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The map label for this gene is cobW [H]

Identifier: 99082049

GI number: 99082049

Start: 2319801

End: 2320835

Strand: Direct

Name: cobW [H]

Synonym: TM1040_2209

Alternate gene names: 99082049

Gene position: 2319801-2320835 (Clockwise)

Preceding gene: 99082048

Following gene: 99082050

Centisome position: 72.47

GC content: 60.97

Gene sequence:

>1035_bases
ATGACCTCATTGAACAAGATCCCCGTCACCGTCATCACCGGCTTTCTGGGCGCGGGCAAAACCACATTGATCCGTCACCT
GATGCAGAACCCGCAGGGCAAGCGCCTCGCTGTGGTGGTGAACGAATTTGGCACCGCCGGTGTGGATGGCGACATCCTGA
AATCCTGCGCGGATGACAACTGCCCCGCAGAGAACATCATGGAGCTCGCAAACGGCTGCATCTGCTGCACCGTGGCGGAT
GATTTCATCCCCACCATCGAGAGCCTGATGGCGCTGCCCGAACCGCCCGAACACATCGTTATCGAGACCTCTGGCCTGGC
GCTGCCCAAACCGCTGCTCAAGGCCTTTGATTGGCCCGCGATCCGCTCGCGCATCACCGTTGACGGTGTGATCGCTCTGG
CTGATGCCGAGGCCGTCGCCAAGGGCCAGTTTGCCCCAGATCTGGACGCCGTGCAGGCCCAGCGCGAGGCAGACGAGAGC
CTCGATCACGAAACCCCGCTCTCCGAAGTCTTTGAAGATCAGATCGCCTGCGCCGATATCGTACTGTTGTCCAAGGCCGA
TCTCGCCGGTGAGGCCGGTGTCGACAAAGCCCGCGCGATCATCGAATCTGAGGCCCCGCGCAAACTGCCGATCCTGCCGA
TGACCGAAGGCGTGATCGATCCTCGCGTGATCCTCGGACTGGAAGCTGCGGCCGAAGACGACCTTGATGCCCGCCCGAGC
CATCACGACGGACATCACGATCACGAACATGACGATTTTGAATCGATCGTGGTCGAAATGGGCGAAGTATCCGACCCCGA
AGACCTGCAAAAACGGATCATCGAGATGGCCCGCAGCCGCAACATCCTGCGGGTGAAGGGCTATGTGGCCGTGGAAGGAA
AACCGATGCGAATGCTGGTACAAGCGGTGGGCGAACGTCTGCGCGCGCAATACGACCAACCCTGGGGCGCACAGGAGCGT
AAAACCCAGCTGGTGGTGATCGCCGAGCATGATAACGTCGACACAGCAGGCATCCACGCCGATCTCGGGGCCTGA

Upstream 100 bases:

>100_bases
GCGCTCACGCCGACACAAGCCCCCGGCGCTCAGACCGAAGACACCCCAGACACACCTGCGTTGCAAAGCGCAAAGGATTG
ATCCGAAAGGCCGATCTCAC

Downstream 100 bases:

>100_bases
GTTTCCACACCAAGGGCGCTGACCTCTCGCCGTGAGGTCCCGCCCGACCCTCCCCCGGGAGGGCGCTTTGCACCCATACA
GGGTCTGACGCTGCCCTCTC

Product: cobalamin (vitamin B12) biosynthesis CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MTSLNKIPVTVITGFLGAGKTTLIRHLMQNPQGKRLAVVVNEFGTAGVDGDILKSCADDNCPAENIMELANGCICCTVAD
DFIPTIESLMALPEPPEHIVIETSGLALPKPLLKAFDWPAIRSRITVDGVIALADAEAVAKGQFAPDLDAVQAQREADES
LDHETPLSEVFEDQIACADIVLLSKADLAGEAGVDKARAIIESEAPRKLPILPMTEGVIDPRVILGLEAAAEDDLDARPS
HHDGHHDHEHDDFESIVVEMGEVSDPEDLQKRIIEMARSRNILRVKGYVAVEGKPMRMLVQAVGERLRAQYDQPWGAQER
KTQLVVIAEHDNVDTAGIHADLGA

Sequences:

>Translated_344_residues
MTSLNKIPVTVITGFLGAGKTTLIRHLMQNPQGKRLAVVVNEFGTAGVDGDILKSCADDNCPAENIMELANGCICCTVAD
DFIPTIESLMALPEPPEHIVIETSGLALPKPLLKAFDWPAIRSRITVDGVIALADAEAVAKGQFAPDLDAVQAQREADES
LDHETPLSEVFEDQIACADIVLLSKADLAGEAGVDKARAIIESEAPRKLPILPMTEGVIDPRVILGLEAAAEDDLDARPS
HHDGHHDHEHDDFESIVVEMGEVSDPEDLQKRIIEMARSRNILRVKGYVAVEGKPMRMLVQAVGERLRAQYDQPWGAQER
KTQLVVIAEHDNVDTAGIHADLGA
>Mature_343_residues
TSLNKIPVTVITGFLGAGKTTLIRHLMQNPQGKRLAVVVNEFGTAGVDGDILKSCADDNCPAENIMELANGCICCTVADD
FIPTIESLMALPEPPEHIVIETSGLALPKPLLKAFDWPAIRSRITVDGVIALADAEAVAKGQFAPDLDAVQAQREADESL
DHETPLSEVFEDQIACADIVLLSKADLAGEAGVDKARAIIESEAPRKLPILPMTEGVIDPRVILGLEAAAEDDLDARPSH
HDGHHDHEHDDFESIVVEMGEVSDPEDLQKRIIEMARSRNILRVKGYVAVEGKPMRMLVQAVGERLRAQYDQPWGAQERK
TQLVVIAEHDNVDTAGIHADLGA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=320, Percent_Identity=32.1875, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI126722884, Length=320, Percent_Identity=31.875, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI148727351, Length=348, Percent_Identity=31.6091954022989, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223941779, Length=320, Percent_Identity=31.25, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI146231952, Length=320, Percent_Identity=31.25, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI223941776, Length=309, Percent_Identity=30.0970873786408, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI119120938, Length=137, Percent_Identity=41.6058394160584, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI87082430, Length=336, Percent_Identity=31.25, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1788499, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324356, Length=188, Percent_Identity=31.3829787234043, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 37210; Mature: 37079

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLNKIPVTVITGFLGAGKTTLIRHLMQNPQGKRLAVVVNEFGTAGVDGDILKSCADDN
CCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHCCCC
CPAENIMELANGCICCTVADDFIPTIESLMALPEPPEHIVIETSGLALPKPLLKAFDWPA
CCHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCHH
IRSRITVDGVIALADAEAVAKGQFAPDLDAVQAQREADESLDHETPLSEVFEDQIACADI
HHCEEEECCEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VLLSKADLAGEAGVDKARAIIESEAPRKLPILPMTEGVIDPRVILGLEAAAEDDLDARPS
HEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCCCCCCCC
HHDGHHDHEHDDFESIVVEMGEVSDPEDLQKRIIEMARSRNILRVKGYVAVEGKPMRMLV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
QAVGERLRAQYDQPWGAQERKTQLVVIAEHDNVDTAGIHADLGA
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSLNKIPVTVITGFLGAGKTTLIRHLMQNPQGKRLAVVVNEFGTAGVDGDILKSCADDN
CCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHCCCC
CPAENIMELANGCICCTVADDFIPTIESLMALPEPPEHIVIETSGLALPKPLLKAFDWPA
CCHHHHHHHHCCEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHCCCHH
IRSRITVDGVIALADAEAVAKGQFAPDLDAVQAQREADESLDHETPLSEVFEDQIACADI
HHCEEEECCEEEEECHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VLLSKADLAGEAGVDKARAIIESEAPRKLPILPMTEGVIDPRVILGLEAAAEDDLDARPS
HEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEHHHCCCCCCCCCC
HHDGHHDHEHDDFESIVVEMGEVSDPEDLQKRIIEMARSRNILRVKGYVAVEGKPMRMLV
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHH
QAVGERLRAQYDQPWGAQERKTQLVVIAEHDNVDTAGIHADLGA
HHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]