BacMap

Definition	Ruegeria sp. TM1040, complete genome.
Accession	NC_008044
Length	3,200,938

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The map label for this gene is fabG [C]

Identifier: 99082082

GI number: 99082082

Start: 2355439

End: 2356188

Strand: Reverse

Name: fabG [C]

Synonym: TM1040_2242

Alternate gene names: 99082082

Gene position: 2356188-2355439 (Counterclockwise)

Preceding gene: 99082083

Following gene: 99082081

Centisome position: 73.61

GC content: 65.87

Gene sequence:

>750_bases
ATGAGCCAAGATCCACGCCAAGAACATGTCCTGATCACGGGCGGCGGCACCGGTGTTGGGGCCGCCTGCGCCCAGGCCTT
CGCGGCCCAGGGGGCCAAAGTGACCCTGATGGGGCGAACGGAGAAAACGCTTGCAGAGCAGGGGCTTCCTTATGAGGTCT
GCGATGTAACGGATGCGCCAAGCGTCACATCCGCGGTGGCGCGCGCAGCCGCCGCGCGCGGGCCGGTGACTGTGGCGATT
GCAAATGCGGGCGCGGCCGAAAGCGTGCCTTTTGCCAAGATGCAGCCAGAGCTTCTCACGGAGATGATGGCGGTGAACCT
CGGAGGCGTCGTGAACCTCTGGCAGGCGGTGTTGCCGGGCATGAAAGAGGCCGGGCGTGGGCGCATGATCGCGGTGGCCT
CGACGGCGGGGCTCAAGGGCTATGCCTATGTCAGCGCCTATTGCGCCGCCAAACACGCGGTGGTCGGGCTTACTCGCTCG
CTCGCCAAGGAACTGGCGCGCACAGGCGTGACGGTCAATGCGATCTGTCCGGGGTTTGTGGAAACGCCGATGCTCCAGCG
CAGCATCGACAATATCCGCGCCAAGACCGGGATGACATCCGAGGAGGCCGCAGGCGCCCTCAAGGCCGACAATCCCCAGG
GTCGTTTTGTGCAGCCCGAAGAGGTCGCGGATGCTGCGCTCTGGCTGGCGTCGGACACTGCGGGATCGGTGAACGGGCAC
GCGTTGGCCCTGACGGGGGGCGAGATATGA

Upstream 100 bases:

>100_bases
AGATCGGTGATCGTGCAGCCCCCGACTGGCCGCTGCCCTATCTGGCGGGGCGCGATCAGAGCTGGCGTCTTGCGGACAAA
GAAGCGGAGACCCTGCGCGC

Downstream 100 bases:

>100_bases
GCGGCACCGCAGCGCAAGCTGATCTCGGCGACACGGCCTCCAAGGCGCGGCTGCGTCTGTGGCTGAAGCTCTTGAAGACG
TCAGGCAGTATCGAGTCCGA

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: ORF5 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSQDPRQEHVLITGGGTGVGAACAQAFAAQGAKVTLMGRTEKTLAEQGLPYEVCDVTDAPSVTSAVARAAAARGPVTVAI
ANAGAAESVPFAKMQPELLTEMMAVNLGGVVNLWQAVLPGMKEAGRGRMIAVASTAGLKGYAYVSAYCAAKHAVVGLTRS
LAKELARTGVTVNAICPGFVETPMLQRSIDNIRAKTGMTSEEAAGALKADNPQGRFVQPEEVADAALWLASDTAGSVNGH
ALALTGGEI

Sequences:

>Translated_249_residues
MSQDPRQEHVLITGGGTGVGAACAQAFAAQGAKVTLMGRTEKTLAEQGLPYEVCDVTDAPSVTSAVARAAAARGPVTVAI
ANAGAAESVPFAKMQPELLTEMMAVNLGGVVNLWQAVLPGMKEAGRGRMIAVASTAGLKGYAYVSAYCAAKHAVVGLTRS
LAKELARTGVTVNAICPGFVETPMLQRSIDNIRAKTGMTSEEAAGALKADNPQGRFVQPEEVADAALWLASDTAGSVNGH
ALALTGGEI
>Mature_248_residues
SQDPRQEHVLITGGGTGVGAACAQAFAAQGAKVTLMGRTEKTLAEQGLPYEVCDVTDAPSVTSAVARAAAARGPVTVAIA
NAGAAESVPFAKMQPELLTEMMAVNLGGVVNLWQAVLPGMKEAGRGRMIAVASTAGLKGYAYVSAYCAAKHAVVGLTRSL
AKELARTGVTVNAICPGFVETPMLQRSIDNIRAKTGMTSEEAAGALKADNPQGRFVQPEEVADAALWLASDTAGSVNGHA
LALTGGEI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.2181069958848, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=31.9838056680162, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI15277342, Length=262, Percent_Identity=29.3893129770992, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI210032110, Length=187, Percent_Identity=29.4117647058824, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI20149619, Length=237, Percent_Identity=29.535864978903, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI142976729, Length=194, Percent_Identity=30.9278350515464, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI31542939, Length=193, Percent_Identity=33.160621761658, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=227, Percent_Identity=29.9559471365639, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI223718074, Length=195, Percent_Identity=32.3076923076923, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4503817, Length=189, Percent_Identity=31.7460317460317, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI210032112, Length=178, Percent_Identity=30.8988764044944, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=27.027027027027, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI40807363, Length=199, Percent_Identity=29.1457286432161, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI59889578, Length=238, Percent_Identity=30.672268907563, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706318, Length=197, Percent_Identity=26.9035532994924, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=28.4552845528455, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI25282469, Length=215, Percent_Identity=29.7674418604651, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI310128830, Length=202, Percent_Identity=28.7128712871287, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI310115468, Length=202, Percent_Identity=28.7128712871287, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI157739938, Length=190, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=32.1243523316062, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI109715829, Length=244, Percent_Identity=27.4590163934426, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19743808, Length=224, Percent_Identity=28.125, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4504505, Length=239, Percent_Identity=29.2887029288703, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI150247226, Length=192, Percent_Identity=33.8541666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7657478, Length=195, Percent_Identity=28.7179487179487, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI33667109, Length=182, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI32455239, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI5031765, Length=237, Percent_Identity=26.5822784810127, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=33.1967213114754, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI87082100, Length=249, Percent_Identity=33.7349397590361, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790717, Length=252, Percent_Identity=29.3650793650794, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=31.2, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=28.2258064516129, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=26.8292682926829, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=26.0700389105058, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1787820, Length=229, Percent_Identity=29.6943231441048, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1789057, Length=252, Percent_Identity=27.3809523809524, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=247, Percent_Identity=27.5303643724696, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1789378, Length=255, Percent_Identity=26.2745098039216, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787526, Length=258, Percent_Identity=27.5193798449612, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI2367175, Length=255, Percent_Identity=28.2352941176471, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI2367365, Length=236, Percent_Identity=29.2372881355932, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=31.9838056680162, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=31.9838056680162, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17567345, Length=196, Percent_Identity=32.6530612244898, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=29.5719844357977, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193203115, Length=198, Percent_Identity=30.3030303030303, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=254, Percent_Identity=28.3464566929134, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI193203117, Length=189, Percent_Identity=30.6878306878307, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17564282, Length=198, Percent_Identity=29.2929292929293, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=29.3893129770992, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=25.296442687747, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=28.2352941176471, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=28.1368821292776, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=28.4046692607004, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=28.4615384615385, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17508895, Length=197, Percent_Identity=28.4263959390863, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=261, Percent_Identity=29.1187739463602, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=266, Percent_Identity=27.4436090225564, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=256, Percent_Identity=30.46875, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=28.2442748091603, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538182, Length=200, Percent_Identity=29.5, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=244, Percent_Identity=29.0983606557377, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=27.6515151515151, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=27.0992366412214, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=27.4436090225564, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17565030, Length=257, Percent_Identity=28.7937743190661, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=202, Percent_Identity=28.7128712871287, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=29.1187739463602, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=27.2030651340996, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=25.4980079681275, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=26.2357414448669, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=184, Percent_Identity=36.4130434782609, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323882, Length=253, Percent_Identity=28.4584980237154, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=23.9043824701195, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=33.6, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643142, Length=245, Percent_Identity=30.6122448979592, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=31.0483870967742, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=30.1960784313725, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21356301, Length=262, Percent_Identity=27.8625954198473, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644339, Length=252, Percent_Identity=30.5555555555556, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=28.90625, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21358495, Length=222, Percent_Identity=27.4774774774775, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=32.9479768786127, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581726, Length=193, Percent_Identity=30.0518134715026, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640492, Length=187, Percent_Identity=28.3422459893048, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17737361, Length=194, Percent_Identity=31.9587628865979, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644337, Length=252, Percent_Identity=31.7460317460317, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640442, Length=192, Percent_Identity=29.6875, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24665264, Length=256, Percent_Identity=27.34375, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007236, Length=208, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24584748, Length=194, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076933, Length=194, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221510726, Length=185, Percent_Identity=30.8108108108108, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859837, Length=182, Percent_Identity=31.8681318681319, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25379; Mature: 25248

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPRQEHVLITGGGTGVGAACAQAFAAQGAKVTLMGRTEKTLAEQGLPYEVCDVTDAP
CCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEECCCCCC
SVTSAVARAAAARGPVTVAIANAGAAESVPFAKMQPELLTEMMAVNLGGVVNLWQAVLPG
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHCCC
MKEAGRGRMIAVASTAGLKGYAYVSAYCAAKHAVVGLTRSLAKELARTGVTVNAICPGFV
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
ETPMLQRSIDNIRAKTGMTSEEAAGALKADNPQGRFVQPEEVADAALWLASDTAGSVNGH
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCC
ALALTGGEI
EEEEECCCC
>Mature Secondary Structure 
SQDPRQEHVLITGGGTGVGAACAQAFAAQGAKVTLMGRTEKTLAEQGLPYEVCDVTDAP
CCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCEEEECCCCCC
SVTSAVARAAAARGPVTVAIANAGAAESVPFAKMQPELLTEMMAVNLGGVVNLWQAVLPG
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHCCCHHHHHHHHHCCC
MKEAGRGRMIAVASTAGLKGYAYVSAYCAAKHAVVGLTRSLAKELARTGVTVNAICPGFV
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHH
ETPMLQRSIDNIRAKTGMTSEEAAGALKADNPQGRFVQPEEVADAALWLASDTAGSVNGH
HHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCCC
ALALTGGEI
EEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1508151 [H]