQRIETMISQTSRMMFLTTRTETEALLLEQNLIKQLKPKYNVLLR
CCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEE
DDKSFPYIMVSKNHAFPQLKKHRGARKGKASFFGPFASAGAVNRTLNQLQKAFLLRNCTD
CCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHH
TMFENRTRPCLQYQIKRCSGPCVGKISQADYADSVRDAERFLAGRSTKIQEELGAEMQAA
HHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHH
SEAMEYERAAALRDRIKALTQVQSAQGINPRGVSEADIIGLHLENGLACVQVFFIRANQN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEEEECCC
WGNQDFYPRVAEDMSAAEVMEAFIGQFYDNKDVPRQLILSDDIENADLMAVALSEKARRK
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEHHHHHHCCE
VEIVVPQRGEKTELVASAVRNARESLARRMSESATQAKLLRGIADAFGLEAPPNRIEVYD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
NSHIQGTNAVGGMIVMGPEGFMKNAYRKFNIKDGEVIAGDDFGMMKAVLNRRFSRLLKED
CCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
PDRQKGMWPDLLLIDGGAGQVSAVAEIMEEHGVQDIPMVGVAKGVDRDHGKEEFYRPGEN
CCHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHCCCCCC
AFALQRNDPVLYFIQRMRDEAHRFAIGTHRAKRAKSLVANPLDDIPGVGARRKKALLTHF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHC
GSAKAVSRANLSDLKAVDGVSDALAETIYNYFQVR
CCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQNHMSETMNDISAESPDQPEPPRTGYGVIQAYLKTLDSSPGVYRMLDHESRVLYVGKA
CCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECC
RNLRARVSNYTRPGHTQRIETMISQTSRMMFLTTRTETEALLLEQNLIKQLKPKYNVLLR
CCHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEE
DDKSFPYIMVSKNHAFPQLKKHRGARKGKASFFGPFASAGAVNRTLNQLQKAFLLRNCTD
CCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHH
TMFENRTRPCLQYQIKRCSGPCVGKISQADYADSVRDAERFLAGRSTKIQEELGAEMQAA
HHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHHH
SEAMEYERAAALRDRIKALTQVQSAQGINPRGVSEADIIGLHLENGLACVQVFFIRANQN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEEEECCC
WGNQDFYPRVAEDMSAAEVMEAFIGQFYDNKDVPRQLILSDDIENADLMAVALSEKARRK
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCEEEEHHHHHHCCE
VEIVVPQRGEKTELVASAVRNARESLARRMSESATQAKLLRGIADAFGLEAPPNRIEVYD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
NSHIQGTNAVGGMIVMGPEGFMKNAYRKFNIKDGEVIAGDDFGMMKAVLNRRFSRLLKED
CCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCC
PDRQKGMWPDLLLIDGGAGQVSAVAEIMEEHGVQDIPMVGVAKGVDRDHGKEEFYRPGEN
CCHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHCCCCCC
AFALQRNDPVLYFIQRMRDEAHRFAIGTHRAKRAKSLVANPLDDIPGVGARRKKALLTHF
EEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHC
GSAKAVSRANLSDLKAVDGVSDALAETIYNYFQVR
CCHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA