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The map label for this gene is lysK [H]

Identifier: 99082101

GI number: 99082101

Start: 2375821

End: 2377464

Strand: Direct

Name: lysK [H]

Synonym: TM1040_2261

Alternate gene names: 99082101

Gene position: 2375821-2377464 (Clockwise)

Preceding gene: 99082099

Following gene: 99082102

Centisome position: 74.22

GC content: 59.06

Gene sequence:

>1644_bases
ATGTCTGTTCTGCGCGAAGAAGCTCTGAAGAGCAAAGCCTGGCCGTTTGAAGAAGCACGCCGCATTCTCAAACGTTACGC
CAAGGGCGCGCCGGAAAAGGGCTATGTGCTCTTTGAAACAGGCTATGGGCCCTCCGGCCTGCCCCATATCGGCACCTTTG
GCGAGGTGGCCCGCACCACCATGATCAAAACCGCTTTCGAGGTGATCTCCGACATTCCGACCAAGCTGATCTGCTTTTCC
GATGACCTTGACGGGATGCGCAAGATCCCCGGCAACGTGCCCAACGCCGAGAGCCTCACCGAGCATCTGCAAAAGCCGCT
CACCTCGGTGCCGGACCCGTTTGGGACGCATGAGAGCTTTGGCCACCATAACAACGCAATGCTCCGCCGCTTCCTCGACA
CCTTCGGCTTTGAGTATGAGTTCTACTCCGCCACCGAGTTCTACGGCTCCGGCCAGTTCGACGAAGTGCTGAAGCGCGCG
GTCGACAAATACGATGACATCATGGCGATCATGCTGAAGTCCCTGCGTGAAGAGCGCCGCCAGACCTATTCGATCTTCCT
GCCGATCCACCCCGAGACCGGCCGCGTCCTTTATGTGCCGATGAAAAAGGTCTGCGCCGAGACCTATACCATCACCTTTG
ACGATGAAGACGGTCGCGAGTGGACCCTGCCGGTGACCGGCGGCAATGTGAAACTGCAGTGGAAGCCTGACTTTGGCGCC
CGCTGGGCCGCGCTTGGCGTCGACTTCGAGATGTACGGCAAGGACCACTCCACCAATACACCGATTTATGACGGCATCTG
CCGGGTGCTGGGCCAGCGCGCGCCGGAGCATTTCACCTATGAATTGTTCCTCGATGAAAACGGCCAGAAGATCTCCAAGA
CCTCCGGCAATGGCGTCTCCATCGACGAATGGCTGACCTACGCTTCGACCGAAAGCCTTGCGTATTTCATGTATCAAAAG
CCCAAGACCGCCAAGCGGATGCATTTTGACGTGATCCCCAAGGCAGTGGATGAATATCACCAGCAATTGCGGGCCTATCA
CGGTCAGGACCTGAAGGCGCAGCTCAGCAACCCGGTCTGGCACATCCACGGCGGCAACGTCCCGCAGTCGGATATGGTGG
TGCCGTTCTCGATGCTCTTGAACATCGCCAGCGTCTCCAACGCCGAAGACAAGGAAACCCTCTGGGGCTTCATCAACAAA
TACGCGCCCGACGCCACTGCCGAGACCCACCCCGGCATGGATCAGGCCGCAGGCCATGCAGTGCGCTATTTCAACGACTT
TGTGAAACCCGCAAAAACCTACCGCCTGCCCACCGATCAGGAGCGCGCTGCGCTCACGGATCTGGCCGATGCGCTGCGCT
CTTCCGAGGCGGCACTGGCCGCGATCGCCAAGAAAAACGAACTGGTCGGCAATGATGATCCGCTGCCCGAGGCCAACTTT
GCCGACGAAGAGTTCCTGCAGTCGGTGGTCTTTGCGATTGGCAAGATCCACGGGTTCGAGCCCCTTCGTGCCTGGTTCTC
TGCGATCTACGAGGTGCTTCTGGGTGCAAGCCAGGGACCACGTTTTGGCGGCTTCATCGCGCTCTATGGCGTCGAGGACA
CCATCACGCTGATCGAAAGCGCCTTGGCGGGCGATCTGGTCTGA

Upstream 100 bases:

>100_bases
GGCGCTTGTTGACTCATGCTGCACAGGCACAATAGAGAAACGCGTCAGTGTGCGTGGTGCCACTGATCATCCCTGAAAAA
GACGCTGACTGGAGTACATC

Downstream 100 bases:

>100_bases
GACCTACAAACACCAATAATCATACAACGGGCGTCCCAAGTGGGCGCCCGTTTTCCGTTGGCCGTTTTCCGTTAATCCAT
CACATCAGCTGCGGAGCTGC

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSVLREEALKSKAWPFEEARRILKRYAKGAPEKGYVLFETGYGPSGLPHIGTFGEVARTTMIKTAFEVISDIPTKLICFS
DDLDGMRKIPGNVPNAESLTEHLQKPLTSVPDPFGTHESFGHHNNAMLRRFLDTFGFEYEFYSATEFYGSGQFDEVLKRA
VDKYDDIMAIMLKSLREERRQTYSIFLPIHPETGRVLYVPMKKVCAETYTITFDDEDGREWTLPVTGGNVKLQWKPDFGA
RWAALGVDFEMYGKDHSTNTPIYDGICRVLGQRAPEHFTYELFLDENGQKISKTSGNGVSIDEWLTYASTESLAYFMYQK
PKTAKRMHFDVIPKAVDEYHQQLRAYHGQDLKAQLSNPVWHIHGGNVPQSDMVVPFSMLLNIASVSNAEDKETLWGFINK
YAPDATAETHPGMDQAAGHAVRYFNDFVKPAKTYRLPTDQERAALTDLADALRSSEAALAAIAKKNELVGNDDPLPEANF
ADEEFLQSVVFAIGKIHGFEPLRAWFSAIYEVLLGASQGPRFGGFIALYGVEDTITLIESALAGDLV

Sequences:

>Translated_547_residues
MSVLREEALKSKAWPFEEARRILKRYAKGAPEKGYVLFETGYGPSGLPHIGTFGEVARTTMIKTAFEVISDIPTKLICFS
DDLDGMRKIPGNVPNAESLTEHLQKPLTSVPDPFGTHESFGHHNNAMLRRFLDTFGFEYEFYSATEFYGSGQFDEVLKRA
VDKYDDIMAIMLKSLREERRQTYSIFLPIHPETGRVLYVPMKKVCAETYTITFDDEDGREWTLPVTGGNVKLQWKPDFGA
RWAALGVDFEMYGKDHSTNTPIYDGICRVLGQRAPEHFTYELFLDENGQKISKTSGNGVSIDEWLTYASTESLAYFMYQK
PKTAKRMHFDVIPKAVDEYHQQLRAYHGQDLKAQLSNPVWHIHGGNVPQSDMVVPFSMLLNIASVSNAEDKETLWGFINK
YAPDATAETHPGMDQAAGHAVRYFNDFVKPAKTYRLPTDQERAALTDLADALRSSEAALAAIAKKNELVGNDDPLPEANF
ADEEFLQSVVFAIGKIHGFEPLRAWFSAIYEVLLGASQGPRFGGFIALYGVEDTITLIESALAGDLV
>Mature_546_residues
SVLREEALKSKAWPFEEARRILKRYAKGAPEKGYVLFETGYGPSGLPHIGTFGEVARTTMIKTAFEVISDIPTKLICFSD
DLDGMRKIPGNVPNAESLTEHLQKPLTSVPDPFGTHESFGHHNNAMLRRFLDTFGFEYEFYSATEFYGSGQFDEVLKRAV
DKYDDIMAIMLKSLREERRQTYSIFLPIHPETGRVLYVPMKKVCAETYTITFDDEDGREWTLPVTGGNVKLQWKPDFGAR
WAALGVDFEMYGKDHSTNTPIYDGICRVLGQRAPEHFTYELFLDENGQKISKTSGNGVSIDEWLTYASTESLAYFMYQKP
KTAKRMHFDVIPKAVDEYHQQLRAYHGQDLKAQLSNPVWHIHGGNVPQSDMVVPFSMLLNIASVSNAEDKETLWGFINKY
APDATAETHPGMDQAAGHAVRYFNDFVKPAKTYRLPTDQERAALTDLADALRSSEAALAAIAKKNELVGNDDPLPEANFA
DEEFLQSVVFAIGKIHGFEPLRAWFSAIYEVLLGASQGPRFGGFIALYGVEDTITLIESALAGDLV

Specific function: Unknown

COG id: COG1384

COG function: function code J; Lysyl-tRNA synthetase (class I)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR001412
- InterPro:   IPR002904
- InterPro:   IPR020754
- InterPro:   IPR020756
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01921 tRNA-synt_1f [H]

EC number: =6.1.1.6 [H]

Molecular weight: Translated: 61372; Mature: 61241

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLREEALKSKAWPFEEARRILKRYAKGAPEKGYVLFETGYGPSGLPHIGTFGEVARTT
CCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
MIKTAFEVISDIPTKLICFSDDLDGMRKIPGNVPNAESLTEHLQKPLTSVPDPFGTHESF
HHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GHHNNAMLRRFLDTFGFEYEFYSATEFYGSGQFDEVLKRAVDKYDDIMAIMLKSLREERR
CCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTYSIFLPIHPETGRVLYVPMKKVCAETYTITFDDEDGREWTLPVTGGNVKLQWKPDFGA
CEEEEEEEECCCCCCEEEEEHHHHCCCEEEEEEECCCCCEEEEEEECCEEEEEECCCCCC
RWAALGVDFEMYGKDHSTNTPIYDGICRVLGQRAPEHFTYELFLDENGQKISKTSGNGVS
CEEEECCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCC
IDEWLTYASTESLAYFMYQKPKTAKRMHFDVIPKAVDEYHQQLRAYHGQDLKAQLSNPVW
HHHHHHHHCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEE
HIHGGNVPQSDMVVPFSMLLNIASVSNAEDKETLWGFINKYAPDATAETHPGMDQAAGHA
EECCCCCCCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VRYFNDFVKPAKTYRLPTDQERAALTDLADALRSSEAALAAIAKKNELVGNDDPLPEANF
HHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
ADEEFLQSVVFAIGKIHGFEPLRAWFSAIYEVLLGASQGPRFGGFIALYGVEDTITLIES
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ALAGDLV
HHHCCCC
>Mature Secondary Structure 
SVLREEALKSKAWPFEEARRILKRYAKGAPEKGYVLFETGYGPSGLPHIGTFGEVARTT
CHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHH
MIKTAFEVISDIPTKLICFSDDLDGMRKIPGNVPNAESLTEHLQKPLTSVPDPFGTHESF
HHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GHHNNAMLRRFLDTFGFEYEFYSATEFYGSGQFDEVLKRAVDKYDDIMAIMLKSLREERR
CCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTYSIFLPIHPETGRVLYVPMKKVCAETYTITFDDEDGREWTLPVTGGNVKLQWKPDFGA
CEEEEEEEECCCCCCEEEEEHHHHCCCEEEEEEECCCCCEEEEEEECCEEEEEECCCCCC
RWAALGVDFEMYGKDHSTNTPIYDGICRVLGQRAPEHFTYELFLDENGQKISKTSGNGVS
CEEEECCCCEECCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCEEECCCCCCCC
IDEWLTYASTESLAYFMYQKPKTAKRMHFDVIPKAVDEYHQQLRAYHGQDLKAQLSNPVW
HHHHHHHHCHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEE
HIHGGNVPQSDMVVPFSMLLNIASVSNAEDKETLWGFINKYAPDATAETHPGMDQAAGHA
EECCCCCCCCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
VRYFNDFVKPAKTYRLPTDQERAALTDLADALRSSEAALAAIAKKNELVGNDDPLPEANF
HHHHHHHHCHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
ADEEFLQSVVFAIGKIHGFEPLRAWFSAIYEVLLGASQGPRFGGFIALYGVEDTITLIES
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHHH
ALAGDLV
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA