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The map label for this gene is ctaDII [H]

Identifier: 99082131

GI number: 99082131

Start: 2409675

End: 2411333

Strand: Direct

Name: ctaDII [H]

Synonym: TM1040_2291

Alternate gene names: 99082131

Gene position: 2409675-2411333 (Clockwise)

Preceding gene: 99082128

Following gene: 99082132

Centisome position: 75.28

GC content: 58.59

Gene sequence:

>1659_bases
ATGGCAGACGCAGCCATTCAAGGTCACGGCCACGAAGACGAGCGGAGCTTTTTCACCCGCTGGTTTATGAGCACGAACCA
CAAGGATATCGGTATCCTTTACCTGATCGTTTCGGCGCTCACCGGCTTCATTTCCGTCGCATTCACCGTCTACATGCGAC
TCGAACTTATGGATCCCGGTGTGCAGTACATGTGTCTGGAAGGCTTTGCCGCAGACCCCTGTACGCCGAATGGCCATCTC
TGGAACGTGCTGATTACAGGCCACGGCGTCTTGATGATGTTCTTCGTCGTCATCCCGGCCCTGTTCGGCGGGTTTGGCAA
CTATTTCATGCCGCTGCAGATCGGCGCGCCGGATATGGCGTTCCCGCGGATGAACAACCTCAGCTTCTGGATGTATGTTG
CAGGCACCGCGCTGGCGGTCTCCTCGGTCTATGCGCCGGGCGGCAACAACCAGCTGGGCGCTGGCGTGGGTTGGGTTCTC
TATCCGCCGCTCTCCGTCAAGGAAGGCGGGATCGCGATGGATCTGGCGATTTTCGCCGTGCACGTCTCCGGTGCCTCCTC
GATCCTGGGCGCGATCAACATGATCACCACCTTCCTGAACATGCGTGCCCCCGGCATGACCCTGTTCAAGGTGCCGCTCT
TCAGCTGGTCGATCTTCGTCACCTCCTGGCTGATCCTTCTGTCCCTGCCGGTTCTGGCAGGCGCAATCACCATGCTGCTG
ATGGATCGTAACTTCGGCTTCACCTTCTTTGATGCCGCAGGCGGCGGGGACCCGGTTCTCTACCAGCACATCCTGTGGTT
CTTCGGCCACCCCGAAGTGTACATCGTGATCCTGCCGGGCTTTGGCATCATCTCCCACGTGATCGCGACCTTCTCGCGCA
AGCCTGTGTTTGGCTACCTGCCGATGGTCTGGGCGATCATCGCGATTGGTGTTCTGGGCTTCGTCGTTTGGGCGCACCAC
ATGTACACCGTCGGCATGAGCCTCAACCAGCAGGCCTACTTCATGCTGGCCACCATGGTGATCGCCGTGCCCACAGGGGT
GAAGGTCTTCTCGTGGATCGCAACCATGTGGGGCGGCTCCATCGAGTTCAAAGCCCCCATGGTCTTTGCTTTCGGCTTCC
TGTTCCTGTTCACCGTTGGCGGTGTGACCGGCGTGGTGCTGTCGCAGGCGGCCGTGGACCGGGCCTATCATGACACCTAT
TACGTGGTGGCACACTTCCACTACGTGATGAGCCTTGGTGCGGTGTTTGCGATCTTCTCCGGCATCTACTTCTACTTTGG
TAAGATGACCGGCCGTCAGTACTCCGAACTGGGCGCACAGATTCACTTCTGGATGTTCTTCATCGGTGCAAACCTGACGT
TCTTCCCGCAGCACTTCCTGGGCCGTCAGGGCATGCCGCGTCGCTACATCGACTATCCCGAAGGCTTTGCATACTGGAAC
AAGATCTCGTCCTATGGCGCGTTCCTGTCCTTTGCCTCCTTCATCTTCTTCTTCGGTGTGGTGATCTATTCACTGCTGCG
TGGCGCGCGTGTGACCCAGAACAACTACTGGAACGAATACGCCGACACGCTGGAGTGGACCCTGCCCTCTCCGCCGCCGG
AGCACACCTTTGAAATCCTGCCCAAGCAGGAAGACTGGGACAAAAGCCACAGCCACTAA

Upstream 100 bases:

>100_bases
ATTGAAGGGCCGCGCAGGCCATTCTAAAACCACCAAGAGTCCAGAGCCGACGGGGAATCCCCCGTGCGGTCTCTGAGGAG
TATAAACAGGAGGCACCCAA

Downstream 100 bases:

>100_bases
GACCGGCTTGAGCTGAAACCAAAACGCCCCGGAGCCACAGGCTTCGGGGCGTTTTCTTTTCTCGCGCAGGGTCTTTTCCA
CCGCCCGCAAAACCGGGTCA

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1-beta; Cytochrome c oxidase polypeptide I-beta [H]

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MADAAIQGHGHEDERSFFTRWFMSTNHKDIGILYLIVSALTGFISVAFTVYMRLELMDPGVQYMCLEGFAADPCTPNGHL
WNVLITGHGVLMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAVSSVYAPGGNNQLGAGVGWVL
YPPLSVKEGGIAMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAITMLL
MDRNFGFTFFDAAGGGDPVLYQHILWFFGHPEVYIVILPGFGIISHVIATFSRKPVFGYLPMVWAIIAIGVLGFVVWAHH
MYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSIEFKAPMVFAFGFLFLFTVGGVTGVVLSQAAVDRAYHDTY
YVVAHFHYVMSLGAVFAIFSGIYFYFGKMTGRQYSELGAQIHFWMFFIGANLTFFPQHFLGRQGMPRRYIDYPEGFAYWN
KISSYGAFLSFASFIFFFGVVIYSLLRGARVTQNNYWNEYADTLEWTLPSPPPEHTFEILPKQEDWDKSHSH

Sequences:

>Translated_552_residues
MADAAIQGHGHEDERSFFTRWFMSTNHKDIGILYLIVSALTGFISVAFTVYMRLELMDPGVQYMCLEGFAADPCTPNGHL
WNVLITGHGVLMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAVSSVYAPGGNNQLGAGVGWVL
YPPLSVKEGGIAMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAITMLL
MDRNFGFTFFDAAGGGDPVLYQHILWFFGHPEVYIVILPGFGIISHVIATFSRKPVFGYLPMVWAIIAIGVLGFVVWAHH
MYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSIEFKAPMVFAFGFLFLFTVGGVTGVVLSQAAVDRAYHDTY
YVVAHFHYVMSLGAVFAIFSGIYFYFGKMTGRQYSELGAQIHFWMFFIGANLTFFPQHFLGRQGMPRRYIDYPEGFAYWN
KISSYGAFLSFASFIFFFGVVIYSLLRGARVTQNNYWNEYADTLEWTLPSPPPEHTFEILPKQEDWDKSHSH
>Mature_551_residues
ADAAIQGHGHEDERSFFTRWFMSTNHKDIGILYLIVSALTGFISVAFTVYMRLELMDPGVQYMCLEGFAADPCTPNGHLW
NVLITGHGVLMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAVSSVYAPGGNNQLGAGVGWVLY
PPLSVKEGGIAMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAITMLLM
DRNFGFTFFDAAGGGDPVLYQHILWFFGHPEVYIVILPGFGIISHVIATFSRKPVFGYLPMVWAIIAIGVLGFVVWAHHM
YTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSIEFKAPMVFAFGFLFLFTVGGVTGVVLSQAAVDRAYHDTYY
VVAHFHYVMSLGAVFAIFSGIYFYFGKMTGRQYSELGAQIHFWMFFIGANLTFFPQHFLGRQGMPRRYIDYPEGFAYWNK
ISSYGAFLSFASFIFFFGVVIYSLLRGARVTQNNYWNEYADTLEWTLPSPPPEHTFEILPKQEDWDKSHSH

Specific function: Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across th

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=525, Percent_Identity=52.7619047619048, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1786634, Length=539, Percent_Identity=38.5899814471243, Blast_Score=347, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6226519, Length=546, Percent_Identity=51.8315018315018, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6226524, Length=336, Percent_Identity=56.25, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6226523, Length=261, Percent_Identity=49.8084291187739, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 61636; Mature: 61504

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAAIQGHGHEDERSFFTRWFMSTNHKDIGILYLIVSALTGFISVAFTVYMRLELMDPG
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VQYMCLEGFAADPCTPNGHLWNVLITGHGVLMMFFVVIPALFGGFGNYFMPLQIGAPDMA
CCEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FPRMNNLSFWMYVAGTALAVSSVYAPGGNNQLGAGVGWVLYPPLSVKEGGIAMDLAIFAV
CCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEE
HVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAITMLL
ECCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDRNFGFTFFDAAGGGDPVLYQHILWFFGHPEVYIVILPGFGIISHVIATFSRKPVFGYL
EECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHH
PMVWAIIAIGVLGFVVWAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
IEFKAPMVFAFGFLFLFTVGGVTGVVLSQAAVDRAYHDTYYVVAHFHYVMSLGAVFAIFS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GIYFYFGKMTGRQYSELGAQIHFWMFFIGANLTFFPQHFLGRQGMPRRYIDYPEGFAYWN
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCEECCHHHHCCCCCCCCCCCCCCHHHHHH
KISSYGAFLSFASFIFFFGVVIYSLLRGARVTQNNYWNEYADTLEWTLPSPPPEHTFEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCEEECCCCCCCCCHHEEC
PKQEDWDKSHSH
CCCCCCCCCCCC
>Mature Secondary Structure 
ADAAIQGHGHEDERSFFTRWFMSTNHKDIGILYLIVSALTGFISVAFTVYMRLELMDPG
CCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VQYMCLEGFAADPCTPNGHLWNVLITGHGVLMMFFVVIPALFGGFGNYFMPLQIGAPDMA
CCEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
FPRMNNLSFWMYVAGTALAVSSVYAPGGNNQLGAGVGWVLYPPLSVKEGGIAMDLAIFAV
CCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEEEEEEE
HVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAITMLL
ECCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDRNFGFTFFDAAGGGDPVLYQHILWFFGHPEVYIVILPGFGIISHVIATFSRKPVFGYL
EECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHH
PMVWAIIAIGVLGFVVWAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGS
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
IEFKAPMVFAFGFLFLFTVGGVTGVVLSQAAVDRAYHDTYYVVAHFHYVMSLGAVFAIFS
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GIYFYFGKMTGRQYSELGAQIHFWMFFIGANLTFFPQHFLGRQGMPRRYIDYPEGFAYWN
HHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCEECCHHHHCCCCCCCCCCCCCCHHHHHH
KISSYGAFLSFASFIFFFGVVIYSLLRGARVTQNNYWNEYADTLEWTLPSPPPEHTFEIL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHCCEEECCCCCCCCCHHEEC
PKQEDWDKSHSH
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2155830; 7651515; 9380672; 10338009; 8794157 [H]