Click here to switch to the map view.

The map label for this gene is cobO [H]

Identifier: 99082047

GI number: 99082047

Start: 2318230

End: 2318916

Strand: Reverse

Name: cobO [H]

Synonym: TM1040_2207

Alternate gene names: 99082047

Gene position: 2318916-2318230 (Counterclockwise)

Preceding gene: 99082055

Following gene: 99082036

Centisome position: 72.44

GC content: 56.48

Gene sequence:

>687_bases
ATGGGCAAACCCTGGGTCAGACCCGCAAGGAGCAAGACAGTGAGCGACCAGACATCCCAAAAGTCCGAAACCGGCATCTC
AGAAGAAGAAGCGGCACGCCATGCCTCGAAGATGGCCAAAAAGAAGGCCGCGCGGGACCGGATGATGAAGACGAAAGATG
GCGAAAAAGGTCTGATTATTGTTCACACCGGCCCGGGCAAGGGCAAATCCTCTTCGGGATTCGGTATGATCATGCGCTGT
ATCGCCCATGGCATGCCCTCGGCGGTGGTGCAGTTCATCAAGGGGGCCTGGCAGACCGGCGAACGGACGCTGATCGAGGA
AAACTTCTCGGATCTCTGTCAGTTTTACGCGATGGGCGAGGGGTTTACCTGGGAGACGCAGGACAAGGCCCGGGATATTG
CCGCTGCGCGCGCGGGCTGGGAAAAGGCCAAGGAGATGATCCTTGATGAGAAGAACACGATGGTTCTGCTCGATGAGATC
AACATTGCGCTGCGCTATGAGTATCTTGACCTTGAGGAGGTTCTTGAGTTCCTCGTCGAGCACAAACCGGCGATGACGCA
TGTGGTGCTCACCGGGCGCAACGCCAAGGAAGAATTGATCGAGATTGCAGATCTGGTCACAGAGATGACTCAGGTGAAGC
ATCCCTTCCGTGCCGGGATCAAGGCGCAGAAGGGCGTGGAATTCTAA

Upstream 100 bases:

>100_bases
GGATGATCCCGGCCCGACACATTCCCTCTTCGCCCAAAGGCTGTCACCTTCGGGAACCAACGAAATTTCCTTGCGCCATG
GGGCATGTCTTTGTCAAGAG

Downstream 100 bases:

>100_bases
ACCCCAAACGCAGGGCGCGGGGTGGGGATGCGAGGCGCTGCCTCGCGCTCCGGGATATTTTTCGTTAGAAGAAGAGGGGC
CGCGGGCCCCTCATTTTTGT

Product: cob(I)yrinic acid a,c-diamide adenosyltransferase

Products: NA

Alternate protein names: Cob(I)alamin adenosyltransferase; Corrinoid adenosyltransferase [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MGKPWVRPARSKTVSDQTSQKSETGISEEEAARHASKMAKKKAARDRMMKTKDGEKGLIIVHTGPGKGKSSSGFGMIMRC
IAHGMPSAVVQFIKGAWQTGERTLIEENFSDLCQFYAMGEGFTWETQDKARDIAAARAGWEKAKEMILDEKNTMVLLDEI
NIALRYEYLDLEEVLEFLVEHKPAMTHVVLTGRNAKEELIEIADLVTEMTQVKHPFRAGIKAQKGVEF

Sequences:

>Translated_228_residues
MGKPWVRPARSKTVSDQTSQKSETGISEEEAARHASKMAKKKAARDRMMKTKDGEKGLIIVHTGPGKGKSSSGFGMIMRC
IAHGMPSAVVQFIKGAWQTGERTLIEENFSDLCQFYAMGEGFTWETQDKARDIAAARAGWEKAKEMILDEKNTMVLLDEI
NIALRYEYLDLEEVLEFLVEHKPAMTHVVLTGRNAKEELIEIADLVTEMTQVKHPFRAGIKAQKGVEF
>Mature_227_residues
GKPWVRPARSKTVSDQTSQKSETGISEEEAARHASKMAKKKAARDRMMKTKDGEKGLIIVHTGPGKGKSSSGFGMIMRCI
AHGMPSAVVQFIKGAWQTGERTLIEENFSDLCQFYAMGEGFTWETQDKARDIAAARAGWEKAKEMILDEKNTMVLLDEIN
IALRYEYLDLEEVLEFLVEHKPAMTHVVLTGRNAKEELIEIADLVTEMTQVKHPFRAGIKAQKGVEF

Specific function: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids [H]

COG id: COG2109

COG function: function code H; ATP:corrinoid adenosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Cob(I)alamin adenosyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1787525, Length=196, Percent_Identity=42.8571428571429, Blast_Score=168, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003724 [H]

Pfam domain/function: PF02572 CobA_CobO_BtuR [H]

EC number: =2.5.1.17 [H]

Molecular weight: Translated: 25534; Mature: 25403

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKPWVRPARSKTVSDQTSQKSETGISEEEAARHASKMAKKKAARDRMMKTKDGEKGLII
CCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VHTGPGKGKSSSGFGMIMRCIAHGMPSAVVQFIKGAWQTGERTLIEENFSDLCQFYAMGE
EECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
GFTWETQDKARDIAAARAGWEKAKEMILDEKNTMVLLDEINIALRYEYLDLEEVLEFLVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCHHHHHHHHHH
HKPAMTHVVLTGRNAKEELIEIADLVTEMTQVKHPFRAGIKAQKGVEF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
GKPWVRPARSKTVSDQTSQKSETGISEEEAARHASKMAKKKAARDRMMKTKDGEKGLII
CCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VHTGPGKGKSSSGFGMIMRCIAHGMPSAVVQFIKGAWQTGERTLIEENFSDLCQFYAMGE
EECCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
GFTWETQDKARDIAAARAGWEKAKEMILDEKNTMVLLDEINIALRYEYLDLEEVLEFLVE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEECCHHHHHHHHHH
HKPAMTHVVLTGRNAKEELIEIADLVTEMTQVKHPFRAGIKAQKGVEF
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1655697; 1917862 [H]