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The map label for this gene is cobK [H]

Identifier: 99082055

GI number: 99082055

Start: 2327557

End: 2328318

Strand: Reverse

Name: cobK [H]

Synonym: TM1040_2215

Alternate gene names: 99082055

Gene position: 2328318-2327557 (Counterclockwise)

Preceding gene: 99082065

Following gene: 99082047

Centisome position: 72.74

GC content: 67.45

Gene sequence:

>762_bases
ATGAGAAAACTTCTGCTTCTGGGCGGCACCACCGAGGCGTCGCGATTGGCTCAGCACCTGGCGCAGAGTTGGGTCCGTGA
CGATCCGGTGGCCGGGCGTCAGGCGGTGTTTTCCTACGCAGGCCGCACCGCGCGCCCGGCGCAGCAGCCGTTGCCCTGCC
GGATTGGCGGCTTTGGGGGCGTGCCCGGCCTGGTCGCCTATCTCGAGCGCGAAGAGATCACGCATGTCGTGGACGCCACA
CATCCTTTTGCCGCGCAGATGAGTCTCAACGCGACCCAGGCCTGCGCCGAGGTGGGTGTGCCACTGGTGGCCTTTGAACG
CCCGGCTTGGCAGCCGCATCCGGGCGATCATTGGACTCATGTGCGCGATATGGCGGGGGCCGTGGCGGCCTTGCCCGAGG
CCGGCGCGCGGGTGTTTCTTGCAATTGGCAAGCAGCATGTGGCGGCGTTTGCGGTAAAGCCCGAGAACCACTATCTGCTG
CGGTTGGTTGATGCGCCCGAGGACGCGCTGAGCCTGCCCAAGGCCACGGTGGTTGTGGCGCGCGGCCCCTTTGATGCGGC
AGGGGATGAGGCTCTGATGCGCAGCCATCGGATCACCCATGTGGTCGCCAAGAACGCGGGCGGCGCGGGGGCCGAAGCCA
AGCTCAGCGCCGCGCGCAGTCTTGCGTTGCCGGTCATTATGATCGACCGGCCCGAGGGGCCCGCACGCGAGGTGCTGGGC
TCGGTGGCAGAGGTGATGCGCTGGCTTGACCACGGGGCTTAA

Upstream 100 bases:

>100_bases
TGCGGATCGGCTTGCATCCGAGAGCCCATCAAGGCCATTTTCGCCAAGCCCGATCAGGGTGAGCCATGGGCGCGAGGGGC
CCTTTGTCAGAGGATCAAAC

Downstream 100 bases:

>100_bases
GCGTCCTTTGTGGCGGTGTTGGCGGCTGTGTGATAAGCGGGCTGGTGTCCAGGCTGGTGTCCGGGTGCAAACCGCGGGGT
GTAGACATAAGAGCCGACGC

Product: precorrin-6A reductase

Products: NA

Alternate protein names: Precorrin-6X reductase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRKLLLLGGTTEASRLAQHLAQSWVRDDPVAGRQAVFSYAGRTARPAQQPLPCRIGGFGGVPGLVAYLEREEITHVVDAT
HPFAAQMSLNATQACAEVGVPLVAFERPAWQPHPGDHWTHVRDMAGAVAALPEAGARVFLAIGKQHVAAFAVKPENHYLL
RLVDAPEDALSLPKATVVVARGPFDAAGDEALMRSHRITHVVAKNAGGAGAEAKLSAARSLALPVIMIDRPEGPAREVLG
SVAEVMRWLDHGA

Sequences:

>Translated_253_residues
MRKLLLLGGTTEASRLAQHLAQSWVRDDPVAGRQAVFSYAGRTARPAQQPLPCRIGGFGGVPGLVAYLEREEITHVVDAT
HPFAAQMSLNATQACAEVGVPLVAFERPAWQPHPGDHWTHVRDMAGAVAALPEAGARVFLAIGKQHVAAFAVKPENHYLL
RLVDAPEDALSLPKATVVVARGPFDAAGDEALMRSHRITHVVAKNAGGAGAEAKLSAARSLALPVIMIDRPEGPAREVLG
SVAEVMRWLDHGA
>Mature_253_residues
MRKLLLLGGTTEASRLAQHLAQSWVRDDPVAGRQAVFSYAGRTARPAQQPLPCRIGGFGGVPGLVAYLEREEITHVVDAT
HPFAAQMSLNATQACAEVGVPLVAFERPAWQPHPGDHWTHVRDMAGAVAALPEAGARVFLAIGKQHVAAFAVKPENHYLL
RLVDAPEDALSLPKATVVVARGPFDAAGDEALMRSHRITHVVAKNAGGAGAEAKLSAARSLALPVIMIDRPEGPAREVLG
SVAEVMRWLDHGA

Specific function: Catalyzes the reduction of the macrocycle of precorrin- 6X into precorrin-6Y [H]

COG id: COG2099

COG function: function code H; Precorrin-6x reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin-6x reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003723 [H]

Pfam domain/function: PF02571 CbiJ [H]

EC number: =1.3.1.54 [H]

Molecular weight: Translated: 26859; Mature: 26859

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS51014 COBK_CBIJ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLLLLGGTTEASRLAQHLAQSWVRDDPVAGRQAVFSYAGRTARPAQQPLPCRIGGFGG
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCC
VPGLVAYLEREEITHVVDATHPFAAQMSLNATQACAEVGVPLVAFERPAWQPHPGDHWTH
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCHHH
VRDMAGAVAALPEAGARVFLAIGKQHVAAFAVKPENHYLLRLVDAPEDALSLPKATVVVA
HHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEECCCHHHHHCCCEEEEEE
RGPFDAAGDEALMRSHRITHVVAKNAGGAGAEAKLSAARSLALPVIMIDRPEGPAREVLG
ECCCCCCCHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHH
SVAEVMRWLDHGA
HHHHHHHHHHCCC
>Mature Secondary Structure
MRKLLLLGGTTEASRLAQHLAQSWVRDDPVAGRQAVFSYAGRTARPAQQPLPCRIGGFGG
CCEEEEECCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCEEECCCCC
VPGLVAYLEREEITHVVDATHPFAAQMSLNATQACAEVGVPLVAFERPAWQPHPGDHWTH
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCHHH
VRDMAGAVAALPEAGARVFLAIGKQHVAAFAVKPENHYLLRLVDAPEDALSLPKATVVVA
HHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEECCCHHHHHCCCEEEEEE
RGPFDAAGDEALMRSHRITHVVAKNAGGAGAEAKLSAARSLALPVIMIDRPEGPAREVLG
ECCCCCCCHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCHHHHHHH
SVAEVMRWLDHGA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]