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The map label for this gene is fadH [H]

Identifier: 99082298

GI number: 99082298

Start: 2599378

End: 2601405

Strand: Direct

Name: fadH [H]

Synonym: TM1040_2458

Alternate gene names: 99082298

Gene position: 2599378-2601405 (Clockwise)

Preceding gene: 99082295

Following gene: 99082301

Centisome position: 81.21

GC content: 61.49

Gene sequence:

>2028_bases
ATGGCTGCGTACCCACATCTGCTGGCCCCGTTGGATCTGGGCTTTACCACGCTGAAGAACCGGGTTCTGATGGGCTCCAT
GCACACCGGGCTCGAAGAGACCCGCGACTGGAATCGCGTGGCCGAGTTCTATGCTGCGCGCGCGCGTGGCGGGGTGGCCT
TGATGGTCACCGGCGGCATTGGCCCCAACCTCGAAGGCTCCGTGCTGCCGGGTGCGGCGATGATGACCACAGAAAAAGAT
GTCGAGAACCATTCGGTCGTCACGAAGGCCGTACATGAGGCAGACGGCAAGATCGCAATGCAAATCCTGCACGCAGGCCG
CTATGCCTATGGTCCCAAATGCGTTGCACCGTCGCCCGTCAAGTCGCCCATCTCGCCCTTCCCCCCGACCGAGCTCGACG
AGGAAGGTATCGAAAAACAGATCTCCGACATCGTGAACGCCGCGCGGCTGGCGCAAGAAGCAGGCTATGATGGTGTCGAG
ATCATGGGGTCGGAGGGGTACTTCCTCAATCAGTTCCTCGTCACACATACCAACAAACGCGAAGACCGCTGGGGCGGATC
CTATGAGAACCGCATGCGTCTGCCGGTCGAGGTGGTGCGCCGTGTACGCGAGGCCGTGGGGCCGGAGTTCATCCTGATTT
ATCGTCTCTCGATGATCGATCTTGTGCCTAATGGCTCCACCTTCGAGGAGGTCGTGCAACTGGCCAAGGCGGTCGAGACC
GCCGGGGCGACGATCATCAACACCGGCATTGGCTGGCACGAAGCGCGCATACCGACGATTGCCACATCGGTGCCGCGCGC
GGCCTTTGCCTGGGTGACGCAGAAACTGATGGGGCAGGTCTCGATTCCGGTGATCACTTCGAACCGGATCAATACGCCCG
AGGTTGCAGAGGACGTCCTCGCGCAGGGCTGTGCCGATATGGTCTCCATGGCGCGGCCAATGCTGGCGGATGCGGATTTT
GTGGCCAAAGCCGCCGCCGGACGCGGAGATGAAATCGCGCCCTGTATCGCCTGCAACCAGGCCTGTCTGGATCACACGTT
TGGTGGCAAGCTCACGTCCTGCTTGGTGAACCCCCGCGCCTGCCACGAAACCGAGCTCACTCTCACCCCTGCTGAGACGA
TCAAATCCGTCGGGATCGTCGGTGCTGGACCTGCGGGTCTGTCGACCGCGCTTGCCGCGGCAGAGCGCGGCCACAAGGTC
ACGTTGTTTGATGCCGCAGATGAAATCGGCGGGCAGCTCAATATGGCCAAACAGGTCCCCGGCAAAGAGGAGTTCTGGGG
GCTTGTTGATTGGTATCGCACTATGATTGCAAAGGCAGGCGTCACTCTGGAATTGGGCCGCCGCGTCGATGCCGCAGATC
TCAAGGACTTCGACGAGGTGATCATCGCGACCGGAGTCACGCCGCGTGATCCACACATTCCGGGTCAGGACCACCCTTCG
GTCCTGAGCTACATCGACGTCCTGCGCCACAAAGCTCCGGTTGGAGAAAAGGTTGCGGTCATCGGGGCGGGCGGCATCGG
GTTTGATGTGTCGGAATACCTGCTGCACGAGGGCGAAAGCCCCGCTGAAAGCCTACCACTTTGGATGCGCGAATGGGGGG
TGACCGACCCGGCCGATCATCGATCGGGCCTCGCTCCCGAGGGCCCTCAGCCCGAGGCTCCGGCACGCAAGGTCACCTTG
CTGCAGCGCAAGGCAGAGCGCCACGGCAAACGTCTGGGAAAAACAACCGGCTGGATTCATCGCGCAACGCTCAAGATGAA
AGACGTCGAATTTGTCGGTGGCGTCAACTACGAGCGCATCGACGATGATGGCCTGCATGTGAGCTTTGGCGAAGCGCGCG
AAAACCCAACCGTGATCAAGGCAGACAACATCGTGCTGTGTGCCGGACAGGTCAGTGAACGCTCTCTTGCGGACAAGCTC
GCCGAAATGGGAATCACCGCCCATGTCATTGGCGGCGCGGATGTTGCGGCAGAACTCGACGCCAAACGGGCCATAAATCA
GGGCACCCGCCTCGCGGCCACGCTCTGA

Upstream 100 bases:

>100_bases
CGCCGCGTCTGCAGGTGACATTCCATGCGCTTCGGGCGATCCTTGCGCCCTCACGCGGTGCCCGTAACAAGTGCCGCGCA
GTACACAGAGGGAGAGTGTC

Downstream 100 bases:

>100_bases
ACAGAGCCCTCTCGTTCATTGGCGCAGCCGAACGAGAGGGTCCTCCTCGCCCGACGGAGAACACGCCACATTTCAGATTG
TAGCGGCAAGTTCAGCCATC

Product: 2,4-dienoyl-CoA reductase

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MAAYPHLLAPLDLGFTTLKNRVLMGSMHTGLEETRDWNRVAEFYAARARGGVALMVTGGIGPNLEGSVLPGAAMMTTEKD
VENHSVVTKAVHEADGKIAMQILHAGRYAYGPKCVAPSPVKSPISPFPPTELDEEGIEKQISDIVNAARLAQEAGYDGVE
IMGSEGYFLNQFLVTHTNKREDRWGGSYENRMRLPVEVVRRVREAVGPEFILIYRLSMIDLVPNGSTFEEVVQLAKAVET
AGATIINTGIGWHEARIPTIATSVPRAAFAWVTQKLMGQVSIPVITSNRINTPEVAEDVLAQGCADMVSMARPMLADADF
VAKAAAGRGDEIAPCIACNQACLDHTFGGKLTSCLVNPRACHETELTLTPAETIKSVGIVGAGPAGLSTALAAAERGHKV
TLFDAADEIGGQLNMAKQVPGKEEFWGLVDWYRTMIAKAGVTLELGRRVDAADLKDFDEVIIATGVTPRDPHIPGQDHPS
VLSYIDVLRHKAPVGEKVAVIGAGGIGFDVSEYLLHEGESPAESLPLWMREWGVTDPADHRSGLAPEGPQPEAPARKVTL
LQRKAERHGKRLGKTTGWIHRATLKMKDVEFVGGVNYERIDDDGLHVSFGEARENPTVIKADNIVLCAGQVSERSLADKL
AEMGITAHVIGGADVAAELDAKRAINQGTRLAATL

Sequences:

>Translated_675_residues
MAAYPHLLAPLDLGFTTLKNRVLMGSMHTGLEETRDWNRVAEFYAARARGGVALMVTGGIGPNLEGSVLPGAAMMTTEKD
VENHSVVTKAVHEADGKIAMQILHAGRYAYGPKCVAPSPVKSPISPFPPTELDEEGIEKQISDIVNAARLAQEAGYDGVE
IMGSEGYFLNQFLVTHTNKREDRWGGSYENRMRLPVEVVRRVREAVGPEFILIYRLSMIDLVPNGSTFEEVVQLAKAVET
AGATIINTGIGWHEARIPTIATSVPRAAFAWVTQKLMGQVSIPVITSNRINTPEVAEDVLAQGCADMVSMARPMLADADF
VAKAAAGRGDEIAPCIACNQACLDHTFGGKLTSCLVNPRACHETELTLTPAETIKSVGIVGAGPAGLSTALAAAERGHKV
TLFDAADEIGGQLNMAKQVPGKEEFWGLVDWYRTMIAKAGVTLELGRRVDAADLKDFDEVIIATGVTPRDPHIPGQDHPS
VLSYIDVLRHKAPVGEKVAVIGAGGIGFDVSEYLLHEGESPAESLPLWMREWGVTDPADHRSGLAPEGPQPEAPARKVTL
LQRKAERHGKRLGKTTGWIHRATLKMKDVEFVGGVNYERIDDDGLHVSFGEARENPTVIKADNIVLCAGQVSERSLADKL
AEMGITAHVIGGADVAAELDAKRAINQGTRLAATL
>Mature_674_residues
AAYPHLLAPLDLGFTTLKNRVLMGSMHTGLEETRDWNRVAEFYAARARGGVALMVTGGIGPNLEGSVLPGAAMMTTEKDV
ENHSVVTKAVHEADGKIAMQILHAGRYAYGPKCVAPSPVKSPISPFPPTELDEEGIEKQISDIVNAARLAQEAGYDGVEI
MGSEGYFLNQFLVTHTNKREDRWGGSYENRMRLPVEVVRRVREAVGPEFILIYRLSMIDLVPNGSTFEEVVQLAKAVETA
GATIINTGIGWHEARIPTIATSVPRAAFAWVTQKLMGQVSIPVITSNRINTPEVAEDVLAQGCADMVSMARPMLADADFV
AKAAAGRGDEIAPCIACNQACLDHTFGGKLTSCLVNPRACHETELTLTPAETIKSVGIVGAGPAGLSTALAAAERGHKVT
LFDAADEIGGQLNMAKQVPGKEEFWGLVDWYRTMIAKAGVTLELGRRVDAADLKDFDEVIIATGVTPRDPHIPGQDHPSV
LSYIDVLRHKAPVGEKVAVIGAGGIGFDVSEYLLHEGESPAESLPLWMREWGVTDPADHRSGLAPEGPQPEAPARKVTLL
QRKAERHGKRLGKTTGWIHRATLKMKDVEFVGGVNYERIDDDGLHVSFGEARENPTVIKADNIVLCAGQVSERSLADKLA
EMGITAHVIGGADVAAELDAKRAINQGTRLAATL

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=672, Percent_Identity=60.1190476190476, Blast_Score=828, Evalue=0.0,
Organism=Escherichia coli, GI1787939, Length=343, Percent_Identity=29.1545189504373, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17564188, Length=315, Percent_Identity=25.0793650793651, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559804, Length=315, Percent_Identity=26.031746031746, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559802, Length=317, Percent_Identity=26.4984227129338, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17566914, Length=320, Percent_Identity=27.1875, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565138, Length=306, Percent_Identity=24.5098039215686, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72001454, Length=254, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540738, Length=256, Percent_Identity=27.734375, Blast_Score=83, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321973, Length=234, Percent_Identity=31.6239316239316, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325086, Length=235, Percent_Identity=28.5106382978723, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 72473; Mature: 72341

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYPHLLAPLDLGFTTLKNRVLMGSMHTGLEETRDWNRVAEFYAARARGGVALMVTGGI
CCCCCCHHHHHHCCHHHHHHHHEECHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GPNLEGSVLPGAAMMTTEKDVENHSVVTKAVHEADGKIAMQILHAGRYAYGPKCVAPSPV
CCCCCCCCCCCCEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
KSPISPFPPTELDEEGIEKQISDIVNAARLAQEAGYDGVEIMGSEGYFLNQFLVTHTNKR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHHHCCCCC
EDRWGGSYENRMRLPVEVVRRVREAVGPEFILIYRLSMIDLVPNGSTFEEVVQLAKAVET
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHH
AGATIINTGIGWHEARIPTIATSVPRAAFAWVTQKLMGQVSIPVITSNRINTPEVAEDVL
CCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCEECEEEECCCCCCHHHHHHHH
AQGCADMVSMARPMLADADFVAKAAAGRGDEIAPCIACNQACLDHTFGGKLTSCLVNPRA
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHCHHHHHCCCCCHHHHHHCCCCC
CHETELTLTPAETIKSVGIVGAGPAGLSTALAAAERGHKVTLFDAADEIGGQLNMAKQVP
CCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHCCCEEHHHCCC
GKEEFWGLVDWYRTMIAKAGVTLELGRRVDAADLKDFDEVIIATGVTPRDPHIPGQDHPS
CHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCHH
VLSYIDVLRHKAPVGEKVAVIGAGGIGFDVSEYLLHEGESPAESLPLWMREWGVTDPADH
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHCCHHHHHCCCCCCCHH
RSGLAPEGPQPEAPARKVTLLQRKAERHGKRLGKTTGWIHRATLKMKDVEFVGGVNYERI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEEEECCHHCCCCCCCEE
DDDGLHVSFGEARENPTVIKADNIVLCAGQVSERSLADKLAEMGITAHVIGGADVAAELD
CCCCCEEEECCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
AKRAINQGTRLAATL
HHHHHCCCCEEEECC
>Mature Secondary Structure 
AAYPHLLAPLDLGFTTLKNRVLMGSMHTGLEETRDWNRVAEFYAARARGGVALMVTGGI
CCCCCHHHHHHCCHHHHHHHHEECHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
GPNLEGSVLPGAAMMTTEKDVENHSVVTKAVHEADGKIAMQILHAGRYAYGPKCVAPSPV
CCCCCCCCCCCCEEEECHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
KSPISPFPPTELDEEGIEKQISDIVNAARLAQEAGYDGVEIMGSEGYFLNQFLVTHTNKR
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEHHHHHHCCCCC
EDRWGGSYENRMRLPVEVVRRVREAVGPEFILIYRLSMIDLVPNGSTFEEVVQLAKAVET
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHH
AGATIINTGIGWHEARIPTIATSVPRAAFAWVTQKLMGQVSIPVITSNRINTPEVAEDVL
CCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCEECEEEECCCCCCHHHHHHHH
AQGCADMVSMARPMLADADFVAKAAAGRGDEIAPCIACNQACLDHTFGGKLTSCLVNPRA
HHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHCHHHHHCCCCCHHHHHHCCCCC
CHETELTLTPAETIKSVGIVGAGPAGLSTALAAAERGHKVTLFDAADEIGGQLNMAKQVP
CCCCEEEECHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECHHHHCCCEEHHHCCC
GKEEFWGLVDWYRTMIAKAGVTLELGRRVDAADLKDFDEVIIATGVTPRDPHIPGQDHPS
CHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHEEEECCCCCCCCCCCCCCCHH
VLSYIDVLRHKAPVGEKVAVIGAGGIGFDVSEYLLHEGESPAESLPLWMREWGVTDPADH
HHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHCCHHHHHCCCCCCCHH
RSGLAPEGPQPEAPARKVTLLQRKAERHGKRLGKTTGWIHRATLKMKDVEFVGGVNYERI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCEEEEEEEEECCHHCCCCCCCEE
DDDGLHVSFGEARENPTVIKADNIVLCAGQVSERSLADKLAEMGITAHVIGGADVAAELD
CCCCCEEEECCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
AKRAINQGTRLAATL
HHHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]